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Section 4 - Pain Management and Other Newborn and Infant Anesthesia Concerns

Published online by Cambridge University Press:  09 February 2018

Mary Ellen McCann
Affiliation:
Harvard Medical School, Boston, MA, USA
Christine Greco
Affiliation:
Harvard Medical School, Boston, MA, USA
Kai Matthes
Affiliation:
Harvard Medical School, Boston, MA, USA
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Print publication year: 2018

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References

References

1.Fitzgerald, M, Walker, SM. Infant pain management: a developmental neurobiological approach. Nat Clin Pract Neurol. 2009;5(1):3550.Google Scholar
2.Flaris, NA, Shindler, KS, Kotzbauer, PT, et al. Development of the primary afferent projection in human spinal cord. J Comp Neurol. 1995;354(1):1112.Google Scholar
3.Kostovic, I. Structural and histochemical reorganization of the human prefrontal cortex during perinatal and postnatal life. Prog Brain Res. 1990;85:223–39.Google Scholar
4.Cornelissen, L, Fabrizi, L, Patten, D, et al. Postnatal temporal spatial and modality tuning of nociceptive cutaneous flexion reflexes in human infants. PLoS One. 2013;8(10). doi: https://doi.org/10.1371/journal.pone.0076470.Google Scholar
5.Fitzgerald, M. Alterations in the ipsi- and contralateral afferent inputs of dorsal horn cells produced by capsaicin treatment of one sciatic nerve in the rat. Brain Res. 1982;248(1):97107.Google Scholar
6.Slater, R, Cantarella, A, Gallella, S, et al. Cortical pain responses in human infants. J Neurosci. 2006;26(14):3662–6.Google Scholar
7.Bartocci, M, Bergqvist, LL, Lagercrantz, H, Anand, K. Pain activates cortical areas in the preterm newborn brain. Pain. 2006;122(1–2):109–17.Google Scholar
8.Taddio, A, Katz, J, Ilersich, AL, Koren, G. Effect of neonatal circumcision on pain response during subsequent routine vaccination [comment]. The Lancet. 1997;349(9052):599603.Google Scholar
9.Anand, KJS, Hansen, DD, Hickey, PR. Hormonal-metabolic stress responses in neonates undergoing cardiac surgery. Anesthesiology. 1990;73(4):661–70.Google Scholar
10.Bhandari, V, Bergqvist, L, Kronsberg, S, Barton, B, Anand, K; NEOPAIN Trial Investigators Group. Morphine admininstration and short-term pulmonary outcomes among ventilated preterm infants. Pediatrics. 2005;116(2):352–9.Google Scholar
11.Carbajal, R, Lenclen, R, Jugie, M, et al. Morphine does not provide adequate analagesia for acute procedural pain among preterm neonates. Pediatrics. 2005;115(6):1494–500.Google Scholar
12.Knaepen, L, Patijn, J, van Kleef, M, et al. Neonatal repetitive needle pricking: plasticity of the spinal nociceptive circuit and extended postoperative pain in later life. Dec Neurobiol. 2013;73(1):8597.Google Scholar
13.Anand, KJ, Coskun, V, Thrivikraman, KV, Nemeroff, CB, Plotsky, PM. Long-term behavioral effects of repetitive pain in neonatal rat pups. Physiol Behav. 1999;66(4):627–37.Google Scholar
14.Grunau, R, Whitfield, M, Petrie, H. Pain sensitivity and temperament in extremely low-birth-weight premature toddlers and preterm and full-term controls. Pain 1994;58:341–6.Google Scholar
15.Slater, R, Cantarella, A, Franck, L, Meek, J, Fitzgerald, M. How well do clinical pain assessment tools reflect pain in infants? PLoS Med. 2008;5(6).Google Scholar
16.Stevens, B, Johnston, C, Petryshen, P, Taddio, A. Premature Infant Pain Profile: development and intial validation. Clin J Pain. 1996;12(1):1322.Google Scholar
17.Lawrence, J, Alcock, D, McGrath, P, et al. The development of a tool to assess neonatal pain. Neonatal Netw. 1993;12(6):5966.Google Scholar
18.Hummel, P, Puchalski, M, Creech, S, Weiss, M. Clinical reliability and validity of the N-PASS: neonatal pain, agitation and sedation scale with prolonged pain. J Perinatol. 2008;28(1):5560.Google Scholar
19.Krechel, S, Bildner, J. CRIES: a new neonatal postoperative pain measurement score. Initial testing of validity and reliability. Paediatr Anaesth. 1995;5(1):5361.Google Scholar
20.van Ganzewinkel, C, Anand, K, Kramer, B, Andriessen, P. Chronic pain in the newborn: toward a definition. Clin J Pain. 2014;30(11):970–7.Google Scholar
21.Pillai Riddell, R, Stevens, B, McKeever, P, et al. Chornic pain in hopsitalized infants: health professionals’ perspectives. J Pain. 2009;10(12):1217–25.Google Scholar
22.Kearns, G, Abdel-Rahman, S, Alander, S, et al. Developmental pharmacology-drug disposition, action, and therapy in infants and children. N Engl J Med. 2003;349(12):1157–67.Google Scholar
23.Lam, J, Woodall, K, Solbeck, P, et al. Codeine-related deaths: the role of pharmacogenetics and drug interactions. Forensic Sci Int. 2014;239:50–6.Google Scholar
24.Cohen, G, Malcolm, G, Henderson-Smart, D. Ventilatory response of the newborn infant to mild hypoxia. Pediatr Pulmonol. 1997;24(3):163–72.Google Scholar
25.Bissonnette, JM. Mechanisms regulating hypoxic respiratory depression during fetal and postnatal life. Am J Physiol. 2000;278(6):R1391–400.Google Scholar
26.Anwar, M, Marotta, F, Fort, MD, et al. The ventilatory response to carbon dioxide in high risk infants. Early Hum Dev. 1993;35(3):183–92.Google Scholar
27.Calder, N, Williams, B, Smyth, J, et al. Absence of ventilatory responses to alternating breaths of mild hypoxia and air in infants who have had bronchopulmonary dysplsia: implications for the risk of sudden infant death. Pediatr Res. 1994;35(6):677–81.Google Scholar
28.American Academy of Pediatrics Committee on Fetus and Newborn; American Academy of Pediatrics Section on Surgery; Canadian Paediatric Society Fetus and Newborn Committee, et al. Prevention and management of pain in the neonate: an update. Pediatrics. 2006;118(5):2231–41.Google Scholar
29.Stevens, B, Yamada, J, Lee, GY, Ohlsson, A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2013;1:CD001069.Google Scholar
30.Johnston, C, Campbell-Yeo, M, Fernandes, A, et al. Skin-to-skin care for procedural pain in neonates. Cochrane Database Syst Rev. 2014;1:CD008435.Google Scholar
31.Lopez, O, Subramanian, P, Rahmat, N, et al. The effect of facilitated tucking on procedural pain control among premature babies. J Clin Nurs. 2015;24(1–2):183–91.Google Scholar
32.Alinejad-Naeini, M, Mohagheghi, P, Peyrovi, H, Mehran, A. The effect of facilitated tucking during endotracheal suctioning on procedural pain in preterm neonates: a randomized controlled crossover study. Glob J Health Sci. 2014;6(4):278–84.Google Scholar
33.Slater, R, Cornelissen, L, Fabrizi, L, et al. Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomized controlled trial. The Lancet. 2010;376(9748):1225–32.Google Scholar
34.Thakkar, P, Arora, K, Goyal, K, et al. To evaluate and compare the efficacy of combined sucrose and non-nutritive sucking for analgesia in newborns undergoing minor painful procedure: a randomized controlled trial. J Perinatol. 2016;36(1):6770.Google Scholar
35.Holsti, L, Grunau, RE. Considerations for using sucrose to reduce procedural pain in preterm infants. Pediatrics. 2010;125(5):1042–7.Google Scholar
36.Johnston, CC, Filion, F, Snider, L, et al. Routine sucrose analgesia during the first week of life in neonates younger than 31 weeks’ postconceptional age. Pediatrics. 2002;110(3):523–8.Google Scholar
37.Allegaert, K, Rayyan, M, Vanhaesebrouck, S, Naulaers, G. Developmental pharmacokinetics in neonates. Expert Rev Clin Pharmacol. 2008;1(3):415–28.Google Scholar
