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Dietary factors and low-grade inflammation in relation to overweight and obesity

  • Philip C. Calder (a1), Namanjeet Ahluwalia (a2), Fred Brouns (a3) (a4), Timo Buetler (a5) (a6), Karine Clement (a7), Karen Cunningham (a8), Katherine Esposito (a9), Lena S. Jönsson (a10), Hubert Kolb (a11), Mirian Lansink (a12), Ascension Marcos (a13), Andrew Margioris (a14), Nathan Matusheski (a15), Herve Nordmann (a16), John O'Brien (a5), Giuseppe Pugliese (a17), Salwa Rizkalla (a7), Casper Schalkwijk (a18), Jaakko Tuomilehto (a19), Julia Wärnberg (a13) (a20), Bernhard Watzl (a21) and Brigitte M. Winklhofer-Roob (a22)...
Abstract

Low-grade inflammation is a characteristic of the obese state, and adipose tissue releases many inflammatory mediators. The source of these mediators within adipose tissue is not clear, but infiltrating macrophages seem to be especially important, although adipocytes themselves play a role. Obese people have higher circulating concentrations of many inflammatory markers than lean people do, and these are believed to play a role in causing insulin resistance and other metabolic disturbances. Blood concentrations of inflammatory markers are lowered following weight loss. In the hours following the consumption of a meal, there is an elevation in the concentrations of inflammatory mediators in the bloodstream, which is exaggerated in obese subjects and in type 2 diabetics. Both high-glucose and high-fat meals may induce postprandial inflammation, and this is exaggerated by a high meal content of advanced glycation end products (AGE) and partly ablated by inclusion of certain antioxidants or antioxidant-containing foods within the meal. Healthy eating patterns are associated with lower circulating concentrations of inflammatory markers. Among the components of a healthy diet, whole grains, vegetables and fruits, and fish are all associated with lower inflammation. AGE are associated with enhanced oxidative stress and inflammation. SFA and trans-MUFA are pro-inflammatory, while PUFA, especially long-chain n-3 PUFA, are anti-inflammatory. Hyperglycaemia induces both postprandial and chronic low-grade inflammation. Vitamin C, vitamin E and carotenoids decrease the circulating concentrations of inflammatory markers. Potential mechanisms are described and research gaps, which limit our understanding of the interaction between diet and postprandial and chronic low-grade inflammation, are identified.

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1 PC Calder , R Albers , JM Antoine , (2009) Inflammatory disease processes and interactions with nutrition. Br J Nutr 101, Suppl. 1, S145.

2 H Kolb & T Mandrup-Poulsen (2010) The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation. Diabetologia 53, 1020.

3 JM Fernandez-Real & JC Pickup (2008) Innate immunity, insulin resistance and type 2 diabetes. Trends Endocrinol Metab 19, 1016.

4 C Herder , M Peltonen , W Koenig , (2006) Systemic immune mediators and lifestyle changes in the prevention of type 2 diabetes: results from the Finnish Diabetes Prevention Study. Diabetes 55, 23402346.

5 C Herder , T Illig , W Rathmann , (2005) Inflammation and type 2 diabetes: results from KORA Augsburg. Gesundheitswesen 67, Suppl. 1, S115S121.

6 S Muller , S Martin , W Koenig , (2002) Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors. Diabetologia 45, 805812.

7 CS Kim , HS Park , T Kawada , (2006) Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. Int J Obes (Lond) 30, 13471355.

8 GS Hotamisligil , NS Shargill & BM Spiegelman (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259, 8791.

9 P Trayhurn & IS Wood (2004) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92, 347355.

10 H Tilg & AR Moschen (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6, 772783.

11 KE Wellen & GS Hotamisligil (2003) Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 112, 17851788.

12 A Koerner , J Kratzsch & W Kiess (2005) Adipocytokines: leptin–the classical, resistin–the controversical, adiponectin–the promising, and more to come. Best Pract Res Clin Endocrinol Metab 19, 525546.

13 ME Trujillo & PE Scherer (2006) Adipose tissue-derived factors: impact on health and disease. Endocr Rev 27, 762778.

15 M Gil-Campos , RR Canete & A Gil (2004) Adiponectin, the missing link in insulin resistance and obesity. Clin Nutr 23, 963974.

