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Reasoning in Biological Discoveries
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Book description

Reasoning in Biological Discoveries brings together a series of essays, which focus on one of the most heavily debated topics of scientific discovery. Collected together and richly illustrated, Darden's essays represent a groundbreaking foray into one of the major problems facing scientists and philosophers of science. Divided into three sections, the essays focus on broad themes, notably historical and philosophical issues at play in discussions of biological mechanism; and the problem of developing and refining reasoning strategies, including interfield relations and anomaly resolution. Darden summarizes the philosophy of discovery and elaborates on the role that mechanisms play in biological discovery. Throughout the book, she uses historical case studies to extract advisory reasoning strategies for discovery. Examples in genetics, molecular biology, biochemistry, immunology, neuroscience and evolutionary biology reveal the process of discovery in action.


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James Bogen (2005), “Regularities and Causality; Generalizations and Causal Explanations,” in Carl F. Craver and Lindley Darden (eds.), Special Issue: “Mechanisms in Biology,” Studies in History and Philosophy of Biological and Biomedical Sciences 36: 397–420.

Burian, Richard M. (1996a), “Underappreciated Pathways Toward Molecular Genetics as Illustrated by Jean Brachet's Cytochemical Embryology,” in S. Sarkar (ed.), The Philosophy and History of Molecular Biology: New Perspectives. Dordrecht: Kluwer, pp. 67–85.

Craver, Carl F. (2002a), “Structures of Scientific Theories,” in P. K. Machamer and M. Silberstein (eds.), Blackwell Guide to the Philosophy of Science. Oxford, UK: Blackwell, pp. 55–79.

Carl F. Craver (2003), “The Making of a Memory Mechanism,” Journal of the History of Biology 36: 153–195.

Kevin Elliott (2004), “Error as Means to Discovery,” Philosophy of Science 71: 174–197.

Scott A. Kleiner (1993), The Logic of Discovery: A Theory of the Rationality of Scientific Research. Dordrecht: Kluwer.

Peter Machamer (2004), “Activities and Causation: The Metaphysics and Epistemology of Mechanisms,” International Studies in the Philosophy of Science 18: 27–39.

James A. Marcum (2002), “From Heresy to Dogma in Accounts of Opposition to Howard Temin's DNA Provirus Hypothesis,” History and Philosophy of the Life Sciences 24: 165–192.

Robert A. Skipper Jr., and Roberta L. Millstein (2005), “Thinking about Evolutionary Mechanisms: Natural Selection,” in Carl F. Craver and Lindley Darden (eds.), Special Issue: “Mechanisms in Biology,” Studies in History and Philosophy of Biological and Biomedical Sciences 36: 327–347.

Paul Thagard (2003), “Pathways to Biomedical Discovery,” Philosophy of Science 70: 235–254.

Machamer, Peter (1998), “Galileo's Machines, His Mathematics and His Experiments,” in Peter Machamer (ed.), Cambridge Companion to Galileo. New York: Cambridge University Press, pp. 27–52.

Machamer, Peter (2000), “The Nature of Metaphor and Scientific Description,” in Fernand Hallyn (ed.), Metaphor and Analogy in the Sciences. Dordrecht: Kluwer, pp. 35–52.

Peter Machamer and Andrea Woody (1994), “A Model of Intelligibility in Science: Using Galileo's Balance as a Model for Understanding the Motion of Bodies,” Science and Education 3: 215–244.

Wesley Salmon (1997), “Causality and Explanation: A Reply to Two Critiques,” Philosophy of Science 64: 461–477.

Wesley Salmon (1998), Causality and Explanation. New York: Oxford University Press.

Paul C. Zamecnik (1969), “An Historical Account of Protein Synthesis, with Current Overtones – A Personalized View,” Cold Spring Harbor Symposia on Quantitative Biology 34: 1–16.

M. Barinaga (1999), “New Clues to How Neurons Strengthen Their Connections,” Science 284: 1755–1757.

James Bogen and J. Woodward (1988), “Saving the Phenomena,” Philosophical Review 97: 303–352.

Lindley Darden (1996), “Generalizations in Biology: Essay Review of K. Schaffner's Discovery and Explanation in Biology and Medicine,” Studies in History and Philosophy of Science 27: 409–419.

Ian Hacking (1988), “On the Stability of the Laboratory Sciences,” Journal of Philosophy 85: 507–514.

Hacking, Ian (1992), “The Self-Vindication of the Laboratory Sciences,” in A. Pickering (ed.), Science as Practice and Culture. Chicago, IL: University of Chicago Press, pp. 29–64.

