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Making medications stick: improving medication adherence by highlighting the personal health costs of non-compliance
- JON M. JACHIMOWICZ, JOE J. GLADSTONE, DAN BERRY, CHARLOTTE L. KIRKDALE, TRACEY THORNLEY, ADAM D. GALINSKY
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- Journal:
- Behavioural Public Policy / Volume 5 / Issue 3 / July 2021
- Published online by Cambridge University Press:
- 27 February 2019, pp. 396-416
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Poor compliance of prescription medication is an ongoing public health crisis. Nearly half of patients do not take their medication as prescribed, harming their own health while also increasing public health care costs. Despite these detrimental consequences, prior research has struggled to establish cost-effective and scalable interventions to improve adherence rates. We suggest that one reason for the limited success of prior interventions is that they make the personal health costs of non-adherence insufficiently prominent, while a higher saliency of these costs may motivate patients to adhere more. In the current research, we test whether an intervention that makes the personal health costs of non-compliance more salient for patients will increase their medication adherence. To do so, we conducted a randomized controlled trial with 16,191 patients across 278 UK pharmacies over a 9-month time period and manipulated the perceived consequences of medication non-adherence. We find that patients who received a treatment highlighting the personal health costs of non-compliance were significantly more likely to adhere to their medication than three comparison groups (odds ratio = 1.84, 95% confidence interval = 1.37–2.47). Shifting patients’ focus to the personal health costs of non-compliance may thus offer a potentially cost-effective and scalable approach to improving medication adherence.
Thermogravimetry/evolved water analysis (TG/EWA) combined with XRD for improved quantitative whole-rock analysis of clay minerals in sandstones
- D. M. Thornley, T. J. Primmer
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- Journal:
- Clay Minerals / Volume 30 / Issue 1 / March 1995
- Published online by Cambridge University Press:
- 09 July 2018, pp. 27-38
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Current methods of quantitative whole-rock clay mineral analysis of sandstones often provide little more than an estimate of clay mineral abundances, especially where the total clay mineral content is <10 wt% of the sandstone. More accurate determinations of clay mineral abundance in the whole rock can be made by combining thermogravimetry/evolved water analysis (TG/EWA) and X-ray diffraction (XRD) data. The TGA/EWA system incorporates a purpose built thermobalance linked to a water specific infrared detector which is used to measure quantitatively the clay mineral dehydroxylation water evolved from the whole rock when heated from 250°C to 900°C. This gives a measure of the total hydroxyl content of the clay minerals in the whole rock which, when combined with XRD analysis of a separated clay size-fraction, enables individual clay mineral abundances in the whole-rock sample to be determined. Results on artificial sand/clay mineral mixtures prepared with known amounts of different clay minerals (chlorite, illite and kaolinite) show that the accuracy of the combined method is most influenced by the accuracy of the XRD data. Errors associated with TG/EWA were found to be negligible by comparison. A case study is included in which the technique has been used to determine accurately the illite abundance in the Magnus Sandstone Reservoir, Northern North Sea.
Contributors
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. 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Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. 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Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. 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Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
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- 05 August 2012
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- 20 September 2010, pp xi-xliv
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A mathematical model of the rumen
- J. France, J. H. M. Thornley, D. E. Beever
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- The Journal of Agricultural Science / Volume 99 / Issue 2 / October 1982
- Published online by Cambridge University Press:
- 27 March 2009, pp. 343-353
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A dynamic model of rumen processes is constructed. The nine state variables considered are: rumen metabolic volume, non-rumen-degradable β-hexose, rumen-degradable β-hexose, α-hexose, water-soluble carbohydrates, non-protein nitrogen, rumendegradable protein and non-rumen-degradable protein. The dietary and salivary inputs to the rumen may be continuous, or pulsed. Rumen outflow given by the model is compared with data on sheep fed with different diets. Reasonable agreement is obtained when the model is run in the continuous mode, but there are considerable discrepancies between the experimental data and the pulsed model.
The lactation curve in cattle: a mathematical model of the mammary gland
- Heather D. St. C. Neal, J. H. M. Thornley
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- The Journal of Agricultural Science / Volume 101 / Issue 2 / October 1983
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- 27 March 2009, pp. 389-400
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A simple model of the mammary gland is described. In this model secretory cells are produced by cell division from undifferentiated cells, and the rate of division is determined by the level of a postulated hormone. The total activity of the milk secreting cells depends on the number of cells, substrate supply (assumed constant), and the amount of milk currently present in the animal. The secretory cells have a finite life, although their death may be expedited by milk remaining in the animal over a longer period of time. The model gives a good description of an experimental lactation curve; it is able to simulate the removal of milk by a suckling calf and machine milking with a variable number of milking periods a day.
