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11 - The role of infectious agents in the causation of bipolar disorder

Published online by Cambridge University Press:  05 May 2016

By
Olaoluwa O. Okusaga
Edited by
Jair C. Soares  and
Allan H. Young
Jair C. Soares
Affiliation:
University of Texas Health Science Center, Houston
Allan H. Young
Affiliation:
King's College London
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Bipolar Disorders
Basic Mechanisms and Therapeutic Implications
 , pp. 120 - 129
Publisher: Cambridge University Press
Print publication year: 2016

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References

Abrahao, A.L., Focaccia, R., Gattaz, W.F. Childhood meningitis increases the risk for adult schizophrenia. World J Biol Psychiatry. 2005; 6:44–8.CrossRefGoogle ScholarPubMed
Anderson, G., Maes, M. Schizophrenia: linking prenatal infection to cytokines, the tryptophan catabolite (TRYCAT) pathway, NMDA receptor hypofunction, neurodevelopment and neuroprogression. Prog Neuropsychopharmacol Biol Psychiatry. 2013;42:5–19.CrossRefGoogle ScholarPubMed
Anticevic, A., Savic, A., Repovs, G., et al. Ventral anterior cingulate connectivity distinguished nonpsychotic bipolar illness from psychotic bipolar disorder and schizophrenia. Schizophr Bull 2015;41(1):133–43.CrossRefGoogle ScholarPubMed
Arias, I., Sorlozano, A., Villegas, E., et al. Infectious agents associated with schizophrenia: a meta-analysis. Schizophr Res. 2012;136:128–36.CrossRefGoogle ScholarPubMed
Baker, J.T., Holmes, A.J., Masters, G.A., et al. Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder. JAMA Psychiatry. 2014;71:109–18.CrossRefGoogle ScholarPubMed
Bauman, M.D., Iosif, A.M., Smith, S.E., et al. Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring. Biol Psychiatry. 2014;75:332–41.CrossRefGoogle ScholarPubMed
Benros, M.E., Waltoft, B.L., Nordentoft, M., et al. Autoimmune diseases and severe infections as risk factors for mood disorders: a nationwide study. JAMA Psychiatry. 2013;70:812–20.CrossRefGoogle ScholarPubMed
Black, S.B., Shinefield, H.R., France, E.K., et al. Effectiveness of influenza vaccine during pregnancy in preventing hospitalizations and outpatient visits for respiratory illness in pregnant women and their infants. Am J Perinatol. 2004;21:333–9.CrossRefGoogle ScholarPubMed
Blomström, A., Karlsson, H., Svensson, A., et al. Hospital admission with infection during childhood and risk for psychotic illness: a population-based cohort study. Schizophr Bull. 2014;40(6):1518–25.CrossRefGoogle ScholarPubMed
Brown, A.S., Derkits, E.J. Prenatal infection and schizophrenia: a review of epidemiologic and translational studies. Am J Psychiatry. 2010;167: 261–80.CrossRefGoogle ScholarPubMed
Brown, A.S., Patterson, P.H. Maternal infection and schizophrenia: implications for prevention. Schizophr Bull. 2011;37:284–90.CrossRefGoogle ScholarPubMed
Brown, A.S., Cohen, P., Greenwald, S., et al. Nonaffective psychosis after renatal exposure to rubella. Am. J. Psychiatry. 2000;157:438–43.CrossRefGoogle Scholar
Brown, A.S., Begg, M.D., Gravenstein, S., et al. Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry. 2004;61:774–80.CrossRefGoogle ScholarPubMed
Brown, A.S., Schaefer, C.A., Quesenberry, C.P., et al. Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. Am J Psychiatry. 2005;162:767–73.CrossRefGoogle ScholarPubMed
Brown, A.S., Schaefer, C.A., Quesenberry, Jr., et al. No evidence of relation between maternal exposure to herpes simplex virus type 2 and risk of schizophrenia? Am. J. Psychiatry. 2006;163:2178–80.CrossRefGoogle ScholarPubMed
Buka, S.L., Tsuang, M.T., Torrey, E.F., et al. Maternal infections and subsequent psychosis among offspring. Arch. Gen. Psychiatry. 2001;58:1032–7.CrossRefGoogle ScholarPubMed
Buka, S.L., Cannon, T.D., Torrey, E.F., et al. Maternal exposure to herpes simplex virus and risk of psychosis among adult offspring. Biol. Psychiatry. 2008;63:809–15.CrossRefGoogle ScholarPubMed