M. Maletic-Savatic , R. Malinow , and K. Svoboda (1999), “Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity,” Science 283: 1923–1926.

R. Malinow (1998), “Silencing the Controversy in LTP?Neuron 21: 1226–1227.

A. Rottenberg , M. Mayford , R. D. Hawkins , E. R. Kandel , and R. U. Muller (1996), “Mice Expressing Activated CaMKII Lack Low Frequency LTP and Do Not Form Stable Place Cells in the CA1 Region of the Hippocampus,” Cell 87: 1351–1361.

W. Roush (1997), “New Knockout Mice Point to Molecular Basis of Memory,” Science 275: 32–33.

E. Tolman (1948), “Cognitive Maps in Rats and Men,” Psychological Review 55: 189–208.

Bechtel, William (1986), “Introduction: The Nature of Scientific Integration,” in W. Bechtel (ed.), Integrating Scientific Disciplines. Dordrecht: Nijhoff, pp. 3–52.

T. R. Cech (2000), “The Ribosome is a Ribozyme,” Science 289: 878.

Soraya Chadarevian (1996), “Sequences, Conformation, Information: Biochemists and Molecular Biologists in the 1950s,” Journal of the History of Biology 29: 361–386.

Soraya Chadarevian and Jean-Paul Gaudilliere (1996), “The Tools of the Discipline: Biochemists and Molecular Biologists,” Introduction to Special Issue, Journal of the History of Biology 29: 327–330.

Jean-Paul Gaudilliere (1996), “Molecular Biologists, Biochemists, and Messenger RNA: The Birth of a Scientific Network,” Journal of the History of Biology 29: 417–445.

Mahlon B. Hoagland (1955), “An Enzymic Mechanism for Amino Acid Activation in Animal Tissues,” Biochimica et Biophysica Acta 16: 288–289.

Mahlon B. Hoagland (1996), “Biochemistry or Molecular Biology? The Discovery of ‘Soluble RNA’,” Trends in Biological Sciences Letters (TIBS) 21: 77–80.

Peter Machamer , Lindley Darden , and Carl Craver (2000), “Thinking About Mechanisms,” Philosophy of Science 67: 1–25.

Arthur B. Pardee , Francois Jacob , and Jacques Monod (1959), “The Genetic Control and Cytoplasmic Expression of ‘Inducibility’ in the Synthesis of beta-galatosidase,” Journal of Molecular Biology 1: 165–178.

Denis Thieffry and Richard M. Burian (1996), “Jean Brachet's Alternative Scheme for Protein Synthesis,” Trends in the Biochemical Sciences 21 (3): 114–117.

James D. Watson and Francis Crick (1953a), “A Structure for Deoxyribose Nucleic Acid,” Nature 171: 737–738.

Paul C. Zamecnik (1984), “The Machinery of Protein Synthesis,” Trends in Biochemical Sciences (TIBS) 9: 464–466.

Theodor Boveri (1904), Ergebnisse über die Konstitution der chromatischen Substanz des Zellkerns. Jena: G. Fischer.

Francis Crick , Leslie Barnett , Sydney Brenner , and R. J. Watts-Tobin (1961), “General Nature of the Genetic Code for Proteins,” Nature 192: 1227–1232.

Fogle, T. (2000), “The Dissolution of Protein Coding Genes in Molecular Biology,” in Peter Beurton , Raphael Falk , and Hans-Jörg Rheinberger (eds.), The Concept of the Gene in Development and Evolution. New York: Cambridge University Press, pp. 3–25.

Stuart S. Glennan (1996), “Mechanisms and The Nature of Causation,” Erkenntnis 44: 49–71.

J. Kemeny and P. Oppenheim (1956), “On Reduction,” Philosophical Studies 7: 6–17.

Martha Keyes (1999b), “The Prion Challenge to the “Central Dogma” of Molecular Biology, 1965–1991, Part II: The Problem with Prions,” Studies in the History and Philosophy of Biological and Biomedical Sciences 30: 181–218.

Philip Kitcher (1984), “1953 and All That: A Tale of Two Sciences,” The Philosophical Review 93: 335–373.

Thomas Hunt Morgan (1910a), “Chromosomes and Heredity,” American Naturalist 44: 449–496.

Thomas Hunt Morgan (1919), The Physical Basis of Heredity. Philadelphia, PA: J. B. Lippincott Co.

Thomas Hunt Morgan and Clara J. Lynch (1912), “The Linkage of Two Factors in Drosophila that Are Not Sex-Linked,” Biological Bulletin 23: 174–182.

