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A principle and practice of sufficiency informs Immanuel Kant’s Toward Perpetual Peace (1795), which concludes by condemning the rapaciousness of Europeans. Responding to that too-muchness, the philosopher experiments with the thought of what he calls “mere hospitality.” Hospitality is not opposed to inhospitality but a species of inhospitality that welcomes the possibility of being alone, together rather than either alone and apart or together as one. Because human beings cannot forever part ways on the curved surface of the planet, and because they must also live among each other on one and the same planet, if they are to live at all, they are obliged, against their inclinations to fight or flee, to dwell alongside others whom they do not necessarily wish to be nearby. The earth’s surface speaks a bare truth to an enclosed, Europeanized world, a world in which so many are denied a place: It is enough.
Hundreds of large stone vessels can be found dispersed across the Xieng Khouang Plateau in northern Laos. Despite nearly a century of research, their purpose remains uncertain.
Here, the authors report on the excavation of the exceptionally large Jar 1 at Site 75, which contains a collective mortuary assemblage of secondary interments. The disarticulated remains of at least 37 individuals hint at the jars’ function within a complex funerary sequence, with direct radiocarbon dating indicating a prolonged period of mortuary activity c. cal AD 890–1160, which was a time of increasing regional interaction and mobility in Southeast Asia.
Myopia is an increasing global health concern and a leading cause of visual impairment. Genetic factors play a major role, and polygenic risk scores (PRSs) may help identify children at high risk of developing myopia. However, most PRSs are based on European populations, and accurately predicting risk across ancestries remains a challenge. We developed and evaluated PRSs for spherical equivalent refractive error (SER) and myopia using multitrait and multi‑ancestry genomewide association study data. A multitrait analysis of SER‑correlated traits identified 709 genomewide significant loci. PRSs were generated with SBayesRC for each ancestry group and for a combined multi‑ancestry model, and validated in the Australian Twins Eye Study and non‑European participants from the UK Biobank. The European PRSs explained approximately 20% of SER variance in Europeans and 18% in admixed Europeans and showed good transferability to South Asian (14%), East Asian (13%), and African (8%) groups. A multi‑ancestry PRS further improved prediction in Africans, explaining 9% of the variance. Predictive accuracy for high myopia was strong in the admixed group (AUC = 0.82, 95% CI [0.78, 0.87]), with all ancestry groups achieving AUCs of at least 0.70; European ancestry data were not available. PRS also predicted axial length in children, particularly those aged 5–8 years, where individuals in the lowest 10% of the PRS distribution had significantly longer axial lengths (β = 0.81 mm, p = 5.71 × 10−3). These findings enhance genetic prediction of SER and myopia, showing the potential of multitrait, multi-ancestry PRS for early, equitable risk stratification.
Urban spaces also become the backdrop for the literary works discussed in this chapter. In his detailed assessment of the Irish crime fiction of the last decade, the author analyses the way in which the novels of John Brady, Gene Kerrigan, Ingrid Black, and Niamh O'Connor, among others, portray immigrants as victims of Irish people, who often exploit them in criminal activities such as the trafficking of narcotics, prostitution, and the illegal movement of other immigrants. These migrant characters usually inhabit the ‘mean streets’ of Dublin, Galway, Limerick, and Cork. This signals the recent interest of Irish crime writers in setting their plots in ‘homegrown’ locations, in contrast to previous novels which tended to fictionalise crime in non-Irish settings.
The school environment plays a key role in adolescents’ emotional development and well-being, yet little research has compared self-harm and related psychosocial problems across different secondary school types.
Methods:
Using data from the Growing Up in Ireland (GUI) longitudinal cohort, this study examined differences in the prevalence of self-harm and psychosocial risk factors across different school types: single-sex versus coeducational, fee-paying versus non-fee-paying, disadvantaged versus non-disadvantaged, and schools with different religious ethos. Multilevel regression models distinguished school-level from individual-level effects.
Results:
Almost all variance in self-harm and most of the variance in psychosocial problems associated with self-harm occurred at the individual level. Higher self-harm prevalence in single-sex girls’ schools was accounted for by the greater concentration of girls, who had over twice the odds of self-harm compared with boys (OR 2.1, 95% CI 1.71–2.69). No significant differences in self-harm were found by school socio-economic status or religious ethos. Disadvantaged schools showed higher prevalence in seven of nine psychosocial problems, although only internalising problems and truancy/absenteeism remained significantly associated with disadvantaged schools in the fully adjusted models. Adolescents whose parents reported having a religion were less likely to self-harm (OR 0.62, 95% CI 0.50–0.75).