16 A Fukuhara , M Matsuda , M Nishizawa , (2005) Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 307, 426430.

17 PG McTernan , CM Kusminski & S Kumar (2006) Resistin. Curr Opin Lipidol 17, 170175.

18 RZ Yang , MJ Lee , H Hu , (2006) Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab 290, E1253E1261.

19 RZ Yang , MJ Lee , H Hu , (2006) Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS Med 3, e287.

20 JK Sethi & A Vidal-Puig (2005) Visfatin: the missing link between intra-abdominal obesity and diabetes? Trends Mol Med 11, 344347.

21 JM Stephens & AJ Vidal-Puig (2006) An update on visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity. Curr Opin Lipidol 17, 128131.

22 I Juhan-Vague , MC Alessi , A Mavri , (2003) Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk. J Thromb Haemost 1, 15751579.

23 C Poitou , N Viguerie , R Cancello , (2005) Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition. Diabetologia 48, 519528.

24 E Somm , P Cettour-Rose , C Asensio , (2006) Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents. Diabetologia 49, 387393.

25 E Somm , E Henrichot , A Pernin , (2005) Decreased fat mass in interleukin-1 receptor antagonist-deficient mice: impact on adipogenesis, food intake, and energy expenditure. Diabetes 54, 35033509.

26 CA Meier , E Bobbioni , C Gabay , (2002) IL-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin? J Clin Endocrinol Metab 87, 11841188.

27 MG Netea , LA Joosten , E Lewis , (2006) Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med 12, 650656.

28 T Skurk , H Kolb , S Muller-Scholze , (2005) The proatherogenic cytokine interleukin-18 is secreted by human adipocytes. Eur J Endocrinol 152, 863868.

29 T Skurk , C berti-Huber , C Herder , (2007) Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab 92, 10231033.

30 M Straczkowski , I Kowalska , A Nikolajuk , (2007) Increased serum interleukin-18 concentration is associated with hypoadiponectinemia in obesity, independently of insulin resistance. Int J Obes (Lond) 31, 221225.

31 R Cancello , C Henegar , N Viguerie , (2005) Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 54, 22772286.

33 T Skurk , C Herder , I Kraft , (2005) Production and release of macrophage migration inhibitory factor from human adipocytes. Endocrinology 146, 10061011.

34 M Straczkowski , S Dzienis-Straczkowska , A Stepien , (2002) Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-alpha system. J Clin Endocrinol Metab 87, 46024606.

35 M Straczkowski , I Kowalska , A Nikolajuk , (2003) Plasma interleukin 8 concentrations in obese subjects with impaired glucose tolerance. Cardiovasc Diabetol 2, 5.

36 CA Curat , V Wegner , C Sengenes , (2006) Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin. Diabetologia 49, 744747.

37 C Herder , H Hauner , K Kempf , (2007) Constitutive and regulated expression and secretion of interferon-gamma-inducible protein 10 (IP-10/CXCL10) in human adipocytes. Int J Obes (Lond) 31, 403410.

38 JN Fain , DS Tichansky & AK Madan (2005) Transforming growth factor beta1 release by human adipose tissue is enhanced in obesity. Metabolism 54, 15461551.

39 BG Gabrielsson , JM Johansson , M Lonn , (2003) High expression of complement components in omental adipose tissue in obese men. Obes Res 11, 699708.

40 M Guerre-Millo (2006) Adipose tissue secretory function: implication in metabolic and cardiovascular complications of obesity. J Soc Biol 200, 3743.

41 TE Graham , Q Yang , M Bluher , (2006) Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med 354, 25522563.

42 Q Yang , TE Graham , N Mody , (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436, 356362.

43 J Janke , S Engeli , M Boschmann , (2006) Retinol-binding protein 4 in human obesity. Diabetes 55, 28052810.

44 VJ Carey , EE Walters , GA Colditz , (1997) Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses’ Health Study. Am J Epidemiol 145, 614619.

45 AH Kissebah , N Vydelingum , R Murray , (1982) Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab 54, 254260.

46 M Visser , LM Bouter , GM McQuillan , (1999) Elevated C-reactive protein levels in overweight and obese adults. JAMA 282, 21312135.

