5 results
Characterisation of age and polarity at onset in bipolar disorder
- Janos L. Kalman, Loes M. Olde Loohuis, Annabel Vreeker, Andrew McQuillin, Eli A. Stahl, Douglas Ruderfer, Maria Grigoroiu-Serbanescu, Georgia Panagiotaropoulou, Stephan Ripke, Tim B. Bigdeli, Frederike Stein, Tina Meller, Susanne Meinert, Helena Pelin, Fabian Streit, Sergi Papiol, Mark J. Adams, Rolf Adolfsson, Kristina Adorjan, Ingrid Agartz, Sofie R. Aminoff, Heike Anderson-Schmidt, Ole A. Andreassen, Raffaella Ardau, Jean-Michel Aubry, Ceylan Balaban, Nicholas Bass, Bernhard T. Baune, Frank Bellivier, Antoni Benabarre, Susanne Bengesser, Wade H Berrettini, Marco P. Boks, Evelyn J. Bromet, Katharina Brosch, Monika Budde, William Byerley, Pablo Cervantes, Catina Chillotti, Sven Cichon, Scott R. Clark, Ashley L. Comes, Aiden Corvin, William Coryell, Nick Craddock, David W. Craig, Paul E. Croarkin, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Udo Dannlowski, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Srdjan Djurovic, Howard J. Edenberg, Mariam Al Eissa, Torbjørn Elvsåshagen, Bruno Etain, Ayman H. Fanous, Frederike Fellendorf, Alessia Fiorentino, Andreas J. Forstner, Mark A. Frye, Janice M. Fullerton, Katrin Gade, Julie Garnham, Elliot Gershon, Michael Gill, Fernando S. Goes, Katherine Gordon-Smith, Paul Grof, Jose Guzman-Parra, Tim Hahn, Roland Hasler, Maria Heilbronner, Urs Heilbronner, Stephane Jamain, Esther Jimenez, Ian Jones, Lisa Jones, Lina Jonsson, Rene S. Kahn, John R. Kelsoe, James L. Kennedy, Tilo Kircher, George Kirov, Sarah Kittel-Schneider, Farah Klöhn-Saghatolislam, James A. Knowles, Thorsten M. Kranz, Trine Vik Lagerberg, Mikael Landen, William B. Lawson, Marion Leboyer, Qingqin S. Li, Mario Maj, Dolores Malaspina, Mirko Manchia, Fermin Mayoral, Susan L. McElroy, Melvin G. McInnis, Andrew M. McIntosh, Helena Medeiros, Ingrid Melle, Vihra Milanova, Philip B. Mitchell, Palmiero Monteleone, Alessio Maria Monteleone, Markus M. Nöthen, Tomas Novak, John I. Nurnberger, Niamh O'Brien, Kevin S. O'Connell, Claire O'Donovan, Michael C. O'Donovan, Nils Opel, Abigail Ortiz, Michael J. Owen, Erik Pålsson, Carlos Pato, Michele T. Pato, Joanna Pawlak, Julia-Katharina Pfarr, Claudia Pisanu, James B. Potash, Mark H Rapaport, Daniela Reich-Erkelenz, Andreas Reif, Eva Reininghaus, Jonathan Repple, Hélène Richard-Lepouriel, Marcella Rietschel, Kai Ringwald, Gloria Roberts, Guy Rouleau, Sabrina Schaupp, William A Scheftner, Simon Schmitt, Peter R. Schofield, K. Oliver Schubert, Eva C. Schulte, Barbara Schweizer, Fanny Senner, Giovanni Severino, Sally Sharp, Claire Slaney, Olav B. Smeland, Janet L. Sobell, Alessio Squassina, Pavla Stopkova, John Strauss, Alfonso Tortorella, Gustavo Turecki, Joanna Twarowska-Hauser, Marin Veldic, Eduard Vieta, John B. Vincent, Wei Xu, Clement C. Zai, Peter P. Zandi, Psychiatric Genomics Consortium (PGC) Bipolar Disorder Working Group, International Consortium on Lithium Genetics (ConLiGen), Colombia-US Cross Disorder Collaboration in Psychiatric Genetics, Arianna Di Florio, Jordan W. Smoller, Joanna M. Biernacka, Francis J. McMahon, Martin Alda, Bertram Müller-Myhsok, Nikolaos Koutsouleris, Peter Falkai, Nelson B. Freimer, Till F.M. Andlauer, Thomas G. Schulze, Roel A. Ophoff
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- Journal:
- The British Journal of Psychiatry / Volume 219 / Issue 6 / December 2021
- Published online by Cambridge University Press:
- 25 August 2021, pp. 659-669
- Print publication:
- December 2021
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Background
Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.
