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Making Organisms Model Human Behavior: Situated Models in North-American Alcohol Research, since 1950

  • Rachel A. Ankeny (a1), Sabina Leonelli (a2), Nicole C. Nelson (a3) and Edmund Ramsden (a4)

We examine the criteria used to validate the use of nonhuman organisms in North-American alcohol addiction research from the 1950s to the present day. We argue that this field, where the similarities between behaviors in humans and non-humans are particularly difficult to assess, has addressed questions of model validity by transforming the situatedness of non-human organisms into an experimental tool. We demonstrate that model validity does not hinge on the standardization of one type of organism in isolation, as often the case with genetic model organisms. Rather, organisms are viewed as necessarily situated: they cannot be understood as a model for human behavior in isolation from their environmental conditions. Hence the environment itself is standardized as part of the modeling process; and model validity is assessed with reference to the environmental conditions under which organisms are studied.

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Bruce K. Alexander , Robert B. Coambs , and Patricia F. Hadaway . 1978. “The Effect of Housing and Gender on Morphine Self-Administration in Rats.” Psychopharmacology 58:175–79.

Rachel A Ankeny . 2001a. “Model Organisms as Models: Understanding the ‘Lingua Franca’ of the Human Genome Project.” Philosophy of Science 68:S25161.

Rachel A Ankeny . 2001b. “The Natural History of C. elegans Research.” Nature Reviews Genetics 2:474–78.

Richard L. Bell , Zachary A. Rodd , Lawrence Lumeng , James M. Murphy , and William J. McBride . 2006. “The Alcohol-Preferring P Rat and Animal Models of Excessive Alcohol Drinking.” Addiction Biology 11:270–88.

Richard M Burian . 1993. “How the Choice of Experimental Organism Matters: Epistemological Reflections on an Aspect of Biological Practice.” Journal of the History of Biology 26:351–67.

Nancy D Campbell . 2007. Discovering Addiction: The Science and Politics of Substance Abuse Research. Ann Arbor: University of Michigan Press.

Elissa J. Chesler , Sonya G. Wilson , William R. Lariviere , Sandra L. Rodriguez-Zas , and Jeffrey S. Mogil . 2002. “Identification and Ranking of Genetic and Laboratory Environment Factors Influencing a Behavioral Trait, Thermal Nociception, via Computational Analysis of a Large Data Archive.” Neuroscience and Biobehavioral Reviews 26:907–23.

Gary A. Churchill , David C. Airey , Hooman Allayee , Joe M. Angel , Alan D. Attie , Jackson Beatty , William D. Beavis , et al.2004. “The Collaborative Cross, a Community Resource for the Genetic Analysis of Complex Traits.” Nature Genetics 36:1133–7.

Adele E Clarke . 1998. Disciplining Reproduction: Modernity, American Life Sciences and the “Problems of Sex.” Berkeley CA: University of California Press.

Bonnie T Clause . 1993. “The Wistar Rat as a Right Choice: Establishing Mammalian Standards and the Ideal of a Standardized Mammal.” Journal of the History of Biology 26:329–49.

John J Conger . 1958. “Perception, Learning, and Emotion: The Role of Alcohol.” Annals of the Political Academy of Political and Social Science 315:31–9.

John C. Crabbe , Douglas Wahlsten , and Bruce C. Dudek . 1999. “Genetics of Mouse Behavior: Interactions with Laboratory Environment.” Science 284:1670–72.

Jacqueline N Crawley . 2007. What's Wrong with My Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice, 2nd ed.Hoboken NJ: Wiley.

Jacqueline N. Crawley , John K. Belknap , Allan Collins , John C. Crabbe , Wayne Frankel , Norman Henderson , Robert J. Hitzemann , et al.1997. “Behavioral Phenotypes of Inbred Mouse Strains: Implications and Recommendations for Molecular Studies.” Psychopharmacology 132:107–24.

Rowland H Davis . 2004. “The Age of Model Organisms.” Nature Reviews Genetics 5:6976.

Soraya de Chadarevian . 1998. “Of Worms and Programmes: Caenorhabditis elegans and the Study of Development.” Studies in History and Philosophy of Biological and Biomedical Sciences 29:81105.

Kalervo Eriksson , 1972. “Behavioral and Physiological Differences among Rat Strains Specially Selected for Their Alcohol Consumption.” Annals of the New York Academy of Sciences 197:3241.

Claudia Fahlke , Joseph G. Lorenz , Jeffrey Long , Maribeth Champoux , Stephen J. Suomi , and J. Dee Higley . 2006. “Rearing Experiences and Stress-Induced Plasma Cortisol as Early Risk Factors for Excessive Alcohol Consumption in Nonhuman Primates.” Alcoholism: Clinical and Experimental Research 24:644–50.

John L Falk . 1961. “Production of Polydipsia in Normal Rats by an Intermittent Food Schedule.” Science 133:195–6.

John L Falk . 1983. “Drug Dependence: Myth or Motive?Pharmacology Biochemistry and Behavior 19:385–91

John L. Falk , Herman H. Samson , and Gail Winger . 1972. “Behavioral Maintenance of High Concentrations of Blood Ethanol and Physical Dependence in the Rat.” Science 177:811–3.

John L. Falk , Herman H. Samson , and Gail Winger . 1976. “Polydipsia-Induced Alcohol Dependency in Rats.” Science 192:492.

Carrie Friese , and Adele E. Clarke . 2011. “Transposing Bodies of Knowledge and Technique: Animal Models at Work in Reproductive Sciences.” Social Studies of Science 42:3152.