Linus Pauling and Robert B. Corey (1950), “Two Hydrogen-Bonded Spiral Configurations of the Polypeptide Chain,” Journal of the American Chemical Society 72: 5349.

Walter Sutton (1903), “The Chromosomes in Heredity,” Biological Bulletin 4: 231–251.

S. Bourgeois , M. Cohen , and L. Orgel (1965), “Suppression of and Complementation among Mutants of the Regulatory Gene of the Lactose Operon of Escherichia coli,” Journal of Molecular Biology 14: 300–302.

E. E. Carothers (1913), “The Mendelian Ratio in Relation to Certain Orthopteran Chromosomes,” The Journal of Morphology 24: 487–509.

William Coleman (1970), “Bateson and Chromosomes: Conservative Thought in Science,” Centaurus 15: 228–314.

W. Gilbert and B. Müller-Hill (1966), “Isolation of the Lac Repressor,” Proceedings of the National Academy of Sciences 56: 1891–1898.

W. Gilbert and B. Müller-Hill (1967), “The Lac Operator is DNA,” Proceedings of the National Academy of Sciences 58: 2415–2421.

Jacques Monod , J-P. Changeux , and Francois Jacob (1963), “Allosteric Proteins and Cellular Control Systems,” Journal of Molecular Biology 6: 306–329.

Kenneth Schaffner (1974b), “The Peripherality of Reduction in the Development of Molecular Biology,” Journal of the History of Biology 7: 111–139.

G. Stent (1964), “The Operon: On Its Third Anniversary,” Science 144: 816–820.

William Bateson (1902), Mendel's Principles of Heredity – A Defense. Cambridge: Cambridge University Press.

Calvin B. Bridges (1914), “Direct Proof Through Non-disjunction that the Sex-linked Genes of Drosophila are Borne by the X-chromosome,” Science, N. S., 40: 107–109.

Elof A. Carlson (1971), “An Unacknowledged Founding of Molecular Biology: H. J. Muller's Contributions to Gene Theory, 1910–1936,” Journal of the History of Biology 4: 149–170.

Lindley Darden (1976), “Reasoning in Scientific Change: Charles Darwin, Hugo de Vries, and the Discovery of Segregation,” Studies in the History and Philosophy of Science 7: 127–169.

G. K. Gilbert (1896), “The Origin of Hypotheses, Illustrated by The Discussion of a Topographic Problem,” Science, N. S., 3: 1–13.

E. Manier (1969), “The Experimental Method in Biology, T. H. Morgan and the Theory of the Gene,” Synthese 20: 185–205.

Thomas Hunt Morgan (1911b), “Random Segregation versus Coupling in Mendelian Inheritance,” Science 34: 384.

Thomas Hunt Morgan , A. H. Sturtevant , H. J. Muller , and C. B. Bridges (1915), The Mechanism of Mendelian Heredity. New York: Henry Holt and Company.

Lindley Darden and Nancy Maull (1977), “Interfield Theories,” Philosophy of Science 44: 43–64.

Francis Galton (1871), “Experiments in Pangenesis,” Proceedings of the Royal Society (Biology) 19: 393–404.

Malcolm Kottler (1979), “Hugo de Vries and the Rediscovery of Mendel's Laws,” Annals of Science 36: 517–538.

Ernst Mayr and William Provine (eds.) (1980), The Evolutionary Synthesis. Cambridge, MA: Harvard University Press.

G. L. Ada and N. Gustav (1987), “The Clonal Selection Theory,” Scientific American 257: 62–69.

A. J. Arnold and K. Fristrup (1982), “The Theory of Evolution by Natural Selection: A Hierarchical Expansion,” Paleobiology 8: 113–129.

M. Conrad (1976), “Complementary Molecular Models of Learning and Memory,” BioSystems 8: 119–138.

Dedre Gentner (1983), “Structure Mapping – A Theoretical Framework for Analogy,” Cognitive Science 7: 155–170.

Stephen J. Gould and Elisabeth S. Vrba (1982), “Exaptation – A Missing Term in the Science of Form,” Paleobiology 8: 4–15.

David Hull (1980), “Individuality and Selection,” Annual Review of Ecology and Systematics 11: 311–332.

Joshua Lederberg ([1959]1961), “Genes and Antibodies,” Science 129: 1649–1653. Reprinted with a postscript in Stanford Medical Bulletin 19: 53–61.

