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1 JS Yudkin , CD Stehouwer , JJ Emeis , SW Coppack . C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arteriosclerosis Thrombosis and Vascular Biology 1999; 19 (4): 972–978.
2 M Bullo , P Garcia-Lorda , I Megias , J Salas-Salvado . Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Obesity Research 2003; 11 (4): 525–531.
4 F Samad , K Yamamoto , DJ Loskutoff . Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide. Journal of Clinical Investigation 1996; 97 (1): 37–46.
5 F Samad , M Pandey , DJ Loskutoff . Tissue factor gene expression in the adipose tissues of obese mice. Proceedings of the National Academic of Science USA 1998; 95 (13): 7591–7596.
6 G De Pergola , N Pannacciulli . Coagulation and fibrinolysis abnormalities in obesity. Journal of Endocrinology Investigation 2002; 25 (10): 899–904.
7 M Perreault , A Marette . Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nature Medicine 2001; 7 (10): 1138–1143.
8 SK Fried , DA Bunkin , AS Greenberg . Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. Journal of Clinical Endocrinology and Metabolism 1998; 83 (3): 847–850.
9 M Bullo , P Garcia-Lorda , J Peinado-Onsurbe , M Hernandez , D Del Castillo , JM Argiles , . TNFalpha expression of subcutaneous adipose tissue in obese and morbid obese females: relationship to adipocyte LPL activity and leptin synthesis. International Journal of Obesity and Related Metabolic Disorders 2002; 26 (5): 652–658.
10 SP Weisberg , D McCann , M Desai , M Rosenbaum , RL Leibel , Jr AW Ferrante . Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation 2003; 112 (12): 1796–1808.
11 S Cinti , G Mitchell , G Barbatelli , I Murano , E Ceresi , E Faloia , . Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. Journal of Lipid Research 2005; 46 (11): 2347–2355.
12 R Cancello , C Henegar , N Viguerie , S Taleb , C Poitou , C Rouault , . Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 2005; 54 (8): 2277–2286.
15 G Charriere , B Cousin , E Arnaud , M Andre , F Bacou , L Penicaud , . Preadipocyte conversion to macrophage. Evidence of plasticity. Journal of Biological Chemistry 2003; 278 (11): 9850–9855.
16 B Zhang , J Berger , E Hu , D Szalkowski , S White-Carrington , BM Spiegelman , . Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha. Molecular Endocrinology 1996; 10 (11): 1457–1466.
17 H Xu , GT Barnes , Q Yang , G Tan , D Yang , CJ Chou , . Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Journal of Clinical Investigation 2003; 112 (12): 1821–1830.
18 CA Curat , A Miranville , C Sengenes , M Diehl , C Tonus , R Busse , . From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes 2004; 53 (5): 1285–1292.
19 D Lacasa , S Taleb , M Keophiphath , A Miranville , K Clement . Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology 2006; 148 (2): 868–877. November 2 [Epub ahead of print].
20 GM Reaven . Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37 (12): 1595–1607.
21 PM Ridker , N Rifai , M Pfeffer , F Sacks , S Lepage , E Braunwald . Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation 2000; 101 (18): 2149–2153.
22 SC Souza , HJ Palmer , YH Kang , MT Yamamoto , KV Muliro , KE Paulson , . TNF-alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes. Journal of Cellular Biochemistry 2003; 89 (6): 1077–1086.
23 M Bullo-Bonet , P Garcia-Lorda , FJ Lopez-Soriano , JM Argiles , J Salas-Salvado . Tumour necrosis factor, a key role in obesity? FEBS Letter 1999; 451 (3): 215–219.
25 G van Hall , A Steensberg , M Sacchetti , C Fischer , C Keller , P Schjerling , . Interleukin-6 stimulates lipolysis and fat oxidation in humans. Journal of Clinical Endocrinology and Metabolism 2003; 88 (7): 3005–3010.
26 AD Pradhan , JE Manson , N Rifai , JE Buring , PM Ridker . C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. Journal of the American Medical Association 2001; 286 (3): 327–334.
29 JL Torres , PM Ridker . Clinical use of high sensitivity C-reactive protein for the prediction of adverse cardiovascular events. Current Opinion in Cardiology 2003; 18 (6): 471–478.
30 JB Dixon , PE O’Brien . Obesity and the white blood cell count: changes with sustained weight loss. Obesity Surgery 2006; 16 (3):
31 Y Arita , S Kihara , N Ouchi , M Takahashi , K Maeda , J Miyagawa , . Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysics Research Communication 1999; 257 (1): 79–83.
