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Does arousal enhance apical amplification and disamplification?

Published online by Cambridge University Press:  05 January 2017

M. E. Larkum  and
W. A. Phillips
M. E. Larkum
Affiliation:
Neurocure Cluster of Excellence, Department of Biology, Humboldt University, 10117 Berlin, Germanymatthew.larkum@gmail.com
W. A. Phillips
Affiliation:
Division of Psychology, School of Natural Sciences, University of Stirling, Stirling FK9 4LA, Scotland, United Kingdomwap1@stir.ac.uk
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Abstract

We summarize evidence that input to the apical tufts of neocortical pyramidal cells modulates their response to basal input. Because this apical amplification and disamplification provide intracortical mechanisms for prioritization, Mather and colleagues' arguments suggest that their effects are enhanced by noradrenergic arousal. Though that is likely, it has not yet been adequately studied. Their article shows that it should be.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 39 , 2016 , e215
Copyright
Copyright © Cambridge University Press 2016 

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