D. W. Talmadge (1957), “Allergy and Immunology,” Annual Review of Medicine 8: 239–256.

Paul Thompson (1983), “The Structure of Evolutionary Theory: A Semantic Approach,” Studies in the History and Philosophy of Science 14: 215–229.

Mary Williams (1970), “Deducing the Consequences of Evolution: A Mathematical Model,” Journal of Theoretical Biology 29: 343–385.

W. E. Castle and C. C. Little (1910), “On a Modified Mendelian Ratio among Yellow Mice,” Science 32: 868–870.

B. Chandrasekaran , John Josephson , Anne Keuneke , and David Herman (1989), “Building Routine Planning Systems and Explaining Their Behaviour,” International Journal of Man-Machine Studies 30: 377–398.

Lakatos, Imre (1970), “Falsification and the Methodology of Scientific Research Programmes,” in I. Lakatos and Alan Musgrave (eds.), Criticism and the Growth of Knowledge. Cambridge: Cambridge University Press, pp. 91–195.

Jarrett Leplin (1975), “The Concept of an Ad Hoc Hypothesis,” Studies in the History and Philosophy of Science 5: 309–345.

(1970b), “Cancer Viruses: More of the Same,” Nature 227: 887–888.

David Baltimore (1970), “Viral RNA-dependent DNA Polymerase,” Nature 226: 1209–1211.

Lindley Darden and Joseph A. Cain (1989), “Selection Type Theories,” Philosophy of Science 56: 106–129.

Philip Kitcher (1981), “Explanatory Unification,” Philosophy of Science 48: 507–531.

Thomas H. Morgan (1911a), “An Attempt to Analyze the Constitution of the Chromosomes on the Basis of Sex-Limited Inheritance in Drosophila,” Journal of Experimental Zoology 11: 365–413.

Kenneth Schaffner (1986b), “Exemplar Reasoning About Biological Models and Diseases: A Relation Between the Philosophy of Medicine and Philosophy of Science,” The Journal of Medicine and Philosophy 11: 63–80.

Howard M. Temin (1964a), “The Participation of DNA in Rous Sarcoma Virus Production,” Virology 23: 486–494.

D. I. Andersson , E. S. Slechta , and J. R. Roth (1998), “Evidence that Gene Amplification Underlies Adaptive Mutability of the Bacterial lac Operon,” Science 282: 1133–1135.

John Beatty (1997), “Why Do Biologists Argue Like They Do?Philosophy of Science 64 (Proceedings): S432–S443.

Ivana Bjedov , Olivier Tenaillon , Benedicte Gerard , Valeria Souze , Erick Denamur , Miraslav Radman , Francois Taddei , and Ivan Matic (2003), “Stress-Induced Mutagenesis in Bacteria,” Science 300: 1404–1409.

Bryn A. Bridges (1995), “Sexual Potency and Adaptive Mutation in Bacteria,” Trends in Microbiology 3: 291–292.

John Cairns (1995), “Response [to Bridges 1995],” Trends in Microbiology 3: 293.

John Cairns , Julie Overbaugh , and S. Miller (1988), “The Origin of Mutants,” Nature 335: 142–145.

Francis Crick (1970), “Central Dogma of Molecular Biology,” Nature 227: 561–563.

Reuben S. Harris , Simonne Longerich , and Susan M. Rosenberg (1994), “Recombination in Adaptive Mutation,” Science 264: 258–260.

Mark Parascandola (1995), “Philosophy in the Laboratory: The Debate Over Evidence for E. J. Steele's Lamarckian Hypothesis,” Studies in History and Philosophy of Science 26: 469–492.

Sarkar, Sahotra (1991), “Lamarck Contre Darwin, Reduction Versus Statistics: Conceptual Issues in the Controversy Over Directed Mutagenesis in Bacteria,” in Alfred I. Tauber (ed.), Organism and the Origins of Self. Dordrecht: Kluwer, pp. 235–271.

James A. Shapiro (1995), “Adaptive Mutation: Who's Really in the Garden?Science 268: 373–374.

Douglas Allchin (2002), “Error Types,” Perspectives on Science 9: 38–58.

William Bechtel and Adele Abrahamsen (2005), “Explanation: A Mechanist Alternative,” in Carl F. Craver and Lindley Darden (eds.), Special Issue: “Mechanisms in Biology,” Studies in History and Philosophy of Biological and Biomedical Sciences 36: 421–441.

Carl Craver F. (2001), “Role Functions, Mechanisms, and Hierarchy,” Philosophy of Science 68: 53–74.

