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“What have we GANEd?” A theoretical construct to explain experimental evidence for noradrenergic regulation of sensory signal processing

Published online by Cambridge University Press:  05 January 2017

Rachel Navarra  and
Barry Waterhouse
Rachel Navarra
Affiliation:
Department of Cell Biology and Neuroscience, Rowan University School of Medicine, Stratford, NJ 08084navarra@rowan.eduwaterhouse@rowan.edu
Barry Waterhouse
Affiliation:
Department of Cell Biology and Neuroscience, Rowan University School of Medicine, Stratford, NJ 08084navarra@rowan.eduwaterhouse@rowan.edu
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Abstract

The GANE (glutamate amplifies noradrenergic effects) theory posits a mechanism for amplifying noradrenergic modulatory actions and enhancing the processing of high-priority sensory signals for immediate or future experience-guided action. This theoretical construct is thought provoking with respect to the central processing of high-priority versus low-priority stimuli, but it requires some refinement to account for physiological fluctuations in NE efflux as a function of naturally occurring transitions in behavioral state and the experimentally observed phenomena associated with noradrenergic regulation of sensory signal transfer.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 39 , 2016 , e219
Copyright
Copyright © Cambridge University Press 2016 

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