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9 - Malnutrition Status of Women, Children, and Adolescents in India and its Relation with Educational Attainment
- Edited by K. S. James, International Institute for Population Sciences, Mumbai, T. V. Sekher, International Institute for Population Sciences, Mumbai
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- India Population Report
- Published online:
- 15 August 2023
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- 27 June 2024, pp 313-346
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Summary
Introduction
India is going through a rapid socio-economic transition resulting in considerable changes in dietary patterns and nutrition levels among different sections of the population. Despite several policy initiatives to combat malnutrition (Ministry of Women and Child Development, n.d.) over the past more than four decades, the level of malnutrition in India remains abysmally high. Malnutrition was the top cause of death and disability in India in 2017, followed by dietary risks, including poor diet choices, according to the 2017 Global Burden of Disease study (Institute for Health Metrics and Evaluation [IHME], 2018). The groups at the greatest risk of malnutrition are children, adolescents, and women. According to the 2020 Global Nutrition Report, every second child under five years of age in India is malnourished in some form or the other, with a prevalence of wasting being 21 per cent and stunting being 38 per cent – both figures notably greater than the than the average for Asia, where the wasting level is over 9 per cent and stunting level 23 per cent (Development Initiatives, 2020). Additionally, 36 per cent of children under five years of age are underweight, while 2 per cent are overweight (International Institute for Population Sciences [IIPS] and ICF International, 2017). A poor nutritional status, particularly in early life, can have lifelong consequences on physical and psychological well-being and can also impair long-term employment opportunities (Black et al., 2013).
The proportion of under-nutrition among women of reproductive ages declined from 36 per cent in 2005–06 to 23 per cent in 2015–16; at the same time, the proportion of over-nourished (overweight or obese) women increased from 13 per cent to 21 per cent. Maternal under-nutrition contributes to foetal growth restriction, which increases the risk of neonatal deaths and, for survivors, stunting by two years of age (Black et al., 2013), thus passing on the burden of under-nutrition to the next generation.
School-age children and adolescents, too, are affected by under-nutrition and over-nutrition, but they failed to gain attention until the recent past; women and child health, particularly the health of children below the age of five years, had been the focus of researchers and policymakers all these years. According to a study on worldwide trends, more children and adolescents aged 5–19 years are moderately or severely underweight than obese (NCD Risk Factor Collaboration [NCD-RisC], 2017).
Processing GOTO survey data with the Rubin Observatory LSST Science Pipelines II: Forced Photometry and lightcurves
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- L. Makrygianni, J. Mullaney, V. Dhillon, S. Littlefair, K. Ackley, M. J. Dyer, J. Lyman, K. Ulaczyk, R. Cutter, Y.-L. Mong, D. Steeghs, D. K. Galloway, P. O’Brien, G. Ramsay, S. Poshyachinda, R. Kotak, L. Nuttall, E. Pallé, D. Pollacco, E. Thrane, S. Aukkaravittayapun, S. Awiphan, R. P. Breton, U. Burhanudin, P. Chote, A. Chrimes, E. Daw, C. Duffy, R. Eyles-Ferris, B. Gompertz, T. Heikkilä, P. Irawati, M. Kennedy, T. Killestein, A. Levan, T. Marsh, D. Mata-Sanchez, S. Mattila, J. Maund, J. McCormac, D. Mkrtichian, E. Rol, U. Sawangwit, E. Stanway, R. Starling, P. A Strøm, S. Tooke, K. Wiersema
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- Journal:
- Publications of the Astronomical Society of Australia / Volume 38 / 2021
- Published online by Cambridge University Press:
- 04 June 2021, e025
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We have adapted the Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) Science Pipelines to process data from the Gravitational-wave Optical Transient Observer (GOTO) prototype. In this paper, we describe how we used the LSST Science Pipelines to conduct forced photometry measurements on nightly GOTO data. By comparing the photometry measurements of sources taken on multiple nights, we find that the precision of our photometry is typically better than 20 mmag for sources brighter than 16 mag. We also compare our photometry measurements against colour-corrected Panoramic Survey Telescope and Rapid Response System photometry and find that the two agree to within 10 mmag (1 $\sigma$ ) for bright (i.e., $\sim 14{\rm th} \mathrm{mag}$ ) sources to 200 mmag for faint (i.e., $\sim 18{\rm th} \mathrm{mag}$ ) sources. Additionally, we compare our results to those obtained by GOTO’s own in-house pipeline, gotophoto, and obtain similar results. Based on repeatability measurements, we measure a $5\sigma$ L-band survey depth of between 19 and 20 magnitudes, depending on observing conditions. We assess, using repeated observations of non-varying standard Sloan Digital Sky Survey stars, the accuracy of our uncertainties, which we find are typically overestimated by roughly a factor of two for bright sources (i.e., $< 15{\rm th} \mathrm{mag}$ ), but slightly underestimated (by roughly a factor of 1.25) for fainter sources ( $> 17{\rm th} \mathrm{mag}$ ). Finally, we present lightcurves for a selection of variable sources and compare them to those obtained with the Zwicky Transient Factory and GAIA. Despite the LSST Software Pipelines still undergoing active development, our results show that they are already delivering robust forced photometry measurements from GOTO data.