38.Ceelie, I, de Wildt, SN, van Dijk, M, et al. Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial. JAMA. 2013;309(2):149–54.Google Scholar
39.Ohlsson, A, Shah, PS. Paracetamol (acetaminophen) for prevention or treatment of pain in newborns. Cochrane Database Syst Rev. 2015;6:CD011219.Google Scholar
40.Ririe, DG, Prout, HD, Barclay, D, et al. Developmental differences in spinal cyclooxygenase 1 expression after surgical incision. Anesthesiology. 2006;104(3):426–31Google Scholar
41.Allegaert, K, Anderson, BJ, Naulaers, G, et al. Intravenous paracetamol (propacetamol) pharmacokinetics in term and preterm neonates. Eur J Clin Pharmacol. 2004;60(3):191–7.Google Scholar
42.Allegaert, K, Palmer, GM, Anderson, BJ. The pharmacokinetics of intravenous paracetamol in neonates: size matters most. Arch Dis Child. 2011;96:575–80.Google Scholar
43.Dani, C, Vangi, V, Bertini, G, et al. High-dose ibuprofen for patent ductus arteriosus in extremely preterm infants: a randomized controlled study. Clin Pharmacol Ther. 2012;91(4):590–6.Google Scholar
44.Ohlsson, A, Walia, R, Shah, SS. Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants. Cochrane Database Syst Rev. 2015;2:CD003481.Google Scholar
45.Gupta, A, Daggett, C, Drant, S, Rivero, N, Lewis, A. Prospective randomized trial of ketorolac after congenital heart surgery. J Cardiothorac Vasc Anesth. 2004;18(4):454–7.Google Scholar
46.Aldrink, JH, Ma, M, Wang, W, et al. Safety of ketorolac in surgical neonates and infants 0 to 3 months old. J Pediatr Surg. 2011;46(6):1081–5.Google Scholar
47.Burd, RS, Tobias, JD. Ketorolac for pain management after abdominal surgical procedures in infants. South Med J. 2002;95(3):331–3.Google Scholar
48.Moffett, BS, Wann, TI, Carberry, KE, Mott, AR. Safety of ketorolac in neonates and infants after cardiac surgery. Paediatr Anaesth. 2006;16(4):424–8.Google Scholar
49.de Graaf, J, van Lingen, RA, Valkenburg, AJ, et al. Does neonatal morphine use affect neuropsychological outcomes at 8 to 9 years of age? Pain. 2013;154(3):449–58.Google Scholar
50.de Graaf, J, van Lingen, RA, Simons, SH, et al. Long-term effects of routine morphine infusion in mechanically ventilated neonates on children’s functioning: five-year follow-up of a randomized controlled trial. PAIN. 2011;152:1391–7.Google Scholar
51.Anand, KJ, Hall, RW, Desai, N, et al. Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial. The Lancet. 2004;363(9422):1673–82.Google Scholar
52.Simons, SH, van Dijk, M, van Lingen, RA, et al. Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. JAMA. 2003;290(18):2419–27.Google Scholar
53.Carbajal, R, Lenclen, R, Jugie, M, et al. Morphine does not provide adequate analgesia for acuteprocedural pain among preterm neonates. Pediatrics. 2005;115(6):1494–500.Google Scholar
54.Anand, KJ, Anderson, BJ, Holford, NH, et al. Morphine pharmacokinetics and pharmacodynamics in preterm and term neonates: secondary results from the NEOPAIN trial. Br J Anaesth. 2008;101(5):680–9.Google Scholar
55.Boyle, EM, Freer, Y, Wong, CM, McIntosh, N, Anand, KJ. Assessment of persistent pain or distress and adequacy of analgesia in preterm ventilated infants. Pain. 2006;124(1–2):8791.Google Scholar
56.Ferguson, SA, Ward, WL, Paule, MG, Hall, RW, Anand, KJ. A pilot study of preemptive morphine analgesia in preterm neonates: effects on head circumference, social behavior, and response latencies in early childhood. Neurotoxicol Teratol. 2012;34(1):4755.Google Scholar
57.Valkenburg, AJ, van den Bosch, GE, de Graaf, J, et al. Long-term effects of neonatal morphine infusion on pain sensitivity: follow-up of a randomized controlled trial. J Pain. 2015;16(9):926–33.Google Scholar
58.Bouwmeester, NJ, Hop, WC, van Dijk, M, et al. Postoperative pain in the neonate: age-related differences in morphine requirements and metabolism. Intensive Care Med. 2009;29(11):2009–15.Google Scholar
59.Santeiro, ML, Christie, J, Stromquist, C, Torres, BA, Markowsky, SJ. Pharmacokinetics of continuous infusion fentanyl in newborns. J Perinatol. 1997;17(2):135–9.Google Scholar
60.Ancora, G, Lago, P, Garetti, E, et al. Efficacy and safety of continuous infusion of fentanyl for pain control in preterm newborns on mechanical ventilation. J Pediatr. 2013;163(3):645–51.Google Scholar
61.Lago, P, Tiozzo, C, Boccuzzo, G, Allegro, A, Zacchello, F. Remifentanil for percutaneous intravenous central catheter placement in preterm infant: a randomized controlled trial. Paediatr Anaesth. 2008;18(8):736–44.Google Scholar
62.Zhao, J, Xin, X, Xie, GX, Palmer, PP, Huang, YG. Molecular and cellular mechanisms of the age-dependency of opioid analgesia and tolerance. Mol Pain. 2012;8:38.Google Scholar
63.Wang, Y, Mitchell, J, Moriyama, K, et al. Age-dependent morphine tolerance development in the rat. Anesth Analg. 2005;100(6):1733–9.Google Scholar
64.Curley, MA, Wypij, D, Watson, RS, et al. Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial. JAMA. 2015;313(4):379–89.Google Scholar
65.Hünseler, C, Balling, G, Röhlig, C, et al. Continuous infusion of clonidine in ventilated newborns and infants: a randomized controlled trial. Pediatr Crit Care Med. 2014;15(6):511–12.Google Scholar
66.Willschke, H, Bosenberg, A, Marhofer, P, et al. Epidural catheter placement in neonates: sonoanatomy and feasibility of ultrasonographic guidance in term and preterm neonates. Reg Anesth Pain Med. 2007;32(1):3440.Google Scholar
67.Tsui, BC, Wagner, A, Cave, D, Kearney, R. Thoracic and lumbar epidural analgesia via the caudal approach using electrical stimulation guidance in pediatric patients: a review of 289 patients. Anesthesiology. 2004;100(3):683–9.Google Scholar
68.Meunier, JF, Goujard, E, Dubousset, AM, Samii, K, Mazoit, JX. Pharmacokinetics of bupivacaine after continuous epidural infusion in infants with and without biliary atresia. Anesthesiology. 2001;95(1):8795.Google Scholar
69.Mazoit, JX, Dalens, BJ. Pharmacokinetics of local anaesthetics in infants and children. Clin Pharmacokinet. 2004;43(1):1732.Google Scholar
70.Larsson, BA, Lonnqvist, PA, Olsson, GL. Plasma concentrations of bupivacaine in neonates after continuous epidural infusion. Anesth Analg. 1997;84(3):501–5.Google Scholar
71.Rapp, HJ, Molnar, V, Austin, S, et al. Ropivacaine in neonates and infants: a population pharmacokinetic evaluation following single caudal block. Paediatr Anaesth. 2004;14(9):724–32.Google Scholar
72.McCann, ME, Sethna, NF, Mazoit, JX, et al. The pharmacokinetics of epidural ropivacaine in infants and young children. Anesth Analg. 2001;93(4):893–7.Google Scholar
73.Lonnqvist, PA, Westrin, P, Larsson, BA, et al. Ropivacaine pharmacokinetics after caudal block in 1–8 year old children. Br J Anaesth. 2000;85(4):506–11.Google Scholar
74.Bosenberg, A, Thomas, J, Cronie, L, et al. Pharmacokinetics and efficacy of ropivacaine for continuous epidural infusion in neonates and infants. Paediatr Anaesth. 2005;15(9):739–49.Google Scholar
75.Veneziano, G, Iliev, P, Tripi, J, et al. Continuous chloroprocaine infusion for thoracic and caudal epidurals as a postoperative analgesia modality in neonates, infants, and children. Paediatr Anaesth. 2016;26(1):8491.Google Scholar
76.Henderson, K, Sethna, NF, Berde, CB. Continuous caudal anesthesia for inguinal hernia repair in former preterm infants. J Clin Anesth. 1993;5(2):129–33.Google Scholar
77.Bouchut, JC, Dubois, R, Godard, J. Clonidine in preterm-infant caudal anesthesia may be responsible for postoperative apnea. Reg Anesth Pain Med. 2001;26(1):83–5.Google Scholar

