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Inflammation, obesity and comorbidities: the role of diet

  • Mónica Bulló (a1), Patricia Casas-Agustench (a1), Pilar Amigó-Correig (a1), Javier Aranceta (a2) and Jordi Salas-Salvadó (a1)
  • DOI:
  • Published online: 01 October 2007

The adipocyte metabolism has been shown to change during the fat enlargement process associated to obesity. Several procoagulant proteins such as plasminogen activator inhibitor type 1, tissue factor or factor VII and also inducible nitric oxide synthase show higher expression in adipose tissue of obese people in comparison to lean. This overexpression could explain at least a part of the atherogenic and cardiovascular risk associated with obesity.

In addition to cytokine secretion, many other features have been observed to be common to adipocyte and monocyte/macrophage lines: for example, phagocytic and microbicidal activities, and possibly a cellular plasticity of adipose precursors.

Overweight and obesity are associated with an increased risk of such metabolic abnormalities as dyslipidemia, hypertension or type 2 diabetes mellitus and cardiovascular diseases, common features of the metabolic syndrome. Initially, insulin resistance or hyperinsulinemia was suggested as the origin of these abnormalities. More recent studies indicate that adipokynes have an important role in obesity-associated metabolic complications, and suggest that chronically elevated local or systemic concentrations of adipokynes contribute to the development of complications associated with obesity and metabolic syndrome.

Considering all the evidence relating to diet and inflammation, the best diet for protecting against the metabolic derangements associated with obesity and metabolic syndrome would be high in fibre-rich cereals, fruit, vegetables, fish, virgin olive oil and nuts; moderate in wine; and low in meat, processed meat foods and trans-fatty acids.

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1JS Yudkin , CD Stehouwer , JJ Emeis , SW Coppack . C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arteriosclerosis Thrombosis and Vascular Biology 1999; 19 (4): 972978.

2M Bullo , P Garcia-Lorda , I Megias , J Salas-Salvado . Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Obesity Research 2003; 11 (4): 525531.

4F Samad , K Yamamoto , DJ Loskutoff . Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide. Journal of Clinical Investigation 1996; 97 (1): 3746.

5F Samad , M Pandey , DJ Loskutoff . Tissue factor gene expression in the adipose tissues of obese mice. Proceedings of the National Academic of Science USA 1998; 95 (13): 75917596.

6G De Pergola , N Pannacciulli . Coagulation and fibrinolysis abnormalities in obesity. Journal of Endocrinology Investigation 2002; 25 (10): 899904.

7M Perreault , A Marette . Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nature Medicine 2001; 7 (10): 11381143.

8SK Fried , DA Bunkin , AS Greenberg . Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. Journal of Clinical Endocrinology and Metabolism 1998; 83 (3): 847850.

9M Bullo , P Garcia-Lorda , J Peinado-Onsurbe , M Hernandez , D Del Castillo , JM Argiles , . TNFalpha expression of subcutaneous adipose tissue in obese and morbid obese females: relationship to adipocyte LPL activity and leptin synthesis. International Journal of Obesity and Related Metabolic Disorders 2002; 26 (5): 652658.

10SP Weisberg , D McCann , M Desai , M Rosenbaum , RL Leibel , AW Ferrante Jr. Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation 2003; 112 (12): 17961808.

11S Cinti , G Mitchell , G Barbatelli , I Murano , E Ceresi , E Faloia , . Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. Journal of Lipid Research 2005; 46 (11): 23472355.

12R Cancello , C Henegar , N Viguerie , S Taleb , C Poitou , C Rouault , . Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 2005; 54 (8): 22772286.

15G Charriere , B Cousin , E Arnaud , M Andre , F Bacou , L Penicaud , . Preadipocyte conversion to macrophage. Evidence of plasticity. Journal of Biological Chemistry 2003; 278 (11): 98509855.

16B Zhang , J Berger , E Hu , D Szalkowski , S White-Carrington , BM Spiegelman , . Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha. Molecular Endocrinology 1996; 10 (11): 14571466.

17H Xu , GT Barnes , Q Yang , G Tan , D Yang , CJ Chou , . Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Journal of Clinical Investigation 2003; 112 (12): 18211830.

18CA Curat , A Miranville , C Sengenes , M Diehl , C Tonus , R Busse , . From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes 2004; 53 (5): 12851292.

19D Lacasa , S Taleb , M Keophiphath , A Miranville , K Clement . Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology 2006; 148 (2): 868877. November 2 [Epub ahead of print].

20GM Reaven . Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37 (12): 15951607.

21PM Ridker , N Rifai , M Pfeffer , F Sacks , S Lepage , E Braunwald . Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation 2000; 101 (18): 21492153.