Processing GOTO data with the Rubin Observatory LSST Science Pipelines I: Production of coadded frames
- J. R. Mullaney, L. Makrygianni, V. Dhillon, S. Littlefair, K. Ackley, M. Dyer, J. Lyman, K. Ulaczyk, R. Cutter, Y.-L. Mong, D. Steeghs, D. K. Galloway, P. O’Brien, G. Ramsay, S. Poshyachinda, R. Kotak, L. Nuttall, E. Pallé, D. Pollacco, E. Thrane, S. Aukkaravittayapun, S. Awiphan, R. Breton, U. Burhanudin, P. Chote, A. Chrimes, E. Daw, C. Duffy, R. Eyles-Ferris, B. Gompertz, T. Heikkilä, P. Irawati, M. Kennedy, T. Killestein, A. Levan, T. Marsh, D. Mata-Sanchez, S. Mattila, J. Maund, J. McCormac, D. Mkrtichian, E. Rol, U. Sawangwit, E. Stanway, R. Starling, S. Tooke, K. Wiersema
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- Journal:
- Publications of the Astronomical Society of Australia / Volume 38 / 2021
- Published online by Cambridge University Press:
- 18 January 2021, e004
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The past few decades have seen the burgeoning of wide-field, high-cadence surveys, the most formidable of which will be the Legacy Survey of Space and Time (LSST) to be conducted by the Vera C. Rubin Observatory. So new is the field of systematic time-domain survey astronomy; however, that major scientific insights will continue to be obtained using smaller, more flexible systems than the LSST. One such example is the Gravitational-wave Optical Transient Observer (GOTO) whose primary science objective is the optical follow-up of gravitational wave events. The amount and rate of data production by GOTO and other wide-area, high-cadence surveys presents a significant challenge to data processing pipelines which need to operate in near-real time to fully exploit the time domain. In this study, we adapt the Rubin Observatory LSST Science Pipelines to process GOTO data, thereby exploring the feasibility of using this ‘off-the-shelf’ pipeline to process data from other wide-area, high-cadence surveys. In this paper, we describe how we use the LSST Science Pipelines to process raw GOTO frames to ultimately produce calibrated coadded images and photometric source catalogues. After comparing the measured astrometry and photometry to those of matched sources from PanSTARRS DR1, we find that measured source positions are typically accurate to subpixel levels, and that measured L-band photometries are accurate to $\sim50$ mmag at $m_L\sim16$ and $\sim200$ mmag at $m_L\sim18$. These values compare favourably to those obtained using GOTO’s primary, in-house pipeline, gotophoto, in spite of both pipelines having undergone further development and improvement beyond the implementations used in this study. Finally, we release a generic ‘obs package’ that others can build upon, should they wish to use the LSST Science Pipelines to process data from other facilities.
Astrophysical entomology: dissecting the black widow population through multi-band light curve modelling
- Daniel Mata Sánchez, Mark R. Kennedy, Colin J. Clark, Rene P. Breton, Vikhram S. Dhillon
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- Journal:
- Proceedings of the International Astronomical Union / Volume 16 / Issue S363 / June 2020
- Published online by Cambridge University Press:
- 27 February 2023, pp. 324-326
- Print publication:
- June 2020
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The population of black widows, binary systems containing a millisecond pulsar and a very low-mass companion star exposed to the high-energy pulsar wind, has grown exponentially in the past few years. The number of black widow candidates is now over 30 systems, but only 14 have been confirmed so far. Their relevance in analysing the extremes of the neutron stars properties led to multiwavelength dedicated studies that revealed a rich phenomenology. In this work, we provide a glimpse into the black widow class through modelling of high-cadence multi-band light curves of 6 systems, accounting for almost half of the confirmed population. A better understanding of the black widow population, which hosts some of the most massive and fastest spinning neutron stars, will ultimately benefit future modelling of compact object mergers.
97 My Inner Blizzard: Effect of Weather on Multiple Sclerosis Exacerbation
- Chevelle R. Winchester, Priya Batta, Dhillon Davinder, Alan R. Hirsch
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- Journal:
- CNS Spectrums / Volume 24 / Issue 1 / February 2019
- Published online by Cambridge University Press:
- 12 March 2019, p. 223
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Study Objective
Exacerbation of Multiple Sclerosis (MS) symptoms prior to weather change has not heretofore been described.
MethodsCase Study: A 60 year old right handed female with lifelong anxiety and four years of depression presented with a 20 year history of MS manifested by bilateral lower extremity pain and weakness and urinary incontinence. Since the onset, she observed that approaching storms or weather changes cause her symptoms to worsen. This manifests one day prior to the meteorological shifts of rain or snow. This occurs whether she is at home or on vacation and unlike the weatherman, “she is never wrong.” The aggravation of symptomatology would consist of worsening leg pain and weakness of both lower extremities so that her functional status changes from using a cane to a wheelchair. These symptoms begin one day prior to the storm and gradually worsen to the point of maximum intensity as the storm arrives. The baseline pain is usually 5/10 in severity but with the storm it increases to 8/10. The pain, which progressively worsens as the storm advances, is a vice-like numbness in her shins and spasm in her legs. The pain and weakness will persist for as long as the storm lasts. The pain diminishes and the motor symptoms improve six hours after the storm is over. She can differentiate approaching snow or rain such that snow causes more intense symptoms. She denies change in symptomatology on airplanes or when she is present at high altitude such as Las Vegas or Colorado. She also affirms that her symptoms are worse when she is in a hot tub and better in a cold-water bath. She reports that there is a family history of similar ability to predict the weather in a cousin and nephew, both who also suffer from MS.
ResultsAbnormalities in Neurological Examination: BP 159/115. Pulse 100. Mental Status Examination: disheveled. Depressed mood with congruent affect. Short-term memory: 5 digits forwards, 2 digits backwards. Recent memory: able to recall none of 4 objects in 3minutes without improvement with reinforcement. Unable to interpret similarities or proverbs. Poor ability to calculate. Reflexes: 3+ bilateral lower extremities. Clock Drawing Test: 1 (abnormal).