References

1.Polaner, DM, Taenzer, AH, Walker, BJ, et al. Pediatric Regional Anesthesia Network (PRAN): a multi-institutional study of the use and incidence of complications of pediatric regional anesthesia Anesth Analg. 2012;115(6):1353–64. doi: 10.1213/ANE.0b013e31825d9f4b.Google Scholar
2.Walker, BJ, Long, JB, De Oliveira, GS, et al. Peripheral nerve catheters in children: an analysis of safety and practice patterns from the pediatric regional anesthesia network (PRAN). Br J Anaesth. 2015;115(3):457–62. doi: 10.1093/bja/aev220.Google Scholar
3.Ecoffey, C, Lacroix, F, Giaufré, E, Orliaguet, G, Courrèges, P; Association des Anesthésistes Réanimateurs Pédiatriques d’Expression Française (ADARPEF). Epidemiology and morbidity of regional anesthesia in children: a follow-up one-year prospective survey of the French-Language Society of Paediatric Anaesthesiologists (ADARPEF). Paediatr Anaesth. 2010;20(12):1061–9. doi: 10.1111/j.1460-9592.2010.03448.Google Scholar
4.Giaufre, E, Dalens, B, Gombert, A. Epidemiology and morbidity of regional anesthesia in children: a one-year prospective survey of the French-Language Society of Pediatric Anesthesiologist. Anesth Analg. 1996;83(5):904–12.Google Scholar
5.Horlocker, TT, Wedel, DJ, Rowlingson, JC, et al. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition). Reg Anesth Pain Med. 2010:35(1):64101.Google Scholar
6.Booker, PD, Taylor, C, Saba, G. Perioperative changes in alpha-1-acid glycoprotein concentrations in infants undergoing major surgery. BJA. 1996;76:365–8.Google Scholar
7.Suresh, A, Polaner, D, Cote, C. Regional anesthesia. In: Cote, C, Lerman, J, Anderson, B, editors. A Practice of Anesthesia for Infants and Children, 5th edn. Philadelphia, PA: Elsevier Saunders; 2013.Google Scholar
8.Meunier, JF, Goujard, E, Dubousset, AM, et al. Pharmacokinetics of bupivacaine after continuous epidural infusion in infants with and without biliary atresia. Anesthesiology. 2001;95(1):8795.Google Scholar
9.Henderson, K, Sethna, N, Berde, CB. Continuous caudal anesthesia for inguinal hernia repair in former preterm infants. J Clin Anesth. 1993;5(2):129–33.Google Scholar
10.Sondekoppam, RV, Brookes, J, Morris, L, Johnson, M, Ganapathy, S. Injectate spread following ultrasound-guided lateral to medial approach for dual transversus abdominis plane blocks. Acta Anaesthesiol Scand. 2015;59(3):369–76.Google Scholar
11.Weintrad, M, Marhofer, P, Bosenberg, A, et al. Ultrasound-guided ilioinguinal/iliohypogastric blocks in children: where do we administer the local anesthetic without direct visualization? Anesth Analg. 2008:106:8993.Google Scholar
12.Willschke, H, Marhofer, P, Bosenberg, A, et al. Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children. Br J Anaesth. 2005;95(2):226–30.Google Scholar
13.Shuying, L, Tan, SWK. Ultrasonography-guided ilioinguinal-iliohypogastric nerve block for inguinal herniotomies in ex-premature neonates. Singapore Med J. 2013;54(11):e218e220.Google Scholar
14.van Schoor, AN, Bosman, MC, Bosenberg, AT. Revisiting the anatomy of the ilioinguinal/iliohypogastric nerve block. Paediatr Anaesth. 2013;23(5):390–4.Google Scholar
15.Albokrinov, AA, Fesenko, UA. Spread of dye after single thoracolumbar paravertebral injection in infants: a cadaveric study. Eur J Anaesthesiol. 2014;31:305–9.Google Scholar
16.Stang, HJ, Gunnar, MR, Snellman, L, Condon, LM, Kestenbaum, R. Local anesthesia for neonatal circumcision: effects on distress and cortisol response. JAMA. 1988;259(10):1507–11.Google Scholar
17.Williamson, PS, Williamson, ML. Physiologic stress reduction by a local anesthetic during newborn circumcision. Pediatrics. 1983;71(1):3640.Google Scholar
18.Dalens, B, Vanneuville, G, Dechelotte, P. Penile block via the subpubic space in 100 children. Anesth Analg. 1989;69:41–5.Google Scholar
19.Mislovic, V. Multimodal analgesia including infraclavicular block in perioperative management of upper extremity amputation in neonate. Pediatr Anesth. 2011;21(12):1272–3.Google Scholar
20.Ecoffey, C, Lacroix, F, Giaufre, E, Orliaguet, G, Courreges, P, Association des Anesthesistes Reanimateurs Pediatriques d’Expression F. Epidemiology and morbidity of regional anesthesia in children: a follow-up one-year prospective survey of the French-Language Society of Paediatric Anaesthesiologists (ADARPEF). Paediatr Anaesth. 2010;20(12):1061–9. doi: 10.1111/j.1460-9592.2010.03448.x.Google Scholar
21.Johr, M, Berger, TM. Caudal blocks. Paediatr Anaesth. 2012;22(1):4450. doi: 10.1111/j.1460-9592.2011.03669.x.Google Scholar
22.Malas, MA, Seker, M, Salbacak, A, et al. The relationship between the lumbosacral enlargement and the conus medullaris during the period of fetal development and adulthood: surgical and radiologic anatomy: SRA. 2000;22(3–4):163–8.Google Scholar
23.Willschke, H, Marhofer, P, Bosenberg, A, et al. Epidural catheter placement in children: comparing a novel approach using ultrasound guidance and a standard loss-of-resistance technique. Br J Anaesth. 2006;97(2):200–7. doi: 10.1093/bja/ael121.Google Scholar
24.Beyaz, SG, Tokgoz, O, Tufek, A. Caudal epidural block in children and infants: retrospective analysis of 2088 cases. Ann Saudi Med. 2011;31(5):494–7. doi: 10.4103/0256-4947.84627.Google Scholar
25.Chen, CP, Tang, SF, Hsu, TC, et al. Ultrasound guidance in caudal epidural needle placement. Anesthesiology. 2004;101(1):181–4.Google Scholar
26.Koo, BN, Hong, JY, Kim, JE, Kil, HK. The effect of flexion on the level of termination of the dural sac in paediatric patients. Anaesthesia. 2009;64(10):1072–6. doi: 10.1111/j.1365-2044.2009.06031.x.Google Scholar
27.Visoiu, M, Lichtenstein, S. 25 years of experience, thousands of caudal blocks, and no dural puncture: what happened today? Paediatr Anaesth. 2012;22(3):304–5. doi: 10.1111/j.1460-9592.2011.03785.x.Google Scholar
28.Park, JH, Koo, BN, Kim, JY, et al. Determination of the optimal angle for needle insertion during caudal block in children using ultrasound imaging. Anaesthesia. 2006;61(10):946–9. doi: 10.1111/j.1365-2044.2006.04795.x.Google Scholar
29.Bösenberg, AT, Bland, BA, Schulte-Steinberg, O, Downing, JW. Thoracic epidural anesthesia via caudal route in infants. Anesthesiology.1988;69(2):265–9.Google Scholar
30.Marhofer, P, Bosenberg, A, Sitzwohl, C, et al. Pilot study of neuraxial imaging by ultrasound in infants and children. Paediatr Anaesth. 2005;15(8):671–6. doi: 10.1111/j.1460-9592.2004.01521.x.Google Scholar
31.Bubeck, J, Boos, K, Krause, H, Thies, KC. Subcutaneous tunneling of caudal catheters reduces the rate of bacterial colonization to that of lumbar epidural catheters. Anesth Analg. 2004;99(3):689–93. doi: 10.1213/01.ANE.0000130023.48259.FB.Google Scholar
32.Vallejo, MC, Phelps, AL, Singh, S, Orebaugh, SL, Sah, N. Ultrasound decreases the failed labor epidural rate in resident trainees. Int J Obstet Anesth. 2010;19(4):373–8. doi: 10.1016/j.ijoa.2010.04.002.Google Scholar
33.Kil, HK, Cho, JE, Kim, WO, et al. Prepuncture ultrasound-measured distance: an accurate reflection of epidural depth in infants and small children. Region Anesth Pain Med. 2007;32(2):102–6. doi: 10.1016/j.rapm.2006.10.005.Google Scholar
34.Rapp, HJ, Folger, A, Grau, T. Ultrasound-guided epidural catheter insertion in children. Anesth Analg. 2005;101(2):333–9. doi: 10.1213/01.ANE.0000156579.11254.D1.Google Scholar
35.Chawathe, MS, Jones, RM, Gildersleve, CD, et al. Detection of epidural catheters with ultrasound in children. Paediatr Anaesth. 2003;13(8):681–4.Google Scholar