47 DG Cook , MA Mendall , PH Whincup , (2000) C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors. Atherosclerosis 149, 139150.

48 JS Yudkin (2003) Adipose tissue, insulin action and vascular disease: inflammatory signals. Int J Obes Relat Metab Disord 27, Suppl. 3, S25S28.

49 KE Wellen & GS Hotamisligil (2005) Inflammation, stress, and diabetes. J Clin Invest 115, 11111119.

50 JP Despres & I Lemieux (2006) Abdominal obesity and metabolic syndrome. Nature 444, 881887.

51 M Lafontan & J Girard (2008) Impact of visceral adipose tissue on liver metabolism. Part I: heterogeneity of adipose tissue and functional properties of visceral adipose tissue. Diabetes Metab 34, 317327.

52 V van Harmelen , A Dicker , M Ryden , (2002) Increased lipolysis and decreased leptin production by human omental as compared with subcutaneous preadipocytes. Diabetes 51, 20292036.

53 MC Alessi , D Bastelica , P Morange , (2000) Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity. Diabetes 49, 13741380.

54 JM Bruun , AS Lihn , AK Madan , (2004) Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue. Am J Physiol Endocrinol Metab 286, E8E13.

55 D Bastelica , P Morange , B Berthet , (2002) Stromal cells are the main plasminogen activator inhibitor-1-producing cells in human fat: evidence of differences between visceral and subcutaneous deposits. Arterioscler Thromb Vasc Biol 22, 173178.

56 JN Fain , AK Madan , ML Hiler , (2004) Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 145, 22732282.

57 H Hauner (2005) Secretory factors from human adipose tissue and their functional role. Proc Nutr Soc 64, 163169.

58 CM de Souza Batista , RZ Yang , MJ Lee , (2007) Omentin plasma levels and gene expression are decreased in obesity. Diabetes 56, 16551661.

59 P Arner (2006) Visfatin–a true or false trail to type 2 diabetes mellitus. J Clin Endocrinol Metab 91, 2830.

60 SW Rabkin (2007) Epicardial fat: properties, function and relationship to obesity. Obes Rev 8, 253261.

61 A Silaghi , MD Piercecchi-Marti , M Grino , (2008) Epicardial adipose tissue extent: relationship with age, body fat distribution, and coronaropathy. Obesity (Silver Spring) 16, 24242430.

62 M Jernas , J Palming , K Sjoholm , (2006) Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression. FASEB J 20, 15401542.

63 C Weyer , JE Foley , C Bogardus , (2000) Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia 43, 14981506.

64 JN Fain (2006) Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm 74, 443477.

65 R Cancello , J Tordjman , C Poitou , (2006) Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes 55, 15541561.

66 SP Weisberg , D McCann , M Desai , (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112, 17961808.

67 H Xu , GT Barnes , Q Yang , (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112, 18211830.

68 C Henegar , J Tordjman , V Achard , (2008) Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol 9, R14.

69 U Kintscher , M Hartge , K Hess , (2008) T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol 28, 13041310.

70 ME Rausch , S Weisberg , P Vardhana , (2008) Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond) 32, 451463.

71 H Wu , S Ghosh , XD Perrard , (2007) T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation 115, 10291038.

72 SR Bornstein , M Abu-Asab , A Glasow , (2000) Immunohistochemical and ultrastructural localization of leptin and leptin receptor in human white adipose tissue and differentiating human adipose cells in primary culture. Diabetes 49, 532538.

74 B Cousin , M Andre , L Casteilla , (2001) Altered macrophage-like functions of preadipocytes in inflammation and genetic obesity. J Cell Physiol 186, 380386.

75 CN Lumeng , JL Bodzin & AR Saltiel (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117, 175184.

76 JM Olefsky & CK Glass (2010) Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72, 219246.

77 K Karastergiou & V Mohamed-Ali (2010) The autocrine and paracrine roles of adipokines. Mol Cell Endocrinol 318, 6978.

78 CA Curat , A Miranville , C Sengenes , (2004) From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes 53, 12851292.

