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Monoamine reuptake inhibition and mood-enhancing potential of a specified oregano extract

Abstract

A healthy, balanced diet is essential for both physical and mental well-being. Such a diet must include an adequate intake of micronutrients, essential fatty acids, amino acids and antioxidants. The monoamine neurotransmitters, serotonin, dopamine and noradrenaline, are derived from dietary amino acids and are involved in the modulation of mood, anxiety, cognition, sleep regulation and appetite. The capacity of nutritional interventions to elevate brain monoamine concentrations and, as a consequence, with the potential for mood enhancement, has not been extensively evaluated. The present study investigated an extract from oregano leaves, with a specified range of active constituents, identified via an unbiased, high-throughput screening programme. The oregano extract was demonstrated to inhibit the reuptake and degradation of the monoamine neurotransmitters in a dose-dependent manner, and microdialysis experiments in rats revealed an elevation of extracellular serotonin levels in the brain. Furthermore, following administration of oregano extract, behavioural responses were observed in mice that parallel the beneficial effects exhibited by monoamine-enhancing compounds when used in human subjects. In conclusion, these data show that an extract prepared from leaves of oregano, a major constituent of the Mediterranean diet, is brain-active, with moderate triple reuptake inhibitory activity, and exhibits positive behavioural effects in animal models. We postulate that such an extract may be effective in enhancing mental well-being in humans.

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Corresponding author
*Corresponding author: Dr A. O. Mechan, fax +41 61 815 8740, email annismechan@mac.com
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4JD Fernstrom (1990) Aromatic amino acids and monoamine synthesis in the central nervous system: influence of the diet. J Nutr Biochem 1, 508517.

6AL Frederick & GD Stanwood (2009) Drugs, biogenic amine targets and the developing brain. Dev Neurosci 31, 722.

7LD Jayanthi & S Ramamoorthy (2005) Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants. AAPS J 7, E728E738.

8I Lucki (1998) The spectrum of behaviors influenced by serotonin. Biol Psychiatry 44, 151162.

11DO Kennedy , AB Scholey , NT Tildesley , (2002) Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 72, 953964.

12NT Tildesley , DO Kennedy , EK Perry , (2005) Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers. Physiol Behav 83, 699709.

13NT Tildesley , DO Kennedy , EK Perry , (2003) Salvia lavandulaefolia (Spanish sage) enhances memory in healthy young volunteers. Pharmacol Biochem Behav 75, 669674.

14AB Scholey , NT Tildesley , CG Ballard , (2008) An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers. Psychopharmacology (Berlin) 198, 127139.

15R Ofir , S Tamir , S Khatib , (2003) Inhibition of serotonin re-uptake by licorice constituents. J Mol Neurosci 20, 135140.

17D Dhingra & A Sharma (2006) Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests. Prog Neuropsychopharmacol Biol Psychiatry 30, 449454.

18D Dhingra , M Parle & SK Kulkarni (2004) Memory enhancing activity of Glycyrrhiza glabra in mice. J Ethnopharmacol 91, 361365.

23A Holt , DF Sharman , GB Baker , (1997) A continuous spectrophotometric assay for monoamine oxidase and related enzymes in tissue homogenates. Anal Biochem 244, 384392.

24HL White , PW Scates & BR Cooper (1996) Extracts of Ginkgo biloba leaves inhibit monoamine oxidase. Life Sci 58, 13151321.

25M Yamada & H Yasuhara (2004) Clinical pharmacology of MAO inhibitors: safety and future. Neurotoxicology 25, 215221.

28K Njung'e & SL Handley (1991) Evaluation of marble-burying behavior as a model of anxiety. Pharmacol Biochem Behav 38, 6367.

29K Njung'e & SL Handley (1991) Effects of 5-HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agents. Br J Pharmacol 104, 105112.

31CL Broekkamp , HW Rijk , D Joly-Gelouin , (1986) Major tranquillizers can be distinguished from minor tranquillizers on the basis of effects on marble burying and swim-induced grooming in mice. Eur J Pharmacol 126, 223229.

33DS Kreiss , S Wieland & I Lucki (1993) The presence of a serotonin uptake inhibitor alters pharmacological manipulations of serotonin release. Neuroscience 52, 295301.

35TM Felton , TB Kang , S Hjorth , (2003) Effects of selective serotonin and serotonin/noradrenaline reuptake inhibitors on extracellular serotonin in rat diencephalon and frontal cortex. Naunyn Schmiedebergs Arch Pharmacol 367, 297305.

36S Maione , E Palazzo , M Pallotta , (1997) Effects of imipramine on raphe nuclei and prefrontal cortex extracellular serotonin levels in the rat. Psychopharmacology (Berl) 134, 401405.

39PR Carlier , MM Lo , PC Lo , (1998) Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group. Bioorg Med Chem Lett 8, 487492.

41P Skolnick , P Popik , A Janowsky , (2003) “Broad spectrum” antidepressants: is more better for the treatment of depression? Life Sci 73, 31753179.

43JF Cryan , RJ Valentino & I Lucki (2005) Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev 29, 547569.

44I Sillaber , M Panhuysen , MS Henniger , (2008) Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine. Psychopharmacology (Berl) 200, 557572.

47M Bourin , JP Redrobe , M Hascoët , (1996) A schematic representation of the psychopharmacological profile of antidepressants. Prog Neuropsychopharmacol Biol Psychiatry 20, 13891402.

50LB Nicolas , Y Kolb & EP Prinssen (2006) A combined marble burying-locomotor activity test in mice: a practical screening test with sensitivity to different classes of anxiolytics and antidepressants. Eur J Pharmacol 547, 106115.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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