References

1.Fogel, MA, Pawlowski, TW, Harris, MA, et al. Comparison and usefulness of cardiac magnetic resonance versus computed tomography in infants six months of age or younger with aortic arch anomalies without deep sedation or anesthesia. Am J Cardiol. 2011;108:120–5.Google Scholar
2.Windram, J, Grosse-Wortmann, L, Shariat, M, et al. Cardiovascular MRI without sedation or general anesthesia using a feed-and-sleep technique in neonates and infants. Pediatr Radiol. 2012;42:183–7.Google Scholar
3.Cote, CJ, Wilson, S. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: an update. Pediatrics. 2006;118:2587–602.Google Scholar
4.Malviya, S, Voepel-Lewis, T, Tait, AR, et al. Depth of sedation in children undergoing computed tomography: validity and reliability of the University of Michigan Sedation Scale (UMSS). Br J Anaesth. 2002;88:241–5.Google Scholar
5.Hummel, P, Puchalski, M, Creech, SD, Weiss, MG. Clinical reliability and validity of the N-PASS: neonatal pain, agitation and sedation scale with prolonged pain. J Perinatol. 2008;28:5560.Google Scholar
6.Cote, CJ, Karl, HW, Notterman, DA, Weinberg, JA, McCloskey, C. Adverse sedation events in pediatrics: analysis of medications used for sedation. Pediatrics. 2000;106:633–44.Google Scholar
7.Waugh, JB, Epps, CA, Khodneva, YA. Capnography enhances surveillance of respiratory events during procedural sedation: a meta-analysis. J Clin Anesth. 2011;23:189–96.Google Scholar
8.Anand, KJ, Barton, BA, McIntosh, N, et al. Analgesia and sedation in preterm neonates who require ventilatory support: results from the NOPAIN trial. Neonatal Outcome and Prolonged Analgesia in Neonates. Arch Pediatr Adolesc Med. 1999;153:331–8.Google Scholar
9.Hsieh, EM, Hornik, CP, Clark, RH, et al. Medication use in the neonatal intensive care unit. Am J Perinatol. 2014;31:811–21.Google Scholar
10.Allegaert, K, Peeters, MY, Knibbe, C. Propofol in (pre)term neonates: consider the extensive interindividual variability in clearance within the neonatal population. Paediatr Anaesth. 2011;21:174–5.Google Scholar
11.Allegaert, K, Peeters, MY, Verbesselt, R, et al. Inter-individual variability in propofol pharmacokinetics in preterm and term neonates. Br J Anaesth. 2007;99:864–70.Google Scholar
12.Sarhan, TS, El‐attar, A. Propofol pharmacokinetics in infants: BAPCAP1–1. Eur J Anaesthesiol. 2010;27:1.Google Scholar
13.Ghanta, S, Abdel-Latif, ME, Lui, K, et al. Propofol compared with the morphine, atropine, and suxamethonium regimen as induction agents for neonatal endotracheal intubation: a randomized, controlled trial. Pediatrics. 2007;119: e1248–55.Google Scholar
14.Welzing, L, Kribs, A, Eifinger, F, et al. Propofol as an induction agent for endotracheal intubation can cause significant arterial hypotension in preterm neonates. Paediatr Anaesth. 2010;20:605–11.Google Scholar
15.Kamat, PP, McCracken, CE, Gillespie, SE, et al. Pediatric critical care physician-administered procedural sedation using propofol: a report from the Pediatric Sedation Research Consortium Database. Pediatr Crit Care Med. 2015;16:1120.Google Scholar
16.Saarenmaa, E, Neuvonen, PJ, Huttunen, P, Fellman, V. Ketamine for procedural pain relief in newborn infants. Arch Dis Child Fetal Neonatal Ed. 2001;85: F53–6.Google Scholar
17.Green, SM, Krauss, B. Clinical practice guideline for emergency department ketamine dissociative sedation in children. Ann Emerg Med. 2004;44:460–71.Google Scholar
18.Green, SM, Rothrock, SG, Lynch, EL, et al. Intramuscular ketamine for pediatric sedation in the emergency department: safety profile in 1,022 cases. Ann Emerg Med. 1998;31:688–97.Google Scholar
19.Ghershanik, JJ Boecler, B, Lertora, JJL, et al. Monitoring levels of trichloroethanol during chloral hydrate administration to sick neonates [abstract]. Clin Res. 1981;29:895.Google Scholar
20.Mayers, DJ, Hindmarsh, KW, Sankaran, K, Gorecki, DK, Kasian, GF. Chloral hydrate disposition following single-dose administration to critically ill neonates and children. Dev Pharmacol Ther. 1991;16:71–7.Google Scholar
21.Litman, RS, Soin, K, Salam, A. Chloral hydrate sedation in term and preterm infants: an analysis of efficacy and complications. Anesth Analg. 2010;110:739–46.Google Scholar
22.Napoli, KL, Ingall, CG, Martin, GR. Safety and efficacy of chloral hydrate sedation in children undergoing echocardiography. J Pediatr. 1996;129(2):287–91.Google Scholar
23.Ebert, TJ, Hall, JE, Barney, JA, Uhrich, TD, Colinco, MD. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology. 2000;93:382–94.Google Scholar
24.Chrysostomou, C, Schulman, SR, Herrera Castellanos, M, et al. A phase II/III, multicenter, safety, efficacy, and pharmacokinetic study of dexmedetomidine in preterm and term neonates. J Pediatr. 2014;164:276–82 e1–3.Google Scholar
25.Tobias, JD. Sedation of infants and children outside of the operating room. Curr Opin Anaesthesiol. 2015;28:478–85.Google Scholar
26.Mason, KP, Zurakowski, D, Zgleszewski, SE, et al. High dose dexmedetomidine as the sole sedative for pediatric MRI. Paediatr Anaesth. 2008;18:403–11.Google Scholar
27.Hasegawa, T, Oshima, Y, Maruo, A, et al. Dexmedetomidine in combination with midazolam after pediatric cardiac surgery. Asian Cardiovasc Thorac Ann. 2015;23:802–8.Google Scholar

