Hostname: page-component-848d4c4894-75dct Total loading time: 0 Render date: 2024-05-09T05:07:35.724Z Has data issue: false hasContentIssue false
  • English
  • Français

The effects of feeding toxic groundnut meal to growing pigs and its interaction with high-copper diets

Published online by Cambridge University Press:  09 March 2007

R. S. Barber ,
R. Braude ,
K. G. Mitchell ,
J. D. J. Harding ,
G. Lewis  and
R. M. Loosmore
R. S. Barber
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading
R. Braude
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading
K. G. Mitchell
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading
J. D. J. Harding
Affiliation:
MAFF, Central Veterinary Laboratory, New Haw, Weybridge
G. Lewis
Affiliation:
MAFF, Central Veterinary Laboratory, New Haw, Weybridge
R. M. Loosmore
Affiliation:
MAFF, Veterinary Investigation Centre, Coley Park, Reading
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Three experiments using sixty individually fed, enzootic pneumonia-free Large White pigs on experiment from 9–11 weeks of age to 200 lb live weight are described.

2. Information was obtained on the effect of different dietary concentrations of aflatoxin B1 on the performance of the pigs, on various biochemical measurements and on the histology of the livers and kidneys.

3. Reduced growth rate and loss of appetite were the main adverse effects observed, their extent being positively related to the dietary level of aflatoxin B1. No marked clinical signs were seen, mortality was very low and there was little or no effect on the feed conversion efficiency of the animals.

4. No evidence for any adverse interaction between aflatoxin B1 and the presence in the diet of a supplement of copper sulphate providing 250 ppm Cu was apparent from either the performance, biochemical or histological results obtained. It was concluded that the few isolated reports of toxicity in growing pigs fed diets containing a supplement of 250 ppm Cu were unlikely to have been the result of the unsuspected presence of aflatoxin B1 in the feedingstuffs used in the diets.

5. Aflatoxin B1 tended to increase the serum alkaline phosphatase level, the concentration of Cu in the kidneys, and liver weight and to reduce the liver vitamin A concentration. No other consistent differences in the measurements made were observed.

6. The extent of the total pathological abnormality observed in the livers and kidneys was closely related to the level of aflatoxin B1 in the diet.

Type
Research Article
Information
British Journal of Nutrition , Volume 22 , Issue 4 , December 1968 , pp. 535 - 554
Copyright
Copyright © The Nutrition Society 1968

