Fertility, pregnancy and childbirth are connected and inseparable realities that ultimately need to combine to result in a “baby at home”; each one of these phenomena possesses their own suite of challenges and limitations. From a biological viewpoint, the factors contributing to a successful “baby at home” are male factors (mainly sperm quality) and female factors (mainly oocyte quality and endometrial receptivity). Any failure or disability in one of these competences shall likely contribute to the reduced probability of having a “baby at home”. However, in modern times a new factor is playing a crucial role in this scenario, the so called “Artificial Reproduction Techniques” (ART). Thus, it is becoming increasingly possible for reproductive biologists and clinicians to apply a range of technologies to transform a biologically infertile couple to an assisted fertile one. To this purpose, a series of novel technologies, some of them with ethical implications at the time of their use on a routine basis, have and will continue to have a remarkable potential impact on fertility treatments [1].