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Case 12 - Losing One’s Mind without Knowing?

from Part 3 - Missing Important Clues in the History

Published online by Cambridge University Press:  03 November 2020

Keith Josephs
Affiliation:
Mayo Clinic Alzheimer’s Disease Research Center
Federico Rodriguez-Porcel
Affiliation:
Medical University of South Carolina
Rhonna Shatz
Affiliation:
University of Cincinnati
Daniel Weintraub
Affiliation:
University of Pennsylvania
Alberto Espay
Affiliation:
University of Cincinnati
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Summary

This 57-year-old right-handed woman presented to the clinic after four episodes of amnesia. The first one occurred six months previously while at her daughter’s house. Abruptly, she became disoriented to location and situation. She knew who she was and could recognize her daughter. She was reoriented by her daughter multiple times but still repeatedly asked where she was. She was taken to the emergency room, and after 45 minutes, she returned to her baseline and could recall the episode of disorientation. Her neurological exam was unremarkable, as well as her laboratory investigations, brain MRI, and EEG. She was discharged back home with the diagnosis of transient global amnesia (TGA). She had three additional episodes of similar characteristics since then, all within the last two months. She was on treatment with amlodipine for hypertension. Her repeat exam in the office setting was unremarkable.

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Publisher: Cambridge University Press
Print publication year: 2020

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References

Bartsch, T. and Butler, C. 2013. Transient amnesic syndromes. Nat Rev Neurol 9(2) 8697.CrossRefGoogle ScholarPubMed
Bartsch, T. and Deuschl, G. 2010. Transient global amnesia: functional anatomy and clinical implications. Lancet Neurol 9(2) 205214.CrossRefGoogle ScholarPubMed
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Lee, H. Y. et al. 2007. Diffusion-weighted imaging in transient global amnesia exposes the CA1 region of the hippocampus. Neuroradiology 49(6) 481487.CrossRefGoogle ScholarPubMed
Markowitsch, H. J. and Staniloiu, A. 2016. Functional (dissociative) retrograde amnesia. Handb Clin Neurol 139 419445.Google Scholar

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