References

Allcroft, R. & Carnaghan, R. B. A. (1963). Chemy Ind. p. 50.Google Scholar
Allcroft, R. & Lewis, G. (1963). Vet. Rec. 75, 487.Google Scholar
Allcroft, R. & Loosmore, R. M. (1963). Proc. int. vet. Congr. XVII. Hanover 1, 175.Google Scholar
Allen, M. M. & Harding, J. D. J. (1962). Vet. Rec. 74, 173.Google Scholar
Annau, E., Corner, A. H., Magwood, S. E. & Jericho, K. (1964). Can. J. comp. Med. 28, 264.Google Scholar
Barber, R. S., Braude, R. & Mitchell, K. G. (1955). Vet. Rec. 67, 348.Google Scholar
Barber, R. S., Braude, R., Mitchell, K. G. & Cassidy, J. (1955). Chemy Ind. p. 601.Google Scholar
Bass, B., McCall, J. T., Wallace, H. D., Combs, G. E., Palmer, A. Z. & Carpenter, J. E. (1956). J. Anim. Sci. 15, 1230.Google Scholar
Bihaly, A., Kostyak, J. & Orosny, D. (1965). Allattenyesztes 14, 243.Google Scholar
Bodnar, M., Dorman, M., Juhasz, B. & Szegedi, B. (1965). Magy Allatorv. Lap. 20, 390.Google Scholar
Braude, R. (1965). Transactions of a Symposium on Cuprum pro VitaVienna, p. 55.Google Scholar
Also published in Wld Rev. Anim. Prod. (1967) 3, 69.Google Scholar
Braude, R. & Mitchell, K. G. (1951). J. Minist. Agric. Fish. 57, 501.Google Scholar
Buntain, D. (1961). Vet. Rec. 73, 707.Google Scholar
Carnaghan, R. B. A. & Allcroft, R. (1962). Vet. Rec. 74, 925.Google Scholar
Carr, F. H. & Price, E. A. (1926). Biochem. J. 20, 497.CrossRefGoogle Scholar
Clare, N. T., Cunningham, I. J. & Perrin, D. D. (1945). N.Z. Jl Sci. Technol. 26A, 340.Google Scholar
Commercial Research Group (1964). Vet. Rec. 76, 498.Google Scholar
de Iongh, H., van Pelt, J. G., Ord, W. O. & Barrett, C. B. (1964). Vet. Rec. 76, 901.Google Scholar
Duncan, D. B. (1955). Biometrics 11, 1.CrossRefGoogle Scholar
Duthie, I. F., Lancaster, M. C., Taylor, J., Thomas, D. C., Shacklady, C. A., Attfield, P. H. & Fuller-Lewis, E. (1966). Vet. Rec. 79, 621.Google Scholar
Eden, A. & Green, H. H. (1940). Biochem. J. 34, 1202.Google Scholar
Gordon, W. A. M. & Luke, D. (1957). Vet. Rec. 69, 37.Google Scholar
Hanrahan, T. J. & O'Grady, J. F. (1966). Anim. Prod. 8, 361.Google Scholar
Harding, J. D. J., Done, J. T., Lewis, G. & Allcroft, R. (1963). Res. vet. Sci. 4, 217.Google Scholar
Harding, J. D. J., Lewis, G., Done, J. T. & Allcroft, R. (1964). Path. Vet. 1, 204.Google Scholar
Hintz, H. F., Booth, A. N., Cucullu, A. F., Gardner, H. K. & Heitman, H. Jr (1967). Proc. Soc. exp. Biol. Med. 124, 266.CrossRefGoogle Scholar
Hornby, R. B., Miller, J. C. & Dabell, J. S. (1962). Vet. Rec. 74, 52.Google Scholar
Horrocks, D., Burt, A. W. A., Thomas, D. C. & Lancaster, M. C. (1965). Anim. Prod. 7, 253.Google Scholar
King, E. J. & Wootton, I. D. P. (1956). Micro-analysis in Medical Biochemistry, 3rd ed. London: Churchill.Google Scholar
Loosmore, R. M., Allcroft, R., Tutton, E. A. & Carnaghan, R. B. A. (1964). Vet. Rec. 76, 64.Google Scholar
Loosmore, R. M. & Harding, J. D. J. (1961). Vet. Rec. 73, 1362.Google Scholar
Lysø, A. (1966). Meld. Norg. LandbrHøgsk. no. 45.Google Scholar
O'Hara, P. J., Newman, A. P. & Jackson, R. (1960). Aust. vet. J. 36, 225.Google Scholar
Okamoto, K. & Utamura, N. (1937). Scholae med. Kioto acta 320, 573.Google Scholar
Raynaud, J. P. (1963). Rev. Elev. Med. vet. Pays trop. 16, 23.Google Scholar
Ritchie, H. D., Luecke, R. W., Baltzer, B. V.Miller, E. R., Ullrey, D. E. & Hoefer, J. A. (1963). J. Nutr. 79, 117.Google Scholar
Thompson, S. Y., Ganguly, J. & Kon, S. K. (1949). Br. J. Nutr. 3, 50.Google Scholar
Umbreit, W. W., Kingsley, G. R., Schaffert, R. R. & Siplet, H. (1957). J. Lab. clin. Med. 49, 454.Google Scholar
Van der Merwe, K. F., Fourie, L. & Scott, de B. (1963). Chemy Ind. p. 1660.Google Scholar
Wallace, H. D., McCall, J. T., Bass, B. & Combs, G. E. (1960). J. Anim. Sci. 19, 1153.Google Scholar
Wroblewski, F. & Caband, P. (1957). Am. J. clin. Path. 27, 235.CrossRefGoogle Scholar