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Serum vitamin-mineral profiles – association with breast cancer risk including dietary patterns and supplements use: a case-control study
- Beata Krusinska, Lidia Wadolowska, Malgorzata Anna Slowinska, Maciej Biernacki, Marek Drozdowski
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- Journal:
- Proceedings of the Nutrition Society / Volume 79 / Issue OCE2 / 2020
- Published online by Cambridge University Press:
- 10 June 2020, E279
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Breast cancer is the most diagnosed cancer among women worldwide. Studies regarding diet and blood levels of vitamins and minerals in the breast cancer aetiology are limited and the results are inconclusive. We investigated the association between serum vitamin-mineral profiles (V-MPs) and breast cancer (BC) risk with including dietary patterns (DPs) and use of supplements. This case-control study involved 420 women aged 40–79 years from north-eastern Poland, including 190 newly-diagnosed breast cancer cases. The serum concentrations of vitamins (folate, cobalamin, 25(OH) vitamin D) and minerals (iron, calcium, magnesium) were marked in 129 post-menopausal women (82 controls, 47 cases) using an immune-analyser Cobas e411 and a Cobas Integra 400plus auto-analyser (Roche Diagnostics®), respectively. A posteriori V-MPs were derived with a Principal Component Analysis (PCA). Three PCA-driven DPs: ‘Non-Healthy’, ‘Prudent’, and ‘Margarine and Sweetened Dairy’ were described previously. A logistic regression analysis was performed. The odds ratios (ORs) and 95% confidence interval (95% CI) were calculated. Two serum V-MPs were identified. The ‘Folate-Cobalamin-Vitamin D’ profile was loaded heavily by the folate (factor loading 0.82), cobalamin (0.81) and vitamin D (0.49). The ‘Iron-Calcium’ profile was loaded heavily by the iron (0.81) and calcium (0.77). The ‘Magnesium-vitamin D’ profile was loaded heavily by the magnesium (0.92) and vitamin D (0.39). The risk of BC was lower by 88% (OR: 0.12; 95%Cl: 0.02–0.88; p < 0.05) in the upper tertile of the serum ‘Iron-Calcium’ profile compared to the bottom tertile. The risk of BC was lower by 67% (OR: 0.33; 95%Cl: 0.11–0.97; p < 0.05) at the level of serum 25(OH) vitamin D ≥ 24.6 ng/mL and lower by 68% (OR: 0.32; 95%Cl: 0.11–0.91; p < 0.05) at the level of serum calcium ≥ 9.6 mg/dL. There was the inverse association of the serum ‘Magnesium-Vitamin D’ profile with the risk of BC, which disappeared after adjustment for DPs. No significant association between BC risk and the serum ‘Folate-Cobalamin-Vitamin D’ profile and also folate, cobalamin, iron or magnesium considered separately was revealed. These findings highlight that the higher-adequate serum concentrations of both iron and calcium as well as close-to-adequate concentrations of calcium and vitamin D considered separately may protect against breast cancer among postmenopausal women, independently of dietary patterns and use of supplements. Therefore, women should be screened for blood concentrations of multiple vitamins and minerals in the breast cancer prevention.