Discussion:
Although schools are important settings for self-harm prevention, findings indicate that interventions should primarily target individuals and high-risk groups. Girls, in particular, may benefit from supports addressing self-harm. Disadvantaged schools, where well-established psychosocial risk factors for self-harm are more common, may benefit from well-being programmes targeting internalising problems and truancy/absenteeism.
This article proposes the examination of the climate politics of labour unions, particularly the strategy of just transition, through the prism of environmental labour studies, an ecosocial approach to labour environmentalism. In the first part, it presents a historical overview in order to highlight how the just energy transition became a central element of labour environmentalism. The paper then examines the double impact of climate politics and just transition on labour environmentalism – narrowing its substantive focus while deepening the intersection of nature and labour within and beyond the workplace. The second part draws on the environmental labour studies approach to propose that labour environmentalism should take into account the inseparable relationship between labour and nature, expand the scope of work and workers, and account for global divisions of labour. In our view, such a programmatic shift will ensure that work and workers are placed centrally within ecosocial politics.
A second-occurrence (SO) focus is the semantic focus of a focus-sensitive operator (e.g. only), but is a repeat of an earlier focused occurrence. We report on the first systematic production and perception experiments to show that SO foci occurring after a nuclear accent are, as Rooth (1996b) has claimed, prosodically marked. We find that (i) there is no mean pitch rise on SO foci, (ii) SO foci are marked by longer duration and greater energy, and (iii) listeners are able to detect the difference between SO foci and nonfoci. On the basis of these results, we argue that SO focus is compatible with theories of focus interpretation that it has been claimed to contradict.
Recruitment for rare disease studies is challenging due to small eligible populations. Traditional clinical research management systems often lack tools to track recruitment contacts prior to enrollment. The NET-PRO study, focused on neuroendocrine tumors (NETs), implemented a participation monitoring system to enhance recruitment efficiency and representativeness.
Methods:
NET-PRO is a multicenter cohort study of 2538 adults diagnosed with gastroenteropancreatic (GEP) or lung NETs between January 2018 and September 2024. Recruitment occurred from January 2022 to February 2025 across 14 U.S. medical centers. Sites used flexible recruitment methods (email, mail, phone, in-clinic) and tracked contacts using REDCap-based tools. Participant characteristics were analyzed by enrollment mode (online or mail) and recruitment difficulty (number of contacts required prior to enrollment) using standardized mean differences, chi-square tests, and ANOVA.
Results:
Of 9279 contacted patients, 2675 consented (28.8%) and 2538 enrolled (27.4%). Most enrolled online (83.2%), while 16.8% enrolled by mail. Mail respondents were older, had lower education and income, and more comorbidities. Among those enrolled, recruitment difficulty was associated with older age, lower education and income, but not comorbidity. Over half of the most difficult-to-recruit participants enrolled online. Contact methods varied by attempt, with email dominating early contacts and phone/mail used more in later attempts.
Conclusions:
A participation monitoring tool supported flexible, multimodal recruitment and improved sample representativeness in a rare cancer study. Tracking recruitment contacts enabled adaptive strategies and may reduce bias in observational research by enabling better outreach to harder-to-reach populations.
The Radio Neutrino Observatory-Greenland (RNO-G, at Summit Station) experiment comprises an extensive fat-dipole antenna array deployed into ice boreholes over an eventual area of approximately 35 km2. Since the RNO-G experimental sensitivity depends on the radio-frequency properties of the firn, which are known to vary laterally on sub-km distance scales and vertically on sub-meter distance scales, a technique for quickly extracting information on firn ice properties with depth ($n(z)$) during drilling and deployment is desirable. Given that a dipole’s resonant wavelength is fixed by geometry, the resonant frequency $f_{res}$ (measured as an S-parameter reflection coefficient [‘$S_{11}$’] minimum) scales inversely with the local refractive index, allowing a translation of a depth-dependent $S_{11}$(z) profile into $n(z)$. $S_{11}$(z) data were initially taken in August 2024 using a dipole lowered into a newly drilled 98 ± 1 mm diameter, 350 m deep borehole at Summit Station, Greenland, approximately 1 km from the site of the original GISP-2 core; improved measurements were subsequently made in May 2025. We conclude that $S_{11}$(z) data can be used to estimate $n(z)$, on 50 cm vertical scales, at the per cent level of accuracy required by experiments such as RN0-G.
