Considerable research has been devoted to the issue of whether the ingestion of glucose enhances cognitive performance in both younger and older adults. However, it has proven difficult to draw firm conclusions from this literature due to the diversity of methodologies that have been used, and it is therefore still unclear what factors might moderate the facilitative effect. The present study investigates methodological variations and their impact on the magnitude of the glucose enhancement effect. In particular, age group (young vs. old) and task domain (memory vs. nonmemory tasks) were considered as moderator variables. In addition, differences in experimental design, glucose dose and fasting regime were examined. The effect size d was extracted from studies comparing cognitive performance after the ingestion of either a glucose or control solution. Subsequent meta-analyses were conducted (using the procedures outlined by Hedges & Olkin, 1985) to examine potential moderators. A moderate overall effect size was found (d = 0.56), which clearly demonstrated the value of glucose ingestion as a cognitive enhancer. However, this effect size was not representative of the 104 individual effect sizes reported. Secondary analyses found larger effect sizes for memory compared to nonmemory tasks. Unexpectedly, no evidence was provided for greater beneficial effects of glucose on cognitive performance for older compared to younger adults. The impact of other methodological variables and the need for further exploration in an elderly population are discussed.