Darden, Lindley (2001), “Discovering Mechanisms: A Computational Philosophy of Science Perspective,” in Klaus P. Jantke and Ayumi Shinohara (eds.), Discovery Science (Proceedings of the 4th International Conference, DS2001). New York: Springer-Verlag, pp. 3–15.

David Didion (2003), “Relevant Bounds on Hierarchical Levels in the Description of Mechanisms,” History and Philosophy of the Life Sciences 25: 5–25.

Scott F. Gilbert and Jessica A. Bolker (2001), “Homologies of Process and Modular Elements of Embryonic Construction,” Journal of Experimental Zoology 291: 1–12.

Rom Harré (1970), The Principles of Scientific Thinking. Chicago, IL: University of Chicago Press.

John R. Josephson and Susan G. Josephson (eds.) (1994), Abductive Inference: Computation, Philosophy, Technology. New York: Cambridge University Press.

Kauffman, Stuart A. (1971), “Articulation of Parts Explanation in Biology and the Rational Search for Them,” in Roger C. Buck and Robert S. Cohen (eds.), PSA 1970. Boston Studies in the Philosophy of Science, v. 8. Dordrecht: Reidel, pp. 257–272.

Elizabeth Lloyd (1987), “Confirmation of Ecological and Evolutionary Models,” Biology and Philosophy 2: 277–293.

W. H. Newton-Smith (1981), The Rationality of Science. Boston, MA: Routledge & Kegan Paul.

Stathis Psillos (2004), “A Glimpse of the Secret Connexion: Harmonizing Mechanisms with Counterfactuals,” Perspectives on Science 12: 288–391.

Alexander Rich and James D. Watson (1954b), “Some Relations Between DNA and RNA,” Proceedings of the National Academy of Sciences 40: 759–764.

Robert A. Skipper Jr. (1999), “Selection and the Extent of Explanatory Unification,” Philosophy of Science 66 (Proceedings): S196-S209.

James G. Tabery (2004), “Synthesizing Activities and Interactions in the Concept of a Mechanism,” Philosophy of Science 71: 1–15.

(1970a), “Central Dogma Reversed,” News and Views, Nature 226: 1198–1199.

F. J. Ayala and T. Dobzhansky (eds.) (1974), Studies in the Philosophy of Biology. Berkeley, CA: University of California Press.

Jason M. Baker (2005), “Adaptive Speciation: The Role of Natural Selection in Mechanisms of Geographic and Non-geographic Speciation,” in Carl F. Craver and Lindley Darden (eds.), Special Issue: “Mechanisms in Biology,” Studies in History and Philosophy of Biological and Biomedical Sciences 36: 303–326.

William Bateson (1913), Problems of Genetics. New Haven, CT: Yale University Press.

William Bateson and R. C. Punnett (1911), “On Gametic Series Involving Reduplication of Certain Terms,” Journal of Genetics 1. Reprinted in R. C. Punnett (1928), Scientific Papers of William Bateson, v. 2. Cambridge: Cambridge University Press, pp. 206–215.

William Bechtel (1984), “Reconceptualizations and Interfield Connections: The Discovery of the Link Between Vitamins and Coenzymes,” Philosophy of Science 51: 265–292.

Andrei N. Belozersky and Alexander S. Spirin (1958), “A Correlation between the Compositions of Deoxyribonucleic and Ribonucleic Acids,” Nature 182: 111–112.

James Bogen (2004), “Analysing Causality: The Opposite of Counterfactual is Factual,” International Studies in the Philosophy of Science 18: 3–26.

Sydney Brenner , Francois Jacob , and M. Meselson (1961), “An Unstable Intermediate Carrying Information from Genes to Ribosomes for Protein Synthesis,” Nature 190: 576–581.

Dustin Brisson (2003), “The Directed Mutation Controversy in an Evolutionary Context,” Critical Reviews in Microbiology 29: 25–35.

Stephen Brush (1978a), “Nettie M. Stevens and the Discovery of Sex Determination by Chromosomes,” Isis 69: 163–172.

Stephen Brush (1978b), “A Geologist Among Astronomers: The Rise and Fall of the Chamberlin–Moulton Cosmogony,” Journal for the History of Astronomy 9: 1–41.

Joseph A. Cain and Lindley Darden (1988), “Hull and Selection,” Biology and Philosophy 3: 165–171.

Nancy Cartwright (2004), “Causation: One Word, Many Things,” Philosophy of Science 71: 805–819.

N. Chapuis , M. Durup , and C. Thinus-Blanc (1987), “The Role of Exploratory Experience in a Shortcut in Golden Hamsters (Mesocricetus auratus),” Animal Learning and Behavior 15: 174–178.

