Caves and rockshelters are critical loci for the analysis and understanding of human trajectories in the past. Use and re-uses of the same context, however, might have had serious impacts on depositional aspects. This is particularly true for the archaeological history of desert environments, such as the central Sahara, where most of the deposits are made of loose sand, rich in organic matter. Besides traditional stratigraphic reconstructions and a detailed study of the material culture, radiocarbon measurements from different contexts analyzing several types of material (bone, dried and charred coprolite, uncharred and charred plant remains, etc.) can highlight intrinsic critical aspects of 14C determinations. These measurements must be carefully evaluated to provide a correct chronological assessment of the life history of the site. We present the statistics derived from the set of about 50 14C measurements from the site of Takarkori, southwest Libya, where early Holocene foragers and then groups of cattle herders inhabited the area from ∼10,200 to 4600 cal yr BP. We have used the BCal Bayesian 14C calibration program designed for statistical presentation of the calibrated data and the estimation of their probability for different phases. Results indicate that the Takarkori rockshelter was occupied during 4 phases of the following cultures: Late Acacus from 10,170 to 8180 cal yr BP; Early Pastoral, 8180–6890 cal yr BP; Middle Pastoral, 7160–5610 cal yr BP; and Late Pastoral, 5700–4650 cal yr BP.