Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

24 results

Page 1 of 2

  • Association between impaired glucose metabolism and long-term prognosis at the time of diagnosis of depression: Impaired glucose metabolism as a promising biomarker proposed through a machine-learning approach

  • Dong Yun Lee, Yong Hyuk Cho, Myoungsuk Kim, Chang-Won Jeong, Jae Myung Cha, Geun Hui Won, Jai Sung Noh, Sang Joon Son, Rae Woong Park
  • Journal:
    European Psychiatry / Volume 66 / Issue 1 / 2023
    Published online by Cambridge University Press:
    03 February 2023, e21
    • Article
      • You have access
      • Open access
    • PDF
    • HTML
    • Export citation
  • Background

    Predicting the course of depression is necessary for personalized treatment. Impaired glucose metabolism (IGM) was introduced as a promising depression biomarker, but no consensus was made. This study aimed to predict IGM at the time of depression diagnosis and examine the relationship between long-term prognosis and predicted results.

    Methods

    Clinical data were extracted from four electronic health records in South Korea. The study population included patients with depression, and the outcome was IGM within 1 year. One database was used to develop the model using three algorithms. External validation was performed using the best algorithm across the three databases. The area under the curve (AUC) was calculated to determine the model’s performance. Kaplan–Meier and Cox survival analyses of the risk of hospitalization for depression as the long-term outcome were performed. A meta-analysis of the long-term outcome was performed across the four databases.

    Results

    A prediction model was developed using the data of 3,668 people, with an AUC of 0.781 with least absolute shrinkage and selection operator (LASSO) logistic regression. In the external validation, the AUCs were 0.643, 0.610, and 0.515. Through the predicted results, survival analysis and meta-analysis were performed; the hazard ratios of risk of hospitalization for depression in patients predicted to have IGM was 1.20 (95% confidence interval [CI] 1.02–1.41, p = 0.027) at a 3-year follow-up.

    Conclusions

    We developed prediction models for IGM occurrence within a year. The predicted results were related to the long-term prognosis of depression, presenting as a promising IGM biomarker related to the prognosis of depression.

  • 15 - Do Lawyers Make Good Gatekeepers?

  • from Part IV - Alternative Regulatory Regimes
  • Edited by Arthur B. Laby
  • Book:
    The Cambridge Handbook of Investor Protection
    Published online:
    20 October 2022
    Print publication:
    27 October 2022, pp 283-301

  • Summary

    As we approach the twentieth anniversary of the Sarbanes–Oxley Act of 2002 (Sarbanes–Oxley), which sought to prevent future frauds such as Enron and WorldCom, it makes sense to revisit one of the statute’s most controversial provisions. Section 307 of Sarbanes–Oxley gave the US Securities and Exchange Commission (SEC) sweeping authority to establish “minimum standards of professional conduct” that would enable it to discipline lawyers “appearing and practicing before the [SEC] in any way in the representation of [public] issuers.”1 Specifically, section 307 ordered the SEC to implement regulations requiring lawyers who encounter “evidence of material violation” of law to report such evidence up the corporate ladder to the full board or an appropriate committee thereof, if necessary, to ensure that “appropriate remedial measures or sanctions” are taken.2

  • Is spiritual well-being related to survival time of inpatients with advanced cancer? An East Asian cohort study

  • Yusuke Hiratsuka, Sang-Yeon Suh, Seon Hye Won, Sung Eun Choi, Sun-Hyun Kim, Shao-Yi Cheng, Ping-Jen Chen, Seok-Joon Yoon, Su-Jin Koh, Shin Ae Park, Ji-Yeon Seo, David Hui, Takashi Yamaguchi, Tatsuya Morita, Satoru Tsuneto, Masanori Mori, Akira Inoue
  • Journal:
    Palliative & Supportive Care / Volume 21 / Issue 3 / June 2023
    Published online by Cambridge University Press:
    27 June 2022, pp. 483-491
  • Objectives

    It has been suggested that psychosocial factors are related to survival time of inpatients with cancer. However, there are not many studies examining the relationship between spiritual well-being (SWB) and survival time among countries. This study investigated the relationship between SWB and survival time among three East Asian countries.

    Methods

    This international multicenter cohort study is a secondary analysis involving newly admitted inpatients with advanced cancer in palliative care units in Japan, South Korea, and Taiwan. SWB was measured using the Integrated Palliative Outcome Scale (IPOS) at admission. We performed multivariate analysis using the Cox proportional hazards model to identify independent prognostic factors.

    Results

    A total of 2,638 patients treated at 37 palliative care units from January 2017 to September 2018 were analyzed. The median survival time was 18.0 days (95% confidence interval [CI] 16.5–19.5) in Japan, 23.0 days (95% CI 19.9–26.1) in Korea, and 15.0 days (95% CI 13.0–17.0) in Taiwan. SWB was a significant factor correlated with survival in Taiwan (hazard ratio [HR] 1.27; 95% CI 1.01–1.59; p = 0.04), while it was insignificant in Japan (HR 1.10; 95% CI 1.00–1.22; p = 0.06), and Korea (HR 1.02; 95% CI 0.77–1.35; p = 0.89).

    Significance of results

    SWB on admission was associated with survival in patients with advanced cancer in Taiwan but not Japan or Korea. The findings suggest the possibility of a positive relationship between spiritual care and survival time in patients with far advanced cancer.

Fiduciary Government
  • Edited by Evan J. Criddle, Evan Fox-Decent, Andrew S. Gold, Sung Hui Kim, Paul B. Miller
  • Published online:
    02 November 2018
    Print publication:
    15 November 2018
  • The idea that the state is a fiduciary to its citizens has a long pedigree - ultimately reaching back to the ancient Greeks, and including Hobbes and Locke among its proponents. Public fiduciary theory is now experiencing a resurgence, with applications that range from international law, to insider trading by members of Congress, to election law and gerrymandering. This book is the first of its kind: a collection of chapters by leading writers on public fiduciary subject areas. The authors develop new accounts of how fiduciary principles apply to representation; to officials and judges; to problems of legitimacy and political obligation; to positive rights; to the state itself; and to the history of ideas. The resulting volume should be of great interest to political theorists and public law scholars, to private fiduciary law scholars, and to students seeking an introduction to this new and increasingly relevant area of study.

Can Delaware Be Dethroned?
  • Evaluating Delaware's Dominance of Corporate Law
  • Edited by Stephen M. Bainbridge, Iman Anabtawi, Sung Hui Kim, James Park
  • Published online:
    11 January 2018
    Print publication:
    11 January 2018
  • Delaware is the state of incorporation for almost two-thirds of the Fortune 500 companies, as well as more than half of all companies listed on the New York Stock Exchange, NASDAQ, and other major stock exchanges. This gives Delaware a seemingly unchallengeable position as the dominant producer of US corporate law. In recent years, however, some observers have suggested that Delaware's competitive position is eroding. Other states have long tried to chip away at Delaware's position, and recent Delaware legal developments may have strengthened the case for incorporating outside Delaware. More importantly, however, the federal government is increasingly preempting corporate governance law. The contributors to this volume are leading academics and practitioners with decades of experience in Delaware corporate law. They bring together a variety of perspectives that collectively provide the reader with a broad understanding of how Delaware achieved its dominant position and the threats it faces.

Page 1 of 2