32 M Bulló , J Salas-Salvado , P Garcia-Lorda . Adiponectin expression and adipose tissue lipolytic activity in lean and obese women. Obesity Surgery 2005; 15 (3): 382–386.
33 K Hotta , T Funahashi , Y Arita , M Takahashi , M Matsuda , Y Okamoto , . Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arteriosclerosis, Thrombosis and Vascular Biology 2000; 20 (6): 1595–1599.
34 N Ouchi , S Kihara , T Funahashi , Y Matsuzawa , K Walsh . Obesity, adiponectin and vascular inflammatory disease. Current Opinión in Lipidology 2003; 14 (6): 561–566.
35 E Tomas , TS Tsao , AK Saha , HE Murrey , Cc C Zhang , SI Itani , . Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proceedings of the National Academic of Science USA 2002; 99 (25): 16309–16313.
36 B Larsson , K Svardsudd , L Welin , L Wilhelmsen , P Bjorntorp , G Tibblin . Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. British Medical Journal (Clinical Research Ed) 1984; 288 (6428): 1401–1404.
37 N Maeda , M Takahashi , T Funahashi , S Kihara , H Nishizawa , K Kishida , . PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001; 50 (9): 2094–2099.
38 Y Matsuzawa . The metabolic syndrome and adipocytokines. FEBS Letter 2006; 580 (12): 2917–2921.
39 A Fukuhara , M Matsuda , M Nishizawa , K Segawa , M Tanaka , K Kishimoto , . Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005; 307 (5708): 426–430.
40 A Hammarstedt , J Pihlajamaki , V Rotter Sopasakis , S Gogg , PA Jansson , M Laakso , . Visfatin is an adipokine, but it is not regulated by thiazolidinediones. Journal of Clinical Endocrinology and Metabolism 2006; 91 (3): 1181–1184.
41 MP Chen , FM Chung , DM Chang , JC Tsai , HF Huang , SJ Shin , . Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 2006; 91 (1): 295–299.
42 E Fleischmann , A Kurz , M Niedermayr , K Schebesta , O Kimberger , DI Sessler , . Tissue oxygenation in obese and non-obese patients during laparoscopy. Obesity Surgery 2005; 15 (6): 813–819.
43 B Kabon , A Nagele , D Reddy , C Eagon , JW Fleshman , DI Sessler , . Obesity decreases perioperative tissue oxygenation. Anesthesiology 2004; 100 (2): 274–280.
44 K Lolmede , V Durand de Saint Front , J Galitzky , M Lafontan , A Bouloumie . Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes. International Journal of Obesity and Related Metabolic Disorders 2003; 27 (10): 1187–1195.
45 K Segawa , A Fukuhara , N Hosogai , K Morita , Y Okuno , M Tanaka , . Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism. Biochemistry and Biophysics Research Communication 2006; 349 (3): 875–882.
46 K Esposito , A Pontillo , C Di Palo , G Giugliano , M Masella , R Marfella , . Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. Journal of the American Medical Association 2003; 289 (14): 1799–1804.
47 M Troseid , KT Lappegard , T Claudi , JK Damas , L Morkrid , R Brendberg , . Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome. European Heart Journal 2004; 25 (4): 349–355.
48 DG Haider , K Schindler , G Schaller , G Prager , M Wolzt , B Ludvik . Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding. Journal of Clinical Endocrinology and Metabolism 2006; 91 (4): 1578–1581.
49 JP Bastard , B Hainque , E Dusserre , E Bruckert , D Robin , P Vallier , . Peroxisome proliferator activated receptor-gamma, leptin and tumor necrosis factor-alpha mRNA expression during very low calorie diet in subcutaneous adipose tissue in obese women. Diabetes and Metabolism Research Review 1999; 15 (2): 92–98.
50 N Viguerie , H Vidal , P Arner , C Holst , C Verdich , S Avizou , . Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets. Diabetologia 2005; 48 (1): 123–131.
52 C Murdoch , A Giannoudis , CE Lewis . Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 2004; 104 (8): 2224–2234.
53 P Trayhurn , IS Wood . Adipokines: inflammation and the pleiotropic role of white adipose tissue. British Journal of Nutrition 2004; 92 (3): 347–355.