References

1.American Society of Anesthesiologists. Statement on practice recommendations for pediatric anesthesia, 2011Google Scholar
2.Castro, PE. At what age is ambulatory surgery safe in infants? A survey of practices of pediatric anesthesiology programs in the United States. Society for Pediatric Anesthesia Winter Meeting, 2007Google Scholar
3.Cote, CJ, Zaslavsky, A, Downes, JJ, et al. Postoperative apnea in former preterm infants after inguinal herniorrhaphy: a combined analysis. Anesthesiology. 1995;82:809–22.Google Scholar
4.Kurth, CD, Spitzer, AR, Broennle, AM, Downes, JJ. Postoperative apnea in preterm infants. Anesthesiology. 1987;66:483–8.Google Scholar
5.Davidson, AJ, Morton, NS, Arnup, SJ, et al. Apnea after awake regional and general anesthesia in infants: the general anesthesia compared to spinal anesthesia study – comparing apnea and neurodevelopmental outcomes, a randomized controlled trial. Anesthesiology. 2015;123(1):3854.Google Scholar
6.Welborn, LG, Hannallah, RS, Luban, NL, Fink, R, Ruttimann, UE. Anemia and postoperative apnea in former preterm infants. Anesthesiology. 1991;74:1003–6.Google Scholar
7.Monto, AS, Ullman, BM. Acute respiratory illness in an American community: the Tecumseh study. JAMA. 1974;227:164–9.Google Scholar
8.Bhananker, SM, Ramamoorthy, C, Geiduschek, JM, et al. Anesthesia-related cardiac arrest in children: update from the Pediatric Perioperative Cardiac Arrest Registry. Anesth Analg. 2007;105:344–50.Google Scholar
9.von Ungern-Sternberg, BS, Boda, K, Chambers, NA, et al. Risk assessment for respiratory complications in paediatric anaesthesia: a prospective cohort study. Lancet. 2010;376:773–83.Google Scholar
10.Flick, RP, Wilder, RT, Pieper, SF, et al. Risk factors for laryngospasm in children during general anesthesia. Paediatr Anaesth. 2008;18:289–96.Google Scholar
11.Rachel Homer, J, Elwood, T, Peterson, D, Rampersad, S. Risk factors for adverse events in children with colds emerging from anesthesia: a logistic regression. Paediatr Anaesth. 2007;17:154–61.Google Scholar
12.Mamie, C, Habre, W, Delhumeau, C, Argiroffo, CB, Morabia, A. Incidence and risk factors of perioperative respiratory adverse events in children undergoing elective surgery. Paediatr Anaesth. 2004;14:218–24.Google Scholar
13.Tait, AR, Malviya, S, Voepel-Lewis, T, et al. Risk factors for perioperative adverse respiratory events in children with upper respiratory tract infections. Anesthesiology. 2001;95:299306.Google Scholar
14.Seyidov, TH, Elemen, L, Solak, M, Tugay, M, Toker, K. Passive smoke exposure is associated with perioperative adverse effects in children. J Clin Anesth. 2011;23:4752.Google Scholar
15.Tait, AR, Pandit, UA, Voepel-Lewis, T, Munro, HM, Malviya, S. Use of the laryngeal mask airway in children with upper respiratory tract infections: a comparison with endotracheal intubation. Anesth Analg. 1998;86:706–11.Google Scholar
16.von Ungern-Sternberg, BS, Boda, K, Schwab, C, et al. Laryngeal mask airway is associated with an increased incidence of adverse respiratory events in children with recent upper respiratory tract infections. Anesthesiology. 2007;107:714–19.Google Scholar
17.Hamilton, ND, Hegarty, M, Calder, A, Erb, TO, von Ungern-Sternberg, BS. Does topical lidocaine before tracheal intubation attenuate airway responses in children? An observational audit. Paediatr Anaesth. 2012;22:345–50.Google Scholar
18.Scalfaro, P, Sly, PD, Sims, C, Habre, W. Salbutamol prevents the increase of respiratory resistance caused by tracheal intubation during sevoflurane anesthesia in asthmatic children. Anesth Analg. 2001;93:898902.Google Scholar

References

1.Liu, LM, Coté, CJ, Goudsouzian, NG, et al. Life-threatening apnea in infants recovering from anesthesia. Anesthesiology. 1983;50(5):506–10.Google Scholar
2.Steward, D. Preterm infants are more prone to complications following minor surgery then the term infants. Anesthesiology. 1982;55:304–6.Google Scholar
3.Sims, C, Johnson, CM. Postoperative apnoea in infants. Anaesth Intensive Care. 1994;22(1):40–5.Google Scholar
4.Moriette, G, Lescure, S, El Ayoubi, M, Lopez, E. Apnea of prematurity: what’s new? Arch Pediatr.2010;17(2):186–90. doi: 10.1016/j.arcped.2009.09.016.Google Scholar
5.Daily, WJ, Klaus, M, Meyer, HB. Apnea in premature infants: monitoring, incidence, heart rate changes, and an effect of environmental temperature. Pediatrics. 1969;43(4):510–18.Google Scholar
6.Kerbl, R, Zotter, H, Schenkeli, R, et al. Persistent hypercapnia in children after treatment of obstructive sleep apnea syndrome by adenotonsillectomy. Wiener klinische Wochenschrift. 2001;113(7–8):229–34.Google Scholar