22SC Souza , HJ Palmer , YH Kang , MT Yamamoto , KV Muliro , KE Paulson , . TNF-alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes. Journal of Cellular Biochemistry 2003; 89 (6): 10771086.

23M Bullo-Bonet , P Garcia-Lorda , FJ Lopez-Soriano , JM Argiles , J Salas-Salvado . Tumour necrosis factor, a key role in obesity? FEBS Letter 1999; 451 (3): 215219.

25G van Hall , A Steensberg , M Sacchetti , C Fischer , C Keller , P Schjerling , . Interleukin-6 stimulates lipolysis and fat oxidation in humans. Journal of Clinical Endocrinology and Metabolism 2003; 88 (7): 30053010.

26AD Pradhan , JE Manson , N Rifai , JE Buring , PM Ridker . C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. Journal of the American Medical Association 2001; 286 (3): 327334.

29JL Torres , PM Ridker . Clinical use of high sensitivity C-reactive protein for the prediction of adverse cardiovascular events. Current Opinion in Cardiology 2003; 18 (6): 471478.

30JB Dixon , PE O’Brien . Obesity and the white blood cell count: changes with sustained weight loss. Obesity Surgery 2006; 16 (3): 251257.

31Y Arita , S Kihara , N Ouchi , M Takahashi , K Maeda , J Miyagawa , . Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysics Research Communication 1999; 257 (1): 7983.

32M Bulló , J Salas-Salvado , P Garcia-Lorda . Adiponectin expression and adipose tissue lipolytic activity in lean and obese women. Obesity Surgery 2005; 15 (3): 382386.

33K Hotta , T Funahashi , Y Arita , M Takahashi , M Matsuda , Y Okamoto , . Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arteriosclerosis, Thrombosis and Vascular Biology 2000; 20 (6): 15951599.

34N Ouchi , S Kihara , T Funahashi , Y Matsuzawa , K Walsh . Obesity, adiponectin and vascular inflammatory disease. Current Opinión in Lipidology 2003; 14 (6): 561566.

35E Tomas , TS Tsao , AK Saha , HE Murrey , Cc C Zhang , SI Itani , . Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proceedings of the National Academic of Science USA 2002; 99 (25): 1630916313.

36B Larsson , K Svardsudd , L Welin , L Wilhelmsen , P Bjorntorp , G Tibblin . Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. British Medical Journal (Clinical Research Ed) 1984; 288 (6428): 14011404.

37N Maeda , M Takahashi , T Funahashi , S Kihara , H Nishizawa , K Kishida , . PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001; 50 (9): 20942099.

38Y Matsuzawa . The metabolic syndrome and adipocytokines. FEBS Letter 2006; 580 (12): 29172921.

39A Fukuhara , M Matsuda , M Nishizawa , K Segawa , M Tanaka , K Kishimoto , . Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005; 307 (5708): 426430.

40A Hammarstedt , J Pihlajamaki , V Rotter Sopasakis , S Gogg , PA Jansson , M Laakso , . Visfatin is an adipokine, but it is not regulated by thiazolidinediones. Journal of Clinical Endocrinology and Metabolism 2006; 91 (3): 11811184.

41MP Chen , FM Chung , DM Chang , JC Tsai , HF Huang , SJ Shin , . Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 2006; 91 (1): 295299.

42E Fleischmann , A Kurz , M Niedermayr , K Schebesta , O Kimberger , DI Sessler , . Tissue oxygenation in obese and non-obese patients during laparoscopy. Obesity Surgery 2005; 15 (6): 813819.

43B Kabon , A Nagele , D Reddy , C Eagon , JW Fleshman , DI Sessler , . Obesity decreases perioperative tissue oxygenation. Anesthesiology 2004; 100 (2): 274280.

44K Lolmede , V Durand de Saint Front , J Galitzky , M Lafontan , A Bouloumie . Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes. International Journal of Obesity and Related Metabolic Disorders 2003; 27 (10): 11871195.

45K Segawa , A Fukuhara , N Hosogai , K Morita , Y Okuno , M Tanaka , . Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism. Biochemistry and Biophysics Research Communication 2006; 349 (3): 875882.

46K Esposito , A Pontillo , C Di Palo , G Giugliano , M Masella , R Marfella , . Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. Journal of the American Medical Association 2003; 289 (14): 17991804.

47M Troseid , KT Lappegard , T Claudi , JK Damas , L Morkrid , R Brendberg , . Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome. European Heart Journal 2004; 25 (4): 349355.

48DG Haider , K Schindler , G Schaller , G Prager , M Wolzt , B Ludvik . Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding. Journal of Clinical Endocrinology and Metabolism 2006; 91 (4): 15781581.

