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Piglets can often suffer impaired antioxidant status and poor immune response during post-weaning, especially when chronic inflammation takes place, leading to lower growth rates than expected. Oral administration of dietary antioxidant compounds during this period could be a feasible way to balance oxidation processes and increase health and growth performance. The aim of the trial was to study the effects of an antioxidant feed supplement (melon pulp concentrate) that contains high concentration of the antioxidant superoxide dismutase (SOD) on inflammation, antioxidant status and growth performance of lipopolysaccharide (LPS) challenged weaned piglets. In total, 48 weaned piglets were individually allocated to four experimental groups in a 2×2 factorial design for 29 days. Two different dietary treatments were adopted: (a) control (CTR), fed a basal diet, (b) treatment (MPC), fed the basal diet plus 30 g/ton of melon pulp concentrate. On days 19, 21, 23 and 25 half of the animals within CTR and MPC groups were subjected to a challenge with intramuscular injections of an increasing dosage of LPS from Escherichia coli (serotype 0.55:B5) (+) or were injected with an equal amount of PBS solution (−). Blood samples were collected at the beginning of the trial and under the challenge period for interleukin 1β, interleukin 6, tumour necrosis factor α, haptoglobin, plasma SOD activity, total antioxidant capacity, reactive oxygen species, red blood cells and plasma resistance to haemolysis, and 8-oxo-7, 8-dihydro-2’-deoxyguanosine. Growth performance was evaluated weekly. A positive effect of melon pulp concentrate was evidenced on total antioxidant capacity, half-haemolysis time of red blood cells, average daily gain (ADG) and feed intake, while LPS challenge increased pro-inflammatory cytokines and haptoglobin serum concentrations, with a reduced feed intake and gain : feed (G : F). The obtained results show that oral SOD supplementation with melon pulp concentrate ameliorates the total antioxidant capacity and the half-haemolysis time in red blood cell of post-weaning piglets, with positive results on growing performance.
Six trials were conducted during 2014/15 and 2015/16 growing seasons in Brazil to determine the effect of 2,4-D formulations and spray nozzles on 2,4-D spray drift under conventional field conditions. An experimental 2,4-D choline formulation with Colex-D® Technology (GF-3073) and a 2,4-D dimethylamine (DMA) formulation were applied with either XR and AIXR flat-fan spray nozzles. Each plot was 30 m wide by 24 m long (720 m2) with 60 glyphosate-resistant soybean rows spaced 50 cm apart and also 35 potted tomato plants distributed on a grid across the plot 5-m apart. Applications were performed one meter away from the plot edge perpendicular to the soybean rows when wind direction was parallel to the rows with less than 30 degrees of angle deviation. Spray drift treatments were applied in 100 L ha−1 with tractor sprayers at 276 kPa equipped with a 7-m wide boom at 50 cm above the canopy of the soybean plant, operating at 6.8 km h−1. The distance from the plot edge to the farthest plant with 2,4-D symptoms was assessed for every four soybean rows at 10 and 20 days after treatment (DAT) and potted tomatoes at 10 DAT. GF-3073 reduced the distance of the farthest injured plant with 2,4-D symptoms compared to the 2,4-D DMA formulation regardless of the spray nozzle, assessment date and sensitive species. GF-3073 applied through the AIXR nozzle reduced the relative drift affected area to the standard by 68% at 10 DAT and 67% at 20 DAT for soybean and 60% at 10 DAT for potted tomatoes.
The invasive but highly profitable snow crab has made its way into the waters of the High Arctic, precipitating a direct confrontation between the EU and Norway over the interpretation of the 1920 Svalbard Treaty. Norway claims the Treaty does not apply due to its strict interpretation of the Treaty's terms, which pertain only to the archipelago's terra firm and territorial sea. The EU claims the Treaty's equal access and non-discrimination provisions follow the evolution of the international law of the sea, and make the living (and mineral) resources of Svalbard's surrounding continental shelf and waters open to all states parties to the Treaty. The dispute has gone on for decades, but this Article maintains, through a review of Norway's increasingly isolated legal and political stance that time is out of joint for Norway and its long-term appropriative design and strategy to territorialize this area of the High North.