7.Krane, EJ, Haberkern, CM, Jacobson, LE. Postoperative apnea, bradycardia, and oxygen desaturation in formerly premature infants: prospective comparison of spinal and general anesthesia. Anesth Analg. 1995;80(1):713.Google Scholar
8.Mishra, S, Agrwal, R, Jeevasankar, M, et al. Apnea in the newborn. Indian J Pediatr. 2008;75(1):5761.Google Scholar
9.Barrington, K, Finer, N. The natural history of the appearance of apnea of prematurity. Pediatr Res. 1991;29:372–5.Google Scholar
10.Lee, SL, Gleason, JM, Sydorak, RM. A critical review of premature infants with inguinal hernias: optimal timing of repair, incarceration risk, and postoperative apnea. J Pediatr Surg. 2011;46(1):217–20.Google Scholar
11.Gregory, GA, Steward, DJ. Life-threatening perioperative apnea in the ex-“premie”. Anesthesiology. 1983;59(6):495–8.Google Scholar
12.Coté, CJ, Zaslavsky, A, Downes, JJ, et al. Postoperative apnea in former preterm infants after inguinal herniorrhaphy: a combined analysis. Anesthesiology. 1995;82(4):809–22.Google Scholar
13.Coté, CJ, Kelly, DH. Postoperative apnea in a full-term infant with a demonstrable respiratory pattern abnormality. Anesthesiology. 1990;72(3):559–61.Google Scholar
14.Tetzlaff, JE, Annand, DW, Pudimat, MA, Nicodemus, HF. Postoperative apnea in a full-term infant. Anesthesiology. 1988;69(3):426–8.Google Scholar
15.Noseworthy, J, Duran, C, Khine, HH. Postoperative apnea in a full-term infant. Anesthesiology. 1989;70(5):879–80.Google Scholar
16.Rigatto, H, Brady, JP, de la Torre Verduzco, R. Chemoreceptor reflexes in preterm infants: I. The effect of gestational and postnatal age on the ventilatory response to inhalation of 100% and 15% oxygen. Pediatrics. 1975;55(5):604–13.Google Scholar
17.Rigatto, H, Brady, JP, de la Torre Verduzco, R. Chemoreceptor reflexes in preterm infants: II. The effect of gestational and postnatal age on the ventilatory response to inhaled carbon dioxide. Pediatrics. 1975;55(5):614–20.Google Scholar
18.Knill, RL, Gelb, AW. Ventilatory responses to hypoxia and hypercapnia during halothane sedation and anesthesia in man. Anesthesiology. 1978;49(4):244–51.Google Scholar
19.Keens, TG, Chen, V, Patel, P, et al. Cellular adaptations of the ventilatory muscles to a chronic increased respiratory load. J App Physiol. 1978;44(6):905–8.Google Scholar
20.Kurth, CD, LeBard, SE. Association of postoperative apnea, airway obstruction, and hypoxemia in former premature infants. Anesthesiology. 1991;75(1):22–6.Google Scholar
21.James, D, Ma, L. Mandibular reconstruction in children with obstructive sleep apnea due to micrognathia. Plast Reconst Surg. 1997;100(5):1131–7.Google Scholar
22.Joshi, A, Gerhardt, T, Shandloff, P, Bancalari, E. Blood transfusion effect on the respiratory pattern of preterm infants. Pediatrics. 1987(80):79.Google Scholar
23.Henderson-Smart, DJ, Butcher-Puech, MC, Edwards, DA. Incidence and mechanism of bradycardia during apnoea in preterm infants. Arch Dis Child. 1986;61:227–32.Google Scholar
24.Welborn, LG, Greenspun, JC. Anesthesia and apnea: perioperative considerations in the former preterm infant. Pediatr Clin North Am. 1994;41(1):181–98.Google Scholar
25.Davidson, AJ, Morton, NS, Arnup, SJ. Apnea after awake regional and general anesthesia in infants: the general anesthesia compared to spinal anesthesia study – comparing apnea and neurodevelopmental outcomes, a randomized controlled trial. Anesthesiology. 2015;123(1):3854.Google Scholar
26.Craven, PD, Badawi, N, Henderson-Smart, DJ, O’Brien, M. Regional (spinal, epidural, caudal) versus general anaesthesia in preterm infants undergoing inguinal herniorrhaphy in early infancy. Cochrane Database Syst Rev. 2003;3:CD00366.Google Scholar
27.Welborn, LG, Rice, LJ, Hannallah, RS, et al. Postoperative apnea in former preterm infants: prospective comparison of spinal and general anesthesia. Anesthesiology. 1990;72(5):838–42.Google Scholar
28.Murphy, JJ, Swanson, T, Ansermino, M, Milner, R. The frequency of apneas in premature infants after inguinal hernia repair: do they need overnight monitoring in the intensive care unit? J Pediatr Surg. 2008;43(5):865–8.Google Scholar
29.Henderson-Smart, DJ, De Paoli, AG. Prophylactic methylxanthine for prevention of apnoea in preterm infants. Cochrane Database Syst Rev. 2010;12:CD000432.Google Scholar
30.. Johnson, CK. Atropine fever in early infancy. N Engl J Med. 1935;213:620–2.Google Scholar
31.McAuliffe, G, Bissonnette, B, Boutin, C. Should the routine use of atropine before succinylcholine in children be reconsidered? Can J Anaesth. 1995;42(8):724–9.Google Scholar
32.Kleinman, ME, Chameides, L, Schexnayder, SM, et al. American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care science. Circulation. 2010;122:S876S908.Google Scholar

