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Making Organisms Model Human Behavior: Situated Models in North-American Alcohol Research, since 1950

  • Rachel A. Ankeny (a1), Sabina Leonelli (a2), Nicole C. Nelson (a3) and Edmund Ramsden (a4)
Argument

We examine the criteria used to validate the use of nonhuman organisms in North-American alcohol addiction research from the 1950s to the present day. We argue that this field, where the similarities between behaviors in humans and non-humans are particularly difficult to assess, has addressed questions of model validity by transforming the situatedness of non-human organisms into an experimental tool. We demonstrate that model validity does not hinge on the standardization of one type of organism in isolation, as often the case with genetic model organisms. Rather, organisms are viewed as necessarily situated: they cannot be understood as a model for human behavior in isolation from their environmental conditions. Hence the environment itself is standardized as part of the modeling process; and model validity is assessed with reference to the environmental conditions under which organisms are studied.

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Alexander, Bruce K., Coambs, Robert B., and Hadaway, Patricia F.. 1978. “The Effect of Housing and Gender on Morphine Self-Administration in Rats.” Psychopharmacology 58:175–79.
Ankeny, Rachel A. 1997. “The Conqueror Worm: An Historical and Philosophical Examination of the Use of the Nematode C. elegans as a Model Organism.” Ph.D. diss., University of Pittsburgh.
Ankeny, Rachel A. 2001a. “Model Organisms as Models: Understanding the ‘Lingua Franca’ of the Human Genome Project.” Philosophy of Science 68:S25161.
Ankeny, Rachel A. 2001b. “The Natural History of C. elegans Research.” Nature Reviews Genetics 2:474–78.
Ankeny, Rachel A. 2010. “Historiographic Considerations on Model Organisms: Or, How the Mureaucracy May Be Limiting Our Understanding of Contemporary Genetics and Genomics.” History and Philosophy of the Life Sciences 32:91104.
Ankeny, Rachel A., and Leonelli, Sabina. 2011. “What's So Special about Model Organisms?Studies in the History and Philosophy of Science 42:313–23.
Bell, Richard L., Rodd, Zachary A., Lumeng, Lawrence, Murphy, James M., and McBride, William J.. 2006. “The Alcohol-Preferring P Rat and Animal Models of Excessive Alcohol Drinking.” Addiction Biology 11:270–88.
Billings, John S., Atwater, W. O., Bowditch, H. P., Chittenden, R. H., Welch, W. H., 1903. “Report to the Sub-Committee on the Physiological and Pathological Aspects of the Drink Problem, Presneted to the Committee of Fifty.” In Physiological Aspects of the Liquor Problem, edited by Atwater, Wilbur O., Billings, John S., Bowditch, Henry P., Chittenden, Russell H., and Welch, William H.. Boston and New York: Houghton, Mifflin and Co.
Blocker, Jack S. Jr. 1989. American Temperance Movements: Cycles of Reform. Boston: Twayne.
Bogue, Molly A., and Grubb, Stephen C.. 2004. “The Mouse Phenome Project.” Genetica 122:71–4.
Broadhurst, Peter L. 1963. The Science of Animal Behaviour. Harmondsworth: Penguin Books.
Burian, Richard M. 1993. “How the Choice of Experimental Organism Matters: Epistemological Reflections on an Aspect of Biological Practice.” Journal of the History of Biology 26:351–67.
Bynum, William F. 1990. “‘C’est un malade’: Animal Models and Concepts of Human Diseases.” Journal of the History of Medicine 45:397413.
Campbell, Nancy D. 2007. Discovering Addiction: The Science and Politics of Substance Abuse Research. Ann Arbor: University of Michigan Press.
Chesler, Elissa J., Wilson, Sonya G., Lariviere, William R., Rodriguez-Zas, Sandra L., and Mogil, Jeffrey S.. 2002. “Identification and Ranking of Genetic and Laboratory Environment Factors Influencing a Behavioral Trait, Thermal Nociception, via Computational Analysis of a Large Data Archive.” Neuroscience and Biobehavioral Reviews 26:907–23.
Chester, Julia A., Blose, Annette M., Zweifel, Mark, and Froehlich, Janice C. 2004. “Effects of Stress on Alcohol Consumption in Rats Selectively Bred for High or Low Alcohol Drinking.” Alcoholism: Clinical and Experimental Research 28:385–93.
