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Interactions of noradrenaline and cortisol and the induction of indelible memories

Published online by Cambridge University Press:  05 January 2017

René Hurlemann ,
Wolfgang Maier  and
Dirk Scheele
René Hurlemann
Affiliation:
Department of Psychiatry, University of Bonn, 53105 Bonn, Germanyrenehurlemann@icloud.comwolfgang.maier@ukb.uni-bonn.dehttp://renehurlemann.squarespace.com/welcome/http://psychiatrie.uni-bonn.de/ Division of Medical Psychology, University of Bonn, 53105 Bonn, Germanydirk-scheele@gmx.de
Wolfgang Maier
Affiliation:
Department of Psychiatry, University of Bonn, 53105 Bonn, Germanyrenehurlemann@icloud.comwolfgang.maier@ukb.uni-bonn.dehttp://renehurlemann.squarespace.com/welcome/http://psychiatrie.uni-bonn.de/ German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany
Dirk Scheele
Affiliation:
Department of Psychiatry, University of Bonn, 53105 Bonn, Germanyrenehurlemann@icloud.comwolfgang.maier@ukb.uni-bonn.dehttp://renehurlemann.squarespace.com/welcome/http://psychiatrie.uni-bonn.de/ Division of Medical Psychology, University of Bonn, 53105 Bonn, Germanydirk-scheele@gmx.de
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Abstract

The glutamate amplifies noradrenergic effects (GANE) model emphasizes the role of focal glutamate–noradrenaline interactions in creating functional hotspots for prioritized processing of salient stimuli. Here, we briefly outline current evidence that synergistic action of noradrenaline and cortisol enables emotional stimuli to gain privileged access to amygdala–hippocampus circuits, eventually resulting in the formation of indelible memories and posttraumatic stress disorder (PTSD).

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 39 , 2016 , e213
Copyright
Copyright © Cambridge University Press 2016 

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