Sociodemographic and family correlates of dietary-lifestyle patterns in young men: cross-sectional study (MeDiSH Project)
- Marta Lonnie, Lidia Wadolowska, Joanna Kowalkowska, Elzbieta Bandurska-Stankiewicz
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- Journal:
- Proceedings of the Nutrition Society / Volume 79 / Issue OCE2 / 2020
- Published online by Cambridge University Press:
- 10 June 2020, E203
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The aim of this study was to identify the sociodemographic and family correlates associated with dietary and lifestyle patterns in young men. In all, 367 men from the Warmia and Mazury region (Poland), aged 19–40 years old participated in the study. Data regarding sociodemographic, family status, dietary and lifestyle characteristics were collected through structured interviews using food frequency questionnaire KomPAN (Jezewska-Zychowicz et al. 2018, http://www.knozc.pan.pl). Dietary and lifestyle patterns were derived using Principal Component Analysis (PCA). In total, 25 dietary and 6 lifestyle standardised variables were included in the PCA. The associations were verified using logistic regression. Four DLPs were derived, explaining 33% of the variance. Men from the upper tertile of “Protein food, fried-food and recreational physical activity” pattern (characterised by frequent intake of white meat, white rice, eggs, red meat, fried food, groats, higher number of meals a day and recreational activity) were more likely to be under 30 years old (odds ratio, OR = 2.20, 95% confidence interval, 95%CI: 1.30–3.70) than men from the bottom tertile. Men from the upper tertile of “Sandwiches and convenience foods” pattern (characterised by frequent intake of cold meats and smoked sausages, white bread, butter, cheese, sweets and tinned meat) were more likely to be in a relationship (1.95, 1.14–3.34) than men from the bottom tertile. Men from the upper tertile of “Fast foods and stimulants” pattern (characterised by frequent intake of sweetened beverages, energy drinks, alcohol, fast foods, and smoking currently or/and in the past) were more likely to be under 30 years old (2.46, 1.46–4.14), to live in towns and rural areas (2.07, 1.21–3.55) and to have lower educational level (2.01, 1.20–3.36) in comparison to men from the bottom tertile. Men from the upper tertile of “Healthy diet, activity at work, former smoking” pattern (characterised by frequent intake of fruit, vegetables, fermented milk products, wholegrain bread, fish, cottage cheese, milk, groats, legumes, higher number of meals a day, physical activity at work and smoking in the past) were more likely to work physically (2.06, 1.22–3.47) and be in a relationship (1.93, 1.12–3.32). Sociodemographic and family correlates were strongly associated with dietary and lifestyle patterns, both healthy and unhealthy, in our sample of young men. The results demonstrate that diet and lifestyle interventions should be particularly targeted at men under 30 years old, those living in small towns and rural areas and with lower educational level.
Serum inflammatory profiles – association with breast cancer risk including dietary patterns: a case-control study
- Beata Krusinska, Lidia Wadolowska, Malgorzata Anna Slowinska, Maciej Biernacki, Marek Drozdowski
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- Journal:
- Proceedings of the Nutrition Society / Volume 79 / Issue OCE2 / 2020
- Published online by Cambridge University Press:
- 10 June 2020, E410
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Breast cancer is the most common cancer among women worldwide. Diet and inflammation have been associated with carcinogenesis. However, there are limited studies regarding both blood levels of inflammatory markers and diet with respect to the risk of breast cancer. We assessed the association between serum inflammatory profiles and breast cancer (BC) risk with including dietary patterns (DPs). This case-control study involved 420 women aged 40–79 years from north-eastern Poland, including 190 newly-diagnosed breast cancer cases. The serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6) and leukocytes (including neutrophil and lymphocyte count) were marked in 129 post-menopausal women (82 controls, 47 cases) using a Cobas Integra 400plus auto-analyser, an immune-analyser Cobas e411 (Roche Diagnostics®) and haematology analyser MEK-7300 (Nihon Kohden®), respectively. A posteriori inflammatory profiles were derived with a Principal Component Analysis (PCA). A logistic regression analysis was performed. The odds ratios (ORs) and 95% confidence interval (95% CI) were calculated. The ORs were adjusted for: age, BMI, socioeconomic status, overall physical activity, smoking status, abuse of alcohol, age at menarche, number of children, oral contraceptive use, hormone-replacement therapy use, family history of breast cancer, vitamin/mineral supplements use, hormone receptor status of breast cancer and PCA-driven DPs (‘Non-Healthy’, ‘Prudent’, and ‘Margarine and Sweetened Dairy’) score. Two serum inflammatoryprofiles were identified. The ‘CRP-IL-6’ profile was loaded heavily by the interleukin-6 (factor loading 0.78) and C-reactive protein (factor loading 0.75). The ‘Neutrophil-Lymphocyte’ profile was loaded heavily by the lymphocyte (factor loading 0.86) and neutrophil count (factor loading 0.70). The risk of BC was six times higher (OR = 6.05; 95%Cl: 1.93–18.91; p < 0.05) in the third tertile of serum ‘CRP-IL-6’ profile compared to the first or second tertile. The risk of BC was three times higher (OR = 3.11; 95%Cl: 1.05–9.20; p < 0.05) at the level of serum IL-6 > 3.10 pg/mL and seven times higher (OR = 7.48; 95%Cl: 2.31–24.29; p < 0.05) at the level of serum neutrophil count > 3.90 103/μL. No significant association between BC risk and serum ‘Neutrophil-Lymphocyte’ profile and also CRP or lymphocyte count considered separately was revealed. Concluding, the elevated serum levels of both C-reactive protein and interleukin-6, as well as elevated levels of interleukin-6 and neutrophil count considered separately, were associated with higher risk of postmenopausal breast cancer, independently of dietary patterns. Therefore, women should be screened for blood concentrations of multiple potential pro-inflammatory markers in the breast cancer prevention.
