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Wholegrain cereals and bread: a duet of the Mediterranean diet for the prevention of chronic diseases

  • Angel Gil (a1), Rosa M Ortega (a2) and José Maldonado (a3)
Abstract
AbstractObjective

The promotion of healthy lifestyles is one of the major goals of governments and international agencies all over the world. Wholegrain cereals are rich in nutrients and many phytochemical compounds, with recognised benefits for health, including dietary fibre, a number of phenolic compounds, lignans, vitamins and minerals and other bioactive components. The aim of the present work is to review the fundamental studies that support the consumption of wholegrain cereals and bread to prevent chronic diseases.

Design

Descriptive review considering human studies.

Setting and subjects

Subjects included in randomised intervention trials and cohort studies from different countries published up to 2010.

Results

Several studies show consistently that subjects who ingest three or more portions of foods per day based on wholegrain cereals have a 20–30 % lower risk of CVD than subjects who ingest low quantities of cereals. This level of protection is not observed with the ingestion of refined cereals, these being even higher than with the intake of fruit and vegetables. Likewise, high intake of wholegrain cereals and their products, such as whole-wheat bread, is associated with a 20–30 % reduction in the risk of type 2 diabetes. Finally, protection against the risk of colorectal cancer and polyps, other cancers of the digestive tract, cancers related to hormones and pancreatic cancer has been associated with the regular consumption of wholegrain cereals and derived products.

Conclusions

The regular intake of wholegrain cereals can contribute to reduction of risk factors related to non-communicable chronic diseases.