Canetta, S.E., Bao, Y., Co, M.D., et al. Serological documentation of maternal influenza exposure and bipolar disorder in adult offspring. Am J Psychiatry. 2014;171:557–63.CrossRefGoogle ScholarPubMed
Cannon, M., Cotter, D., Coffey, V.P., et al. Prenatal exposure to the 1957 influenza epidemic and adult schizophrenia: a follow-up study. Br J Psychiatry. 1996;168:368–71.CrossRefGoogle Scholar
Chaplin, D.D. Overview of the immune response. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S3–23.CrossRefGoogle ScholarPubMed
Clarke, M.C., Tanskanen, A., Huttunen, M., et al. Evidence for an interaction between familial liability and prenatal exposure to infection in the causation of schizophrenia. Am J Psychiatry. 2009;166:1025–30.CrossRefGoogle ScholarPubMed
Crow, T.J. and Done, D.J. Prenatal exposure to influenza does not cause schizophrenia. Br J Psychiatry. 1992;161: 390–3.CrossRefGoogle ScholarPubMed
Cunningham, A., Williams, P. (eds) The Laboratory Revolution in Medicine. Cambridge: Cambridge University Press; 1992.Google Scholar
Curran, T., D’Arcangelo, G. Role of reelin in the control of brain development. Brain Res Brain Res Rev. 1998;26:285–94.Google ScholarPubMed
Deecke, T. On the germ-theory of disease. Am J Insanity. 1874;24:443–63.Google Scholar
Deverman, B.E., Patterson, P.H. Cytokines and CNS development. Neuron, 2009;64:61–78.CrossRefGoogle ScholarPubMed
Dickerson, F., Stallings, C., Origoni, A., et al. Antibodies to Toxoplasma gondii in individuals with mania. Bipolar Disord. 2014;16:129–36.CrossRefGoogle ScholarPubMed
Elmer, B.M., Estes, M.L., Barrow, S.L., et al. MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease. J Neurosci. 2013;33:13791–804.CrossRefGoogle ScholarPubMed
Fatemi, S.H., Emamian, E.S., Kist, D., et al. Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice. Mol Psychiatry. 1999;4:145–54.CrossRefGoogle ScholarPubMed
Fatemi, S.H., Reutiman, T.J., Folsom, T.D., et al. Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders. Schizophr Res. 2008; 99:56–70.CrossRefGoogle ScholarPubMed
Fellerhoff, B., Laumbacher, B., Mueller, N., et al. Associations between Chlamydophila infections, schizophrenia and risk of HLA-A10. Mol Psychiatry. 2007;12:264–72.CrossRefGoogle ScholarPubMed
Fillman, S.G., Cloonan, N., Catts, V.S., et al. Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia. Mol Psychiatry. 2013;18:206–14.Google ScholarPubMed
Garay, P.A., Hsiao, E.Y., Patterson, P.H., et al. Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development. Brain Behav Immun. 2013;31:54–68.CrossRefGoogle ScholarPubMed
Hare, E.H. Manic-depressive psychosis and season of birth. Acta Psychiatr Scand. 1975;52:69–79.CrossRefGoogle ScholarPubMed
Jones-Brando, L., Torrey, E.F., Yolken, R. Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondii. Schizophr Res. 2003;62:237–44.CrossRefGoogle ScholarPubMed
Kaufmann, C.A., Stevens, J.R., Torrey, E.F. 1983 World Health Organization symposium on psychovirology. Arch Gen Psychiatry. 1984;41:1184–5.CrossRefGoogle ScholarPubMed
Khadka, S., Meda, S.A., Stevens, M.C., et al. Is aberrant functional connectivity a psychosis endophenotype? A resting state functional magnetic resonance imaging study. Biol Psychiatry. 2013;74:458–66.CrossRefGoogle ScholarPubMed
Khandaker, G.M., Zimbron, J., Dalman, C., et al. Childhood infection and adult schizophrenia: a meta-analysis of population-based studies. Schizophr Res. 2012;139:161–8.CrossRefGoogle ScholarPubMed
Khandaker, G.M., Zimbron, J., Lewis, G., et al. Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies. Psychol Med. 2013;43:239–57.CrossRefGoogle ScholarPubMed
Koponen, H., Rantakallio, P., Veijola, J., et al. Childhood central nervous system infections and risk for schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2004;254:9–13.CrossRefGoogle ScholarPubMed
Kuswanto, C.N., Sum, M.Y., Sim, K. Neurocognitive functioning in schizophrenia and bipolar disorder: clarifying concepts of diagnostic dichotomy vs. continuum. Front Psychiatry. 2013;4:162.CrossRefGoogle ScholarPubMed