AimsTo examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.
MethodGenome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.
ResultsEarlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.
ConclusionsAAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
Effects of rehabilitation pruning and agroforestry on cacao tree development and yield in an older full-sun plantation
- Judith Riedel, Nora Kägi, Laura Armengot, Monika Schneider
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- Journal:
- Experimental Agriculture / Volume 55 / Issue 6 / December 2019
- Published online by Cambridge University Press:
- 06 February 2019, pp. 849-865
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Overaged full-sun cacao plantations and the need for sustainable production systems call for combining rehabilitation of plantations with the establishment of agroforestry. We tested the effect of drastic rehabilitation pruning of old cacao tree stock and the introduction of both high- and low-diversity agroforestry on survival, growth and yield of T. cacao in a commercial plantation in peninsular Malaysia over a period of 5 years. We further determined the incidence of pests and diseases of cacao pods and assessed the performance of the whole system for smallholder farmers, including yields of by-crops. Rehabilitation pruning negatively affected cacao tree development and short-term yield. No more effects of pruning on cacao yield were observed starting in the third year on in the monoculture and starting in the fourth year on in low-diversity agroforestry. We found similar cacao tree development and yield in the low-diversity agroforestry and a common practice monoculture, suggesting that the implementation of agroforestry is a commercially feasible strategy, due to additional income generated through timber production. Reduced cacao tree development and yield in the high-diversity agroforestry were compensated by additional harvests of cassava and banana compared to monoculture. Incidence of cocoa pod borer (Conopomorpha cramerella) was lower in the agroforestry systems, especially the high-diversity system, while the incidence of black pod disease (Phytophthora spp.) did not differ between agroforestry and monoculture. The findings highlight the potential of agroforestry to reconcile ecologically sustainable land use with natural, cost-effective pest management. While pruning needs to be done with timing and disease pressure in mind to minimize short-term yield losses, this measure proved to be a feasible strategy for establishing agroforestry on extant plantations.
CARBON STOCKS, LITTERFALL AND PRUNING RESIDUES IN MONOCULTURE AND AGROFORESTRY CACAO PRODUCTION SYSTEMS
- ULF SCHNEIDEWIND, WIEBKE NIETHER, LAURA ARMENGOT, MONIKA SCHNEIDER, DANIELA SAUER, FELIX HEITKAMP, GERHARD GEROLD
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- Journal:
- Experimental Agriculture / Volume 55 / Issue 3 / June 2019
- Published online by Cambridge University Press:
- 06 May 2018, pp. 452-470
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Agroforestry systems (AFS) can serve to decrease ecosystem carbon (C) losses caused by deforestation and inadequate soil management. Because of their shade tolerance, cacao plants are suitable to be grown in AFS, since they can be combined with other kinds of trees and shrubs. The potential for C sequestration in cacao farming systems depends on various factors, such as management practices, stand structure and plantation age. We compared conventionally and organically managed cacao monoculture systems (MCS) and AFS in Sara Ana (Bolivia) with respect to C stocks in plant biomass and to amounts of litterfall and pruning residues. The total aboveground C stocks of the AFS (26 Mg C ha−1) considerably exceeded those of the MCS (~7 Mg C ha−1), although the biomass of cacao trees was greater in the MCS compared to the AFS. Due to higher tree density, annual litterfall in the AFS (2.2 Mg C ha−1 year−1) substantially exceeded that in the MCS (1.2 Mg C ha−1 year−1). The amounts of C in pruning residues (2.6 Mg C ha−1 year−1 in MCS to 4.3 Mg C ha−1 year−1 in AFS) was more than twice those in the litterfall. Annual nitrogen (N) inputs to the soil through pruning residues of cacao and N-fixing trees were up to 10 times higher than the N inputs through external fertiliser application. We conclude that appropriate management of cacao AFS, involving the pruning of leguminous trees, will lead to increases in biomass, litter quantity and quality as well as soil C and N stocks. Thus, we recommend stimulating the expansion of well-managed AFS to improve soil fertility and enhance C sequestration in soils.
