Prostatic Lesions and Tumors

Section 3 - Prostatic Lesions and Tumors

Published online by Cambridge University Press: 12 February 2019

Edited by

Maria Rosaria Raspollini and

Antonio Lopez-Beltran

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Maria Rosaria Raspollini: Affiliation:
University Hospital Careggi, Florence
Antonio Lopez-Beltran: Affiliation:
Cordoba University Medical School

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Type: Chapter
Information: Gynecologic and Urologic Pathology
Similarities, Differences and Challenges
, pp. 121 - 230

DOI: https://doi.org/10.1017/9781316756423 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2019

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References

Bostwick, G.D., Hull, D., Ma, J., Hossain, D.. Non neoplastic disease of the prostate. In: Bostick, D.G., Cheng, L., editors, Urological Surgical Pathology. Philadelphia, PA: Elsevier; 2014, p. 353–354.Google Scholar

Santoni, M., Scarpelli, M., Mazzucchelli, R., et al. Current histopathologic and molecular characterisations of prostate cancer: towards individualised prognosis and therapies. Eur Urol 2016; 69: 186–190.CrossRef Google Scholar PubMed

Wernert, N., Kern, L., Heitz, P., et al. Morphological and immunohistochemical investigations of the utriculus prostaticus from the fetal period up to adulthood. Prostate 1990; 17: 19–30.CrossRef Google Scholar PubMed

Shapiro, E., Huang, H., McFadden, D.E., et al. The prostatic utricle is not a Müllerian duct remnant: immunohistochemical evidence for a distinct urogenital sinus origin. J Urol 2004; 172: 1753–1756.Google Scholar

Kato, H., Komiyama, I., Maejima, T., Nishizawa, O.. Histopathological study of the müllerian duct remnant: clarification of disease categories and terminology. J Urol 2002; 167: 133–136.Google Scholar

Montironi, R., Mazzucchelli, R., Lopez-Beltran, A., Scarpelli, M., Cheng, L.. Prostatic intraepithelial neoplasia: its morphological and molecular diagnosis and clinical significance. BJU Int 2011; 108: 1394–1401.Google Scholar

Erdamar, S., Slawin, K.M., Wheeler, T.M.. High grade prostatic intraepithelial neoplasia involving the prostatic utricle: a case report. J Urol Pathol 1998; 8: 167–170.Google Scholar

Civantos, F., Marcial, M.A., Banks, E.R., et al. Pathology of androgen deprivation therapy in prostate carcinoma: a comparative study of 173 patients. Cancer 1995; 75: 1634–1641.Google Scholar

Reuter, V.E.. Pathological changes in benign and malignant prostatic tissue following androgen deprivation therapy. Urology 1997; 49: 16–22.CrossRef Google Scholar PubMed

McNeal, J.E.. The zonal anatomy of the prostate. Prostate 1981; 2: 35–49.Google Scholar

Epstein, J.I., Oxley, J., Ro, J.Y., van der Kwast, T., Zhou, M.. Intraductal carcinoma. In: Moch, H., Humphrey, P.A., Ulbright, T.M., Reuter, V.E., editors, WHO Classification of Tumours of the Urinary System and Male Genital Organs. Lyon: WHO Press; 2016, p. 164–165.Google Scholar

Moch, H., Humphrey, P.A., Cubilla, A.L., Ulbright, R.M., Reuter, V.E.. The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs. B: Prostate and bladder tumours. Eur Urol 2016; 70: 106–119.CrossRef Google Scholar

Watts, K., Li, J., Magi-Galluzzi, C., Zhou, M.. Incidence and clinicopathological characteristics of intraductal carcinoma detected in prostate biopsies: a prospective cohort study. Histopathology 2013; 63: 574–579.Google Scholar

Wobker, S.E., Epstein, J.I.. Differential diagnosis of intraductal lesions of the prostate. Am J Surg Pathol 2016; 40: e67–e82.Google Scholar

Morais, C.L., Han, J.S., Gordetsky, J., et al. Utility of PTEN and ERG immunostaining for distinguishing high-grade PIN from intraductal carcinoma of the prostate on needle biopsy. Am J Surg Pathol 2015; 39: 169–178.Google Scholar

