Book contents
- Frontmatter
- Contents
- Foreword
- Preface
- Acknowledgments
- MICROARRAY BIOINFORMATICS
- 1 Microarrays: Making Them and Using Them
- 2 Sequence Databases for Microarrays
- 3 Computer Design of Oligonucleotide Probes
- 4 Image Processing
- 5 Normalisation
- 6 Measuring and Quantifying Microarray Variability
- 7 Analysis of Differentially Expressed Genes
- 8 Analysis of Relationships Between Genes, Tissues or Treatments
- 9 Classification of Tissues and Samples
- 10 Experimental Design
- 11 Data Standards, Storage and Sharing
- Appendix: MIAME Glossary
- Index
- Plate section
Preface
Published online by Cambridge University Press: 15 January 2010
- Frontmatter
- Contents
- Foreword
- Preface
- Acknowledgments
- MICROARRAY BIOINFORMATICS
- 1 Microarrays: Making Them and Using Them
- 2 Sequence Databases for Microarrays
- 3 Computer Design of Oligonucleotide Probes
- 4 Image Processing
- 5 Normalisation
- 6 Measuring and Quantifying Microarray Variability
- 7 Analysis of Differentially Expressed Genes
- 8 Analysis of Relationships Between Genes, Tissues or Treatments
- 9 Classification of Tissues and Samples
- 10 Experimental Design
- 11 Data Standards, Storage and Sharing
- Appendix: MIAME Glossary
- Index
- Plate section
Summary
DNA microarrays are devices that measure the expression of many thousands of genes in parallel. They have revolutionised molecular biology, and in the past five years their use has grownrapidly in academia, medicine, and the pharmaceutical, biotechnology, agrochemical and food industries.
One of the principal features of microarrays is the volume of quantitative data that they generate. As a result, the major challenge in the field is how to handle, interpret and make use of this data. The field of bioinformatics has come to mean the applications of mathematics, statistics and information technology in the biological sciences, and the bioinformatics of microarrays is the answer to that challenge.
This book is a comprehensive guide to all of the bioinformatics you will need to successfully operate DNA microarray experiments. It is written for researchers, clinicians, laboratory heads and managers, from both biology and bioinformatics backgrounds, who work with or who intend to work with microarrays. The book covers all aspects of microarray bioinformatics, giving you the tools to design arrays and experiments, to analyze your data, and to share you results with your organisation or with the international community. It has been inspired by the Microarray Bioinformatics professional course at Oxford University, and thus would also be suitable for teaching the subject at postgraduate or professional level.
The book assumes a minimum knowledge of molecular biology, computer use and statistics. On the biology front, readers will find it helpful if they have an understanding of the basic principles of molecular biology, i.e., DNA, RNA, transcription and translation, as well as the notions of genome sequencing and the existence of sequence databases.
- Type
- Chapter
- Information
- Microarray Bioinformatics , pp. xi - xiiPublisher: Cambridge University PressPrint publication year: 2003