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8 - Mechanisms of immunity to Salmonella infections

Published online by Cambridge University Press:  04 December 2009

Duncan Maskell
By
Pietro Mastroeni
Edited by
Pietro Mastroeni
Duncan Maskell
Affiliation:
University of Cambridge
Pietro Mastroeni
Affiliation:
Senior Lecturer in the Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, UK
Pietro Mastroeni
Affiliation:
University of Cambridge
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Summary

INTRODUCTION

Salmonella enterica affects humans and animals worldwide. It can be found in sewage-, sea-, and river- water and can contaminate food. Asymptomatic carriage in domestic animals can result in the introduction of the bacteria into the food chain.

Interest in understanding the mechanisms of pathogenesis and immunity that operate in S. enterica infections is twofold. Firstly, development of vaccines against salmonellosis has been too empirical due to insufficient understanding of how the host controls these infections, and how the bacteria evade immune surveillance. The fact that S. enterica-based vaccines are also being evaluated as systems to deliver recombinant antigens or DNA vaccines to the immune system and as new tools for the therapy of cancer has further increased the need to study how these vaccines work (Chabalgoity et al., 2002; Mastroeni et al., 2001; Reisfeld et al., 2004).

Secondly, S. enterica provides a model to understand how bacterial pathogens interact with the immune system. S. enterica is an intriguing bacterium in the way it interacts with the immune system and the immunological requirements for host resistance to this bacterium are affected by a very large number of variables.

MODELS FOR THE STUDY OF IMMUNITY TO S. ENTERICA

The study of the immunobiology of S. enterica infections has been facilitated by the availability of reliable models and by improved genetic tools that allow identification of polymorphic differences or mutations in genes involved in immune functions.

Type
Chapter
Information
Salmonella Infections
Clinical, Immunological and Molecular Aspects
 , pp. 207 - 254
Publisher: Cambridge University Press
Print publication year: 2006

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