ConclusionsUhthoff’s phenomena (hot bath test) is well described in MS (Humm, 2004), however the worsening of symptoms prior to weather change has not been reported. Possible mechanisms include meteorological induced anxiety and depression with associated exacerbation (Ackerman, 1998). Other possible mechanisms include misattribution, selective recall, or a misreporting due to psychological needs for acceptance by examiner, similar to the Hawthorne effect (observer effect) (Adair, 1984). With the approaching storms there could be a change in internal temperature, which then preferentially affects areas of demyelination (Kudo, 2014). It is worth querying those with epoch associated neurological disorders as to linkage with meteorological events.
125 Short Duration Monoballismus
- Davinder Dhillon, Priya Batta, Alan R. Hirsch
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- Journal:
- CNS Spectrums / Volume 23 / Issue 1 / February 2018
- Published online by Cambridge University Press:
- 15 June 2018, pp. 79-80
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Study Objective
While monoballismus has been reported to be associated with hemorrhagic lesions in the subthalamic nucleus (Ohnishi, 2009) and multiple sclerosis (MS) (Rosa, 2011), the duration has been reported to be at least six days (Soysal, 2012). A patient with epochs of monoballismus lasting for 45 minutes is presented.
MethodsCase Study: A 57 year old right handed female with attention deficit hereditary disorder predominantly inattentive on amphetamine sulphate, presented with two years of memory loss. For instance, after ordering food in restaurants, by the time the food arrives, she could not recall what she ordered. At the onset of this symptom, she noted three epochs of her left arm jerking for 45 minutes. The jerking would begin with low amplitude and low frequency and rapidly progress to the forearm and arm of greater magnitude and low frequency. With her right hand she would try to hold down her left arm without success. There was no associated paresis, sensory phenomena, headaches, dizziness, presyncope, loss of consciousness, or strong emotions. She admitted to frequent jamais vu.
ResultsAbnormalities: Neurological Examination: Mental Status Examination: Memory: Immediate Recall: 5 digits forward and 2 digits backwards. Cranial Nerve (CN) Examination: CN I: Alcohol Sniff Test 8 (hyposmia). CN XII: tongue tremor on protrusion. Motor Examination: Drift Test: positive right pronator drift. Gait Examination: Tandem Gait: unstable. Reflexes: 0-1 throughout. Neuropsychiatric Examination: Go-No-Go Test: 6/6 (normal). Animal Fluency Test: 15 (normal). Clock Drawing Test: 3 (abnormal). Center for Neurologic Study Lability Scale: 16 (pseudobulbar affect). Other: MRI with and without infusion: normal.
ConclusionTransient tonic-clonic movements of one limb have been described with focal epilepsy associated with diabetic non-ketotic hyperglycemia (Grant, 1985). A metabolic abnormality such as transient hypoglycemia or hyperkalemia can cause a focal dystonia (Soysal, 2012), which theoretically could manifest with monoballismus. This could be a somatic manifestation of underlying conflict, conversion disorder, or as a result of a physical manifestation of panic attack with hyperventilation and tetany (Mihai, 2008). This may be the first manifestation of a generalized cerebral disorder associated with chorea or ballismus such as Wilson’s disease, or Huntington’s Chorea (Mihai, 2008). It is possible that this is a variant of Alien Hand Syndrome with parietal lobe involvement (Shrestha, 2015). But this is unlikely given the absence of hemineglect or hemiagnosia. It is possible that amphetamines may have induced a monochorea. Chronic amphetamine use has been demonstrated to cause chorea (Klawans, 1974) and it theoretically could have caused ballismus movements in this case. In patients who present with short duration monoballismus, evaluation for subthalamic nuclei function, seizure disorders and other origins of ballismus are warranted.
Funding AcknowledgementsSmell & Taste Treatment and Research Foundation
175 Burning Mouth Syndrome Equivalent to Restless Leg Syndrome
- Priya Batta, Sarosh Majeed, Davinder Dhillon, Alan R Hirsch
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- Journal:
- CNS Spectrums / Volume 23 / Issue 1 / February 2018
- Published online by Cambridge University Press:
- 15 June 2018, p. 101
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Study Objective
Stuginski-Barbosa reported a patient with Burning Mouth Syndrome (BMS), whose symptoms were transiently improved with tongue movement, postulated to be an oral equivalent of restless leg syndrome (RLS) (Stuginski-Barbosa, 2008).
MethodsFour Case Studies are described.
ResultsCase 1: A 35 year old pathological left handed woman presented with one-year history of burning and stinging sensations on the sides of the tongue and lips without any known precipitant. It is reduced with chewing gum and eating. For the last few months she noticed tongue movement reduced the burning sensation. Two to three seconds of tongue movement alleviated the burning from 3/10 to 0/10 in intensity, which persists for one minute after cessation of tongue movement.
Case 2: A 57 year old right handed female, three years prior to presentation, had multiple teeth extractions. Four months later, she perceived a rough sensation of her tongue, which has gradually changed to a burning sensation which has persisted since then. The burning is 10/10 in severity and constant. Chewing 24 pieces of gum a day reduces the pain. Movement of the tongue including anterior-posterior protrusion and retraction, side to side movements without contacting surrounding oral mucosa, converted pain from 9/10 to 5/10, which lasted approximately 1 minute.
Case 3: Eight years prior to presentation, this 60 year old woman developed BMS, after dental extraction. The pain involves the tongue (right and center of palate) accompanied by a gritty sandpaper-like sensation. The burning is a level 5/10 in intensity and progressively worsens throughout the day. Burning mouth pain is made less intense with chewing gum and using dental wax. Baseline burning mouth severity is at level 5/10 however, with protrusion, retraction, and side-to-side movement of the tongue, the intensity dropped to 3/10.