Churchill, Gary A., Airey, David C., Allayee, Hooman, Angel, Joe M., Attie, Alan D., Beatty, Jackson, Beavis, William D., et al. 2004. “The Collaborative Cross, a Community Resource for the Genetic Analysis of Complex Traits.” Nature Genetics 36:1133–7.
Cicero, Theodore J. 1979. “Critique of Animal Analogues of Alcoholism.” In Biochemistry and Pharmacology of Ethanol, vol. 2, edited by Majchrowicz, Edward and Noble, Ernest P., 533–60. New York: Plenum.
Cicero, Theodore J. 1980. “Animal Models of Alcoholism?” In Animal Models in Alcohol Research, edited by Eriksson, Kalervo, Sinclair, John D., and Kiianmaa, Kalervo, 99118. London: Academic Press.
Cicero, Theodore J., Snider, Stuart R., Perez, Vernon J., and Swanson, Larry W.. 1971. “Physical Dependence on and Tolerance to Alcohol in the Rat.” Physiology and Behavior 6:191–8.
Clarke, Adele E. 1998. Disciplining Reproduction: Modernity, American Life Sciences and the “Problems of Sex.” Berkeley CA: University of California Press.
Clarke, Adele E., and Fujimura, Joan H., eds. 1992. The Right Tools for the Job: At Work in Twentieth-Century Life Sciences. Princeton NJ: Princeton University Press.
Clause, Bonnie T. 1993. “The Wistar Rat as a Right Choice: Establishing Mammalian Standards and the Ideal of a Standardized Mammal.” Journal of the History of Biology 26:329–49.
Conger, John J. 1951. “The Effects of Alcohol on Conflict Behavior in the Albino Rat.” Quarterly Journal of Studies on Alcohol 12:129.
Conger, John J. 1956. “Reinforcement Theory and the Dynamics of Alcoholism.” Quarterly Journal of Studies on Alcohol 17:296305.
Conger, John J. 1958. “Perception, Learning, and Emotion: The Role of Alcohol.” Annals of the Political Academy of Political and Social Science 315:31–9.
Conrad, Peter. 1999. “A Mirage of Genes.” Sociology of Health and Illness 21:228–41.
Conrad, Peter, and Schneider, Joseph W.. 1980. Deviance and Medicalization: From Badness to Sickness. St. Louis MO: Mosby.
Crabbe, John C. 2012. “Translational Behaviour-Genetic Studies of Alcohol: Are We There Yet?Genes, Brain and Behavior 11:375386.
Crabbe, John C., Wahlsten, Douglas, and Dudek, Bruce C.. 1999. “Genetics of Mouse Behavior: Interactions with Laboratory Environment.” Science 284:1670–72.
Crawley, Jacqueline N. 1996. “Unusual Behavioral Phenotypes in Inbred Mouse Strains.” Trends in Neuroscience 19:181–2.
Crawley, Jacqueline N. 2007. What's Wrong with My Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice, 2nd ed.Hoboken NJ: Wiley.
Crawley, Jacqueline N., Belknap, John K., Collins, Allan, Crabbe, John C., Frankel, Wayne, Henderson, Norman, Hitzemann, Robert J., et al. 1997. “Behavioral Phenotypes of Inbred Mouse Strains: Implications and Recommendations for Molecular Studies.” Psychopharmacology 132:107–24.
Crist, Eileen. 1999. Images of Animals: Anthropomorphism and the Animal Mind. Philadelphia: Temple University Press.
Davis, Rowland H. 2004. “The Age of Model Organisms.” Nature Reviews Genetics 5:6976.
de Chadarevian, Soraya. 1998. “Of Worms and Programmes: Caenorhabditis elegans and the Study of Development.” Studies in History and Philosophy of Biological and Biomedical Sciences 29:81105.
Degeling, Chris. 2010. “Cutting a Bone to Heal a Ligament: Idealized Animals and Orthopaedics.” Medicine Studies 2:101–19.
Degeling, Chris, and Johnson, Jane. 2013. “Evaluating Animal Models: Some Taxonomic Worries.” Journal of Medicine and Philosophy 38 (2):91106.
Degler, Carl N. 1991. In Search of Human Nature: The Decline and Revival of Darwinism in American Social Thought. New York: Oxford University Press.