The increased use of the MATRICS Consensus Cognitive Battery (MCCB) to investigate cognitive dysfunctions in schizophrenia fostered interest in its sensitivity in the context of family studies. As various measures of the same cognitive domains may have different power to distinguish between unaffected relatives of patients and controls, the relative sensitivity of MCCB tests for relative–control differences has to be established. We compared MCCB scores of 852 outpatients with schizophrenia (SCZ) with those of 342 unaffected relatives (REL) and a normative Italian sample of 774 healthy subjects (HCS). We examined familial aggregation of cognitive impairment by investigating within-family prediction of MCCB scores based on probands’ scores.
Multivariate analysis of variance was used to analyze group differences in adjusted MCCB scores. Weighted least-squares analysis was used to investigate whether probands’ MCCB scores predicted REL neurocognitive performance.
SCZ were significantly impaired on all MCCB domains. REL had intermediate scores between SCZ and HCS, showing a similar pattern of impairment, except for social cognition. Proband's scores significantly predicted REL MCCB scores on all domains except for visual learning.
In a large sample of stable patients with schizophrenia, living in the community, and in their unaffected relatives, MCCB demonstrated sensitivity to cognitive deficits in both groups. Our findings of significant within-family prediction of MCCB scores might reflect disease-related genetic or environmental factors.
We present the results of a multifrequency observation of the WO star Sand 2 in the LMC. Two ROSAT PSPC observations, with exposure times of 8953 s and 4540 s, are used to investigate possible X-ray emission from Sand 2. The optical spectrum observed with the ESO 2.2m telescope close to the time of the ROSAT observations, shows strong emission lines of HeII, CIV, OV and OVI. All lines have a velocity broadening of 4 200±100 km s−1. The UV spectrum from the IUE archive shows a CIV resonance doublet at 155 nm with a P-Cygni absorption at ∼ −5 000 km s−1, with wings extending to about −8 000 km s−1. A combination of two different BB temperatures (80 000 K and 25 000 K) are required to fit the UV-optical continuum, dereddened by EB-V = 0.25.
The WO stars form a subgroup of the WR class characterized by a strong O VI emission at 382 nm (Sanduleak 1971; Barlow & Hummer 1982). In 1989–90 we observed intermediate resolution spectra of the four Sanduleak WO stars and of their surrounding nebulosities using the Bologna-Loiano 1.52m and ESO-La Silla 1.52m and 2.2m telescopes (e.g., Polcaro et al. 1991, 1992, 1994 in preparation). Fig. 1 shows that the spectra are similar but with some striking differences among the four stars. They can be arranged in a sequence in order of increasing ionization: Sand 2, Sand 1, Sand 5, Sand 4 (see Table 1). Sand 4 is a binary system, and the continuum of the O4 companion dominates over that of the WO star. In the other objects, the reddening-corrected continuum can be fitted by a 80 000 K BB, in agreement with the high ionization level of their emission spectra.
Some of the high luminosity stars in our Galaxy are surrounded by planetary-like nebulae formed by material ejected from the central star. The most interesting case is that of the ring nebula PK 289-0° 1 around the P Cygni star AG Car. Long slit spectroscopy shows that nitrogen is overabundant and oxygen underabundant in the nebula. The Hα/[NII] ratio is lower in the nebula with respect to the surrounding H II region, possibly as a result of the N overabundance in the stellar wind. The emission line peak separation confirms a model of a distorted spherical shell expanding at 66 km s−1. The scattered star's spectrum is observable near the star, suggesting the presence of circumstellar dust grains. A nebular mass of at least 2.7 M⊙ is derived. While the nebula in the Hα imagery reveals the ring-like shape with many structures, in the blue it is much fainter and smoother. No nebular emission was detected in the JHK bands, suggesting a low dust temperature.
The very peculiar object Eta Car is one of the best laboratory for the study of those physical processes - such as mass loss, superionization, dust condensation, wind interaction with the i.s. medium - that presently are of great astrophysical interest, especially for the study of the most luminous stars. For its light history and high luminosity Eta Car may also be considered as the galactic counterpart of the Hubble-Sandage variables. Eta Car is one of the rare astrophysical objects with evidence of dust condensation from ejected stellar matter (Andriesse et al. 78) On the other side the star is also producing a strong, hard X-ray flux (Chlebowski et al. 1984), and the problem is whether there is any physical reason to have these two quite different processes in the same stellar environment. In any case rather extreme physical conditions are required which cannot be verified in a uniformly, spherically symmetric atmospheric enevelope. Andriesse et al. in fact suggested the presence of strong inhomogeneities, such as filaments, possibly related to the presence of a strong magnetic field. This may also explain the X-ray emission. In the following we shall present new optical and UV observations of Eta Car and its small nebula with the aim of clearfying the physical nature of its wind.