80 SP Weisberg , D Hunter , R Huber , (2006) CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116, 115124.

81 KE Inouye , H Shi , JK Howard , (2007) Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes 56, 22422250.

82 P Trayhurn , B Wang & IS Wood (2008) Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? Br J Nutr 100, 227235.

83 M Guerre-Millo , A Grosfeld & T Issad (2002) Leptin is a hypoxia-inducible gene. Obes Res 10, 856858.

84 S Cinti , G Mitchell , G Barbatelli , (2005) Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46, 23472355.

85 A Bouloumie , L Casteilla & M Lafontan (2008) Adipose tissue lymphocytes and macrophages in obesity and insulin resistance: makers or markers, and which comes first? Arterioscler Thromb Vasc Biol 28, 12111213.

86 C Lagathu , JP Bastard , M Auclair , (2003) Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochem Biophys Res Commun 311, 372379.

87 D Lacasa , S Taleb , M Keophiphath , (2007) Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology 148, 868877.

88 VA Constant , A Gagnon , A Landry , (2006) Macrophage-conditioned medium inhibits the differentiation of 3T3-L1 and human abdominal preadipocytes. Diabetologia 49, 14021411.

89 PA Permana , C Menge & PD Reaven (2006) Macrophage-secreted factors induce adipocyte inflammation and insulin resistance. Biochem Biophys Res Commun 341, 507514.

90 T Suganami , J Nishida & Y Ogawa (2005) A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol 25, 20622068.

91 A Kumar , Y Takada , AM Boriek , (2004) Nuclear factor-kappaB: its role in health and disease. J Mol Med 82, 434448.

92 ND Perkins (2007) Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8, 4962.

93 LH Sigal (2006) Basic science for the clinician 39: NF-kappaB-function, activation, control, and consequences. J Clin Rheumatol 12, 207211.

94 E Maury & SM Brichard (2010) Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol 314, 116.

95 T Suganami , K Tanimoto-Koyama , J Nishida , (2007) Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol 27, 8491.

96 Y Lin , H Lee , AH Berg , (2000) The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem 275, 2425524263.

97 H Shi , MV Kokoeva , K Inouye , (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116, 30153025.

98 Y Matsuzawa (2006) The metabolic syndrome and adipocytokines. FEBS Lett 580, 29172921.

99 Y Matsuzawa (2006) Therapy insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat Clin Pract Cardiovasc Med 3, 3542.

100 H Chen (2006) Cellular inflammatory responses: novel insights for obesity and insulin resistance. Pharmacol Res 53, 469477.

101 AE Malavazos , E Cereda , L Morricone , (2005) Monocyte chemoattractant protein 1: a possible link between visceral adipose tissue-associated inflammation and subclinical echocardiographic abnormalities in uncomplicated obesity. Eur J Endocrinol 153, 871877.

102 AE Malavazos , MM Corsi , F Ermetici , (2007) Proinflammatory cytokines and cardiac abnormalities in uncomplicated obesity: relationship with abdominal fat deposition. Nutr Metab Cardiovasc Dis 17, 294302.

103 N Ouchi , S Kihara , T Funahashi , (2003) Obesity, adiponectin and vascular inflammatory disease. Curr Opin Lipidol 14, 561566.

104 C Herder , B Haastert , S Muller-Scholze , (2005) Association of systemic chemokine concentrations with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4). Diabetes 54, Suppl. 2, S11S17.

105 FB Stentz , GE Umpierrez , R Cuervo , (2004) Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises. Diabetes 53, 20792086.

106 C de Luca & JM Olefsky (2006) Stressed out about obesity and insulin resistance. Nat Med 12, 4142.

107 I Harman-Boehm , M Bluher , H Redel , (2007) Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity. J Clin Endocrinol Metab 92, 22402247.

108 AH Berg & PE Scherer (2005) Adipose tissue, inflammation, and cardiovascular disease. Circ Res 96, 939949.

109 P Kopelman (2007) Health risks associated with overweight and obesity. Obes Rev 8, Suppl. 1, 1317.

110 P Ziccardi , F Nappo , G Giugliano , (2002) Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation 105, 804809.

111 K Esposito , A Pontillo , C Di Palo , (2003) Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 289, 17991804.

112 LK Heilbronn & PM Clifton (2002) C-reactive protein and coronary artery disease: influence of obesity, caloric restriction and weight loss. J Nutr Biochem 13, 316321.