As far as the composition of the House of Commons is concerned the 2001 British general election was a rerun of its 1997 predecessor. Labour won 413 seats, almost two-thirds of the total, and their 167 seat majority represents only a marginal change in the 179 seat majority they achieved in 1997. The hapless Conservatives had a net gain of only one seat and they remain as far from government as ever with only 161 seats in the House overall. The Liberal Democrats picked up a useful additional six seats and now have their largest representation in the House of Commons since the 1920s. With very minor changes in the representation of other parties, the 2001 House of Commons looks a lot like the 1997 House of Commons, as can be seen in Table 1 .
In one crucially important respect, however, the 2001 election was very different from its predecessor.
A stepped care approach to treating anxiety and depression is common in mental health services. Low-intensity interventions, typically based on cognitive behavioural principles, are offered first, followed by high-intensity therapy if required. In the English National Health Service Talking Therapies (NHS TT) programme, different types of therapists deliver low- and high-intensity interventions. ‘Stepping up’ therefore involves changing therapist, and often an additional wait, which could both disrupt treatment flow.
In NHS TT, many low-intensity therapists subsequently train at high intensity. Once dual-trained, they typically deliver only high-intensity treatment. With both skillsets, they could theoretically deliver a full stepped care pathway, avoiding potential disruption linked to stepping up.
Aims
To explore a blended treatment approach, where dual-trained therapists move between low- and high-intensity flexibly based on patient need.
Method
Ten dual-trained therapists across 4 services treated 43 patients. Patients with clinical complexities more likely to eventually require high-intensity support were selected. Propensity score matching was used to identify matched control groups from a pool of patients who received stepped care. Treatment characteristics and clinical outcomes were compared. Feedback was obtained from patients, therapists and supervisors.
Results
Compared with matched controls, who received low- then high-intensity treatment, blended treatment required four fewer sessions on average, saving a third of therapist time and was completed 121 days sooner. The reliable recovery rate (54.1%) was 9% higher than the stepped care group (44.7%), which is clinically, although not statistically, significant. Blended treatment showed a non-significantly higher reliable deterioration rate. Patient feedback was positive. Therapists and supervisors highlighted advantages alongside practical challenges.
Conclusions
The blended approach showed promise as an efficient and effective method to deliver therapy when clinicians are dual-trained. Larger-scale studies, and consideration of implementation challenges, are needed. However, results suggest that this approach could potentially offer more flexible and seamless care delivery.
Three models of a partially ionised fluid are considered by examining together three sets of (M)HD equations for the neutral, ionised, and electron components of a fluid. The first assumes low ionisation and isothermality leading to the one-fluid, isothermal model where all three non-ideal terms–resistance, the Hall effect, ambipolar diffusion–appear in the induction equation. New quantities introduced include: the ambipolar force density; coupling, rate, and ambipolar coefficients; and resistivity, all helping to determine the relative role of each non-ideal term. For resistive MHD, the Sweet–Parker model for magnetic reconnection, and dynamo theory are discussed. For the Hall effect, a two-fluid, isothermal model is introduced that refines the Sweet–Parker model to give a reconnection time scale in better keeping with observations of solar flares. Finally, the section on ambipolar diffusion derives the full two-fluid, non-isothermal model applicable for a fluid with arbitrary ionisation. Here, exchange terms are introduced to account for mass, momentum, and energy transfers when neutrals ionise or ions recombine.
This chapter looks at four important fluid instabilities – Kelvin–Helmholtz, Rayleigh–Taylor, magneto-rotational, and Parker–where normal mode analysis of the lin-earised equations is taught using each instability as an exemplar. All are examined from the linear regime in which conditions for instability and rates of growth of the fastest mode are developed from first principles. For the KHI, RTI, and MRI, numerical simulations are presented which recover the results of linear analysis from the early stages of a non-linear calculation. For the KHI and RTI, numerical simulations well into the non-linear regime are presented where the onset of fluid turbulence is noted. For the MRI, a section describing how it solved the angular momentum transport problem for accretion discs is included. For the Parker instability, an account is given how this purely astrophysical phenomenon explains the clumpy structure of the interstellar medium.
After some historical perspective on the subject, the introduction attempts to define, distinguish, and link in the broadest terms the various areas of physics related to fluid dynamics. These include fluid mechanics, hydrodynamics, gas dynamics, magnetohydrodynamics, and plasma physics. In particular, the link between ordinary hydrodynamics and magnetohydro-dynamics is made, and the approach this text takes in teaching both, namely wave mechanics, is revealed.