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Copyright
Corresponding author
*Corresponding author: Email agil@ugr.es
References
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1.Liu SM, Stampfer MJ, Hu FB et al. (1999) Whole-grain consumption and risk of coronary heart disease: results from the Nurses’ Health Study. Am J Clin Nutr 70, 412429.
2.Slavin J (2004) Whole grains and human health. Nutr Res Rev 17, 99110.
3.Venn BJ & Green TJ (2007) Glycemic index and glycemic load: measurement issues and their effect on diet-disease relationships. Eur J Clin Nutr 61, Suppl. 1, S122S131.
4.Lajous M, Boutron-Ruault MC, Fabre A et al. (2008) Carbohydrate intake, glycemic index, glycemic load, and risk of postmenopausal breast cancer in a prospective study of French women. Am J Clin Nutr 87, 13841391.
5.Livesey G, Taylor R, Hulshof T et al. (2008) Glycemic response and health – a systematic review and meta-analysis: relations between dietary glycemic properties and health outcomes. Am J Clin Nutr 87, Suppl. 1, S258S268.
6.Jensen MK, Koh-Banarjee P, Hu FB et al. (2004) Intakes of whole grains, bran, and germ and the risk of coronary heart disease in men. Am J Clin Nutr 80, 14921499.
7.Pereira MA, Pins JJ, Jacobs DR et al. (1993) Whole grains, cereal fiber, and chronic diseases: epidemiologic evidence. In CRC Handbook of Dietary Fiber in Human Nutrition, pp. 461479 [GA Spiller, editor]. Boca Raton, FL: CRC Press.
8.Englyst HN, Kingman SM & Cummings JH (1992) Classification and measurement of nutritionally important starch fractions. Eur J Clin Nut 46, Suppl. 2, S33S50.
9.Englyst HN, Kingman SM, Hudson GJ et al. (1996) Measurement of resistant starch in vitro and in vivo. Br J Nutr 75, 749755.
10.Rizkalla SW, Laromiguiere M, Champ M et al. (2007) Effect of baking process on postprandial metabolic consequences: randomized trials in normal and type 2 diabetic subjects. Eur J Clin Nutr 61, 175183.
11.Gil A, Ortega RM & Lozano JM (2010) Importancia del pan en la prevención de las enfermedades crónicas. In Libro Blanco del Pan, pp. 141158 [A Gil and L Serra, editors]. Madrid: Editorial Medica Panamericana.
12.Zarzuelo A & Gálvez J (2010) Fibra dietética. In Tratado de Nutrición, 2nd ed., pp. 233256 [A Gil, editor]. Madrid: Editorial Médica Panamericana.
13.Anderson JW (2002) Whole-grains intake and risk for coronary heart disease. In Whole Grain Foods in Health and Disease, pp. 187200 [L Marquart, JL Slavin and RG Fulcher, editors]. St. Paul, MN: Eagan Press.
14.Truswell AS (2002) Cereal grains and coronary heart disease. Eur J Clin Nutr 56, 114.
15.Jacobs DR, Meyer KA, Kushi LH et al. (1998) Whole-grain intake may reduce the risk of ischemic heart disease death in postmenopausal women: the Iowa Women's Health Study. Am J Clin Nutr 68, 248257.
16.Pietinen P, Rimm EB, Korhonen P et al. (1996) Intake of dietary fiber and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Circulation 94, 27202727.
17.Morris JN, Marr JW & Clayton DG (1977) Diet and heart: a postscript. BMJ 2, 13071314.
18.Pereira MA, O'Reilly E, Augustsson K et al. (2004) Dietary fiber and risk of coronary heart disease. A pooled analysis of cohort studies. Arch Intern Med 164, 370376.
19.Rimm EB, Ascherio A, Giovannucci E et al. (1996) Vegetable, fruit and cereal fiber intake and risk of coronary heart disease among men. JAMA 275, 447451.
20.Van Dam RM, Grievink L, Ocké MC et al. (2003) Patterns of food consumption and risk factors for cardiovascular disease in the general Dutch population. Am J Clin Nutr 77, 11561163.
21.Lopez-Garcia E, Schulze MB, Fung TT et al. (2004) Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction. Am J Clin Nutr 80, 10291035.
22.Wu T, Giovannucci E, Pischon T et al. (2004) Fructose, glycemic load, and quantity and quality of carbohydrate in relation to plasma C-peptide concentrations in US women. Am J Clin Nutr 80, 10431049.
23.Erkkilä AT, Herrington DM, Mozaffarian D et al. (2005) Cereal fiber and whole-grain intake are associated with reduced progression of coronary-artery atherosclerosis in postmenopausal women with coronary artery disease. Am Heart J 150, 94101.
24.Jensen MK, Koh-Banerjee P, Franz M et al. (2006) Whole grains, bran, and germ in relation to homocysteine and markers of glycemic control, lipids, and inflammation 1. Am J Clin Nutr 83, 275283.
25.Sahyoun NR, Jacques PF, Zhang XL et al. (2006) Whole-grain intake is inversely associated with the metabolic syndrome and mortality in older adults. Am J Clin Nutr 83, 124131.
26.Murtaugh MA, Jacobs DR Jr, Jacob B et al. (2003) Epidemiological support for the protection of whole grains against diabetes. Proceed Nutr Soc 62, 143149.
27.Montonen J, Knekt P, Järvinen R et al. (2003) Whole-grain and fiber intake and the incidence of type 2 diabetes. Am J Clin Nutr 77, 622629.
28.Riccardi G, Rivellese AA & Giacco R (2008) Role of glycemic index and glycemic load in the healthy state, in prediabetes, and in diabetes. Am J Clin Nutr 87, Suppl. 1, S269S274.
29.Henry CJ, Lightowler HJ, Tydeman EA et al. (2006) Use of low-glycaemic index bread to reduce 24-h blood glucose: implications for dietary advice to non-diabetic and diabetic subjects. Int J Food Sci Nutr 57, 273278.