113 JP Bastard , C Jardel , E Bruckert , (2000) Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 85, 33383342.

114 K Esposito , A Pontillo , M Ciotola , (2002) Weight loss reduces interleukin-18 levels in obese women. J Clin Endocrinol Metab 87, 38643866.

115 JP Bastard , H Vidal , C Jardel , (2000) Subcutaneous adipose tissue expression of plasminogen activator inhibitor-1 gene during very low calorie diet in obese subjects. Int J Obes Relat Metab Disord 24, 7074.

116 J Gomez-Ambrosi , J Salvador , F Rotellar , (2006) Increased serum amyloid A concentrations in morbid obesity decrease after gastric bypass. Obes Surg 16, 262269.

117 S Taleb , R Cancello , C Poitou , (2006) Weight loss reduces adipose tissue cathepsin S and its circulating levels in morbidly obese women. J Clin Endocrinol Metab 91, 10421047.

119 CW Kopp , HP Kopp , S Steiner , (2003) Weight loss reduces tissue factor in morbidly obese patients. Obes Res 11, 950956.

120 TS Church , MS Willis , EL Priest , (2005) Obesity, macrophage migration inhibitory factor, and weight loss. Int J Obes (Lond) 29, 675681.

121 T Christiansen , B Richelsen & JM Bruun (2005) Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. Int J Obes (Lond) 29, 146150.

122 AR Vasudevan , H Wu , AM Xydakis , (2006) Eotaxin and obesity. J Clin Endocrinol Metab 91, 256261.

123 K Krzyzanowska , F Mittermayer , W Krugluger , (2006) Increase in visfatin after weight loss induced by gastroplastic surgery. Obesity (Silver Spring) 14, 18861889.

124 JP Bastard , B Hainque , E Dusserre , (1999) Peroxisome proliferator activated receptor-gamma, leptin and tumor necrosis factor-alpha mRNA expression during very low calorie diet in subcutaneous adipose tissue in obese women. Diabetes Metab Res Rev 15, 9298.

125 HP Kopp , CW Kopp , A Festa , (2003) Impact of weight loss on inflammatory proteins and their association with the insulin resistance syndrome in morbidly obese patients. Arterioscler Thromb Vasc Biol 23, 10421047.

126 C Poitou , C Coussieu , C Rouault , (2006) Serum amyloid A: a marker of adiposity-induced low-grade inflammation but not of metabolic status. Obesity (Silver Spring) 14, 309318.

127 K Clement , N Viguerie , C Poitou , (2004) Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J 18, 16571669.

128 C de Luca & JM Olefsky (2008) Inflammation and insulin resistance. FEBS Lett 582, 97105.

129 L Li , M Naples , H Song , (2007) LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signaling. Am J Physiol Endocrinol Metab 293, E587E594.

130 HL Rui , E Fan , HM Zhou , (2002) SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. J Biol Chem 277, 4298142986.

131 K Ueki , T Kondo & CR Kahn (2004) Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 24, 54345446.

132 JH Kim , JE Kim , HY Liu , (2008) Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway. J Biol Chem 283, 708715.

133 CH Lang , C Dobrescu & GJ Bagby (1992) Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 130, 4352.

134 PD Miles , OM Romeo , K Higo , (1997) TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazone. Diabetes 46, 16781683.

135 T Atsumi , YR Cho , L Leng , (2007) The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation. J Immunol 179, 53995406.

136 N Houstis , ED Rosen & ES Lander (2006) Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440, 944948.

137 T Nishikawa , D Kukidome , K Sonoda , (2007) Impact of mitochondrial ROS production in the pathogenesis of insulin resistance. Diabetes Res Clin Pract 77, Suppl. 1, S161S164.

138 Y Li , C Jiang , G Xu , (2008) Homocysteine upregulates resistin production from adipocytes in vivo and in vitro. Diabetes 57, 817827.