Case 4: Three years prior to presentation, a 59 year old female patient suffered severe allergies with onset of burning mouth and absent taste. The burning is in the middle of her tongue, rarely, her palate, but never on her lips. Severity is 2/10 and is worse in the morning, with drinking red wine, and hot drinks. It is better with cold drinks and ice cream. Movement of her tongue side-to-side eliminates the burning severity from 2/10 to 0/10, lasting one minute.
ConclusionLike the patients described by Stuginski & Barbosa 2008, these four patients showed reduced pain in response to tongue kinesia (Stuginski-Barbosa, 2008). Their mandibulation of gum as an analgesic maneuver may have been due, not to the taste of the gum, but rather to the associated tongue movement that mastication induces. Through moving, large nerve fibers of proprioception are stimulated, which may act through the Gate Controlled Theory of Pain of Melzac and Wall, to reduce unrestricted small nerve fiber discharge, thus inhibiting pain. Query regarding movement or gum chewing inhibition of BMS is warranted.
Funding AcknowledgementsSmell & Taste Treatment and Research Foundation.
174 Pseudogout Induced by Vortioxetine
- Priya Batta, Davinder Dhillon, Alan R Hirsch
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- Journal:
- CNS Spectrums / Volume 23 / Issue 1 / February 2018
- Published online by Cambridge University Press:
- 15 June 2018, p. 100
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Study Objective
Vortioxetine induced monoarticular pain has not heretofore been described. Such a case is presented.
MethodCase study: A 49 year old right handed female with a past history of multiple hospitalizations for chronic severe migraine, presented with complaints of depression and stress. She has had depression for 20 years, which has been constant and worsened in the past 5 years. As her migraines became more frequent, her depression also worsened. She has never been suicidal, but does endorse sadness, crying spells, fatigue, demotivation, lack of interest, poor concentration, irritability, anger, guilt, hopelessness, helplessness, anorexia, PM insomnia with frequent awakenings, absent libido and racing thoughts.
ResultsAbnormalities in her mental status examination: Orientated times 2. Disheveled. Defensive. Motor retardation. Mood: depressed, anxious and irritable with blunted affect. Remote memory: President: Obama,?. Beck Depression Inventory II: 23 (moderate depression). Beck Anxiety Inventory: 25 (moderate anxiety).
The patient was begun on 5 mg of vortioxetine every night. Within two days, she developed pain and swelling of the distal interphalangeal joint of the left great toe. The pain was so severe that she demonstrated an antalgic gait. After five days the medication was discontinued and two days later, there was full resolution of the swelling and pain, and ambulation returned to normal.
ConclusionsThe mechanism whereby vortioxetine induced this monoarticular pain is unclear. Underlying depression alone can precipitate arthritic exacerbation (Trivedi, 2004). This was unlikely given the long duration of her depression as well as the timing of the precipitant (vortioxetine use) and resolution shortly after the medication was discontinued. Alternatively, in the depressed state, there may be a greater perception of somatic pain, which allowed her to appreciate any arthritic pain which may have pre-existed the use of vortioxetine (Howard, 1991). As such, this may have represented a correspondence bias (Gilbert, 1995). Furthermore, mild new pain is perceived as more intense in those who are depressed (Howard, 1991). Thus, any minimal arthritic injury may be viewed as more intense. Vortioxetine may have paradoxically exacerbated anxiety and anxiety can precipitate pain (Narasimhan & Campbell). Alternatively, vortioxetine could have caused a generalized allergic reaction, which may have initially manifest in the great toe. If the patient continued the medication, she may have developed a generalized systemic reaction including involvement of multiple joints. Another possibility is that it caused an allergic histamine mediated hive like reaction, generalized, as well as on the toe. Continued use of the joint may have caused this to be intensified, with associated swelling, while the general reaction subsided. Inquiry about monoarticular involvement in those taking vortioxetine is warranted.
Funding AcknowledgementsSmell & Taste Treatment and Research Foundation
124 Epochs of Anosmia and Ageusia in Multiple Sclerosis: Chemosensory Uhthoff’s Phenomenon
- Davinder Dhillon, Jasir T Nayati, Priya Batta, Alan R. Hirsch
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- Journal:
- CNS Spectrums / Volume 23 / Issue 1 / February 2018
- Published online by Cambridge University Press:
- 15 June 2018, pp. 78-79
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Study Objective
To reveal that while long duration of anosmia and ageusia has been seen with Multiple Sclerosis (MS) [Doty 1997], repetitive shorter epochs ofanosmia and ageusia has not heretofore been presented.
MethodsCase Study: A 39 year old right-handed male, with a history of MS, presents with six years MS concurrent with epochs of anosmia and ageusia. The anosmia andageusia present concurrently, preventing him from smelling and tasting his meal. At baseline, he is able to smell and taste coffee, peppermint, gum, sweet and salty foods, rating his smell and taste at 70% normal. However, during the epochal events, he reports the inability to smell and taste white rice, shrimp, meat, butter, carrots, onions, spinach, and sour foods. He states that these episodes occur approximately ten times a week, last for two hours, and rates his smell and taste from 0-10% during these events.
ResultsAbnormalities Neurological Examination: Cranial Nerve (CN) Examination: CN II: bilateral pale discs. CN III, IV, VI: bilateral ptosis. CN IX, X: decreased gag reflex bilaterally. Motor Examination: Drift Test: positive left pronator drift, with right adductor digiti minimi sign and right cerebellar spooning. Sensory Examination: Ipswich Touch Test: decreased in left lower extremity. Temperature: decreased in left lower extremity. Rydel-Seiffer Vibratory Test: bilateral upper extremities 5 and bilateral lower extremities 3. Tandem Gait: unstable. Cerebellar Examination: Holmes Rebound Phenomena: positive with left greater than right. Reflexes: 1+ bilateral upper extremities, absent bilateral lower extremities. Neuropsychiatric Examination: Animal Fluency Test: 15 (abnormal). Clock Drawing Test: 3 (abnormal). Center for Neurologic Study Lability Scale: 16 (pseudobulbar affect).