Leask, S.J., Done, D.J., Crow, T.J. Adult psychosis, common childhood infections and neurological soft signs in a national birth cohort. Br J Psychiatry. 2002;181:387–92.CrossRefGoogle Scholar
Liang, W., Chikritzhs, T. Early childhood infections and risk of schizophrenia. Psychiatry Res. 2012;200:214–17.CrossRefGoogle ScholarPubMed
Machón, R.A., Mednick, S.A., Schulsinger, F. The interaction of seasonality, place of birth, genetic risk and subsequent schizophrenia in a high risk sample. Br J Psychiatry. 1983;143:383–8.CrossRefGoogle Scholar
Machón, R.A., Mednick, S.A., Huttunen, M.O. Adult major affective disorder after prenatal exposure to an influenza epidemic. Arch Gen Psychiatry. 1997;54:322–8.CrossRefGoogle Scholar
Maynard, T.M., Sikich, L., Lieberman, J.A., et al. Neural development, cell-cell signaling, and the “two-hit” hypothesis of schizophrenia. Schizophr Bull. 2001;27:457–76.CrossRefGoogle ScholarPubMed
McAllister, A.K. Major histocompatibility complex I in brain development and schizophrenia. Biol Psychiatry. 2014;75:262–8.CrossRefGoogle ScholarPubMed
Menninger, K.A. Psychoses associated with influenza, I: general data: statistical analysis. JAMA. 1919;72(4):235–41.Google Scholar
Meyer, U. Prenatal poly(I:C) exposure and other developmental immune activation models in rodent systems. Biol Psychiatry. 2014;75:307–15.CrossRefGoogle ScholarPubMed
Meyer, U., Feldon, J. To poly(I:C) or not to poly(I:C): advancing preclinical schizophrenia research through the use of prenatal immune activation models. Neuropharmacology. 2012;62:1308–21.CrossRefGoogle Scholar
Meyer, U., Feldon, J., Fatemi, S.H. In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders. Neurosci Biobehav Rev. 2009;33:1061–79.CrossRefGoogle ScholarPubMed
Montoya, J.G., Liesenfeld, O. Toxoplasmosis. Lancet. 2004;363:1965–76.CrossRefGoogle ScholarPubMed
Mortensen, P.B., Norgaard-Pedersen, B., Waltoft, B.L., et al. Toxoplasma gondii as a risk factor for early-onset schizophrenia: analysis of filter paper blood samples obtained at birth. Biol Psychiatry. 2007;61:688–93.CrossRefGoogle ScholarPubMed
Mortensen, P.B., Pedersen, C.B., Hougaard, D.M., et al. A Danish National Birth Cohort study of maternal HSV-2 antibodies as a risk factor for schizophrenia in their offspring. Schizophr Res. 2010;122:257–63.CrossRefGoogle ScholarPubMed
Mortensen, P.B., Pedersen, C.B., McGrath, J.J., et al. Neonatal antibodies to infectious agents and risk of bipolar disorder: a population-based case-control study. Bipolar Disord. 2011;13:624–9.CrossRefGoogle ScholarPubMed
Morozov, V.M. On the problem of the viral aetiology of schizophrenia. J Neuropath Psychiat, Korsakov. 1954;54:732–4.Google Scholar
Nascimento, F.S., de Rosalmeida Dantas, C., Netto, M.P., et al. Prevalence of antibodies to Toxoplasma gondii in patients with schizophrenia and mood disorders. Schizophr Res. 2012;142, 244–5.CrossRefGoogle ScholarPubMed
Nielsen, P.R., Benros, M.E., Mortensen, P.B. Hospital contacts with infection and risk of schizophrenia: a population-based cohort study with linkage of Danish national registers. Schizophr Bull. 2014;40(6):1526–32.CrossRefGoogle ScholarPubMed
Noll, R. Historical review: Autointoxication and focal infection theories of dementia praecox. World J Biol Psychiatry. 2004;5:66–72.CrossRefGoogle ScholarPubMed
Noll, R. Infectious insanities, surgical solutions: Bayard Taylor Holmes, dementia praecox and laboratory science in early 20th-century America. Part 2. Hist Psychiatry. 2006;17:299–311.CrossRefGoogle Scholar
Noll, R. Kraepelin’s ‘lost biological psychiatry’? Autointoxication, organotherapy and surgery for dementia praecox. Hist Psychiatry. 2007;18:301–20.CrossRefGoogle ScholarPubMed
Norris, A.S., Chowning, J.R. Season of birth and mental illness. A critical examination. Arch Gen Psychiatry. 1962;7:206–12.CrossRefGoogle ScholarPubMed
Nunes, S.O., Itano, E.N., Amarante, M.K., et al. RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives. J Clin Lab Anal. 2008;22:314–20.CrossRefGoogle ScholarPubMed