Howard Gest . 1995. “Arabidopsis to Zebrafish: A Commentary on ‘Rosetta Stone’ Model Systems in the Biological Sciences.” Perspectives in Biology and Medicine 39:7785.

Alexis S. Green , and Nicholas J. Grahame . 2008. “Ethanol Drinking in Rodents: Is Free-Choice Drinking Related to the Reinforcing Effects of Ethanol?Alcohol 42:111.

Donna Haraway . 1988. “Situated Knowledges: the Science Question in Feminism and the Privilege of Partial Perspective.” Feminist Studies 14:575–99.

Frederic L Holmes . 1993. “The Old Martyr of Science: The Frog in Experimental Physiology.” Journal of the History of Biology 26:311–28.

Petri Hyytiä , and John D. Sinclair . 1989. “Demonstration of Lever Pressing for Oral Ethanol by Rats with no Prior Training or Ethanol Experience.” Alcohol 6:161164.

E. Morton Jellinek , and Norman Jolliffe . 1940. “Effects of Alcohol on the Individual: Review of the Literature of 1939.” Quarterly Journal of Studies in Alcohol 1:110181.

Sabina Leonelli . 2008. “Performing Abstraction: Two Ways of Modeling Arabidopsis thaliana.” Biology and Philosophy 23:509–28.

David Lester , and Earl X. Freed . 1972. “A Rat Model of Alcoholism?Annals of the New York Academy of Sciences 197:54–9.

David Lester , and Earl X. Freed . 1973. “Criteria for an Animal Model of Alcoholism.” Pharmacology Biochemistry and Behavior 1:103–7.

Cheryl A Logan . 1999. “The Altered Rationale for the Choice of a Standard Animal in Experimental Psychology: Henry H. Donaldson, Adolf Meyer, and ‘the’ Albino Rat.” History of Psychology 2:32–4.

Cheryl A Logan . 2002. “Before There Were Standards: The Role of Test Animals in the Production of Scientific Generality in Physiology.” Journal of the History of Biology 35:329–63.

Jules H. Masserman , and K. S. Yum . 1946. “An Analysis of the Influence of Alcohol on Experimental Neuroses in Cats.” Psychosomatic Medicine 8:3652.

William J. McBride , and Ting Kai Li . 1998. “Animal Models of Alcoholism: Neurobiology of High Alcohol-Drinking Behavior in Rodents.” Critical Reviews in Neurobiology 12:339–69.

Nancy K Mello . 1973. “A Review of Methods to Induce Alcohol Addiction in Animals.” Pharmacology Biochemistry and Behavior 1:89101.

Nancy K. Mello , and Jack H. Mendelson . 1971. “Evaluation of a Polydipsia Technique to Induce Alcohol Consumption in Monkeys.” Physiology and Behavior 7:827–36.

Walter R Miles . 1930. “On the History of Research with Rats and Mazes: A Collection of Notes.” Journal of General Psychology 3:324337.

Mary S Morgan ., and Margaret Morrison . 1999. Models as Mediators: Perspectives on Natural and Social Science. Cambridge UK: Cambridge University Press.

Robert M. Morse , and Daniel K. Flavin . 1992. “The Definition of Alcoholism.” Journal of the American Medical Association 268:1012–14.

Megan K. Mulligan , Igor Ponomarev , Stephen L. Boehm II , Julie A. Owen , Patricia S. Levin , Ari E. Berman , Yuri A. Blednov , et al.2008. “Alcohol Trait and Transcriptional Genomic Analysis of C57BL/6 Substrains.” Genes, Brain and Behavior 7:677–89.

Philip J Pauly . 1994. “Is Liquor Intoxicating? Scientists, Prohibition, and the Normalization of Drinking.” American Journal of Public Health 84:305–13.

Edmund Ramsden . 2011a. “From Rodent Utopia to Urban Hell: Population, Pathology, and the Crowded Rats of NIMH.” Isis 102:659–88.

Hans-Jörg Rheinberger . 2010. An Epistemology of the Concrete: Twentieth-Century Histories of Life. Chapel Hill NC: Duke University Press.

Curt P Richter . 1926. “A Study of the Effect of Moderate Doses of Alcohol on the Growth and Behavior of the Rat.” Journal of Experimental Zoology 44:397418.

Curt P. Richter , and Kathryne H. Campbell . 1940. “Alcohol Taste Thresholds and Concentrations of Solution Preferred by Rats.” Science 91:507–8.

S. Helene Richter , Joseph P. Garner , and Hanno Würbel . 2009. “Environmental Standardization: Cure or Cause of Poor Reproducibility in Animal Experiments?Nature Methods 6:257–61.

Herman H. Samson , Gerald A. Tolliver , Lawrence Lumeng and Ting Kai Li . 1989. “Ethanol Reinforcement in the Alcohol Nonpreferring Rat: Initiation Using Behavioral Techniques without Food Restriction.” Alcohol: Clinical and Experimental Research 13:378–85.

Boris Tabakoff , Laura Saba , Morton Printz , Pam Flodman , Coling Hodgkinson , David Goldman , George Koob , et al.2009. “Genetical Genomic Determinants of Alcohol Consumption in Rats and Humans.” BMC Biology 7:70.

Hanno Würbel . 2002. “Behavioral Phenotyping Enhanced: Beyond (Environmental) Standardization.” Genes, Brain and Behavior 1:38.

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Science in Context
  • ISSN: 0269-8897
  • EISSN: 1474-0664
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