ConclusionPrimary olfactory dysfunction with secondary inhibition of retronasal smell and perceived taste [Gruss 2015] can be an etiology. Such an olfactory dysfunction may reflect variation in nasal mucosal engorgement due to normal variability of the olfactory cycle [Eccles 1978]. This phenomenon is an unlikely due to the short duration ofepochs.
The cause of anosmia and ageusia in this patient suggests a central lesion involved in the processing of both smell and taste. Transient rapid symptoms associated with temperature change, as in Uhthoff’s phenomenon seen in MS, can manifest with deficiency in special senses including visual field loss [Davis 2010]. Such also may be the origin for the chemosensory loss seen here. While this phenomenon may be induced by hot baths, more subtle temperature changes may also induce such symptoms [Romani 2000]. Given that olfactory threshold changes have been demonstrated in acute inflammatory changes in MS, such a temperature related etiology is more likely to manifest [Lutterotti 2011]. MS patients should be screened for chemosensory dysfunction, and those with chemosensory dysfunction should be assessed for demyelinating disease.
Funding AcknowledgementsSmell and Taste Treatment and Research Foundation
Simazine Distribution and Degradation in Red Pine Seedlings
- P. S. Dhillon, W. R. Byrnes, C. Merritt
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- Journal:
- Weed Science / Volume 16 / Issue 3 / July 1968
- Published online by Cambridge University Press:
- 12 June 2017, pp. 374-376
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Distribution and degradation of 2-chloro-4,6-bis(ethylamino)-s-triazine (simazine) at 5, 10, 15, and 20 ppmw in red pine (Pinus resinosa Ait.) seedlings were investigated using 14C-ring-labeled simazine dispersed in agar medium. Simazine readily entered red pine roots and moved rapidly into stem and needles. Accumulation was greatest in roots, next in stems, and least in needles. Significant differences in simazine uptake by roots were observed among concentrations between 5 and 20 ppmw in the incubation medium. Radiochromatographic scans revealed that a small amount of simazine was degraded to three unknown compounds by both fresh and boiled homogenates from whole plants, needles, stems, and roots. There were no observable differences in the amount of simazine degraded by homogenates of each separate plant part.
OS2 - 166 A Novel Model of Human Lung-to-Brain Metastasis and its Application to the Identification of Essential Metastatic Regulatory Genes
- M Singh, C Venugopal, T Tokar, K R Brown, N McFarlane, D Bakhshinyan, T Vijayakumar, B Manoranjan, S Mahendram, P Vora, M Qazi, M Dhillon, A Tong, K Durrer, N Murty, R Hallett, J A Hassell, D Kaplan, JC Cutz, I Jurisica, J Moffat, S K Singh
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- Journal:
- Canadian Journal of Neurological Sciences / Volume 43 / Issue S4 / October 2016
- Published online by Cambridge University Press:
- 18 October 2016, p. S2
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Brain Metastases (BM) represent a leading cause of cancer mortality. While metastatic lesions contain subclones derived from their primary lesion, their functional characterization has been limited by a paucity of preclinical models accurately recapitulating the stages of metastasis. This work describes the isolation of a unique subset of metastatic stem-like cells from primary human patient samples of BM, termed brain metastasis initiating cells (BMICs). Utilizing these BMICs we have established a novel patient-derived xenograft (PDX) model of BM that recapitulates the entire metastatic cascade, from primary tumor initiation to micro-metastasis and macro-metastasis formation in the brain. We then comprehensively interrogated human BM to identify genetic regulators of BMICs using in vitro and in vivo RNA interference screens, and validated hits using both our novel PDX model as well as primary clinical BM specimens. We identified SPOCK1 and TWIST2 as novel BMIC regulators, where in our model SPOCK1 regulated BMIC self-renewal and tumor initiation, and TWIST2 specifically regulated cell migration from lung to brain. A prospective cohort of primary lung cancer specimens was used to establish that SPOCK1 and TWIST2 were only expressed in patients who ultimately developed BM, thus establishing both clinical and functional utility for these gene products. This work offers the first comprehensive preclinical model of human brain metastasis for further characterization of therapeutic targets, identification of predictive biomarkers, and subsequent prophylactic treatment of patients most likely to develop BM. By blocking this process, metastatic lung cancer would effectively become a localized, more manageable disease.
Varietal and harvesting stage variation in the content of carotenoids, ascorbic acid and tocopherols in the fruit of bitter gourd (Momordica charantia L.)
