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Distinct age-related associations for body mass index and cognition in cognitively healthy very old veterans

Published online by Cambridge University Press:  05 February 2019

James Schmeidler ,
Cecilia N. Mastrogiacomo ,
Michal S. Beeri ,
Clive Rosendorff  and
Jeremy M. Silverman
James Schmeidler
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Cecilia N. Mastrogiacomo
Affiliation:
Carnegie Mellon University, Pittsburgh, PA, USA
Michal S. Beeri
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel
Clive Rosendorff
Affiliation:
Research & Development Service, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Jeremy M. Silverman*
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA Research & Development Service, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA
*
Correspondence should be addressed to: Jeremy M. Silverman, Research & Development (151), James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA. Phone: 718 584-9000, x1700. Email: jeremy.silverman@mssm.edu.
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Abstract

Associations between high body mass index (BMI) and subsequent cognitive decline, reported in elderly averaging below age 75, become less consistent at older ages. We compared the associations of BMI with cognition in moderately old (ages 75–84, N = 154) and oldest-old (85+, N = 93) samples. BMI and cognition were assessed cross-sectionally in cognitively intact elderly (mean age = 84.5, SD = 4.4) male veterans. Regression analyses of three cognitive domains — executive functions/language, attention, and memory—compared relationship with BMI between the moderately old and oldest-old. Higher BMI was associated with relatively poorer executive functions/language performance in the moderately old, while the opposite relationship, higher BMI associated with relatively better performance, was found in the oldest-old. Associations for the other two cognitive domains did not differ significantly between age groups. The reversal of association direction for executive functions/language performance with higher BMI is consistent with the protected survivor model. This model posits a minority subpopulation with a protective factor—genetic or otherwise—against both mortality and cognitive decline associated with risk factor status. The very old who remain cognitively intact despite the presence of risk factors are more likely to possess protection.

Keywords

body mass indexdementiaoldest-oldsuccessful cognitive agingprotected survivor
Type
Brief Report
Information
International Psychogeriatrics , Volume 31 , Issue 6: Issue Theme: Frailty, Cognition, and Mental Health , June 2019 , pp. 895 - 899
Copyright
© International Psychogeriatric Association 2019 

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References

Beeri, M. S. et al. (2006). Age, gender, and education norms on the CERAD neuropsychological battery in the oldest old. Neurology, 67, 1006–1010. doi: 10.1212/01.wnl.0000237548.15734.cd.CrossRefGoogle ScholarPubMed
Crum, R. M., Anthony, J. C., Bassett, S. S. and Folstein, M. F. (1993). Population-based norms for the Mini-Mental State examination by age and educational level. Journal of the American Medical Association, 269, 2386–2391. doi: 10.1001/jama.1993.03500180078038.CrossRefGoogle ScholarPubMed
Emmerzaal, T. L., Kiliaan, A. J. and Gustafson, D. R., (2015). 2003–2013: a decade of body mass index, Alzheimer’s disease, and dementia. Journal of Alzheimer’s Disease, 43, 739–755. doi: 10.3233/JAD-141086.CrossRefGoogle ScholarPubMed
Flegal, K. M., Graubard, B. I., Williamson, D. F. and Gail, M. H. (2007). Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA, 298, 2028–2037. doi: 10.1001/jama.298.17.2028.CrossRefGoogle ScholarPubMed
Gustafson, D. R. et al. (2009). Adiposity indicators and dementia over 32 years in Sweden. Neurology, 73, 1559–1566. doi: 10.1212/WNL.0b013e3181c0d4b6.CrossRefGoogle ScholarPubMed
Kivimaki, M., Singh-Manoux, A., Shipley, M. J. and Elbaz, A. (2015). Does midlife obesity really lower dementia risk? Lancet Diabetes Endocrinology, 3, 498. doi: 10.1016/S2213-8587(15)00216-8.CrossRefGoogle ScholarPubMed
Kuo, H.-K. et al. (2006). Cognitive function in normal- Weight, overweight, and obese older adults: an analysis of the advanced cognitive training for independent and vital elderly cohort. Journal of the American Geriatrics Society, 54, 97–103.CrossRefGoogle ScholarPubMed
Launer, L. J. and Harris, T. (1996). Weight, height and body mass index distributions in geographically and ethnically diverse samples of older persons. Ad Hoc Committee on the Statistics of Anthropometry and Aging. Age and Ageing, 25, 300–306. doi: 10.1093/ageing/25.4.300.CrossRefGoogle ScholarPubMed
Luchsinger, J. A., Patel, B., Tang, M. X., Schupf, N. and Mayeux, R. (2007). Measures of adiposity and dementia risk in elderly persons. Archives of Neurology, 64, 392–398. doi: 10.1001/archneur.64.3.392.CrossRefGoogle ScholarPubMed
Qizilbash, N. et al. (2015). BMI and risk of dementia in two million people over two decades: a retrospective cohort study. Lancet Diabetes & Endocrinology, 3, 431–436. doi: 10.1016/S2213-8587(15)00033-9.CrossRefGoogle ScholarPubMed
Silverman, J. M. and Schmeidler, J. (2018). The protected survivor model: using resistant successful cognitive aging to identify protection in the very old. Medical Hypotheses, 110, 9–14. doi: 10.1016/j.mehy.2017.10.022.CrossRefGoogle ScholarPubMed
Stewart, R. et al. (2005). A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging study. Archives of Neurology, 62, 55–60. doi: 10.1001/archneur.62.1.55.CrossRefGoogle ScholarPubMed
Tolppanen, A. M. et al. (2014). Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort. Journal of Alzheimer's Disease, 38, 201–209. doi: 10.3233/JAD-130698.CrossRefGoogle ScholarPubMed
Visser, M. and Harris, T. B. (2012). Body composition and ageing. In: Newman, A. B. and Cauley, J. A. (eds.), The Epidemiology of Aging (pp. 275–292). Dordrecht, Netherlands: Springer Science+Business Media.CrossRefGoogle Scholar
Winter, J. E., MacInnis, R. J., Wattanapenpaiboon, N. and Nowson, C. A. (2014). BMI and all-cause mortality in older adults: a meta-analysis. The American Journal of Clinical Nutrition, 99, 875–890. doi: 10.3945/ajcn.113.68122.CrossRefGoogle ScholarPubMed
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