Montironi, R., Cheng, L., Scarpelli, M., Lopez-Beltran, A.. Pathology and genetics: tumours of the urinary system and male genital system: clinical implications of the 4th edition of the WHO classification and beyond. Eur Urol 2016; 70: 120–123.Google Scholar

Epstein, J.I.. Prostatic ductal adenocarcinoma: a mini review. Med Princ Pract 2010; 19: 82–85.CrossRef Google Scholar PubMed

Egevad, L., Epstein, J.I., Hameed, O., Humphrey, P.A., Samaratunga, H.. Ductal carcinoma. In: Moch, H., Humphrey, P.A., Ulbright, T.M., Reuter, V.E., editors, WHO Classification of Tumours of the Urinary System and Male Genital Organs. Lyon: WHO Press; 2016, p. 166–167.Google Scholar

Lee, T.K., Miller, J.S., Epstein, J.I.. Rare histological patterns of prostatic ductal adenocarcinoma. Pathology 2010; 42: 319–324.CrossRef Google Scholar PubMed

Lin, J.Z., Wu, H.F., Wang, J.C., et al. Ectopic opening of cystic dilatation of the ejaculatory duct into enlarged prostatic utricle. J Androl 2012; 33: 574–577.CrossRef Google Scholar PubMed

Montironi, R., Lopez-Beltran, A., Cheng, L., Galosi, A.B., Montorsi, F., Scarpelli, M.. Seminal vesicle intraepithelial neoplasia versus basal cell hyperplasia in a seminal vesicle. Eur Urol 2014; 66: 623–627.CrossRef Google Scholar

Sanchez-Salazar, A.J., Basler, J.W., Nicolas, M.M.. Intraductal carcinoma of the prostate in the ejaculatory duct. Int J Surg Pathol 2010; 18: 298–299.CrossRef Google Scholar PubMed

References

Galosi, A.B., Montironi, R., Fabiani, A., et al. Cystic lesions of the prostate gland: an ultrasound classification with pathological correlation. J Urol 2009; 181(2): 647–657.Google Scholar

Shebel, H.M., Farg, H.M., Kolokythas, O., El-Diasty, T.. Cysts of the lower male genitourinary tract: embryologic and anatomic considerations and differential diagnosis. Radiographics 2013; 33(4): 1125–1143.CrossRef Google Scholar PubMed

Nghiem, H.T., Kellman, G.M., Sandberg, S.A., Craig, B.M.. Cystic lesions of the prostate. Radiographics 1990; 10(4): 635–650.Google Scholar

Hamper, U.M., Epstein, J.I., Sheth, S., Walsh, P.C., Sanders, R.C.. Cystic lesions of the prostate gland: a sonographic–pathologic correlation. J Ultrasound Med 1990; 9(7): 395–402.Google Scholar

Paner, G.P., Lopez-Beltran, A., So, J.S., et al. Spectrum of cystic epithelial tumors of the prostate: most cystadenocarcinomas are ductal type with intracystic papillary pattern. Am J Surg Pathol 2016; 40(7): 886–895.Google Scholar

Reikie, B.A., Yilmaz, A., Medlicott, S., Trpkov, K.. Mixed epithelial-stromal tumor (MEST) of seminal vesicle: a proposal for unified nomenclature. Adv Anat Pathol 2015; 22(2): 113–120.Google Scholar

Moch, H.P., Humphery, P. A., Ulbright, T.M., Reuter, V.E., editors. WHO Classification of Tumours of the Urinary System and Male Genital Organs. Geneva, Switzerland: WHO Press; 2016.Google Scholar PubMed

Herawi, M., Epstein, J.I.. Specialized stromal tumors of the prostate: a clinicopathologic study of 50 cases. Am J Surg Pathol 2006; 30(6): 694–704.Google Scholar

Pradhan, S., Tobon, H.. Vaginal cysts: a clinicopathological study of 41 cases. Int J Gynecol Pathol 1986; 5(1): 35–46.CrossRef Google Scholar PubMed

Kondi-Pafiti, A., Grapsa, D., Papakonstantinou, K., Kairi-Vassilatou, E., Xasiakos, D.. Vaginal cysts: a common pathologic entity revisited. Clin Exp Obstet Gynecol 2008; 35(1): 41–44.Google Scholar

Eilber, K.S., Raz, S.. Benign cystic lesions of the vagina: a literature review. J Urol 2003; 170(3): 717–722.Google Scholar

