This study evaluated the influence of cognitive reserve on
neuropsychological test performance in 198 patients infected with the
hepatitis C virus. IQ scores, educational level, and occupational rating
were combined to calculate a Cognitive Reserve Score (CRS) for each
patient. Similar to studies of infection with the human immunodeficiency
virus, there was a significantly increased risk of impairment in
neuropsychological test performance in individuals with lower CRSs. It is
important to account for CRS when assessing cognitive findings in
large-scale clinical trials. (JINS, 2007, 13,
687–692.)Financial relationships of
the authors with Hoffmann-La Roche, Inc., are as follows: K.L. Lindsay is
a consultant and receives research support; A.S.F. Lok is a consultant and
receives grant support; and R.J. Fontana is on the speaker's bureau.
Authors with no financial relationships related to this project are as
follows: L.A. Bieliauskas, C. Back-Madruga, E.C. Wright, and Z.
Kronfol.