Carl F. Craver (2005), “Beyond Reduction: Mechanisms, Multifield Integration, and the Unity of Neuroscience,” in Carl F. Craver and Lindley Darden (eds.), Special Issue: “Mechanisms in Biology,” Studies in History and Philosophy of Biological and Biomedical Sciences 36: 373–397.

Carl F. Craver and Lindley Darden (2005), “Introduction: Mechanisms Then and Now,” in Special Issue, “Mechanisms in Biology,” Studies in History and Philosophy of Biological and Biomedical Sciences 36: 233–244.

Francis Crick and James D. Watson (1956), “Structure of Small Viruses,” Nature 177: 473–475.

Elizabeth Culotta (1994), “A Boost for ‘Adaptive’ Mutation,” Science 265: 318–319.

Sylvia Culp (1997), “Establishing Genotype/Phenotype Relationships: Gene Targeting as an Experimental Approach,” Philosophy of Science (Proceedings) 64: S268–S278.

Lindley Darden (1977), “William Bateson and the Promise of Mendelism,” Journal of the History of Biology 10: 87–106.

Darden, Lindley (1980), “Theory Construction in Genetics,” in Thomas Nickles (ed.), Scientific Discovery, Case Studies. Dordrecht: Reidel, pp. 151–170.

Lindley Darden and Carl Craver (2002), “Strategies in the Interfield Discovery of the Mechanism of Protein Synthesis,” Studies in History and Philosophy of Biological and Biomedical Sciences 33: 1–28.

Darden, Lindley and Roy Rada (1988a), “Hypothesis Formation Using Part-Whole Interrelations,” in David Helman (ed.), Analogical Reasoning. Dordrecht: Reidel, pp. 341–375.

Bernard D. Davis (1980), “Frontiers of the Biological Sciences,” Science 209: 78–89.

E. Fischer (1894), “Einfluss der Konfiguration auf die Wirkung der Enzyme,” Berichte der deutschen chemische Gesellschaft 27: 2985–2993.

Patricia L. Foster (2000), “Adaptive Mutation: Implications for Evolution,” BioEssays 22: 1067–1074.

Patricia L. Foster and Jeffrey M. Trimarchi (1994), “Adaptive Reversion of a Frameshift Mutation in Escherichia coli by Simple Base Deletions in Homopolymeric Runs,” Science 265: 407–409.

U. Frey and R. G. Morris (1998), “Synaptic Tagging: Implications for Late Maintenance of Hippocampal Long-Term Potentiation,” Trends in Neuroscience 21: 181–188.

George Gamow (1954), “Possible Relation between Deoxyribonucleic Acid and Protein Structures,” Nature 173: 318.

Jean-Paul Gaudilliere (1993), “Molecular Biology in the French Tradition? Redefining Local Traditions and Disciplinary Patterns,” Journal of the History of Biology 26: 473–498.

Stuart S. Glennan (2005), “Modeling Mechanisms,” in Carl F. Craver and Lindley Darden (eds.), Special Issue: “Mechanisms in Biology,” Studies in History and Philosophy of Biological and Biomedical Sciences 36: 443–464.

Francois Gros , Howard Hiatt , Walter Gilbert , Chuck G. Kurland , R. W. Risebrough , and James D. Watson (1961), “Unstable Ribonucleic Acid Revealed by Pulse Labeling of E. coli,” Nature 190: 581–585.

Heather Hendrickson , E. Susan Slechta , Ulfar Bergthorsson , Dan I. Andersson , and John R. Roth (2002), “Amplification Mutagenesis: Evidence that ‘Directed’ Adaptive Mutation and General Hypermutability Result from Growth with a Selected Gene Amplification,” Proceedings of the National Academy of Sciences 99: 2164–2169.

Keith J. Holyoak and Paul Thagard (1989), “Analogical Mapping by Constraint Satisfaction,” Cognitive Science 13: 295–355.

Francois Jacob and Jacques Monod (1961), “Genetic Regulatory Mechanisms in the Synthesis of Proteins,” Journal of Molecular Biology 3: 318–356.

Niels K. Jerne (1955), “The Natural-Selection Theory of Antibody Formation,” Proceedings of the National Academy of Sciences 41: 849–857.

John R. Josephson , B. Chandrasekaran , J. Smith , and M. Tanner (1987), “A Mechanism for Forming Composite Explanatory Hypotheses,” IEEE Transactions on Systems, Man, and Cybernetics, SMC- 17: 445–454.