49JP Bastard , B Hainque , E Dusserre , E Bruckert , D Robin , P Vallier , . Peroxisome proliferator activated receptor-gamma, leptin and tumor necrosis factor-alpha mRNA expression during very low calorie diet in subcutaneous adipose tissue in obese women. Diabetes and Metabolism Research Review 1999; 15 (2): 9298.

50N Viguerie , H Vidal , P Arner , C Holst , C Verdich , S Avizou , . Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets. Diabetologia 2005; 48 (1): 123131.

52C Murdoch , A Giannoudis , CE Lewis . Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 2004; 104 (8): 22242234.

53P Trayhurn , IS Wood . Adipokines: inflammation and the pleiotropic role of white adipose tissue. British Journal of Nutrition 2004; 92 (3): 347355.

54PM Ridker . High-sensitivity C-reactive protein, inflammation, and cardiovascular risk: from concept to clinical practice to clinical benefit. American Heart Journal 2004; 148 (Suppl. 1): S19S26.

55J Danesh , P Whincup , M Walker , L Lennon , A Thomson , P Appleby , . Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. British Medical Journal 2000; 321 (7255): 199204.

56J Danesh , JG Wheeler , GM Hirschfield , S Eda , G Eiriksdottir , A Rumley , . C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. New England Journal of Medicine 2004; 350 (14): 13871397.

57G Zhao , TD Etherton , KR Martin , JP Vanden Heuvel , PJ Gillies , SG West , . Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. Biochemical Biophysics Research Communication 2005; 336 (3): 909917.

58EA Miles , P Zoubouli , PC Calder . Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood cultures. Nutrition 2005; 21 (3): 389394.

59SK Manna , A Mukhopadhyay , BB Aggarwal . Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. Journal of Immunology 2000; 164 (12): 65096519.

60D Giugliano , R Marfella , L Coppola , G Verrazzo , R Acampora , R Giunta , . Vascular effects of acute hyperglycemia in humans are reversed by L-arginine. Evidence for reduced availability of nitric oxide during hyperglycemia. Circulation 1997; 95 (7): 17831790.

61D Giugliano , A Ceriello , K Esposito . The effects of diet on inflammation: emphasis on the metabolic syndrome. Journal of American College of Cardiology 2006; 48 (4): 677685.

62L Qi , JB Meigs , S Liu , JE Manson , C Mantzoros , FB Hu . Dietary fibers and glycemic load, obesity, and plasma adiponectin levels in women with type 2 diabetes. Diabetes Care 2006; 29 (7): 15011505.

65S Liu , JE Buring , HD Sesso , EB Rimm , WC Willett , JE Manson . A prospective study of dietary fiber intake and risk of cardiovascular disease among women. Journal of American Collage of Cardiology 2002; 39 (1): 4956.

66DS Ludwig , MA Pereira , CH Kroenke , JE Hilner , L Van Horn , ML Slattery , . Dietary fiber, weight gain, and cardiovascular disease risk factors in young adults. Journal of the American Medical Association 1999; 282 (16): 15391546.

67MA Pereira , E O’Reilly , K Augustsson , GE Fraser , U Goldbourt , BL Heitmann , . Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies. Archives of Internal Medicine 2004; 164 (4): 370376.

68T Pischon , SE Hankinson , GS Hotamisligil , N Rifai , WC Willett , EB Rimm . Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation 2003; 108 (2): 155160.

70A Zampelas , DB Panagiotakos , C Pitsavos , UN Das , C Chrysohoou , Y Skoumas , . Fish consumption among healthy adults is associated with decreased levels of inflammatory markers related to cardiovascular disease: the ATTICA study. Journal of American College of Cardiology 2005; 46 (1): 120124.

71T Madsen , HA Skou , VE Hansen , L Fog , JH Christensen , E Toft , . C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease. American Journal of Cardiology 2001; 88 (10): 11391142.

72I Ciubotaru , YS Lee , RC Wander . Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT. Journal of Nutrition Biochem 2003; 14 (9): 513521.

73LS Rallidis , G Paschos , GK Liakos , AH Velissaridou , G Anastasiadis , A Zampelas . Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. Atherosclerosis 2003; 167 (2): 237242.

74WJ Bemelmans , JD Lefrandt , EJ Feskens , PL van Haelst , J Broer , B Meyboom-de Jong , . Increased alpha-linolenic acid intake lowers C-reactive protein, but has no effect on markers of atherosclerosis. European Journal of Clinical Nutrition 2004; 58 (7): 10831089.

78AH Lichtenstein , AT Erkkila , B Lamarche , US Schwab , SM Jalbert , LM Ausman . Influence of hydrogenated fat and butter on CVD risk factors: remnant-like particles, glucose and insulin, blood pressure and C-reactive protein. Atherosclerosis 2003; 171 (1): 97107.