Dole, Vincent P., and Gentry, R. Thomas. 1984. “Toward an Analogue of Alcoholism in Mice: Scale Factors in the Model.” Proceedings of the National Academy of the Sciences 81:3543–3546.
Egli, Mark. 2005. “Can Experimental Paradigms and Animal Models Be Used to Discover Clinically Effective Medications for Alcoholism?Addiction Biology 10:309–19.
Endersby, Jim. 2007. A Guinea Pig's History of Biology. London: Random House.
Engber, Daniel. 2011. “The Trouble with Black-6.” Slate, November 17. http://www.slate.com/articles/health_and_science/the_mouse_trap/2011/11/black_6_lab_mice_and_the_history_of_biomedical_research.html (last accessed 1 April 2014).
Eriksson, Kalervo, 1972. “Behavioral and Physiological Differences among Rat Strains Specially Selected for Their Alcohol Consumption.” Annals of the New York Academy of Sciences 197:3241.
Eriksson, Kalervo., Sinclair, John D., and Kiianmaa, Kalervo, eds. 1980. Animal Models in Alcohol Research. London: Academic Press.
Fahlke, Claudia, Lorenz, Joseph G., Long, Jeffrey, Champoux, Maribeth, Suomi, Stephen J., and Higley, J. Dee. 2006. “Rearing Experiences and Stress-Induced Plasma Cortisol as Early Risk Factors for Excessive Alcohol Consumption in Nonhuman Primates.” Alcoholism: Clinical and Experimental Research 24:644–50.
Falk, John L. 1961. “Production of Polydipsia in Normal Rats by an Intermittent Food Schedule.” Science 133:195–6.
Falk, John L. 1983. “Drug Dependence: Myth or Motive?Pharmacology Biochemistry and Behavior 19:385–91
Falk, John L., Samson, Herman H., and Winger, Gail. 1972. “Behavioral Maintenance of High Concentrations of Blood Ethanol and Physical Dependence in the Rat.” Science 177:811–3.
Falk, John L., Samson, Herman H., and Winger, Gail. 1976. “Polydipsia-Induced Alcohol Dependency in Rats.” Science 192:492.
Freed, Earl X., and Lester, David. 1970. “Schedule-Induced Consumption of Ethanol: Calories or Chemotherapy?Physiology and Behavior 5:555–60.
Freund, Gerhard. 1969. “Alcohol and Withdrawal Syndrome in Mice.” Archives of Neurology 21:315–20.
Friese, Carrie, and Clarke, Adele E.. 2011. “Transposing Bodies of Knowledge and Technique: Animal Models at Work in Reproductive Sciences.” Social Studies of Science 42:3152.
Froehlich, . 2004. “Effects of Stress on Alcohol Consumption in Rats Selectively Bred for High or Low Alcohol Drinking.” Alcoholism: Clinical and Experimental Research 28:385–93.
Gauvin, David V., Moore, Kyle R., and Holloway, Frank A.. 1993. “Do Rat Strain Differences in Ethanol Consumption Reflect Differences in Ethanol Sensitivity or the Preparedness to Learn?Alcohol 10:3743.
Gest, Howard. 1995. “Arabidopsis to Zebrafish: A Commentary on ‘Rosetta Stone’ Model Systems in the Biological Sciences.” Perspectives in Biology and Medicine 39:7785.
Grahame, Nicholas J., and Cunningham, Christopher L.. 1997. “Intravenous Ethanol Self-Administration in C57BL/6J and DBA/2J Mice.” Alcohol: Clinical and Experimental Research 21:5662.
Green, Alexis S., and Grahame, Nicholas J.. 2008. “Ethanol Drinking in Rodents: Is Free-Choice Drinking Related to the Reinforcing Effects of Ethanol?Alcohol 42:111.
Guerrini, Anita. 2003. Experimenting with Humans and Animals: From Galen to Animal Rights. Baltimore MD: The Johns Hopkins University Press.
Hannigan, John H., Berman, Robert F., and Zajac, Carol S.. 1993. “Environmental Enrichment and the Behavioral Effects of Prenatal Exposure to Alcohol in Rats.” Neurotoxicology and Teratology 154:261–6.