W. B. Kirkham (1919), “The Fate of Homozygous Yellow Mice,” Journal of Experimental Zoology 28: 125–135.

Philip Kitcher (1999), “The Hegemony of Molecular Biology,” Biology & Philosophy 14: 195–210.

Robert E. Kohler (1982), From Medical Chemistry to Biochemistry: The Making of a Biomedical Discipline. New York: Cambridge University Press.

D. E. Koshland (1973), “Protein Shape and Biological Control,” Scientific American 229: 52–64.

Otto E. Landman (1991), “The Inheritance of Acquired Characteristics,” Annual Review of Genetics 25: 1–20.

Jill C. Layton and Patricia L. Foster (2003), “Error-prone DNA Polymerase IV Is Controlled by the Stress-response Sigma Factor, RpoS, in Escherichia coli,” Molecular Microbiology 50: 549–561.

Joshua Lederberg (1965), “Signs of Life: Criterion-System of Exobiology,” Nature 207: 9–13.

Richard C. Lewontin (1970), “The Units of Selection,” Annual Review of Ecology and Systematics 1: 1–18.

Elizabeth Lloyd (1984), “A Semantic Approach to the Structure of Population Genetics,” Philosophy of Science 51: 242–264.

Nancy Maull (1977), “Unifying Science Without Reduction,” Studies in the History and Philosophy of Science 8: 143–162.

Deborah G. Mayo (1996), Error and the Growth of Experimental Knowledge. Chicago, IL: University of Chicago Press.

T. J. McHugh , K. I. Blum , J. Z. Tsien , S. Tonegawa , and M. A. Wilson (1996), “Impaired Hippocampal Representation of Space in CA1-Specific NMDARI Knockout Mice,” Cell 87: 1339–1349.

Tom M. Mitchell (1982), “Generalization as Search,” Artificial Intelligence 18: 203–226.

John E. Mittler and Richard E. Lenski (1990a), “New Data on Excisions of Mu from E. coli MCS2 Cast Doubt on Directed Mutation Hypothesis,” Nature 344: 173–175.

John E. Mittler and Richard E. Lenski (1990b), “Mittler and Lenski Reply,” Nature 345: 213.

J. Monod , J. Wyman , and J-P. Changeux (1965), “On the Nature of Allosteric Transitions: A Plausible Model,” Journal of Molecular Biology 12: 88–118.

Thomas Hunt Morgan (1910b), “Sex-Limited Inheritance in Drosophila,” Science 32: 120–122.

Thomas Hunt Morgan (1917), “The Theory of the Gene,” American Naturalist 51: 513–544.

R. G. M. Morris , P. Garrud , J. N. P. Rawlins , and J. O'Keefe (1982), “Place Navigation Impaired in Rats with Hippocampal Lesions,” Nature 297: 681–683.

Thomas Nickles (1981), “What Is a Problem That We May Solve It?Synthese 47: 85–118.

Nickles, Thomas (1987), “Methodology, Heuristics, and Rationality,” in J. C. Pitt and M. Pera (eds.), Rational Changes in Science. Dordrecht: Reidel, pp. 103–132.

M. W. Nirenberg and J. H. Matthaei (1961), “The Dependence of Cell-Free Protein Synthesis in E. coli upon Naturally Occurring or Synthetic Polyribonucleotides,” Proceedings of the National Academy of Sciences 47:1588–1602.

J. O'Keefe and J. Dostrovsky (1971), “The Hippocampus as a Spatial Map: Preliminary Evidence from Unit Activity in the Freely Moving Rat,” Brain Research 34: 171–175.

Linus Pauling (1940), “A Theory of the Structure and Process of Formation of Antibodies,” Journal of the American Chemical Society 62: 2643–2657.

Alexander Rich and James D. Watson (1954a), “Physical Studies on Ribonucleic Acid,” Nature 173: 995–996.

Susan M. Rosenberg (1994), “In Pursuit of a Molecular Mechanism for Adaptive Mutation,” Genome 37: 893–899.

Susan M. Rosenberg and P. J. Hastings (2003), “Modulating Mutation Rates in the Wild,” Science 300: 1382–1384.

Susan M. Rosenberg , Simonne Longerich , Pauline Gee , and Reuben S. Harris (1994), “Adaptive Mutation by Deletions in Small Mononucleotide Repeats,” Science 265: 405–407.

David W. Rudge (1999), “Taking the Peppered Moth with a Grain of Salt,” Biology & Philosophy 14: 9–37.

Kenneth Schaffner (1974a), “Logic of Discovery and Justification in Regulatory Genetics,” Studies in the History and Philosophy of Science 4: 349–385.