AG Car is a Luminous Blue Variable which recently evolved from AIe to Ofpe/WN9 in four years at about constant bolometric luminosity, while in the visual the star faded by two magnitudes. This change is probably associated with variable opacity of an unstable massive expanding envelope of a hot star. We discuss the main spectral features of the star and of its ring nebula, and the spectral variations.
New oral treatments are needed for all forms of leishmaniasis. Here, the improved oral efficacy of quercetin (Qc) and its penta-acetylated derivative (PQc) was evaluated in cutaneous leishmaniasis after encapsulation in lipid-core nanocapsules (LNCs) of poly(ε-caprolactone). Leishmania amazonensis-infected BALB/c mice were given 51 daily oral doses of free drugs (16 mg kg−1) or LNC-loaded drugs (0·4 mg kg−1). While treatment with free Qc reduced the lesion sizes and parasite loads by 38 and 71%, respectively, LNC-Qc produced 64 and 91% reduction, respectively. The antileishmanial efficacy of PQc was similar but not as potently improved by encapsulation as Qc. None of the treatments increased aspartate aminotransferase, alanine aminotransferase or creatinine serum levels. These findings indicate that when encapsulated in LNC, Qc and, to a lesser extent, PQc can safely produce an enhanced antileishmanial effect even at a 40-fold lower dose, with implications for the development of a new oral drug for cutaneous leishmaniasis.
Leishmania amazonensis promastigotes are known to express furosemide (Lasix®)-sensitive P-type membrane Na+-ATPase. In the present study, furosemide activity was studied in intracellular amastigotes and infected BALB/c mice to investigate its efficacy in cutaneous leishmaniasis (CL). Intracellular parasites, but not macrophages, were found to be sensitive to killing by furosemide (IC50 = 87 µmvs CC50 ≫ 1000 µm, respectively). Although furosemide did not induce nitric oxide production or intracellular pH changes in infected macrophages, it led to a significant reactive oxygen species (ROS) burst. Freshly isolated tissue parasites expressed a high degree of Na+-ATPase activity that decreased with culture, indicative of a higher enzyme expression in amastigotes than in promastigotes. Both intraperitoneal and oral treatment of L. amazonensis-infected mice with furosemide dosages equivalent to that prescribed as a diuretic significantly reduced the parasite's growth compared with the situation in untreated mice. Combination with oral furosemide increased the efficacy and safety of intraperitoneal treatment with sodium stibogluconate (SSG). To summarize, furosemide control of intracellular leishmanial growth by means of parasite Na+-ATPase inhibition, and macrophage ROS activation may help explain its sole and SSG-combined therapeutic effect against murine CL.
Our understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. Research showed that impairments in value processing and executive functioning, which have been associated with prefrontal brain areas [particularly the medial orbitofrontal cortex (MOFC)], are linked to negative symptoms. Here we tested the hypothesis that MOFC thickness is associated with negative symptom severity.
This study included 1985 individuals with schizophrenia from 17 research groups around the world contributing to the ENIGMA Schizophrenia Working Group. Cortical thickness values were obtained from T1-weighted structural brain scans using FreeSurfer. A meta-analysis across sites was conducted over effect sizes from a model predicting cortical thickness by negative symptom score (harmonized Scale for the Assessment of Negative Symptoms or Positive and Negative Syndrome Scale scores).
Meta-analytical results showed that left, but not right, MOFC thickness was significantly associated with negative symptom severity (βstd = −0.075; p = 0.019) after accounting for age, gender, and site. This effect remained significant (p = 0.036) in a model including overall illness severity. Covarying for duration of illness, age of onset, antipsychotic medication or handedness weakened the association of negative symptoms with left MOFC thickness. As part of a secondary analysis including 10 other prefrontal regions further associations in the left lateral orbitofrontal gyrus and pars opercularis emerged.
Using an unusually large cohort and a meta-analytical approach, our findings point towards a link between prefrontal thinning and negative symptom severity in schizophrenia. This finding provides further insight into the relationship between structural brain abnormalities and negative symptoms in schizophrenia.