- Narinder P. S. Dhillon, Chung-Cheng Lin, Zhanyong Sun, Peter M. Hanson, Dolores R. Ledesma, Sandra D. Habicht, Ray-Yu Yang
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- Journal:
- Plant Genetic Resources / Volume 15 / Issue 3 / June 2017
- Published online by Cambridge University Press:
- 15 January 2016, pp. 248-259
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Bitter gourd (Momordica charantia L.) is an important market vegetable in the tropics. The objectives of this study were to (1) conduct a preliminary evaluation of genetic diversity in bitter gourd flesh (without seeds) for phytonutrient (carotenoid, ascorbic acid and tocopherol) contents with the aim to understand which phytonutrients might be increased through breeding, (2) assess the association between fruit traits and phytonutrient contents and (3) evaluate the effect of the fruit harvest stage on phytonutrient contents. A total of 17 diverse bitter gourd entries of various commercial market types were evaluated for fruit traits and phytonutrient contents for 2 years. Significant differences (P= 0.05) among the entries were detected for total carotenoids, total tocopherols, dry matter and fruit traits. Mean total carotenoid contents of the entries ranged from 10 to 1335 μg/100 g fresh weight in year 1 and 10 to 1185 μg/100 g fresh weight in year 2. Mean ascorbic acid contents were 69 and 61 mg/100 g fresh weight in year 1 and year 2, respectively. Total tocopherol contents among the entries ranged from 480 to 1345 and 445 to 2145 μg/100 g fresh weight in year 1 and year 2, respectively. Total carotenoid and ascorbic acid contents were highest at 12 days after fruit set (DAFS), but total tocopherol contents were highest from 14 to 20 DAFS. A 100 g portion of bitter gourd fruit can meet 190, 17 and 8% of the recommended daily allowances of vitamin C, vitamin E and vitamin A, respectively, for adults.
Contributors
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- By Rony A. Adam, Gloria Bachmann, Nichole M. Barker, Randall B. Barnes, John Bennett, Inbar Ben-Shachar, Jonathan S. Berek, Sarah L. Berga, Monica W. Best, Eric J. Bieber, Frank M. Biro, Shan Biscette, Anita K. Blanchard, Candace Brown, Ronald T. Burkman, Joseph Buscema, John E. Buster, Michael Byas-Smith, Sandra Ann Carson, Judy C. Chang, Annie N. Y. Cheung, Mindy S. Christianson, Karishma Circelli, Daniel L. Clarke-Pearson, Larry J. Copeland, Bryan D. Cowan, Navneet Dhillon, Michael P. Diamond, Conception Diaz-Arrastia, Nicole M. Donnellan, Michael L. Eisenberg, Eric Eisenhauer, Sebastian Faro, J. Stuart Ferriss, Lisa C. Flowers, Susan J. Freeman, Leda Gattoc, Claudine Marie Gayle, Timothy M. Geiger, Jennifer S. Gell, Alan N. Gordon, Victoria L. Green, Jon K. Hathaway, Enrique Hernandez, S. Paige Hertweck, Randall S. Hines, Ira R. Horowitz, Fred M. Howard, William W. Hurd, Fidan Israfilbayli, Denise J. Jamieson, Carolyn R. Jaslow, Erika B. Johnston-MacAnanny, Rohna M. Kearney, Namita Khanna, Caroline C. King, Jeremy A. King, Ira J. Kodner, Tamara Kolev, Athena P. Kourtis, S. Robert Kovac, Ertug Kovanci, William H. Kutteh, Eduardo Lara-Torre, Pallavi Latthe, Herschel W. Lawson, Ronald L. Levine, Frank W. Ling, Larry I. Lipshultz, Steven D. McCarus, Robert McLellan, Shruti Malik, Suketu M. Mansuria, Mohamed K. Mehasseb, Pamela J. Murray, Saloney Nazeer, Farr R. Nezhat, Hextan Y. S. Ngan, Gina M. Northington, Peggy A. Norton, Ruth M. O'Regan, Kristiina Parviainen, Resad P. Pasic, Tanja Pejovic, K. Ulrich Petry, Nancy A. Phillips, Ashish Pradhan, Elizabeth E. Puscheck, Suneetha Rachaneni, Devon M. Ramaeker, David B. Redwine, Robert L. Reid, Carla P. Roberts, Walter Romano, Peter G. Rose, Robert L. Rosenfield, Shon P. Rowan, Mack T. Ruffin, Janice M. Rymer, Evis Sala, Ritu Salani, Joseph S. Sanfilippo, Mahmood I. Shafi, Roger P. Smith, Meredith L. Snook, Thomas E. Snyder, Mary D. Stephenson, Thomas G. Stovall, Richard L. Sweet, Philip M. Toozs-Hobson, Togas Tulandi, Elizabeth R. Unger, Denise S. Uyar, Marion S. Verp, Rahi Victory, Tamara J. Vokes, Michelle J. Washington, Katharine O'Connell White, Paul E. Wise, Frank M. Wittmaack, Miya P. Yamamoto, Christine Yu, Howard A. Zacur
- Edited by Eric J. Bieber, Joseph S. Sanfilippo, University of Pittsburgh, Ira R. Horowitz, Emory University, Atlanta, Mahmood I. Shafi
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- Book:
- Clinical Gynecology
- Published online:
- 05 April 2015
- Print publication:
- 23 April 2015, pp viii-xiv
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Bone-anchored hearing aids and unilateral sensorineural hearing loss: why do patients reject them?
- D Siau, B Dhillon, R Andrews, K M J Green
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- Journal:
- The Journal of Laryngology & Otology / Volume 129 / Issue 4 / April 2015
- Published online by Cambridge University Press:
- 17 March 2015, pp. 321-325
- Print publication:
- April 2015
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Objectives:
This study aimed to report the bone-anchored hearing aid uptake and the reasons for their rejection by unilateral sensorineural deafness patients.
Methods:A retrospective review of 90 consecutive unilateral sensorineural deafness patients referred to the Greater Manchester Bone-Anchored Hearing Aid Programme between September 2008 and August 2011 was performed.
Results:In all, 79 (87.8 per cent) were deemed audiologically suitable: 24 (30.3 per cent) eventually had a bone-anchored hearing aid implanted and 55 (69.6 per cent) patients declined. Of those who declined, 26 (47.3 per cent) cited perceived limited benefits, 18 (32.7 per cent) cited reservations regarding surgery, 13 (23.6 per cent) preferred a wireless contralateral routing of sound device and 12 (21.8 per cent) cited cosmetic reasons. In all, 32 (40.5 per cent) suitable patients eventually chose the wireless contralateral routing of sound device.