Haraway, Donna. 1988. “Situated Knowledges: the Science Question in Feminism and the Privilege of Partial Perspective.” Feminist Studies 14:575–99.
Haraway, Donna. 1997. Modest_Witness@Second_Millennium.FemaleMan©_Meets_OncoMouse™: Feminism and Technoscience. New York: Routledge.
Hodge, Clifton F. 1903. “The Influence of Alcohol on Growth and Development.” In Physiological Aspects of the Liquor Problem, edited by Atwater, Wilbur O., Billings, John S., Bowditch, Henry P., Chittenden, Russell H., and Welch, William H., 359–75. Boston: Houghton Mifflin.
Holmes, Frederic L. 1993. “The Old Martyr of Science: The Frog in Experimental Physiology.” Journal of the History of Biology 26:311–28.
Huss, Magnus. 1849. Alcoholismus Chronicus eller Chronisk Alkoholssjukdom. Ett Bidrag till Dyskrasiernas Kännedom: Enlight egen och andras erfarenhet [Chronic Alcohol Disease: A Contribution to Diagnostic Knowledge, to Enlighten One's Own and Others’ Experience]. Stockholm: Beckman.
Hyman, Steven E. 2006. “Using Genetics to Understand Human Behavior: Promises and Risks.” In Wrestling with Behavioral Genetics: Science, Ethics, and Public Conversation, edited by Parens, Erik, Chapman, Audrey R., and Press, Nancy, 109–30. Baltimore MD: Johns Hopkins University Press.
Hyytiä, Petri, and Sinclair, John D.. 1989. “Demonstration of Lever Pressing for Oral Ethanol by Rats with no Prior Training or Ethanol Experience.” Alcohol 6:161164.
Laboratory, Jackson. 2003. “JAX Notes. Issue 492, Winter 2003,” http://jaxmice.jax.org/jaxnotes/archive/492a.html (last accessed August 29, 2012).
Jellinek, E. Morton, ed. 1942. Alcohol Addiction and Chronic Alcoholism. New Haven: Yale University Press.
Jellinek, E. Morton. 1960. The Disease Concept of Alcoholism. New Haven: Hillhouse.
Jellinek, E. Morton, and McFarland, Ross A.. 1940. “Analysis of Psychological Experiments on the Effects of Alcohol.” Quarterly Journal of Studies in Alcohol 1:272371.
Jellinek, E. Morton, and Jolliffe, Norman. 1940. “Effects of Alcohol on the Individual: Review of the Literature of 1939.” Quarterly Journal of Studies in Alcohol 1:110181.
Keehn, J. D. 1969. “‘Voluntary’ Consumption of Alcohol by Rats.” Quarterly Journal of Studies on Alcohol 30:320–9.
Keehn, J. D. 1986. Animal Models for Psychiatry. London: Routledge and Kegan.
Kirk, Robert G. W. 2010. “A Brave New Animal for a Brave New World: The British Laboratory Animal Bureau and the Constitution of International Standards of Laboratory Animal Production and Use, circa 1947–1968.” Isis 101:6294.
Kirk, Robert G. W. 2012. “‘Standardization through Mechanization’: Germ-Free Life and the Engineering of the Ideal Laboratory Animal.” Technology and Culture 53:6193.
Kohler, Robert E. 1994. Lords of the Fly: Drosophila Genetics and the Experimental Life. Chicago: University of Chicago Press.
La Follette, Hugh, and Shanks, Niall. 1997. Brute Science: The Dilemmas of Animal Experimentation. New York: Routledge.
Leonelli, Sabina. 2007. “Growing Weed, Producing Knowledge: An Epistemic History of Arabidopsis thaliana.” History and Philosophy of the Life Sciences 29:5587.
Leonelli, Sabina. 2008. “Performing Abstraction: Two Ways of Modeling Arabidopsis thaliana.” Biology and Philosophy 23:509–28.
Lester, David. 1961. “Self-Maintenance of Intoxication in the Rat.” Quarterly Journal of Studies in Alcohol 22:223–31.
Lester, David. 1966. “Self-Selection of Alcohol by Animals, Human Variation, and the Etiology of Alcoholism: A Critical Review.” Quarterly Journal of Studies in Alcohol 27:395438.
Lester, David, and Freed, Earl X.. 1972. “A Rat Model of Alcoholism?Annals of the New York Academy of Sciences 197:54–9.