Within-country, regional variations in dietary patterns in a representative sample of Polish females 13–21-year-old: finding from the GEBaHealth study
- Lidia Wadolowska, Jolanta Czarnocinska, Joanna Kowalkowska, Marta Lonnie, Marzena Jezewska-Zychowicz, Ewa Babicz-Zielinska
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- Journal:
- Proceedings of the Nutrition Society / Volume 79 / Issue OCE2 / 2020
- Published online by Cambridge University Press:
- 10 June 2020, E200
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Some dietary patterns (DPs) identified across the world are classified as universal (e.g. ‘Western’ or ‘Prudent’) while other patterns are country-specific, often labelled as ‘Traditional’. Regional, country-level variations in DPs adherence were not extensively studied to date. The aim of this study was to analyse differences in DPs adherence among Polish females between country regions. A cross-sectional study was performed using data from a representative sample (n = 1107) of Polish females 13–21-year-old, enrolled for the Girls Eating Behaviours and Health Study. Initially, 2104 females were randomly selected from the Universal Electronic System of Population Register database. The response rate was 52.6%. All data were adjusted for survey weights to maintain the representativeness. Three short form food frequency questionnaires were applied. Four DPs were identified by principal component analysis: ‘Traditional Polish’ (positively loaded by higher consumption frequency of white bread, potatoes, meat and fat), ‘Vegetables and fruit’, ‘Fast-food and sweets’ and ‘Dairy and fats’. In line with the Polish database of Central Statistical Office, six Polish regions were considered: East (with the lowest Gross Domestic Product, GDP = 69.7; Poland = 100), North (DP = 84.8), North-West (GDP = 95.1), South (GDP = 98.8), South-West (GDP = 104.8) and Central (the highest GDP = 140.4). Multiple logistic regression analysis was used. Odds ratios (ORs) were adjusted for age and body mass index. Higher adherence to ‘Traditional Polish’ DP was found in 4 out of 5 regions (OR 2.02 to 2.53) when compared to the East region. Higher adherence to ‘Vegetables and fruit’ DP was found in 2 out of 5 regions (the South and the South-West; OR 1.71 and 1.81, respectively), when compared to the East region, and in 3 out of 5 regions (the South, the South-West and the Central; OR 1.69 to 2.23), when compared to the North-West region. Higher adherence to ‘Fast-food and sweets’ DP was found in the North region when compared to the three other regions as reference: the East (OR 1.94), the North-West (OR 1.93), and the South (OR 2.10). In young Polish females, high adherence to the ‘Traditional Polish’ DP was observed across the country, except of the poorest region (the East). The study highlights that young females from economically deprived regions are at higher risk of unhealthy (westernized) dietary behaviors while those living in more affluent regions more frequently consume fruit and vegetables being a high-cost food. Increasing the affordability of healthy foods should be considered as an important component of public health interventions, particularly in more deprived regions.
