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Chapter 18 - Childhood Myelodysplastic Syndrome

from Section IV - Precursor Hematopoietic Neoplasms and Related Neoplasms

Published online by Cambridge University Press:  25 November 2023

By
Alina Dulau-Florea ,
Nisha Patel ,
Kristian T. Schafernak  and
Katherine R. Calvo
Edited by
Silvia Tse Bunting ,
Xiayuan Liang ,
Michele E. Paessler  and
Satheesh Chonat
Silvia Tse Bunting
Affiliation:
Cleveland Clinic Florida Weston
Xiayuan Liang
Affiliation:
University of Colorado
Michele E. Paessler
Affiliation:
University of Pennsylvania School of Medicine
Satheesh Chonat
Affiliation:
Emory University, Atlanta
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Summary

Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal disorders characterized by ineffective hematopoiesis causing cytopenias, dysplastic morphology, and risk for progression to acute myeloid leukemia (AML) [1]. Sporadic MDS is typically a disease of the elderly, whereas, in the pediatric population, the annual incidence is very low with one to two cases per million [2]. Pediatric MDS constitutes less than 5% of childhood hematologic malignancies [3].

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Atlas of Pediatric Hematopathology , pp. 198 - 206
Publisher: Cambridge University Press
Print publication year: 2023

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References

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