A recurring salmonellosis epidemic in New Zealand linked to contact with sheep
- M. G. BAKER, C. N. THORNLEY, L. D. LOPEZ, N. K. GARRETT, C. M. NICOL
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- Epidemiology & Infection / Volume 135 / Issue 1 / January 2007
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- 02 June 2006, pp. 76-83
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One strain of Salmonella Brandenburg began causing large numbers of human infections in New Zealand in 1998. We investigated the emergence of this strain using combined notification and laboratory data on human and animal disease and a case-control study. S. Brandenburg infection in humans was characterized by spring peaks and high rates in the southern half of the South Island. This epidemic pattern followed very closely that seen in sheep. The case-control study found that infection was significantly associated with occupational contact with sheep and having a household member who had occupational contact with sheep, during the 3 days prior to illness or interview. We conclude that S. Brandenburg has become established as a zoonotic disease in New Zealand. Preventing infection requires control of the epidemic in sheep through vaccination, changes in farm management practices, and promotion of hand washing and other precautions to protect farmers and their families.
30 Doradus as a Nearby Infrared Guide to Starbursts
- M. D. Thornley, N.M. Förster Schreiber, H.W.W. Spoon, R. Genzel, D. Lutz, D. Kunze
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- Journal:
- Symposium - International Astronomical Union / Volume 190 / 1999
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- 25 May 2016, pp. 247-248
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- 1999
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We are exploring the properties of obscured starburst galaxies, using observations of atomic fine structure lines taken with the Short Wavelength Spectrometer aboard ISO. However, it is important to ascertain how well our starburst models can recover the properties of the stellar populations in more distant starbursts. For this purpose, we use observations of a nebular “shell” in the 30 Doradus region, to show that our models reliably predict the presence of the very massive stars observed directly in the 30 Doradus region.
NGC 7027: New 7.8–20.0 μm Array Camera and Hα/Hβ CCD Image Analysis of Dust, PAH and Ionized Gas Distribution
- D. Y. Gezari, M. D. Thornley, S. R. Heap, S. N. Shore, F. Varosi, S. J. Meatheringham, S. P. Maran
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- Journal:
- Symposium - International Astronomical Union / Volume 155 / 1993
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- 07 August 2017, p. 230
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- 1993
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Infrared array camera images of the planetary nebula NGC7027 at seven wavelenghts between 7.8 and 20μm taken at the IRTF telescope are compared to Hα and Hβ images obtained at the CFHT, and published 2-, 6-, and 20-cm VLA maps, all made with better than ∼ 1 arcsec resolution. The mid-infrared images have also been deconvolved using the Maximum Residual Likelihood algorithm to show structural details on the ∼ 0.3 arcsec scale. The visible, infrared and radio images are aligned with ±0.2 arcsec astrometric precision using common features and visible stars. Image algebra can then be readily performed. The images are analysed to determine the spatial distribution of poly cyclic aromatic hydrocarbon (PAH) grains and ionized gas relative to the continuum dust emission. The results show the extent of the mid-infrared dust continuum, the PAH emission features at 8.65 and 11.25μm, and would reveal any contribution from 9.8 μm “silicate” emission. The optically thicker 20-cm emission more closely resembles the extinction-corrected Hα distribution. The large grains giving rise to the visible extinction (derived from the Hα/Hβ ratio) are distribued differently from the mid-infrared and ionized gaz, indicating the location of the outer cold dust. The 11.6μm image could contain both PAH and continuum grain emission, and we have attempted to separate the two components. It appears that the overall emission distributions are quite similar for all the infrared wavelengths, so the various dust constituents are generally uniformly mixed. However there are indications that the 11.6μm PAH emission distribution is patchy and not identical to the continuum dust, although not distinctly different in radial distance from the center. The ionized gas distribution peaks inside that of the dust continuum. The visible/infrared/radio spatial analysis, and color indices calculated from the infrared images, are used to develop a detailed new morphological model of NGC7027 based on this comprehensive multi-wavelength data set.
Simulation of the metabolism of absorbed energy-yielding nutrients in young sheep
- Margaret Gill, J. H. M. Thornley, J. L. Black, J. D. Oldham, D. E. Beever
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- Journal:
- British Journal of Nutrition / Volume 52 / Issue 3 / November 1984
- Published online by Cambridge University Press:
- 09 March 2007, pp. 621-649
- Print publication:
- November 1984
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1. A mathematical model is described, which simulates the metabolism of absorbed nutrients (amino acids, acetic acid, butyric acid, glucose, lipid and propionic acid) in growing sheep.
2. The basic assumption of the model is that each nutrient is partitioned between synthetic, oxidative or intermediate reactions with rates of reaction which are described using enzyme kinetics. These rates depend on the relationship between maximum reaction rates, constants of affinity and inhibition and the concentrations of metabolites as determined by the model.
3. Synthetic reactions calculate fat and protein deposition while intermediate reactions involve the production of ATP and NADPH. There is a total of twelve state variables and the model, programmed in CSMP and ACSL, is solved by integration of twelve differential equations.
4. The model calculates the efficiency of utilization of metabolizable energy for different nutrient inputs and the results may be interpreted in terns of fluxes through the metabolite pools. Simulations using inputs representing forage- and concentrate-based diets indicated decreased efficiency for the forage at high levels of intake and possible reasons for this were further studied in simulations where the inputs of protein and glucose were varied.