References

1.Concato, J, Shah, N, Horwitz, RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. New Eng J Med. 2000;342(25):1887–92.Google Scholar
2.Dalton, J, Kurz, A. Registry research: the new frenemy. AUA Newsletter. Winter 2011.Google Scholar
3.Shi, Q, Pavey, ES, Carter, RE. Bonferroni-based correction factor for multiple, correlated endpoints. Pharm Stat.;11(4):300–9.Google Scholar
4.Arts, DG, De Keizer, NF, Scheffer, GJ. Defining and improving data quality in medical registries: a literature review, case study, and generic framework. J Am Med Inform Assoc. 2002;9(6):600–11.Google Scholar
5.Senn, S, Graf, E, Caputo, A. Stratification for the propensity score compared with linear regression techniques to assess the effect of treatment or exposure. Stat Med. 2007;26(30):5529–44.Google Scholar
6.Grzywacz, JG, Daniel, SS, Tucker, J, Walls, J, Leerkes, E. Nonstandard work schedules and developmentally generative parenting practices: an application of propensity score techniques. Fam Relat. 2011;60(1):4559.Google Scholar
7.Schneeweiss, S. Sensitivity analysis and external adjustment for unmeasured confounders in epidemiologic database studies of therapeutics. Pharmacoepidemiol Drug Saf. 2006;15(5):291303.Google Scholar
8.Sturmer, T, Glynn, RJ, Rothman, KJ, Avorn, J, Schneeweiss, S. Adjustments for unmeasured confounders in pharmacoepidemiologic database studies using external information. Med Care. 2007;45(10 Supl 2):S158–165.Google Scholar
9.MacKinnon, D. Introduction to Statistical Mediation Analysis. New York: Erlbaum; 2008.Google Scholar
10.Evans, JM, MacDonald, TM. Misclassification and selection bias in case-control studies using an automated database. Pharmacoepidemiol Drug Saf. 1997;6(5):313–18.Google Scholar
11.Leung, WC. Balancing statistical and clinical significance in evaluating treatment effects. Postgrad Med J. 2001;77(905):201–4.Google Scholar
12.Bucher, BT, Guth, RM, Saito, JM, Najaf, T, Warner, BW. Impact of hospital volume on in-hospital mortality of infants undergoing repair of congenital diaphragmatic hernia. Ann Surg. 2010;252(4):635–42.Google Scholar
13.Moss, RL, Dimmitt, RA, Barnhart, DC, et al. Laparotomy versus peritoneal drainage for necrotizing enterocolitis and perforation. New Eng J Med. 2006;354(21):2225–34.Google Scholar
14.Abdullah, F, Zhang, Y, Camp, M, et al. Necrotizing enterocolitis in 20,822 infants: analysis of medical and surgical treatments. Clin Pediatr. 2010;49(2):166–71.Google Scholar
15.Lillehei, CW, Gauvreau, K, Jenkins, KJ. Risk adjustment for neonatal surgery: a method for comparison of in-hospital mortality. Pediatrics. 2012;130(3):e568–74.Google Scholar
16.Bhutta, AT, Rovnaghi, C, Simpson, PM, et al. Interactions of inflammatory pain and morphine in infant rats: long-term behavioral effects. Physiol Behav. 2001;73(1–2):51–8.Google Scholar
17.Johnson, S, Hennessy, E, Smith, R, et al. Academic attainment and special educational needs in extremely preterm children at 11 years of age: the EPICure study. Arch Dis Child Fetal Neonatal Ed. 2009;94(4):F283–9.Google Scholar
18.Johnson, S, Marlow, N. Preterm birth and childhood psychiatric disorders. Pediatr Res. 2011;69(5 Pt 2):11R18R.Google Scholar
19.Filan, PM, Hunt, RW, Anderson, PJ, Doyle, LW, Inder, TE. Neurologic outcomes in very preterm infants undergoing surgery. J Pediatr. 2012;160(3):409–14.Google Scholar
20.Walker, K, Badawi, N, Holland, AJ, Halliday, R. Developmental outcomes following major surgery: what does the literature say? J Paediatr Child Health. 2011;47(11):766–70.Google Scholar
21.Walker, K, Badawi, N, Halliday, R, et al. Early developmental outcomes following major noncardiac and cardiac surgery in term infants: a population-based study. J Pediatr. 2012;161(4):748–52.Google Scholar
22.Anand, KJ, Hansen, DD, Hickey, PR. Hormonal-metabolic stress responses in neonates undergoing cardiac surgery. Anesthesiology. 1990;73(4):661–70.Google Scholar
23.Bouwmeester, NJ, Anand, KJ, van Dijk, M, et al. Hormonal and metabolic stress responses after major surgery in children aged 0–3 years: a double-blind, randomized trial comparing the effects of continuous versus intermittent morphine. Br J Anaesth. 2001;87(3):390–9.Google Scholar
24.Elsinga, RM, Roze, E, Van Braeckel, KN, Hulscher, JB, Bos, AF. Motor and cognitive outcome at school age of children with surgically treated intestinal obstructions in the neonatal period. Early Hum Dev. 2013;89(3):181–5.Google Scholar
25.Blakely, ML, Lally, KP, McDonald, S, et al. Postoperative outcomes of extremely low birth-weight infants with necrotizing enterocolitis or isolated intestinal perforation: a prospective cohort study by the NICHD Neonatal Research Network. Ann Surg. 2005;241(6):984–9.Google Scholar
26.Hintz, SR, Kendrick, DE, Stoll, BJ, et al. Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis. Pediatrics. 2005;115(3):696703.Google Scholar
27.Padley, JR, Cole, AD, Pye, VE, et al. Five-year analysis of operative mortality and neonatal outcomes in congenital heart disease. Heart Lung Circ. 2011;20(7):460–7.Google Scholar
28.Kumar, TK, Charpie, JR, Ohye, RG, et al. Timing of neonatal cardiac surgery is not associated with perioperative outcomes. J Thorac Cardiovasc Surg. 2013;147(5):1573–9.Google Scholar
29.Kaza, AK, Lim, HG, Dibardino, DJ, et al. Long-term results of right ventricular outflow tract reconstruction in neonatal cardiac surgery: options and outcomes. J Thorac Cardiovasc Surg. 2009;138(4):911–16.Google Scholar
30.Ohye, RG, Sleeper, LA, Mahony, L, et al. Comparison of shunt types in the Norwood procedure for single-ventricle lesions. New Eng J Med. 2010;362(21):1980–92.Google Scholar
31.Hovels-Gurich, HH, Konrad, K, Wiesner, M, et al. Long term behavioural outcome after neonatal arterial switch operation for transposition of the great arteries. Arch Dis Child. 2002;87(6):506–10.CrossRefGoogle ScholarPubMed
32.Heinrichs, AK, Holschen, A, Krings, T, et al. Neurologic and psycho-intellectual outcome related to structural brain imaging in adolescents and young adults after neonatal arterial switch operation for transposition of the great arteries. J Thorac Cardiovasc Surg.2014;148(5):2190–9.Google Scholar
33.Hovels-Gurich, HH, Seghaye, MC, Ma, Q, et al. Long-term results of cardiac and general health status in children after neonatal arterial switch operation. Ann Thorac Surg. 2003;75(3):935–43.Google Scholar
34.Anand, KJ, Sippell, WG, Aynsley-Green, A. Randomised trial of fentanyl anaesthesia in preterm babies undergoing surgery: effects on the stress response. Lancet. 1987;1(8527):243–8.Google ScholarPubMed
35.Beggs, S, Currie, G, Salter, MW, Fitzgerald, M, Walker, SM. Priming of adult pain responses by neonatal pain experience: maintenance by central neuroimmune activity. Brain. 2012;135(Pt 2):404–17.Google Scholar
36.Alvares, D, Torsney, C, Beland, B, Reynolds, M, Fitzgerald, M. Modelling the prolonged effects of neonatal pain. Prog Brain Res. 2000;129:365–73.CrossRefGoogle ScholarPubMed
37.Grunau, RE, Holsti, L, Haley, DW, et al. Neonatal procedural pain exposure predicts lower cortisol and behavioral reactivity in preterm infants in the NICU. Pain. 2005;113(3):293300.Google Scholar
38.Walker, SM, Franck, LS, Fitzgerald, M, et al. Long-term impact of neonatal intensive care and surgery on somatosensory perception in children born extremely preterm. Pain. 2009;141(1–2):7987.Google Scholar
39.Anand, KJ, Hall, RW, Desai, N, et al. Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial. Lancet. 2004;363(9422):1673–82.Google Scholar

