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Effect of antidepressive therapy on retinal contrast processing in depressive disorder

  • Emanuel Bubl (a1), Dieter Ebert (a1), Elena Kern (a1), Ludger Tebartz van Elst (a1) and Michael Bach (a2)...
Abstract
Background

Recently, we reported a reduced retinal contrast gain in unmedicated and medicated patients with major depression.

Aims

To analyse whether the contrast gain normalises after successful antidepressive therapy by recording the pattern electroretinogram (PERG) in healthy controls and patients with depression before and after antidepressive therapy.

Method

Fourteen patients diagnosed with major depression were repeatedly scanned and the results compared with that from 40 matched controls.

Results

The retinal contrast gain was lower at baseline in patients with depression, was normalised with remission and correlated with the severity of depression. Patients who did not achieve remission retained significantly lower contrast gain at follow-up.

Conclusions

The study provides evidence for a state-dependent modulation of retinal contrast gain in patients with major depression. Reduced contrast gain normalised after therapy. A PERG-based contrast gain could serve as a state marker of depression.

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Copyright
Corresponding author
Ludger Tebartz van Elst, Department of Psychiatry and Psychotherapy, Albert-Ludwigs-Universität, Hauptstr. 5, 79104 Freiburg, Germany. Email: tebartzvanelst@uniklinik-freiburg.de
Footnotes
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These authors contributed equally to the work.

Declaration of interest

None.

Footnotes
References
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Effect of antidepressive therapy on retinal contrast processing in depressive disorder

  • Emanuel Bubl (a1), Dieter Ebert (a1), Elena Kern (a1), Ludger Tebartz van Elst (a1) and Michael Bach (a2)...
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