54 PM Ridker . High-sensitivity C-reactive protein, inflammation, and cardiovascular risk: from concept to clinical practice to clinical benefit. American Heart Journal 2004; 148 (Suppl. 1): S19–S26.
55 J Danesh , P Whincup , M Walker , L Lennon , A Thomson , P Appleby , . Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. British Medical Journal 2000; 321 (7255): 199–204.
56 J Danesh , JG Wheeler , GM Hirschfield , S Eda , G Eiriksdottir , A Rumley , . C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. New England Journal of Medicine 2004; 350 (14): 1387–1397.
57 G Zhao , TD Etherton , KR Martin , JP Vanden Heuvel , PJ Gillies , SG West , . Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. Biochemical Biophysics Research Communication 2005; 336 (3): 909–917.
58 EA Miles , P Zoubouli , PC Calder . Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood cultures. Nutrition 2005; 21 (3): 389–394.
59 SK Manna , A Mukhopadhyay , BB Aggarwal . Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. Journal of Immunology 2000; 164 (12): 6509–6519.
60 D Giugliano , R Marfella , L Coppola , G Verrazzo , R Acampora , R Giunta , . Vascular effects of acute hyperglycemia in humans are reversed by L-arginine. Evidence for reduced availability of nitric oxide during hyperglycemia. Circulation 1997; 95 (7): 1783–1790.
61 D Giugliano , A Ceriello , K Esposito . The effects of diet on inflammation: emphasis on the metabolic syndrome. Journal of American College of Cardiology 2006; 48 (4): 677–685.
62 L Qi , JB Meigs , S Liu , JE Manson , C Mantzoros , FB Hu . Dietary fibers and glycemic load, obesity, and plasma adiponectin levels in women with type 2 diabetes. Diabetes Care 2006; 29 (7): 1501–1505.
65 S Liu , JE Buring , HD Sesso , EB Rimm , WC Willett , JE Manson . A prospective study of dietary fiber intake and risk of cardiovascular disease among women. Journal of American Collage of Cardiology 2002; 39 (1): 49–56.
66 DS Ludwig ,
MA Pereira , CH Kroenke , JE Hilner , L Van Horn , ML Slattery , . Dietary fiber, weight gain, and cardiovascular disease risk factors in young adults. Journal of the American Medical Association 1999; 282 (16): 1539–1546.
67 MA Pereira , E O’Reilly , K Augustsson , GE Fraser , U Goldbourt , BL Heitmann , . Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies. Archives of Internal Medicine 2004; 164 (4): 370–376.
68 T Pischon , SE Hankinson , GS Hotamisligil , N Rifai , WC Willett , EB Rimm . Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation 2003; 108 (2): 155–160.
70 A Zampelas , DB Panagiotakos , C Pitsavos , UN Das , C Chrysohoou , Y Skoumas , . Fish consumption among healthy adults is associated with decreased levels of inflammatory markers related to cardiovascular disease: the ATTICA study. Journal of American College of Cardiology 2005; 46 (1): 120–124.
71 T Madsen , HA Skou , VE Hansen , L Fog , JH Christensen , E Toft , . C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease. American Journal of Cardiology 2001; 88 (10): 1139–1142.
72 I Ciubotaru , YS Lee , RC Wander . Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT. Journal of Nutrition Biochem 2003; 14 (9): 513–521.
73 LS Rallidis , G Paschos , GK Liakos , AH Velissaridou , G Anastasiadis , A Zampelas . Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. Atherosclerosis 2003; 167 (2): 237–242.
74 WJ Bemelmans , JD Lefrandt , EJ Feskens , PL van Haelst , J Broer , B Meyboom-de Jong , . Increased alpha-linolenic acid intake lowers C-reactive protein, but has no effect on markers of atherosclerosis. European Journal of Clinical Nutrition 2004; 58 (7): 1083–1089.
78 AH Lichtenstein , AT Erkkila , B Lamarche , US Schwab , SM Jalbert , LM Ausman . Influence of hydrogenated fat and butter on CVD risk factors: remnant-like particles, glucose and insulin, blood pressure and C-reactive protein. Atherosclerosis 2003; 171 (1): 97–107.
80 M Fito , M Cladellas , R de la Torre , J Marti , M Alcantara , M Pujadas-Bastardes , . Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial. Atherosclerosis 2005; 181 (1): 149–158.