Conclusion:The uptake rate was 30 per cent for audiologically suitable patients. Almost half of suitable patients did not perceive a sufficient benefit to proceed to device implantation and a significant proportion rejected it. It is therefore important that clinicians do not to rush to implant all unilateral sensorineural hearing loss patients with a bone-anchored hearing aid.
Contributors
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- By Shamsuddin Akhtar, Greg Albert, Sidney Allison, Muhammad Anwar, Haruo Arita, Amanda Barker, Mary Hanna Bekhit, Jeanna Blitz, Tyson Bolinske, David Burbulys, Asokumar Buvanendran, Gregory Cain, Keith A. Candiotti, Daniel B. Carr, Derek Chalmers, John Charney, Rex Cheng, Roger Chou, Keun Sam Chung, Anna Clebone, Frederick Conlin, Susan Dabu-Bondoc, Tiffany Denepitiya-Balicki, Jeanette Derdemezi, Anahat Kaur Dhillon, Ho Dzung, Juan Jose Egas, Stephen M. Eskaros, Zhuang T. Fang, Claudia R. Fernandez Robles, Victor A. Filadora, Ellen Flanagan, Dan Froicu, Allison Gandey, Nehal Gatha, Boris Gelman, Christopher Gharibo, Muhammad K. Ghori, Brian Ginsberg, Michael E. Goldberg, Jeff Gudin, Thomas Halaszynski, Martin Hale, Dorothea Hall, Craig T. Hartrick, Justin Hata, Lars E. Helgeson, Joe C. Hong, Richard W. Hong, Balazs Horvath, Eric S. Hsu, Gabriel Jacobs, Jonathan S. Jahr, Rongjie Jaing, Inderjeet Singh Julka, Zeev N. Kain, Clinton Kakazu, Kianusch Kiai, Mary Keyes, Michael M. Kim, Peter G. Lacouture, Ryan Lanier, Vivian K. Lee, Mark J. Lema, Oscar A. de Leon-Casasola, Imanuel Lerman, Philip Levin, Steven Levin, JinLei Li, Eric C. Lin, Sharon Lin, David A. Lindley, Ana M. Lobo, Marisa Lomanto, Mirjana Lovrincevic, Brenda C. McClain, Tariq Malik, Jure Marijic, Joseph Marino, Laura Mechtler, Alan Miller, Carly Miller, Amit Mirchandani, Sukanya Mitra, Fleurise Montecillo, James M. Moore, Debra E. Morrison, Philip F. Morway, Carsten Nadjat-Haiem, Hamid Nourmand, Dana Oprea, Sunil J. Panchal, Edward J. Park, Kathleen Ji Park, Kellie Park, Parisa Partownavid, Akta Patel, Bijal Patel, Komal D. Patel, Neesa Patel, Swati Patel, Paul M. Peloso, Danielle Perret, Anthony DePlato, Marjorie Podraza Stiegler, Despina Psillides, Mamatha Punjala, Johan Raeder, Siamak Rahman, Aziz M. Razzuk, Maggy G. Riad, Kristin L. Richards, R. Todd Rinnier, Ian W. Rodger, Joseph Rosa, Abraham Rosenbaum, Alireza Sadoughi, Veena Salgar, Leslie Schechter, Michael Seneca, Yasser F. Shaheen, James H. Shull, Elizabeth Sinatra, Raymond S. Sinatra, Neil Singla, Neil Sinha, Denis V. Snegovskikh, Dmitri Souzdalnitski, Julie Sramcik, Zoreh Steffens, Alexander Timchenko, Vadim Tokhner, Marc C. Torjman, Co T. Truong, Nalini Vadivelu, Ashley Vaughn, Anjali Vira, Eugene R. Viscusi, Dajie Wang, Shu-ming Wang, J. Michael Watkins-Pitchford, Steven J. Weisman, Ira Whitten, Bryan S. Williams, Jeremy M. Wong, Thomas Wong, Christopher Wray, Yaw Wu, Anthony T. Yarussi, Laurie Yonemoto, Bita H. Zadeh, Jill Zafar, Martha Zegarra, Keren Ziv
- Edited by Raymond S. Sinatra, Jonathan S. Jahr, University of California, Los Angeles, School of Medicine, J. Michael Watkins-Pitchford
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- Book:
- The Essence of Analgesia and Analgesics
- Published online:
- 06 December 2010
- Print publication:
- 14 October 2010, pp xi-xviii
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DE CVn: A Bright, Eclipsing Red Dwarf – White Dwarf Binary
- E. J. M. van den Besselaar, R. Greimel, L. Morales-Rueda, G. Nelemans, J. R. Thorstensen, T. R. Marsh, V. S. Dhillon, R. M. Robb, D. D. Balam, E. W. Guenther, J. Kemp, T. Augusteijn, P. J. Groot
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- Journal:
- Proceedings of the International Astronomical Union / Volume 2 / Issue S240 / August 2006
- Published online by Cambridge University Press:
- 12 July 2007, pp. 105-108
- Print publication:
- August 2006
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DE CVn is a relatively unstudied eclipsing binary where one of the components is an M dwarf and the other is a white dwarf. Its brightness makes it an ideal system for a detailed study in the context of common-envelope evolution of a detached white dwarf – red dwarf binary with a relatively short orbital period (∼8.7 hours). We present a detailed study of the basic parameters (e.g. orbital period, components' masses and spectral types) for this system from photometric and spectroscopic studies. The eclipses observed during several photometric observing runs were used to derive the ephemeris. We have used spectroscopic data to derive the radial velocity variations of the emission lines and these are used to determine the components' masses and the orbital separation. The secondary component in DE CVn is an M3 main-sequence star and the primary star, which only contributes to the blue continuum, is a cool white dwarf with a temperature of ∼8000 K. From the photometry and spectroscopy together, we have set a limit on the binary inclination. This system is a post-common-envelope system where the progenitor of the present day white dwarf was a low-mass star (M≤2M⊙). The time before DE CVn becomes a semi-detached system is longer than the Hubble time.