Implementation of a Market Entry Reward within the United States
- Gregory W. Daniel, Monika Schneider, Marianne Hamilton Lopez, Mark B. McClellan
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- Journal:
- Journal of Law, Medicine & Ethics / Volume 46 / Issue S1 / Spring 2018
- Published online by Cambridge University Press:
- 01 January 2021, pp. 50-58
- Print publication:
- Spring 2018
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As part of a multifactorial approach to address weak incentives for innovative antimicrobial drug development, market entry rewards (MERs) are an emerging solution. Recently, the Duke-Margolis Center for Health Policy released the Priority Antimicrobial Value and Entry (PAVE) Award proposal, which combines a MER with payment reforms, transitioning from volume-based to “value-based” payments for antimicrobials. Here, the PAVE Award and similar MERs are reviewed, focusing on further refinement and avenues for implementation.
Agroecosystem resilience and farmers’ perceptions of climate change impacts on cocoa farms in Alto Beni, Bolivia
- Johanna Jacobi, Monika Schneider, Patrick Bottazzi, Maria Pillco, Patricia Calizaya, Stephan Rist
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- Journal:
- Renewable Agriculture and Food Systems / Volume 30 / Issue 2 / April 2015
- Published online by Cambridge University Press:
- 19 August 2013, pp. 170-183
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Cocoa-based small-scale agriculture is the most important source of income for most farming families in the region of Alto Beni in the sub-humid foothills of the Andes. Cocoa is grown in cultivation systems of varying ecological complexity. The plantations are highly susceptible to climate change impacts. Local cocoa producers mention heat waves, droughts, floods and plant diseases as the main impacts affecting plants and working conditions, and they associate these impacts with global climate change. From a sustainable regional development point of view, cocoa farms need to become more resilient in order to cope with the climate change related effects that are putting cocoa-based livelihoods at risk. This study assesses agroecosystem resilience under three different cocoa cultivation systems (successional agroforestry, simple agroforestry and common practice monocultures). In a first step, farmers’ perceptions of climate change impacts were assessed and eight indicators of agroecological resilience were derived in a transdisciplinary process (focus groups and workshop) based on farmers’ and scientists’ knowledge. These indicators (soil organic matter, depth of Ah horizon, soil bulk density, tree species diversity, crop varieties diversity, ant species diversity, cocoa yields and infestation of cocoa trees with Moniliophthora perniciosa) were then surveyed on 15 cocoa farms and compared for the three different cultivation systems. Parts of the socio-economic aspects of resilience were covered by evaluating the role of cocoa cooperatives and organic certification in transitioning to more resilient cocoa farms (interviews with 15 cocoa farmers combined with five expert interviews). Agroecosystem resilience was higher under the two agroforestry systems than under common practice monoculture, especially under successional agroforestry. Both agroforestry systems achieved higher cocoa yields than common practice monoculture due to agroforestry farmers’ enhanced knowledge regarding cocoa cultivation. Knowledge sharing was promoted by local organizations facilitating organic certification. These organizations were thus found to enhance the social process of farmers’ integration into cooperatives and their reorientation toward organic principles and diversified agroforestry.
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