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10 - Sociobiological Transition and Cancer

Prospects for Africa

Published online by Cambridge University Press:  02 December 2019

By
Sulma I. Mohammed ,
Khalid O. Alfarouk ,
Ahmed M. Elhassan ,
Kamal Hamad  and
Muntaser E. Ibrahim
Edited by
Muntaser E. Ibrahim  and
Charles N. Rotimi
Muntaser E. Ibrahim
Affiliation:
University of Khartoum
Charles N. Rotimi
Affiliation:
National Human Genome Research Institute/NIH
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Summary

This chapter addresses key questions about the basis of cancer susceptibility in African people, as well as the uniqueness of the population genetics and genotype–phenotype relationship that resulted during social transition. Social transition encompasses the change of lifestyle from a rural subsistence one into an urban market-oriented, technology dependent, and predominantly sedentary mode of life, as well as changes that occur in the population genetics as a result of changes from ethnically defined structured populations into panmictic populations of an urban nature, as currently seen in megacities. Although humans passed through several periods of transition in history, the current one is the most profound.

Type
Chapter
Information
The Genetics of African Populations in Health and Disease , pp. 217 - 232
Publisher: Cambridge University Press
Print publication year: 2019

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