Abstracts for the British Congenital Cardiac Association Annual Meeting: The Barbican, London, 24–25 November 2005: Poster Presentations: Transcatheter closure of ventricle-pulmonary artery communications after cavopulmonary shunt or Fontan procedure
- T. Desai, J. G. C. Wright, R. Dhillon, O. Stumper
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- Journal:
- Cardiology in the Young / Volume 16 / Issue 3 / June 2006
- Published online by Cambridge University Press:
- 01 June 2006, pp. 321-322
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Background: Ventricle-pulmonary artery connections are rare in patients after the Fontan procedure. However, these can cause significant long term problems. Hence the catheter occlusion of the anterograde flow in these patients would be beneficial. Further, in patients with a cavopulmonary shunt anterograde pulmonary blood flow is frequently maintained, but, in some patients, can cause significant volume loading of the heart or can complicate the subsequent Fontan procedure. Objective: To evaluate the use of interventional catheter closure of a ventricle-pulmonary artery communication in the setting of a cavopulmonary shunt or after the Fontan procedure. Patients and methods:This was a retrospective study at a tertiary referral centre. Eight patients (Age: 1.5–18 years, mean 7.8 years) underwent transcatheter closure of a ventricle-pulmonary artery communication. Indications were cardiac failure or persistent pleural effusions after cavopulmonary shunt (n = 2) or after Fontan (n = 3) and abolishing the volume load of the single ventricle prior to Fontan completion (n = 3). Results: Devices used were 17 mm Rashkind Umbrella device (n = 1), Amplatzer PDA device (n = 7) and Amplatzer ASD device (n = 1). One patient required two devices. There were no procedural complications. All 3 patients with prolonged pleural effusions (1 post CP shunt and 2 post Fontan) showed complete resolution of effusions between 4 and 10 days after catheter closure. Two patients underwent transcatheter occlusion for progressive ventricular dilatation and cardiac failure. The first patient was post Fontan and showed gradual improvement in ventricular function. The second patient after CP shunt died 48 hours post intervention (non procedure related cardiac death). Three patients underwent catheter closure to off-load the systemic ventricle prior to the Fontan procedure. The device had to be removed prior to release in 1 patient, due to unsatisfactory position. All 3 patients underwent successful completion of Fontan 6 weeks to 3 months post catheter. Conclusions: Transcatheter closure of ventricle-pulmonary artery communication is a safe and effective technique in the treatment of selected patients after CP shunt or Fontan procedure with early or late complications due to inappropriate pulmonary blood flow. This intervention should also be considered prior to the Fontan procedure in selected patients with ventricular overload.
Multiwavelength observations of eclipsing polars
- A. Schwope, V. Hambaryan, A. Staude, R. Schwarz, G. Kanbach, H. Steinle, F. Schrey, T. Marsh, V. Dhillon, J. Osborne, P. Wheatley, S. Potter
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- Journal:
- International Astronomical Union Colloquium / Volume 190 / 2004
- Published online by Cambridge University Press:
- 12 April 2016, pp. 92-105
- Print publication:
- 2004
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Multiwavelength observations of polars are essential for developing the big picture of these systems, particularly to gain understanding of the relevant accretion-induced heating and cooling processes. Eclipsing polars are prime targets for such studies since different radiation processes can be disentangled by observations with high-time resolution. We present a preliminary combined analysis of space-based observations (XMM-Newton, ROSAT, HST) with ground-based high-speed photometry (MCCP, OPTIMA, ULTRACAM) of DP Leo, HU Aqr and UZ For. We determine the location and extent of different emission components and find secular and short-term changes in the accretion geometries. We find displaced optical and X-ray emission regions in DP Leo and HU Aqr as well as mini-bursts and accretion arcs of variable size in HU Aqr. We report marked changes in the X-ray eclipse length of UZ For between high and low states.
Low Mass White Dwarfs in Binaries
- T. R. Marsh, V. S. Dhillon, S. R. Duck
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- Journal:
- International Astronomical Union Colloquium / Volume 158 / 1996
- Published online by Cambridge University Press:
- 12 April 2016, pp. 465-468
- Print publication:
- 1996
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The lowest mass white dwarfs that can have been produced by single star evolution in the lifetime of the Galaxy have masses of about 0.53 M⊙. There are however several white dwarfs known with significantly lower masses. Evolution in a binary provides a straightforward explanation as the star can lose its envelope before ever burning helium. The products are expected to be short-period binary stars. To test this we have looked at 15 such stars and have found that 8 of them are close binaries. Thus binary evolution does have a major role in the formation of low-mass white dwarfs. We discuss whether the non-detections could also be binary stars.
Temperature Structure of the Disk in V1315 AQL
- C. Moreno, R. G. M. Rutten, V. S. Dhillon
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- Journal:
- International Astronomical Union Colloquium / Volume 158 / 1996
- Published online by Cambridge University Press:
- 12 April 2016, pp. 15-16
- Print publication:
- 1996
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We present a progress report on the analysis of time-resolved spectrophotometric observations of the cataclysmic variable V1315 Aql. The spectral range of the data covers the entire Balmer series up to and including the Balmer jump. We aim to use these data to test the steady-state accretion disk model.