Lester, David, and Freed, Earl X.. 1973. “Criteria for an Animal Model of Alcoholism.” Pharmacology Biochemistry and Behavior 1:103–7.
Levine, Harry G. 1983. “The Committee of Fifty and the Origins of Alcohol Control.” Journal of Drug Issues Winter:95–116.
Lewens, Tim. 2004. Organisms and Artifacts: Design in Nature and Elsewhere. Cambridge MA: MIT Press.
Lewis, W. Bevan. 1899. A Text-Book of Mental Diseases with Special Reference to the Pathological Aspects of Insanity. London: Charles Griffin.
Logan, Cheryl A. 1999. “The Altered Rationale for the Choice of a Standard Animal in Experimental Psychology: Henry H. Donaldson, Adolf Meyer, and ‘the’ Albino Rat.” History of Psychology 2:32–4.
Logan, Cheryl A. 2002. “Before There Were Standards: The Role of Test Animals in the Production of Scientific Generality in Physiology.” Journal of the History of Biology 35:329–63.
Löwy, Ilana. 1992. “From Guinea Pigs to Man: The Development of Haffkine's Anticholera Vaccine.” Journal of the History of Medicine and Allied Sciences 47:270309.
Magnan, Valentin. 1876. On Alcoholism: The Various Forms of Alcoholic Delirium and Their Treatment, translated by W. S. Greenfield. London: Lewis.
Mardones, Jorge. 1951. “On the Relationship between Deficiency of B Vitamins and Alcohol Intake in Rats.” Quarterly Journal of Studies on Alcohol 12:563–75.
Masserman, Jules H. 1943. Behavior and Neurosis: An Experimental Psychoanalytic Approach to Psychobiologic Principles. Chicago: University of Chicago Press.
Masserman, Jules H. 1968. “Comparative and Clinical Approaches to Biodynamic Therapy.” In Animal and Human: Scientific Proceedings of the American Academy of Psychoanalysis, edited by Jules H. Masserman, 251–261 New York: Grune & Stratton.
Masserman, Jules H., and Yum, K. S.. 1946. “An Analysis of the Influence of Alcohol on Experimental Neuroses in Cats.” Psychosomatic Medicine 8:3652.
McBride, William J., and Kai Li, Ting. 1998. “Animal Models of Alcoholism: Neurobiology of High Alcohol-Drinking Behavior in Rodents.” Critical Reviews in Neurobiology 12:339–69.
McClearn, Gerald E., and Rodgers, David A.. 1959. “Differences in Alcohol Preference among Inbred Strains of Mice.” Quarterly Journal of Studies in Alcohol 20:691–5.
Mello, Nancy K. 1973. “A Review of Methods to Induce Alcohol Addiction in Animals.” Pharmacology Biochemistry and Behavior 1:89101.
Mello, Nancy K., and Mendelson, Jack H.. 1971. “Evaluation of a Polydipsia Technique to Induce Alcohol Consumption in Monkeys.” Physiology and Behavior 7:827–36.
Miles, Walter R. 1930. “On the History of Research with Rats and Mazes: A Collection of Notes.” Journal of General Psychology 3:324337.
Mitman, Gregg, and Fausto-Sterling, Anne. 1992. “Whatever Happened to Planaria? C. M. Child and the Physiology of Inheritance.” In The Right Tools for the Job: At Work in Twentieth-Century Life Sciences, edited by Clarke, Adele E. and Fujimura, Joan H., 172–97. Princeton NJ: Princeton University Press.
Morgan, Mary S., and Morrison, Margaret. 1999. Models as Mediators: Perspectives on Natural and Social Science. Cambridge UK: Cambridge University Press.
Morse, Robert M., and Flavin, Daniel K.. 1992. “The Definition of Alcoholism.” Journal of the American Medical Association 268:1012–14.
Mulligan, Megan K., Ponomarev, Igor, Boehm II, Stephen L., Owen, Julie A., Levin, Patricia S., Berman, Ari E., Blednov, Yuri A., et al. 2008. “Alcohol Trait and Transcriptional Genomic Analysis of C57BL/6 Substrains.” Genes, Brain and Behavior 7:677–89.