Schaffner, Kenneth (1974c), “The Unity of Science and Theory Construction in Molecular Biology,” in R. J. Seeger and R. S. Cohen (eds.), Philosophical Foundations of Science: Proceedings of Section L, AAAS 1969. Boston Studies in the Philosophy of Science, v. 11. Dordrecht: D Reidel Publishing, pp. 497–533.

Kenneth Schaffner (1980), “Theory Structure in the Biomedical Sciences,” The Journal of Medicine and Philosophy 5: 57–97.

W. B. Scoville and B. Millner (1957), “Loss of Recent Memory after Bilateral Hippocampal Lesions,” Journal of Neurology, Neurosurgery, and Psychiatry. 20: 11–20.

Shapere, Dudley (1980), “The Character of Scientific Change,” in Thomas Nickles (ed.), Scientific Discovery, Logic and Rationality. Dordrecht: Reidel, pp. 61–101.

S. Shi , Y. Hayashi , R. S. Petralia , S. H. Zaman , R. J. Wenthold , K. Svoboda , and R. Malinow (1999), “Rapid Spine Delivery and Redistribution of AMPA Receptors after Synaptic NMDA Receptor Activation,” Science 284: 1811–1816.

Robert A. Skipper Jr. (2002), “The Persistence of the R. A. Fisher-Sewall Wright Controversy,” Biology and Philosophy 17: 341–367.

F. W. Stahl (1988), “A Unicorn in the Garden,” Nature 335: 112–113.

C. F. Stevens (1996), “Spatial Learning and Memory: The Beginning of a Dream,” Cell 87: 1147–1148.

A. H. Sturtevant (1913), “The Linear Arrangement of Six Sex-linked Factors in Drosophila, as Shown by Their Mode of Association,” Journal of Experimental Zoology 14: 43–59.

Howard M. Temin (1963), “The Effects of Actinomycin D on Growth of Rous Sarcoma Virus in Vitro,” Virology 20: 577–582

Howard M. Temin (1964b), “Homology between RNA from Rous Sarcoma Virus and DNA from Rous Sarcoma Virus-infected Cells,” Proceedings of the National Academy of Sciences 52: 323–329.

Howard M. Temin and Satoshi Mizutani (1970), “RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus,” Nature 226: 1211–1213.

David S. Thaler (1994), “The Evolution of Genetic Intelligence,” Science 264: 224–225.

J. Z. Tsien , D. E. Chen , D. Gerber , C. Tom , E. Mercer , D. Anderson , M. Mayford , and E. R. Kandel (1996a), “Subregion- and Cell Type-Restricted Gene Knockout in Mouse Brain,” Cell 87: 1317–1326.

J. Z. Tsien , P. T. Huerta , and S. Tonegawa (1996b), “The Essential Role of Hippocampal CA1 NMDA Receptor-Dependent Synaptic Plasticity in Spatial Memory,” Cell 87: 1327–1338.

Elisabeth S. Vrba and Stephen J. Gould (1986), “The Hierarchical Expansion of Sorting and Selection: Sorting and Selection Cannot Be Equated,” Paleobiology 12: 217–228.

C. Kenneth Waters (1994), “Genes Made Molecular,” Philosophy of Science 61: 163–185.

M. A. Wilson and B. McNaughton (1993), “Dynamics of the Hippocampal Ensemble Code for Space,” Science 261: 1055–1058.

Wimsatt, William (1976), “Reductive Explanation: A Functional Account,” in Robert S. Cohen (ed.), PSA 1974. Dordrecht: Reidel, pp. 671–710. Reprinted in Elliott Sober (ed.) (1984), Conceptual Issues in Evolutionary Biology: An Anthology. 1st ed. Cambridge, MA: MIT Press, pp. 477–508.

Paul C. Zamecnik (1958), “The Microsome,” Scientific American 198 (March): 118–124.

Paul C. Zamecnik (1962a), “History and Speculation on Protein Synthesis,” Proceedings of the Symposia on Mathematical Problems in the Biological Sciences 14: 47–53.

Paul C. Zamecnik (1962b), “Unsettled Questions in the Field of Protein Synthesis,” Biochemical Journal 85: 257–264.

Paul C. Zamecnik (1979), “Historical Aspects of Protein Synthesis,” Annals of the New York Academy of Sciences 325: 269–301.

S. Zola-Morgan and L. Squire (1993), “Neuroanatomy of Memory,” Annual Review of Neuroscience 16: 547–563.


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