Dietary-lifestyle patterns associated with adiposity and metabolic abnormalities in young men: cross-sectional study (MeDiSH Project)
- Marta Lonnie, Lidia Wadolowska, Joanna Kowalkowska, Elzbieta Bandurska-Stankiewicz
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- Journal:
- Proceedings of the Nutrition Society / Volume 79 / Issue OCE2 / 2020
- Published online by Cambridge University Press:
- 10 June 2020, E114
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The aim of this study was to examine the associations of dietary-lifestyle patterns (DLPs) with adiposity and metabolic abnormalities in young Polish men. The cross-sectional study included 367 men 19–40-year-old. Dietary and lifestyle behaviours were determined with food frequency questionnaire (Jezewska-Zychowicz et al. 2018, http://www.knozc.pan.pl). DPLs were derived with Principal Component Analysis. Body size and composition was assessed using measuring tapes and bioelectrical impedance analysis (BIA) method. Adiposity was determined by the assessment of excessive body weight (body mass index, BMI = 25–29.9kg/m2 for overweight and ≥ 30kg/m2 for obesity), body-fat content (percentage body fat, %BF > 25%), central obesity status (waist circumference, WC > 102cm) and skeletal muscle mass (SMM < 31kg/m2). Metabolic abnormalities were determined if parameters exceeded: 100mg/dL for fasting blood glucose (FBG), 150mg/dL for triglycerides (TG), 200mg/dL for total cholesterol (TC) and at least one component of blood pressure (BP) was above the norm (SBP ≥ 130mmHg or/and DBP ≥ 80mmHg). Multivariate logistic regression was used to calculate odds ratio (OR) and verify the association between variables. Four DLPs were derived, explaining 33% of the variance. Greater adherence (upper vs. bottom tertile) to “Protein food, fried-food and recreational physical activity” (DLP1) and “Healthy diet, activity at work, former smoking” (DLP4) patterns was associated with higher odds of being overweight (odds ratio, OR = 2.12, 95% confidence interval, 95%CI: 1.15–3.89; 3.05,1.69–5.53) but with high SMM (2.62, 1.53–4.49; 3.27, 1.91–5.59) and lower odds of central obesity (0.36, 0.16–0.83; 0.30, 0.12–0.74) and high body-fat content (0.22, 0.11–0.43; 0.37, 0.19–0.72). In addition, men from the upper tertile of DLP1 had lower odds of increased TC (0.43, 0.24–0.75). Greater adherence to “Sandwiches and convenience foods” pattern (DPL2) was associated with higher odds of central obesity (3.36,1.38–8.12), high body-fat content (3.69, 1.88–7.24) and high TC (2.50, 1.47–4.59) and lower odds of high SMM (0.54,0.32–0.90). Greater adherence to “Fast foods and stimulants” pattern (DLP3) was associated with higher odds of general and central obesity (2.56,1.00–6.56; 3.54, 1.53–8.19), high body-fat content (4.47, 2.05–9.73), but not with metabolic abnormalities. No associations between upper tertiles of DLPs and FBG, TG and BP were found. The clustering of dietary and lifestyle behaviours in men revealed that healthy diet attempts combined with active lifestyle, at work or leisure time, reduced risk of adiposity and metabolic abnormalities, despite some unhealthy components, former smoking or fried-food consumption. The study strengthens previous findings that unhealthy dietary behaviours have an adverse effect on adiposity outcomes and metabolic health, potentially through the mechanisms associated with central obesity.
Changes in Attitudes toward Nutrition after an Education Program in Polish Teenagers: Report from the ABC of Healthy Eating Study
- Jadwiga Hamulka, Lidia Wadolowska, Joanna Kowalkowska, Marta Jeruszka-Bielak, Joanna Frackiewicz, Krystyna Gutkowska
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- Journal:
- Proceedings of the Nutrition Society / Volume 79 / Issue OCE2 / 2020
- Published online by Cambridge University Press:
- 10 June 2020, E591
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The sustainability of education focused on improving teenagers’ attitudes toward nutrition from a longer-term perspective has not yet been studied extensively. The aim of this study was to determine the sustainability of attitudes toward nutrition after 3 and 9 months among Polish teenagers in a follow-up study. An education-based intervention study was carried out among 464 Polish teenagers aged 11–12 years (educated/control group: 319/145). In the educated group, a multicomponent, school-based education program lasting three weeks and covering five diet-related and lifestyle-related topics was implemented. Attitudes toward nutrition were determined with a shorter version (TFEQ10; 10 statements) of a three-factor eating questionnaire (TFEQ13) dedicated to school-aged adolescents, where three subscales were developed: Emotional Eating (EE: 2 statements, 0–6 points), Uncontrolled Eating (UE: 5 statements, 0–15 points), and Cognitive Restraint of Eating (CRE: 3 statements, 0–9 points). The data was collected 3 times: (i) before education (at baseline), (ii) after 3 months to measure the short-term effect of education, (iii) after 9 months to measure the medium-term effect of education. Differences between groups (educated vs. control or baseline vs. follow-up) were verified with the Mann–Whitney test. At the baseline, the mean values for all three scales were not significantly different between educated and control groups, calculated separately for boys and girls as well as for normal or overweight/obese teenagers, with the exception for Emotional Eating in the total sample and normal weight students. After 3-month follow-up, the mean values decreased in an educated group for all three subscales, for the total sample (EE: 1.3 vs 1.2; UE: 5.2 vs 4.7; CRE: 4.2 vs 4.0), for both sexes, and both body weight subpopulations, while increased or remained on the same level in control group (for total sample EE: 1.5 vs 1.6; UE: 5.6 vs 5.8; CRE: 4.1 vs 4.2). After 9 months, in the educated group, the means slightly increased when compared to the means after 3 months, but were still lower than those at the baseline. This study has shown that nutritional education of teenagers 11–12 years gives a long-lasting effect of attitudes toward nutrition (Emotional Eating and Uncontrolled Eating) visible after 3 months, and to a less extent after 9 months. We suppose, that improvement of the attitudes toward nutrition in teenagers, education programs should be regularly conducted and addressed not only to children but also to the adults responsible for children's nutrition.