NCBI (National Center for Biotechnology Information). 2012 “Model Organisms Guide.” http://www.ncbi.nlm.nih.gov/About/model/mammal.html (last accessed August 26, 2012).
Nelson, Nicole C. 2011. “Capturing Complexity: Experimental Systems and Epistemic Scaffolds in Animal Behavior Genetics.” Ph.D. diss., Cornell University.
Nelson, Nicole C. 2013. “Modeling Mouse, Human and Discipline: Epistemic Scaffolds in Animal Behavior Genetics.” Social Studies of Science 43 (1):329.
NIH (National Institutes of Health). 2012. “Model Organisms for Biomedical Research.” http://www.nih.gov/science/models/ (last accessed August 26, 2012).
NIH News. 2002a. “NIAAA Steps Up Search for Brain Mechanisms of Alcohol Abuse, Alcoholism.” Press release, March 8. http://www.niaaa.nih.gov/news-events/news-releases/niaaa-steps-search-brain-mechanisms-alcohol-abuse-alcoholism (last accessed April 1, 2014).
NIH News. 2002b. “Ting-Kai Li, M.D. Named New Director of NIH's Alcohol Research Institute.” Press release, September 10. http://www.nih.gov/news/pr/sep2002/niaaa-10.htm (last accessed April 1, 2014).
Ogata, Hiroshi, Ogata, Fumilo, Mendelson, Jack H., and Mello, Nancy K.. 1972. “A Comparison of Techniques to Induce Alcohol Dependence in the Mouse.” Journal of Pharmacology and Experimental Therapeutics 180:216–30.
Pauly, Philip J. 1994. “Is Liquor Intoxicating? Scientists, Prohibition, and the Normalization of Drinking.” American Journal of Public Health 84:305–13.
Rader, Karen A. 2004. Making Mice: Standardizing Animals for American Biomedical Research, 1900–1955. Princeton NJ: Princeton University Press.
Ramsden, Edmund. 2011a. “From Rodent Utopia to Urban Hell: Population, Pathology, and the Crowded Rats of NIMH.” Isis 102:659–88.
Ramsden, Edmund. 2011b. “Model Organisms and Model Environments: A Rodent Laboratory in Science, Medicine and Society.” Medical History 55:365368.
Rheinberger, Hans-Jörg. 2010. An Epistemology of the Concrete: Twentieth-Century Histories of Life. Chapel Hill NC: Duke University Press.
Rheinberger, Hans-Jörg, and Müller-Wille, Staffan W.. 2010. “Gene.” In Stanford Encyclopedia of Philosophy, Spring 2010 ed. Stanford University. http://plato.stanford.edu/entries/gene/ (last accessed April 1, 2014).
Rhodes, Justin S., Best, Karyn, Belknap, John K., Finn, Deborah A., and Crabbe, John C.. 2005. “Evaluation of a Simple Model of Ethanol Drinking to Intoxication in C57BL/6J Mice.” Physiology and Behavior 84:5363.
Richter, Curt P. 1926. “A Study of the Effect of Moderate Doses of Alcohol on the Growth and Behavior of the Rat.” Journal of Experimental Zoology 44:397418.
Richter, Curt P. 1957. “Production and Control of Alcohol Cravings in Rats.” In Neuropharmacology, Transactions of the Third Conference, May 21, 22, and 23, 1956, edited by Abramson, Harold A., 39146. New York: Josiah Macy, Jr. Foundation.
Richter, Curt P. 1968. “Experiences of a Reluctant Rat-Catcher: The Common Norway Rat–Friend or Enemy?Proceedings of the American Philosophical Society 112:403–15.
Richter, Curt P. 1985. “It's a Long Long Way to Tipperary, the Land of My Genes.” In Leaders in the Study of Animal Behavior: Autobiographical Perspectives, edited by Dewsbury, Donald A., 356–86. Lewisburg PA: Bucknell University Press.
Richter, Curt P., and Campbell, Kathryne H.. 1940. “Alcohol Taste Thresholds and Concentrations of Solution Preferred by Rats.” Science 91:507–8.
Richter, S. Helene, Garner, Joseph P., and Würbel, Hanno. 2009. “Environmental Standardization: Cure or Cause of Poor Reproducibility in Animal Experiments?Nature Methods 6:257–61.