Okusaga, O., Yolken, R.H., Langenberg, P., et al. Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts. J Affect Disord. 2011;130:220–5.CrossRefGoogle ScholarPubMed
Pang, D., Syed, S., Fine, P., et al. No association between prenatal viral infection and depression in later life–a long-term cohort study of 6152 subjects. Can J Psychiatry. 2009;54:565–70.CrossRefGoogle ScholarPubMed
Parboosing, R., Bao, Y., Shen, L., et al. Gestational influenza and bipolar disorder in adult offspring. JAMA Psychiatry. 2013;70:677–85.CrossRefGoogle ScholarPubMed
Park, M.H., Kwon, Y.J., Jeong, H.Y., et al. Association between intracellular infectious agents and schizophrenia. Clin Psychopharmacol Neurosci. 2012;10:117–23.CrossRefGoogle ScholarPubMed
Pearce, B.D., Kruszon-Moran, D., Jones, J.L., et al. The relationship between Toxoplasma gondii infection and mood disorders in the third National Health and Nutrition Survey. Biol Psychiatry. 2012;72:290–5.CrossRefGoogle ScholarPubMed
Rantakallio, P., Jones, P., Moring, J., et al. Association between central nervous system infections during childhood and adult onset schizophrenia and other psychoses: a 28-year follow-up. Int J Epidemiol. 1997;26:837–43.CrossRefGoogle ScholarPubMed
Rao, J.S., Harry, G.J., Rapoport, S.I., et al. Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol Psychiatry. 2010;15:384–92.CrossRefGoogle ScholarPubMed
Rapoport, J.L., Giedd, J.N., Gogtay, N. Neurodevelopmental model of schizophrenia: update 2012. Mol Psychiatry. 2012;17:1228–38.CrossRefGoogle ScholarPubMed
Roybal, D.J., Singh, M.K., Cosgrove, V.E., et al. Biological evidence for a neurodevelopmental model of pediatric bipolar disorder. Isr J Psychiatry Relat Sci. 2012;49:28–43.Google ScholarPubMed
Scull, A. Madhouse: A Tragic Tale of Megalomania and Modern Medicine. New Haven, CT: Yale University Press; 2005.Google Scholar
Short, S.J., Lubach, G.R., Karasin, A.I., et al. Maternal influenza infection during pregnancy impacts postnatal brain development in the rhesus monkey. Biol Psychiatry. 2010;67:965–73.CrossRefGoogle ScholarPubMed
Solomon, G.F. Psychoneuroimmunology: interactions between central nervous system and immune system. J Neurosci Res. 1987;18:1–9.CrossRefGoogle ScholarPubMed
Sørensen, H.J., Mortensen, E.L., Reinisch, J.M., et al. Association between prenatal exposure to bacterial infection and risk of schizophrenia. Schizophr Bull. 2009;35:631–7.CrossRefGoogle ScholarPubMed
Suvisaari, J., Mautemps, N., Haukka, J., et al. Childhood central nervous system viral infections and adult schizophrenia. Am J Psychiatry. 2003;160:1183–5.CrossRefGoogle ScholarPubMed
Terayama, H., Nishino, Y., Kishi, M., et al. Detection of anti-Borna disease virus (BDV) antibodies from patients with schizophrenia and mood disorders in Japan. Psychiatry Res. 2003;120:201–6.CrossRefGoogle ScholarPubMed
Torrey, E.F., Peterson, M.R. Slow and latent viruses in schizophrenia. Lancet. 1973;2:22–4.Google ScholarPubMed
Torrey, E.F., Bartko, J.J., Lun, R.Z., et al. Antibodies to Toxoplasma gondii in patients with schizophrenia: a meta-analysis. Schizophr Bull. 2007;33:729–36.CrossRefGoogle ScholarPubMed
Tselibeev, B.A., Brusilovskaia, M.I. [Psychological disturbances in influenza.] Zh Nevropatol Psikhiatr Im S S Korsakova. 1968;68:425–31.Google ScholarPubMed
Tuke, D.H., Dictionary of Psychological Medicine. London: J. & A. Churchill; 1892.Google Scholar
Vojtechovska, M., Vojtechovsky, M., Petru, M. Some problems of parasitology in mental patients (in Czechoslovakian). Casopis Lekaru Ceskych. 1956;95:559–66.Google Scholar
Weiser, M., Werbeloff, N., Levine, A., et al. CNS infection in childhood does not confer risk for later schizophrenia: a case-control study. Schizophr Res. 2010;124:231–5.CrossRefGoogle Scholar
Yolken, R.H., Torrey, E.F. Are some cases of psychosis caused by microbial agents? A review of the evidence. Mol Psychiatry. 2008;13(5):470–9.CrossRefGoogle ScholarPubMed
Yolken, R.H., Dickerson, F.B., Torrey, EF. Toxoplasma and schizophrenia. Parasite Immunol. 2009;31:706–15.CrossRefGoogle ScholarPubMed

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