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Chapter 16 - Myeloproliferative Neoplasms

from Section IV - Precursor Hematopoietic Neoplasms and Related Neoplasms

Published online by Cambridge University Press:  25 November 2023

Silvia Tse Bunting
Affiliation:
Cleveland Clinic Florida Weston
Xiayuan Liang
Affiliation:
University of Colorado
Michele E. Paessler
Affiliation:
University of Pennsylvania School of Medicine
Satheesh Chonat
Affiliation:
Emory University, Atlanta
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Summary

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by a proliferation of one or more of the myeloid lineages [1]. These components include erythroid cells, megakaryocytes, and granulocytes, the latter of which include eosinophils. In many cases, these MPNs are associated with acquired clonal genetic abnormalities involving cytoplasmic or receptor protein tyrosine kinases.

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Publisher: Cambridge University Press
Print publication year: 2023

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References

Arber, DA, Orazi, A, Hasserjian, RP, Brunning, RD, Le Beau, MM, Porwit, A, et al. Introduction and overview of the classification of myeloid neoplasms. In Swerdlow, SH, Campo, E, Harris, NL, Jaffe, ES, Pileri, SA, Stein, H, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2017:1627.Google Scholar
Vardiman, JW, Melo, JV, Baccarani, M, Radich, JP, Kvasnicka, HM. Chronic myeloid leukaemia, BCR-ABL1-positive. In Swerdlow, SH, Campo, E, Harris, NL, Jaffe, ES, Pileri, SA, Stein, H, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2017:30–6.Google Scholar
Ianotto, JC, Curto-Garcia, N, Lauermanova, M, Radia, D, Kiladjian, JJ, Harrison, CN. Characteristics and outcomes of patients with essential thrombocythemia or polycythemia vera diagnosed before 20 years of age: A systematic review. Haematologica. 2019; 104(8): 1580–8.CrossRefGoogle ScholarPubMed
Thiele, J, Kvasnicka, HM, Orazi, A, Gianelli, U, Tefferi, A, Gisslinger, H, et al. Essential thrombocythaemia. In Swerdlow, SH, Campo, E, Harris, NL, Jaffe, ES, Pileri, SA, Stein, H, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2017:50–3.Google Scholar
Kucine, N, Al-Kawaaz, M, Hajje, D, Bussel, J, Orazi, A. Difficulty distinguishing essential thrombocythaemia from polycythaemia vera in children with JAK2 V617F-positive myeloproliferative neoplasms. Br J Haematol. 2019; 185(1): 136–9.CrossRefGoogle ScholarPubMed
Giona, F, Teofili, L, Capodimonti, S, Laurino, M, Martini, M, Marzella, D, et al. CALR mutations in patients with essential thrombocythemia diagnosed in childhood and adolescence. Blood. 2014; 123(23): 3677–9.CrossRefGoogle ScholarPubMed
Giona, F, Teofili, L, Moleti, ML, Martini, M, Palumbo, G, Amendola, A, et al. Thrombocythemia and polycythemia in patients younger than 20 years at diagnosis: Clinical and biologic features, treatment, and long-term outcome. Blood. 2012; 119(10): 2219–27.CrossRefGoogle ScholarPubMed
Thiele, J, Kvasnicka, HM, Orazi, A, Tefferi, A, Birgegard, G, Barbui, T. Polycythaemia vera. In Swerdlow, SH, Campo, E, Harris, NL, Jaffe, ES, Pileri, SA, Stein, H, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2017:3943.Google Scholar
Teofili, L, Giona, F, Martini, M, Cenci, T, Guidi, F, Torti, L, et al. The revised WHO diagnostic criteria for Ph-negative myeloproliferative diseases are not appropriate for the diagnostic screening of childhood polycythemia vera and essential thrombocythemia. Blood. 2007; 110(9): 3384–6.CrossRefGoogle Scholar
Karow, A, Nienhold, R, Lundberg, P, Peroni, E, Putti, MC, Randi, ML, et al. Mutational profile of childhood myeloproliferative neoplasms. Leukemia. 2015; 29(12): 2407–9.CrossRefGoogle ScholarPubMed
Teofili, L, Giona, F, Martini, M, Cenci, T, Guidi, F, Torti, L, et al. Markers of myeloproliferative diseases in childhood polycythemia vera and essential thrombocythemia. J Clin Oncol. 2007; 25(9): 1048–53.CrossRefGoogle ScholarPubMed
Thiele, J, Kvasnicka, HM, Orazi, A, Gianelli, U, Barbui, T, Barosi, G, et al. Primary myelofibrosis. In Swerdlow, SH, Campo, E, Harris, NL, Jaffe, ES, Pileri, SA, Stein, H, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2017:4450.Google Scholar
DeLario, MR, Sheehan, AM, Ataya, R, Bertuch, AA, Vega, C, 2nd, Webb, CR, et al. Clinical, histopathologic, and genetic features of pediatric primary myelofibrosis: An entity different from adults. Am J Hematol. 2012; 87(5): 461–4.CrossRefGoogle ScholarPubMed
An, W, Wan, Y, Guo, Y, Chen, X, Ren, Y, Zhang, J, et al. CALR mutation screening in pediatric primary myelofibrosis. Pediatr Blood Cancer. 2014; 61(12): 2256–62.CrossRefGoogle ScholarPubMed
Druhan, LJ, McMahon, DP, Steuerwald, N, Price, AE, Lance, A, Gerber, JM, et al. Chronic neutrophilic leukemia in a child with a CSF3 R T618I germ line mutation. Blood. 2016; 128(16): 2097–9.CrossRefGoogle Scholar
Hasle, H. Incidence of essential thrombocythaemia in children. Br J Haematol. 2000; 110(3): 751.CrossRefGoogle ScholarPubMed
Uygun, V, Daloglu, H, Ozturkmen, S, Karasu, G, Avci, Z, Yesilipek, A. Chronic neutrophilic leukemia, an extremely rare cause of neutrophilia in childhood: Cure with hematopoietic stem cell transplantation. Pediatr Transplant. 2018; 22(5): e13199.CrossRefGoogle ScholarPubMed
Bain, BJ, Brunning, RD, Orazi, A, Thiele, J. Chronic neutrophilic leukaemia. In Swerdlow, SH, Campo, E, Harris, NL, Jaffe, ES, Pileri, SA, Stein, H, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2017:37–8.Google Scholar
Kvasnicka, HM, Thiele, J, Orazi, A, Horny, H-P, Bain, BJ. Myeloproliferative neoplasm, unclassifiable. In Swerdlow, SH, Campo, E, Harris, NL, Jaffe, ES, Pileri, SA, Stein, H, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2017:57–9.Google Scholar

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