Rodd, Zachary A., Bell, Richard L., Sable, Helen J. K., Murphy, James M., and McBride, William J.. 2004. “Recent Advances in Animal Models of Alcohol Craving and Relapse.” Pharmacology Biochemistry and Behavior 79:439–50.
Rose, Steven. 1997. Lifelines: Biology beyond Determinism. New York: Oxford University Press.
Samson, Herman H. 1986. “Initiation of Ethanol Reinforcement using a Sucrose-Substitution Procedure in Food and Water Sated Rats.” Alcohol: Clinical and Experimental Research 10:436–42.
Samson, Herman H., Tolliver, Gerald A., Lumeng, Lawrence and Kai Li, Ting. 1989. “Ethanol Reinforcement in the Alcohol Nonpreferring Rat: Initiation Using Behavioral Techniques without Food Restriction.” Alcohol: Clinical and Experimental Research 13:378–85.
Schneider, Joseph W. 1978. “Deviant Drinking as Disease: Alcoholism as a Social Accomplishment.” Social Problems 25:361–72.
Sillaber, Inge, Rammes, Gerhard, Zimmermann, Stephan, Mahal, Beatrice, Zieglgänsberger, Walter, Wurst, Wolfgang, Holsboer, Florian, et al. 2002. “Enhanced and Delayed Stress-Induced Alcohol Drinking in Mice Lacking Functional CRH1 Receptors.” Science 296:931–3.
Spradling, Allan, Ganetsky, Barry, Hieter, Phil, Johnston, Mark, Olson, Maynard, Orr-Weaver, Terry, Rossant, Janet, et al. 2006. “New Roles for Model Genetic Organisms in Understanding and Treating Human Disease: Report from the 2006 Genetics Society of America Meeting.” Genetics 172:2025–32.
Stewart, Colin C. 1898. “Variations in Daily Activity Produced by Alcohol and by Changes in Barometric Pressure and Diet, with a Description of Recording Methods.” American Journal of Physiology 1:4056.
Tabakoff, Boris, Saba, Laura, Printz, Morton, Flodman, Pam, Hodgkinson, Coling, Goldman, David, Koob, George, et al. 2009. “Genetical Genomic Determinants of Alcohol Consumption in Rats and Humans.” BMC Biology 7:70.
Todes, Daniel P. 2001. Pavlov's Physiology Factory: Experiment, Interpretation, Laboratory Enterprise. Baltimore MD: Johns Hopkins University Press.
Valverde, Mariana. 1998. Diseases of the Will: Alcohol and the Dilemmas of Freedom. Cambridge: Cambridge University Press.
Wahlsten, Douglas, Bachmanov, Alexander, Finn, Deborah A., and Crabbe, John C.. 2006. “Stability of Inbred Mouse Strain Differences in Behavior and Brain Size between Laboratories and Across Decades.” Proceedings of the National Academy of Sciences 103:16364–69.
Weber, Marcel. 2005. Philosophy of Experimental Biology. Cambridge: Cambridge University Press.
Weiss, Friedbert, Lorang, Marge T., Bloom, Floyd E., and Koob, George F.. 1993. “Oral Alcohol Self-Administration Stimulates Dopamine Release in the Rat Nucleus Accumbens: Genetic and Motivational Determinants.” Journal of Pharmacology and Experimental Therapeutics 267:250–8.
WHO (World Health Organization). 1955. Alcohol and Alcoholism: Report of an Expert Committee. Geneva: WHO.
Williams, Roger J. 1981. The Prevention of Alcoholism Through Nutrition. New York: Bantam Books.
Williams, Roger J., Berry, L. Joe, and Beerstecher, Ernest Jr. 1949. “Individual Metabolic Patterns, Alcoholism, Genetotrophic Diseases.” Proceedings of the National Academy of Sciences 35:265–71.
Würbel, Hanno. 2000. “Behavior and the Standardization Fallacy.” Nature Genetics 26:263.
Würbel, Hanno. 2002. “Behavioral Phenotyping Enhanced: Beyond (Environmental) Standardization.” Genes, Brain and Behavior 1:38.
Yoneyama, Naomi, Crabbe, John C., Ford, Matthew M., Murillo, Andrea, and Finn, Deborah A.. 2008. “Voluntary Ethanol Consumption in 22 Inbred Mouse Strains.” Alcohol 42:149–60.
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