139 P Arner (2005) Insulin resistance in type 2 diabetes – role of the adipokines. Curr Mol Med 5, 333339.

140 SF Yan , GR Barile , V D'Agati , (2007) The biology of RAGE and its ligands: uncovering mechanisms at the heart of diabetes and its complications. Curr Diab Rep 7, 146153.

141 T Nomiyama , D Perez-Tilve , D Ogawa , (2007) Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest 117, 28772888.

142 K Clement & D Langin (2007) Regulation of inflammation-related genes in human adipose tissue. J Intern Med 262, 422430.

143 JK Kim , YJ Kim , JJ Fillmore , (2001) Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 108, 437446.

145 SE Shoelson , J Lee & M Yuan (2003) Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord 27, Suppl. 3, S49S52.

146 A Fleischman , SE Shoelson , R Bernier , (2008) Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care 31, 289294.

147 MC Wasko , HB Hubert , VB Lingala , (2007) Hydroxychloroquine and risk of diabetes in patients with rheumatoid arthritis. JAMA 298, 187193.

148 CM Larsen , M Faulenbach , A Vaag , (2007) Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 356, 15171526.

149 R Barbuio , M Milanski , MB Bertolo , (2007) Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet. J Endocrinol 194, 539550.

150 H Dominguez , H Storgaard , C Rask-Madsen , (2005) Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes. J Vasc Res 42, 517525.

151 LS Tam , B Tomlinson , TT Chu , (2007) Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis. Clin Rheumatol 26, 14951498.

152 P Di Rocco , M Manco , G Rosa , (2004) Lowered tumor necrosis factor receptors, but not increased insulin sensitivity, with infliximab. Obes Res 12, 734739.

153 SE Borst , Y Lee , CF Conover , (2004) Neutralization of tumor necrosis factor-alpha reverses insulin resistance in skeletal muscle but not adipose tissue. Am J Physiol Endocrinol Metab 287, E934E938.

156 DS Bell , JH O'Keefe & P Jellinger (2008) Postprandial dysmetabolism: the missing link between diabetes and cardiovascular events? Endocr Pract 14, 112124.

157 JH O'Keefe , NM Gheewala & JO O'Keefe (2008) Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol 51, 249255.

158 M Napolitano & E Bravo (2005) Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages. Eur J Clin Invest 35, 482490.

159 AJ van Oostrom , TP Sijmonsma , C Verseyden , (2003) Postprandial recruitment of neutrophils may contribute to endothelial dysfunction. J Lipid Res 44, 576583.

161 A Alipour , AJ van Oostrom , A Izraeljan , (2008) Leukocyte activation by triglyceride-rich lipoproteins. Arterioscler Thromb Vasc Biol 28, 792797.

162 GC Burdge & PC Calder (2005) Plasma cytokine response during the postprandial period: a potential causal process in vascular disease? Br J Nutr 93, 39.

163 PJ Manning , WH Sutherland , MM McGrath , (2008) Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity (Silver Spring) 16, 20462052.

164 A Jellema , J Plat & RP Mensink (2004) Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state. Eur J Clin Invest 34, 766773.

165 K Esposito , M Ciotola , FC Sasso , (2007) Effect of a single high-fat meal on endothelial function in patients with the metabolic syndrome: role of tumor necrosis factor-alpha. Nutr Metab Cardiovasc Dis 17, 274279.

166 F Nappo , K Esposito , M Cioffi , (2002) Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol 39, 11451150.

167 A Ceriello , R Assaloni , RR Da , (2005) Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress, and inflammation in type 2 diabetic patients. Circulation 111, 25182524.

169 A Ceriello , N Bortolotti , E Motz , (1998) Meal-generated oxidative stress in type 2 diabetic patients. Diabetes Care 21, 15291533.

170 KE Wellen , R Fucho , MF Gregor , (2007) Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell 129, 537548.

171 A Abedini & SE Shoelson (2007) Inflammation and obesity: STAMPing out insulin resistance? Immunol Cell Biol 85, 399400.

172 G Candore , G Colonna-Romano , CR Balistreri , (2006) Biology of longevity: role of the innate immune system. Rejuvenation Res 9, 143148.

173 KS Krabbe , M Pedersen & H Bruunsgaard (2004) Inflammatory mediators in the elderly. Exp Gerontol 39, 687699.