This study reports the environmental conditions of temperature, moisture and radiation for four years (May 2004 to July 2008) in the area known as Pampas de La Joya in southern Peru, which recently has been considered as a new Mars analogue. The period of evaluation includes the El Niño Southern Oscillation (ENSO) during the months of September 2006 to March 2007, which, despite not having catastrophic effects like its predecessor on 1997–1998, showed an interesting increase in humidity. Our data describe the extreme conditions present in the region and their relationship with the presence of potential habitats that could allow for the survival of micro-organisms. The average environmental temperature was 18.9°C, with a maximum of 35.9°C and a minimum of −4.5°C. The annual average incident solar radiation was 508 W m−2, with high near 1060 W m−2 at noon during the driest period between September and March. The average relative humidity (RH) was 29.5, 20.1 and 20.4% for air, soil and rock, respectively. The RH had higher values at night due to fog during the months of June and August, and during the early morning between December and March. During the months of ENSO event there were four episodes of precipitation (1.1, 1.5, 2.0 and 0.9 mm), of which three increased soil and rock moisture on an average more than 45% and persisted for over 15 days after precipitation, while the atmospheric environment had no significant variations. Finally, quartz rocks and evaporite minerals colonized with micro-organisms were found as the only micro-habitats, in this region, capable of supporting life in this extreme environment.