Empirically derived dietary-lifestyle patterns and cardiometabolic health in young men: a review
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- Marta Lonnie, Lidia Wadolowska
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- Journal:
- Proceedings of the Nutrition Society / Volume 79 / Issue 3 / August 2020
- Published online by Cambridge University Press:
- 27 April 2020, pp. 324-330
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Sex and gender are important factors that impact cardiometabolic traits. Men have lower life expectancy and higher prevalence of fatal chronic conditions at younger age. Lifestyle risk profiles in young men have been rarely studied in the context of cardiometabolic health. This review aimed to summarise the evidence regarding the patterns of dietary-lifestyle behaviours in a population of young men (age <40years) and their associations with cardiometabolic health. Overall, unfavourable clusters of health behaviours are more prominent in men, when compared to women and more prevalent in younger adults, when compared to older age groups. Early signs of cardiometabolic health abnormalities have been reported among men with higher adherence to patterns which consistently shared poor dietary habits as a common denominator, combined with stimulant use, inadequate sleep or insufficient physical activity. In the majority of studies, dietary assessment was limited to the investigation of one or two behaviours, most frequently fruit and vegetable intake. Since young men may engage in a mixture of explicit behaviours, the examination of a singular dietary habit may not represent the overall diet quality. To conclude, the data regarding the synergistic effects of a broad spectrum of dietary and lifestyle behaviours in the context of cardiometabolic health remain scarce in this population. The inclusion of a broader range of dietary and lifestyle variables into the multicomponent pattern analysis might have a greater potential in explaining the association with cardiometabolic health. Defining behavioural clusters can help to develop interventions, tailored to the specific needs of the targeted group.
The elimination of meat from the diet selectively decreases pancreatic elastase secretion
- Jaroslaw Walkowiak, Lidia Wadolowska, Anna Szaflarska-Poplawska, Aleksandra Lisowska, Alina Bugajewska, Juliusz Przyslawski
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- Journal:
- British Journal of Nutrition / Volume 98 / Issue 1 / July 2007
- Published online by Cambridge University Press:
- 01 July 2007, pp. 154-158
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- July 2007
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Since the vegetarian diet lacks the substrate for pancreatic elastase-1 as an enzyme, a decreased secretion of this enzyme could be expected. We aimed therefore to assess the changes of exocrine pancreatic secretion in a prospective way in a group of healthy omnivores who modified their diet by abstaining from meat for 1 month. Twenty healthy omnivores (fourteen females and six males) were used in the study. The nutrient intake was assessed for 7 d before commencing the study (omnivore diet) and after 1 month of dietary modification (modified diet; meat excluded). Similarly, the faecal output of pancreatic enzymes (elastase-1, chymotrypsin and lipase) was assessed before and 1 month after the period of dietary modification. Statistical differences between two points of the assessment (paired data) were calculated with the use of the Wilcoxon rank test. The relationship between the changes of faecal enzyme output and the changes in nutrient intake was assessed using multiple regression analysis. The dietary changes resulted in statistically significant decrease of faecal elastase-1 output (P < 0·05), whereas for chymotrypsin and lipase no changes were observed. No significant change in stool weight was recorded. No statistically significant correlation between changes in energy and nutrient consumption and changes in faecal output of pancreatic enzymes has been found. It was concluded that the exclusion of meat from the diet for a 1-month period results in significant changes in pancreatic secretion with a selective decrease of elastase-1 output. However, the underlying factor remains unclear.