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Prolonged breast-feeding protects mothers from later-life obesity and related cardio-metabolic disorders

  • Petri Wiklund (a1), Leiting Xu (a1), Arja Lyytikäinen (a1) (a2), Juha Saltevo (a2), Qin Wang (a1) (a3), Eszter Völgyi (a1), Eveliina Munukka (a1), Shumei Cheng (a1), Markku Alen (a4), Sirkka Keinänen-Kiukaanniemi (a5) and Sulin Cheng (a1) (a6)...

Abstract

Objective

To investigate the long-term effects of duration of postpartum lactation on maternal body composition and risk for cardio-metabolic disorders in later life.

Design

Retrospective study. Body composition was measured using dual-energy X-ray absorptiometry and serum glucose, insulin and lipids were analysed using enzymatic photometric methods 16–20 years after the last pregnancy. Medical history and lifestyle factors were collected via a self-administered questionnaire. Detailed information regarding weight change patterns during each pregnancy was obtained from personal maternity tracking records.

Setting

City of Jyväskylä and surroundings in Central Finland.

Subjects

Two hundred and twelve women (mean age 48, range 36–60 years).

Results

At 16–20 years after their last pregnancy, women who had breast-fed for less than 6 months had higher total body fat mass and fat mass percentage, particularly in the android region (46·5 (sd 8·2) %) than mothers who had breast-fed for longer than 6 months (39·0 (sd 10·2) %) or for longer than 10 months (38·4 (sd 10·9) %, P < 0·01). These differences were independent of pre-pregnancy weight and BMI, menopausal status, smoking status, level of education, participation in past and present leisure-time physical activity, and current dietary energy intake. Higher body fat mass was also associated with higher fasting serum glucose concentration and insulin resistance, TAG, LDL cholesterol and total cholesterol concentrations, as well as higher systolic and diastolic blood pressure (P < 0·05 for all).

Conclusions

Short duration of breast-feeding may induce weight retention and fat mass accumulation, resulting in increased risk of cardio-metabolic disorders in later life.