82 MA Carluccio , L Siculella , MA Ancora , M Massaro , E Scoditti , C Storelli , . Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of mediterranean diet phytochemicals. Arteriosclerosis, Thrombosis and Vascular Biology 2003; 23 (4): 622–629.
84 J Salas-Salvado , M Bullo , A Perez-Heras , E Ros . Dietary fibre, nuts and cardiovascular diseases. British Journal of Nutrition 2006; 96 (Suppl. 2): S45–S51.
86 JP Cooke , P Tsao , A Singer , BY Wang , J Kosek , H Drexler . Anti-atherogenic effect of nuts: is the answer NO? Archives of Internal Medicine 1993; 153 (7): 896–902.
87 DF Fitzpatrick , SL Hirschfield , T Ricci , P Jantzen , RG Coffey . Endothelium-dependent vasorelaxation caused by various plant extracts. Journal of Cardiovascular Pharmacology 1995; 26 (1): 90–95.
89 L Zwarts , GP Savage , DL McNeil . Fatty acid content of new zealand-grown walnuts (juglans regia L.). International Journal of Food Science Nutrition 1999; 50 (3): 189–194.
90 R Jiang , Jr DR Jacobs , E Mayer-Davis , M Szklo , D Herrington , NS Jenny , . Nut and seed consumption and inflammatory markers in the multi-ethnic study of atherosclerosis. American Journal of Epidemiology 2006; 163 (3): 222–231.
91 E Ros , I Nunez , A Perez-Heras , M Serra , R Gilabert , E Casals , . A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation 2004; 109 (13): 1609–1614.
92 SD Nash , M Westpfal . Cardiovascular benefits of nuts. American Journal of Cardiology 2005; 95 (8): 963–965.
93 FJ He , CA Nowson , GA MacGregor . Fruit and vegetable consumption and stroke: meta-analysis of cohort studies. Lancet 2006; 367 (9507): 320–326.
94 WM van Herpen-Broekmans , IA Klopping-Ketelaars , ML Bots , C Kluft , H Princen , HF Hendriks , . Serum carotenoids and vitamins in relation to markers of endothelial function and inflammation. European Journal of Epidemiology 2004; 19 (10): 915–921.
96 S Devaraj , I Jialal . Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients. Free Radical Biology and Medicine 2000; 29 (8): 790–792.
98 R Estruch , E Sacanella , E Badia , E Antunez , JM Nicolas , J Fernandez-Sola , . Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markers. Atherosclerosis 2004; 175 (1): 117–123.
99 MA Albert , RJ Glynn , PM Ridker . Alcohol consumption and plasma concentration of C-reactive protein. Circulation 2003; 107 (3): 443–447.
101 I Rahman , SK Biswas , PA Kirkham . Regulation of inflammation and redox signaling by dietary polyphenols. Biochemical Pharmacology 2006; 72 (11): 1439–1452.
103 SB Lotito , B Frei . Dietary flavonoids attenuate TNFalpha-induced adhesion molecule expression in human aortic endothelial cells: structure–function relationships and activity after first-pass metabolism. Journal of Biological Chemistry 2006 September 20 [Epub ahead of print].
104 EB Rimm , MJ Stampfer . Wine, beer, and spirits: are they really horses of a different color? Circulation 2002; 105 (24): 2806–2807.
105 R Estruch , A Coca , JL Rodicio . High blood pressure, alcohol and cardiovascular risk. Journal of Hypertension 2005; 23 (1): 226–229.
106 A Trichopoulou , T Costacou , C Bamia , D Trichopoulos . Adherence to a Mediterranean diet and survival in a Greek population. New England Journal of Medicine 2003; 348 (26): 2599–2608.
107 K Esposito , R Marfella , M Ciotola , C Di Palo , F Giugliano , G Giugliano , . Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. Journal of the American Medical Association 2004; 292 (12): 1440–1446.
108 R Estruch , MA Martinez-Gonzalez , D Corella , J Salas-Salvado , V Ruiz-Gutierrez , MI Covas , . Effects of a mediterranean-style diet on cardiovascular risk factors: a randomized trial. Annals of Internal Medicine 2006; 145 (1): 1–11.
109 A Michalsen , N Lehmann , C Pithan , NT Knoblauch , S Moebus , F Kannenberg , . Mediterranean diet has no effect on markers of inflammation and metabolic risk factors in patients with coronary artery disease. European Journal of Clinical Nutrition 2006; 60 (4): 478–485.