References

1.Sachdeva, T, Morris, MC. Higher-hazard, no benefit research involving children: parental perspectives. Pediatrics. 2013;132: e1302–9.Google Scholar
2.Wendler, D, Jenkins, T. Children’s and their parents’ views on facing research risks for the benefit of others. Arch Pediatr Adolesc Med. 2008;162:914.Google Scholar
3.Truog, RD. Informed consent and research design in critical care medicine. Crit Care. 1999;3: R29R33.Google Scholar
4.De Lourdes Levy, M, Larcher, V, Kurz, R, Ethics Working Group of the Confederation of European Specialists in Paediatrics. Informed consent/assent in children: statement of the Ethics Working Group of the Confederation of European Specialists in Paediatrics (CESP). Eur J Pediatr. 2003;162:629–33.Google Scholar
5.Miller, VA, Drotar, D, Burant, C, Kodish, E. Clinician–parent communication during informed consent for pediatric leukemia trials. J Pediatr Psychol. 2005;30:219–29.CrossRefGoogle ScholarPubMed
6.DeMauro, SB, Foglia, EE, Schmidt, B. The ethics of neonatal research: a trialists’ perspective. Semin Fetal Neonatal Med. 2015;20:431–5.Google Scholar
7.Psaty, BM, Platt, R, Altman, RB. Neurotoxicity of generic anesthesia agents in infants and children: an orphan research question in search of a sponsor. JAMA. 2015;313:1515–16.Google Scholar
8.Olsen, EA, Brambrink, AM. Anesthetic neurotoxicity in the newborn and infant. Curr Opin Anaesthesiol. 2013;26:535–42.Google Scholar
9.McCann, ME, Bellinger, DC, Davidson, AJ, Soriano, SG. Clinical research approaches to studying pediatric anesthetic neurotoxicity. Neurotoxicology. 2009;30:766–71.Google Scholar
10.Long, Q, Johnson, BA. Variable selection in the presence of missing data: resampling and imputation. Biostatistics. 2015;16:596610.Google Scholar
11.Nelson, R, Staggers, N. Privacy, confidentiality, security, and data integrity. In Nelson, R, Staggers, N, editors. Health Informatics: An Interprofessional Approach. St. Louis, MO: Mosby; 2013.Google Scholar
12.Hartung, DM, Touchette, D. Overview of clinical research design. Am J Health Syst Pharm. 2009;66:398408.Google Scholar
13.Pagano, M Gauvreau, K, editors. Principles of Biostatistics. Pacific Grove, CA: Duxbury Press; 2000.Google Scholar
14.Glover, T Mitchell, K, editors. An Introduction to Biostatistics. Pacific Grove, CA: Duxbury Press; 2000.Google Scholar
15.Sharma, AK, editor. Textbook of Biostatistics: Volume 1. New Delhi: Discovery Publishing; 2008.Google Scholar

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