Copyright

Corresponding author

*Corresponding author: Email shulin.cheng@jyu.fi

References

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1.Butte, NF & Hopkinson, JM (1998) Body composition changes during lactation are highly variable among women. J Nutr 128, 2 Suppl., 381S385S.
2.Zafon, C (2007) Oscillations in total body fat content through life: an evolutionary perspective. Obes Rev 8, 525530.
3.Magee, LA, Abalos, E, von Dadelszen, P et al. (2009) Control of hypertension in pregnancy. Curr Hypertens Rep 11, 429436.
4.Lain, KY & Catalano, PM (2007) Metabolic changes in pregnancy. Clin Obstet Gynecol 50, 938948.
5.Butte, NF, Garza, C, Stuff, JE et al. (1984) Effect of maternal diet and body composition on lactational performance. Am J Clin Nutr 39, 296306.
6.Despres, JP & Lemieux, I (2006) Abdominal obesity and metabolic syndrome. Nature 444, 881887.
7.World Health Organization/UNICEF (1990) The Innocenti Declaration on the Protection, Promotion and Support of Breastfeeding. Geneva: WHO/UNICEF.
8.Erkkola, M, Salmenhaara, M, Kronberg-Kippila, C et al. (2010) Determinants of breast-feeding in a Finnish birth cohort. Public Health Nutr 13, 504513.
9.Gartner, LM, Morton, J, Lawrence, RA et al. (2005) Breastfeeding and the use of human milk. Pediatrics 115, 496506.
10.Yngve, A & Sjostrom, M (2001) Breastfeeding in countries of the European Union and EFTA: current and proposed recommendations, rationale, prevalence, duration and trends. Public Health Nutr 4, 631645.
11.Jen, KL, Juuhl, N & Lin, PK (1988) Repeated pregnancy without lactation: effects on carcass composition and adipose tissue cellularity in rats. J Nutr 118, 9398.
12.Zhong, S, Almario, R, Dubrinsky, M et al. (1990) Repeated pregnancy without lactation: effects on maternal glycemic control, pregnancy outcome, carcass composition, and fat distribution in rats. Metabolism 39, 11271132.
13.Hatsu, IE, McDougald, DM & Anderson, AK (2008) Effect of infant feeding on maternal body composition. Int Breastfeed J 3, 18.
14.Baker, JL, Gamborg, M, Heitmann, BL et al. (2008) Breastfeeding reduces postpartum weight retention. Am J Clin Nutr 88, 15431551.
15.Dewey, KG, Heinig, MJ & Nommsen, LA (1993) Maternal weight-loss patterns during prolonged lactation. Am J Clin Nutr 58, 162166.
16.Dugdale, AE & Eaton-Evans, J (1989) The effect of lactation and other factors on post-partum changes in body-weight and triceps skinfold thickness. Br J Nutr 61, 149153.
17.Boardley, DJ, Sargent, RG, Coker, AL et al. (1995) The relationship between diet, activity, and other factors, and postpartum weight change by race. Obstet Gynecol 86, 834838.
18.Flegal, KM, Carroll, MD, Ogden, CL et al. (2010) Prevalence and trends in obesity among US adults, 1999–2008. JAMA 303, 235241.
19.Kautiainen, S, Koivisto, AM, Koivusilta, L et al. (2009) Sociodemographic factors and a secular trend of adolescent overweight in Finland. Int J Pediatr Obes 4, 360370.
20.Cheng, S, Volgyi, E, Tylavsky, FA et al. (2009) Trait-specific tracking and determinants of body composition: a 7-year follow-up study of pubertal growth in girls. BMC Med 7, 5.
21.Xu, L, Nicholson, P, Wang, QJ et al. (2010) Fat mass accumulation compromises bone adaptation to load in Finnish women – a cross-sectional study spanning three generations. J Bone Miner Res 25, 23412349.
22.Lyytikainen, A, Lamberg-Allardt, C, Kannas, L et al. (2005) Food consumption and nutrient intakes with a special focus on milk product consumption in early pubertal girls in Central Finland. Public Health Nutr 8, 284289.
23.Friedewald, WT, Levy, RI & Fredrickson, DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18, 499502.
24.Bland, JM & Altman, DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1, 307310.
25.Hardin, JW & Hilbe, JM (2003) Generalized Estimating Equations. Boca Raton, FL: Chapman & Hall.
26.Pansini, F, Bonaccorsi, G, Genovesi, F et al. (1990) Influence of estrogens on serum free fatty acid levels in women. J Clin Endocrinol Metab 71, 13871389.
27.Ben-Jonathan, N, Hugo, ER, Brandebourg, TD et al. (2006) Focus on prolactin as a metabolic hormone. Trends Endocrinol Metab 17, 110116.
28.Nilsson, LA, Roepstorff, C, Kiens, B et al. (2009) Prolactin suppresses malonyl-CoA concentration in human adipose tissue. Horm Metab Res 41, 747751.
29.Stuebe, AM, Rich-Edwards, JW, Willett, WC et al. (2005) Duration of lactation and incidence of type 2 diabetes. JAMA 294, 26012610.
30.Brewer, MM, Bates, MR & Vannoy, LP (1989) Postpartum changes in maternal weight and body fat depots in lactating vs nonlactating women. Am J Clin Nutr 49, 259265.
31.Janney, CA, Zhang, D & Sowers, M (1997) Lactation and weight retention. Am J Clin Nutr 66, 11161124.
32.Gigante, DP, Victora, CG & Barros, FC (2001) Breast-feeding has a limited long-term effect on anthropometry and body composition of Brazilian mothers. J Nutr 131, 7884.
33.Li, R, Scanlon, KS & Serdula, MK (2005) The validity and reliability of maternal recall of breastfeeding practice. Nutr Rev 63, 103110.
34.Kark, JD, Troya, G, Friedlander, Y et al. (1984) Validity of maternal reporting of breast feeding history and the association with blood lipids in 17 year olds in Jerusalem. J Epidemiol Community Health 38, 218225.
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Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
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