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4 - Phenomena That Favor Fed-Batch Operations

Published online by Cambridge University Press:  05 April 2013

Henry C. Lim  and
Hwa Sung Shin
Henry C. Lim
Affiliation:
University of California, Irvine
Hwa Sung Shin
Affiliation:
Inha University, Seoul
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Summary

One of the primary objectives of reaction engineering is to optimize the rate of formation of the product (productivity) and/or the relative rates (selectivity or yield). For an existing plant, a faster product formation rate implies a higher productivity and corresponding reductions in plant operating time and operating cost. For a new plant to be built, the increased rate implies, in addition to improved productivity, a smaller reactor and therefore a lower capital investment cost. Likewise, an improved yield implies a lower raw material cost and a lower capital investment for existing and new plants.

Fed-batch operations are well suited for situations in which the cell growth and/or product formation rates are sensitive to the concentration of the limiting substrate, an intermediate, or a product so that the overall rate increases with the limiting substrate concentration, reaches a maximum, and decreases with further increases in the substrate concentration. Fed-batch operation finds wide applications in bioindustry as it takes advantages of various biochemical and physiological phenomena of cell cultures and is also able to overcome adverse physical effects. Fed-batch operations provide potential advantages for autocatalytic reactions, to which cellular processes belong, and multiple reactions in which the relative rates vary with the reactant concentration.

Type
Chapter
Information
Fed-Batch Cultures
Principles and Applications of Semi-Batch Bioreactors
 , pp. 52 - 61
Publisher: Cambridge University Press
Print publication year: 2013

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