80M Fito , M Cladellas , R de la Torre , J Marti , M Alcantara , M Pujadas-Bastardes , . Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial. Atherosclerosis 2005; 181 (1): 149158.

82MA Carluccio , L Siculella , MA Ancora , M Massaro , E Scoditti , C Storelli , . Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of mediterranean diet phytochemicals. Arteriosclerosis, Thrombosis and Vascular Biology 2003; 23 (4): 622629.

84J Salas-Salvado , M Bullo , A Perez-Heras , E Ros . Dietary fibre, nuts and cardiovascular diseases. British Journal of Nutrition 2006; 96 (Suppl. 2): S45S51.

86JP Cooke , P Tsao , A Singer , BY Wang , J Kosek , H Drexler . Anti-atherogenic effect of nuts: is the answer NO? Archives of Internal Medicine 1993; 153 (7): 896902.

87DF Fitzpatrick , SL Hirschfield , T Ricci , P Jantzen , RG Coffey . Endothelium-dependent vasorelaxation caused by various plant extracts. Journal of Cardiovascular Pharmacology 1995; 26 (1): 9095.

89L Zwarts , GP Savage , DL McNeil . Fatty acid content of new zealand-grown walnuts (juglans regia L.). International Journal of Food Science Nutrition 1999; 50 (3): 189194.

90R Jiang , DR Jacobs Jr, E Mayer-Davis , M Szklo , D Herrington , NS Jenny , . Nut and seed consumption and inflammatory markers in the multi-ethnic study of atherosclerosis. American Journal of Epidemiology 2006; 163 (3): 222231.

91E Ros , I Nunez , A Perez-Heras , M Serra , R Gilabert , E Casals , . A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation 2004; 109 (13): 16091614.

92SD Nash , M Westpfal . Cardiovascular benefits of nuts. American Journal of Cardiology 2005; 95 (8): 963965.

93FJ He , CA Nowson , GA MacGregor . Fruit and vegetable consumption and stroke: meta-analysis of cohort studies. Lancet 2006; 367 (9507): 320326.

94WM van Herpen-Broekmans , IA Klopping-Ketelaars , ML Bots , C Kluft , H Princen , HF Hendriks , . Serum carotenoids and vitamins in relation to markers of endothelial function and inflammation. European Journal of Epidemiology 2004; 19 (10): 915921.

96S Devaraj , I Jialal . Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients. Free Radical Biology and Medicine 2000; 29 (8): 790792.

98R Estruch , E Sacanella , E Badia , E Antunez , JM Nicolas , J Fernandez-Sola , . Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markers. Atherosclerosis 2004; 175 (1): 117123.

99MA Albert , RJ Glynn , PM Ridker . Alcohol consumption and plasma concentration of C-reactive protein. Circulation 2003; 107 (3): 443447.

101I Rahman , SK Biswas , PA Kirkham . Regulation of inflammation and redox signaling by dietary polyphenols. Biochemical Pharmacology 2006; 72 (11): 14391452.

103SB Lotito , B Frei . Dietary flavonoids attenuate TNFalpha-induced adhesion molecule expression in human aortic endothelial cells: structure–function relationships and activity after first-pass metabolism. Journal of Biological Chemistry 2006 September 20 [Epub ahead of print].

104EB Rimm , MJ Stampfer . Wine, beer, and spirits: are they really horses of a different color? Circulation 2002; 105 (24): 28062807.

105R Estruch , A Coca , JL Rodicio . High blood pressure, alcohol and cardiovascular risk. Journal of Hypertension 2005; 23 (1): 226229.

106A Trichopoulou , T Costacou , C Bamia , D Trichopoulos . Adherence to a Mediterranean diet and survival in a Greek population. New England Journal of Medicine 2003; 348 (26): 25992608.

107K Esposito , R Marfella , M Ciotola , C Di Palo , F Giugliano , G Giugliano , . Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. Journal of the American Medical Association 2004; 292 (12): 14401446.

108R Estruch , MA Martinez-Gonzalez , D Corella , J Salas-Salvado , V Ruiz-Gutierrez , MI Covas , . Effects of a mediterranean-style diet on cardiovascular risk factors: a randomized trial. Annals of Internal Medicine 2006; 145 (1): 111.

109A Michalsen , N Lehmann , C Pithan , NT Knoblauch , S Moebus , F Kannenberg , . Mediterranean diet has no effect on markers of inflammation and metabolic risk factors in patients with coronary artery disease. European Journal of Clinical Nutrition 2006; 60 (4): 478485.

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