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Maternal carbohydrate intake and pregnancy outcome

  • James F. Clapp III (a1)
Abstract

Experimental evidence indicates that the primary maternal environmental factor that regulates feto–placental growth is substrate delivery to the placental site, which is the product of maternal substrate levels and the rate of placental-bed blood flow. Thus, maternal factors which change either substrate level or flow alter feto–placental growth rate. The best-studied substrate in human pregnancy is glucose, and there is a direct relationship between maternal blood glucose levels and size at birth. Altering the type of carbohydrate eaten (high- v. low-glycaemic sources) changes postprandial glucose and insulin responses in both pregnant and non-pregnant women, and a consistent change in the type of carbohydrate eaten during pregnancy influences both the rate of feto–placental growth and maternal weight gain. Eating primarily high-glycaemic carbohydrate results in feto–placental overgrowth and excessive maternal weight gain, while intake of low-glycaemic carbohydrate produces infants with birth weights between the 25th and the 50th percentile and normal maternal weight gain. The calculated difference in energy retention with similar total energy intakes is of the order of 80 000 kJ. Preliminary information from subsequent metabolic studies indicates that the mechanisms involved include changes in: daily digestible energy requirements (i.e. metabolic efficiency), substrate utilization (glucose oxidation v. lipid oxidation), and insulin resistance and sensitivity. Thus, altering the source of maternal dietary carbohydrate may prove to be a valuable tool in the management of pregnancies at risk for anomalous feto–placental growth and for the prevention and/or treatment of obesity and insulin resistance in the non-pregnant state.

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Corresponding author
Corresponding author: Dr J. F. Clapp III, fax +1 216 778 8847, email JFCLAPP@METROHEALTH.ORG
References
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JF Clapp & EL Capeless (1990) Neonatal morphometrics after endurance exercise during pregnancy. American Journal of Obstetrics and Gynecology 163, 18051811.

JF Clapp & EL Capeless (1991) The changing glycemic response to exercise during pregnancy. American Journal of Obstetrics and Gynecology 165, 16781683.

JF Clapp , H Kim , B Burciu & B Lopez (2000 a) Beginning regular exercise in early pregnancy: effect on feto-placental growth. American Journal of Obstetrics and Gynecology 183, 14841488.

JF Clapp & KH Rizk (1992) Effect of recreational exercise on mid-trimester placental growth. American Journal of Obstetrics and Gynecology 167, 15181521.

JF Clapp , W Stepanchak , M Kortan & S Fanselow (2000 b) Portal vein blood flow – effects of pregnancy, gravity, and exercise. American Journal of Obstetrics and Gynecology 183, 167172.

HM De Marco , KP Sucher , CJ Cisar & GE Butterfield (1999) Pre-exercise carbohydrate meals: application of the glycemic index. Medicine and Science in Sports and Exercise 31, 164170.

RB Fraser , FA Ford & GF Lawrence (1988) Insulin sensitivity in third trimester pregnancy. A randomized study of dietary effects. British Journal of Obstetrics and Gynaecology 95, 223229.

G Frost , B Keogh , D Smith , K Akinsanaya & A Leeds (1996) The effect of low-glycemic carbohydrate on insulin and glucose response in vivo and in vitro in patients with coronary heart disease. Metabolism 45, 669672.

G Frost , A Leeds , G Trew , R Margara & A Dornhorst (1998) Insulin sensitivity in women at risk of coronary heart disease and the effect of a low glycemic diet. Metabolism 47, 12451251.

MR Jackson , P Gott , SJ Lye , JWK Ritchie & JF Clapp (1995) The effects of maternal exercise on human placental development: placental volumetric composition and surface areas. Placenta 16, 179191.

AE Jarvi , BE Karlstrom , YE Granfeldt , IE Bjorck , NGL Asp & BOH Vesby (1999) Improved glycemic control and lipid profile and normalized fibrinolytic activity on a low-glycemic index diet in type 2 diabetic patients. Diabetes Care 22, 1018.

O Langer , A Anyaegbunam , L Brustman & M Divon (1989 a) Management of women with one abnormal oral glucose tolerance test value reduces adverse outcome in pregnancy. American Journal of Obstetrics and Gynecology 161, 593599.

O Langer , J Levy , L Brustman , A Anyaegbunam , R Merkatz & M Divon (1989 b) Glycemic control in diabetes mellitus – How tight is tight enough: small for gestational age versus large for gestational age. American Journal of Obstetrics and Gynecology 161, 646653.

M Matsuda & RA DeFronzo (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing. Diabetes Care 22, 14621470.

J Metcalfe , C Catz , JF Clapp , KJ Cureton , SE Fabro , LD Longo & D McNellis (1984) Summary report on the NICHD research planning workshop on physical activity in pregnancy. American Journal of Perinatology 1, 276279.

KL Morris & MB Zemel (1999) Glycemic index, cardiovascular disease, and obesity. Nutrition Reviews 57, 273276.

SB Roberts (2000) High-glycemic index foods, hunger and obesity: is there a connection. Nutrition Reviews 58, 163169.

E Saltzman , JC Moriguti , SK Das , A Corrales , P Fuss , AS Greenberg & SB Roberts (2001) Effects of a cereal rich in soluble fiber on body composition and dietary compliance during consumption of a hypocaloric diet. Journal of the American College of Nutrition 20, 5057.

CA Smith (1947) Effects of maternal undernutrition upon the newborn infant in Holland (1944–45). Journal of Pediatrics 30, 229243.

LE Spieth , JD Harnish , CM Lenders , LB Raezer , MA Periera , J Hangen & DS Ludwig (2000) A low-glycemic index diet in the treatment of pediatric obesity. Archives of Pediatric Adolescent Medicine 154, 947951.

S-L Wee , C Williams , S Gray & J Horabin (1999) Influence of high and low glycemic index meals on endurance running capacity. Medicine and Science in Sports and Exercise 31, 393399.

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Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
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