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“What have we GANEd?” A theoretical construct to explain experimental evidence for noradrenergic regulation of sensory signal processing

Published online by Cambridge University Press:  05 January 2017

Rachel Navarra  and
Barry Waterhouse
Rachel Navarra
Affiliation:
Department of Cell Biology and Neuroscience, Rowan University School of Medicine, Stratford, NJ 08084 navarra@rowan.edu waterhouse@rowan.edu
Barry Waterhouse
Affiliation:
Department of Cell Biology and Neuroscience, Rowan University School of Medicine, Stratford, NJ 08084 navarra@rowan.edu waterhouse@rowan.edu
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Abstract

The GANE (glutamate amplifies noradrenergic effects) theory posits a mechanism for amplifying noradrenergic modulatory actions and enhancing the processing of high-priority sensory signals for immediate or future experience-guided action. This theoretical construct is thought provoking with respect to the central processing of high-priority versus low-priority stimuli, but it requires some refinement to account for physiological fluctuations in NE efflux as a function of naturally occurring transitions in behavioral state and the experimentally observed phenomena associated with noradrenergic regulation of sensory signal transfer.

Information

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 39 , 2016 , e219
Copyright
Copyright © Cambridge University Press 2016 

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