30.Marangoni F & Poli A (2008) The glycemic index of bread and biscuits is markedly reduced by the addition of a proprietary fiber mixture to the ingredients. Nutr Metab Cardiovasc Dis 18, 602605.
31.Monro JA & Shaw M (2008) Glycemic impact, glycemic glucose equivalents, glycemic index, and glycemic load: definitions, distinctions, and implications. Am J Clin Nutr 87, Suppl. 1, S237S243.
32.Salmerón J, Manson JE, Stampfer MJ et al. (1997) Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. JAMA 277, 472477.
33.Salmerón J, Ascherio A, Rimm EB et al. (1997) Dietary fiber, glycemic load, and risk of NIDDM in men. Diabetes Care 20, 545550.
34.Meyer KA, Kushi LH, Jacobs DR Jr et al. (2000) Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr 71, 921930.
35.Liu S, Manson JE, Stampfer MJ et al. (2000) A prospective study of whole grain intake and risk of type 2 diabetes mellitus in US women. Am J Public Health 90, 14091415.
36.Fung TT, Hu FB, Pereira MA et al. (2002) Whole-grain intake and the risk of type 2 diabetes: a prospective study in men. Am J Clin Nutr 76, 535540.
37.Liu S (2003) Whole-grain foods, dietary fiber, and type 2 diabetes: searching for a kernel of truth. Am J Clin Nutr 77, 527529.
38.Pereira MA, Jacobs DJ Jr, Pins JJ et al. (2002) Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. Am J Clin Nutr 75, 848855.
39.Juntunen KS, Niskanen LK, Liukkonen KH et al. (2002) Postprandial glucose, insulin, and incretin responses to grain products in healthy subjects. Am J Clin Nutr 75, 254262.
40.McKeown NM, Meigs JB, Liu S et al. (2002) Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study. Am J Clin Nutr 76, 390398.
41.Juntunen KS, Laaksonen DE, Poutanen KS et al. (2003) High-fiber rye bread and insulin secretion and sensitivity in healthy postmenopausal women. Am J Clin Nutr 77, 385391.
42.McIntosh GH, Noakes M, Royle PJ et al. (2003) Whole-grain rye and wheat foods and markers of bowel health in overweight middle-aged men. Am J Clin Nutr 77, 967974.
43.Qi L, van Dam RM, Liu S et al. (2006) Whole-grain, bran, and cereal fiber intakes and markers of systemic inflammation in diabetic women. Diabetes Care 29, 207211.
44.Jacobs DR Jr, Marquart L, Slavin J et al. (1998) Whole-grain intake and cancer: an expanded review and meta-analysis. Nutr Cancer 30, 8596.
45.Chatenoud L, Tavani A, La Vecchia C et al. (1998) Whole-grain food intake and cancer risk. Int J Cancer 77, 2428.
46.Larsson SC, Giovannucci E, Bergkvist L et al. (2005) Whole grain consumption and risk of colorectal cancer: a population-based cohort of 60 000 women. BJC 92, 18031807.
47.Terry P, Lagergren J, Ye W et al. (2001) Inverse association between intake of cereal fiber and risk of gastric cardia cancer. Gastroenterology 120, 387391.
48.Kasum CM, Jacobs DR Jr, Nicodemus K et al. (2002) Dietary risk factors for upper aerodigestive tract cancers. Int J Cancer 99, 267272.
49.Kasum CM, Nicodemus K, Harnack LJ et al. (2001) Whole grain intake and incident endometrial cancer: the Iowa Women's Health Study. Nutr Cancer 39, 180186.
50.Jacobs DR Jr, Andersen LF & Blomhoff R (2007) Whole grain consumption is associated with a reduced risk of non cardiovascular, non cancer death attributed to inflammatory diseases in the Iowa Women's Health Study. Am J Clin Nutr 85, 16061614.
51.Schatzkin A, Mouw T, Park Y et al. (2007) Dietary fiber and whole-grain consumption in relation to colorectal cancer in the NIH-AARP Diet and Health Study. Am J Clin Nutr 85, 13531360.
52.Gnagnarella P, Gandini S, La Vecchia C et al. (2008) Glycemic index, glycemic load, and cancer risk: a meta-analysis. Am J Clin Nutr 87, 17931801.
53.World Cancer Research Fund/Institute for Cancer Research (2007) Food, Nutrition, Physical Activity and the Prevention of Cancer – A Global Perspective. Washington, DC: WCRF/AICR; available at http://www.dietandcancerreport.org/
54.Mulholland HG, Murray LJ, Cardwell CR et al. (2009) Glycemic index, glycemic load, and risk of digestive tract neoplasms: a systematic review and meta-analysis. Am J Clin Nutr 89, 568576.
55.Borriello SP, Setchell KD, Axelson M et al. (1985) Production and metabolism of lignans by the human faecal flora. J Applied Bact 58, 3743.
56.Adlercreutz H, Fotsis T, Bannwart C et al. (1986) Urinary estrogen profile determination in young Finnish vegetarian and omnivorous women. J Steroid Biochem 24, 289296.
57.Kilkkinen A, Valsta LM, Virtamo J et al. (2003) Intake of lignans is associated with serum enterolactone concentration in Finnish men and women. J Nutr 133, 18301833.
58.Jacobs DR Jr, Pereira MA, Stumpf K et al. (2002) Whole grain food intake elevates serum enterolactone. Br J Nutr 88, 111116.
59.Vanharanta M, Voutilainen S, Rissanen TH et al. (2003) Risk of cardiovascular disease-related and all-cause death according to serum concentrations of enterolactone. Kuopio Ischaemic Heart Disease Risk Factor Study. Arch Inter Med 163, 10991104.
60.Marlett JA, McBurney MI & Slavin JL (2002) Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Ass 102, 9931000.
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