Book contents
- Brain Fables
- Brain Fables
- Copyright page
- Dedication
- Contents
- Preface 1 – The Question
- Preface 2 – Enter Patient
- Acknowledgements
- Special Thanks from Benjamin Stecher
- Chapter 1 The Shaky Six and the “Second Reality”
- Chapter 2 Pieces of a Puzzle?
- Chapter 3 Disease “Redefinition”: A Tough Pill to Swallow
- Chapter 4 Disease Subtypes: The Promise and the Fallacy
- Chapter 5 Protein Paradox
- Chapter 6 The Fault in Our Models
- Chapter 7 Biomarkers: The Promise and the Fallacy
- Chapter 8 Lessons from Oncology
- Chapter 9 Symptomatic vs. Disease-Modifying Therapies
- Chapter 10 The Hypothesis That Refuses to Die
- Chapter 11 Our Living Dissonance
- Chapter 12 The Scientific and Lay Narratives
- Chapter 13 Challenges Viewed from Afar
- Chapter 14 The Moonshot: Population-Based Studies of Aging
- Chapter 15 Predictions for the 2020s and Beyond
- Epilogue
- Note Added at Press Time – Reviving LOF
- References
- Index
Chapter 14 - The Moonshot: Population-Based Studies of Aging
Published online by Cambridge University Press: 29 June 2020
- Brain Fables
- Brain Fables
- Copyright page
- Dedication
- Contents
- Preface 1 – The Question
- Preface 2 – Enter Patient
- Acknowledgements
- Special Thanks from Benjamin Stecher
- Chapter 1 The Shaky Six and the “Second Reality”
- Chapter 2 Pieces of a Puzzle?
- Chapter 3 Disease “Redefinition”: A Tough Pill to Swallow
- Chapter 4 Disease Subtypes: The Promise and the Fallacy
- Chapter 5 Protein Paradox
- Chapter 6 The Fault in Our Models
- Chapter 7 Biomarkers: The Promise and the Fallacy
- Chapter 8 Lessons from Oncology
- Chapter 9 Symptomatic vs. Disease-Modifying Therapies
- Chapter 10 The Hypothesis That Refuses to Die
- Chapter 11 Our Living Dissonance
- Chapter 12 The Scientific and Lay Narratives
- Chapter 13 Challenges Viewed from Afar
- Chapter 14 The Moonshot: Population-Based Studies of Aging
- Chapter 15 Predictions for the 2020s and Beyond
- Epilogue
- Note Added at Press Time – Reviving LOF
- References
- Index
Summary
Throughout this book there has been one theme permeating each chapter: Parkinson’s and Alzheimer’s are not two distinct diseases but a spectrum of disorders. The stories created for each are as compelling as they are fictitious. There is no such thing as Parkinson’s disease. There is not such thing as Alzheimer’s disease. These are but powerful ideas. The time has come to accept that any mechanistic discoveries related to a form of Parkinson’s, especially the genetic ones, such as those due to GBA mutations, are potential targets for therapeutic development for only those subtypes. No treatment revolving around one mechanistic discovery can be expected to slow the progression of diseases as complex and multifaceted as Parkinson’s or Alzheimer’s, let alone “cure” them.
- Type
- Chapter
- Information
- Brain FablesThe Hidden History of Neurodegenerative Diseases and a Blueprint to Conquer Them, pp. 133 - 138Publisher: Cambridge University PressPrint publication year: 2020