Furuya, R., Furuya, S., Kato, H., et al. New classification of midline cysts of the prostate in adults via a transrectal ultrasonography-guided opacification and dye-injection study. BJU Int 2008; 102(4): 475–478.Google Scholar

Coppens, L., Bonnet, P., Andrianne, R., de Leval, J.. Adult mullerian duct or utricle cyst: clinical significance and therapeutic management of 65 cases. J Urol 2002; 167(4): 1740–1744.Google Scholar

Kang, P.M., Seo, W.I., Yoon, J.H., Kim, T.S., Chung, J.I.. Transutricular seminal vesiculoscopy in the management of symptomatic midline cyst of the prostate. World J Urol 2016; 34(7): 985–992.Google Scholar

Nogueira March, J.L., Figueiredo, L., Mata, J., et al. Coexisting cyst of the utricle and carcinoma of the endometrial type in the prostate. Eur Urol 1982; 8(1): 42–44.Google Scholar

Warmann, S.W., Vogel, M., Wehrmann, M., et al. Giant mullerian duct cyst with malignant transformation in 15-year-old boy. Urology 2006; 67(2): 424e3–424e6.Google Scholar

Lajvardi, A., Theodorescu, D., Older, R.A.. A mullerian duct cyst presenting as a large complex pelvic mass. J Urol 1997; 157(3): 958.Google Scholar

Furuya, S., Hisasue, S., Kato, H., Shimamura, S.. Novel insight for midline cyst formation in prostate: the involvement of decreased prenatal testosterone suggested by second-to-fourth digit ratio study. Int J Urol 2015; 22(11): 1063–1067.Google Scholar

De Marzo, A.M., Platz, E.A., Epstein, J.I., et al. A working group classification of focal prostate atrophy lesions. Am J Surg Pathol 2006; 30(10): 1281–1291.Google Scholar

Milord, R.A., Kahane, H., Epstein, J.I.. Infarct of the prostate gland: experience on needle biopsy specimens. Am J Surg Pathol 2000; 24(10): 1378–1384.Google Scholar

Nouira, Y., Binous, M.Y., Nouira, K., et al. Intraprostatic hydatid cyst: an unusual presentation. Sci World J 2006; 6: 2315–2318.Google Scholar

Shebel, H.M., Elsayes, K.M., Abou El Atta, H.M., Elguindy, Y.M., El-Diasty, T.A.. Genitourinary schistosomiasis: life cycle and radiologic-pathologic findings. Radiographics 2012; 32(4): 1031–1046.Google Scholar

Patel, B., Gujral, S., Jefferson, K., Evans, S., Persad, R.. Seminal vesicle cysts and associated anomalies. BJU Int 2002; 90(3): 265–271.Google Scholar

Sheih, C.P., Hung, C.S., Wei, C.F., Lin, C.Y.. Cystic dilatations within the pelvis in patients with ipsilateral renal agenesis or dysplasia. J Urol 1990; 144(2 Pt 1): 324–327.Google Scholar

Mushtaque, M., Mir, M.F., Nazir, P., Khan, P.S.. Primary isolated echinococcal cyst of the seminal vesicle: a rare case. Urol Ann 2012; 4(2): 122–125.Google Scholar

Melquist, J., Sharma, V., Sciullo, D., McCaffrey, H., Khan, S.A.. Current diagnosis and management of syringocele: a review. Int Braz J Urol 2010; 36(1): 3–9.Google Scholar

Bevers, R.F., Abbekerk, E.M., Boon, T.A.. Cowper’s syringocele: symptoms, classification and treatment of an unappreciated problem. J Urol 2000; 163(3): 782–784.CrossRef Google Scholar PubMed

Sharifi-Aghdas, F., Ghaderian, N.. Female paraurethral cysts: experience of 25 cases. BJU Int 2004; 93(3): 353–356.CrossRef Google Scholar PubMed

Sharifiaghdas, F., Daneshpajooh, A., Mirzaei, M.. Paraurethral cyst in adult women: experience with 85 cases. Urol J 2014; 11(5): 1896–1899.Google Scholar

Molina Escudero, R., Navas Martinez, M.C., Castillo, O.A.. Vaginal Gartner cysts: clinical report of four cases and a bibliographic review. Arch Esp Urol 2014; 67(2): 181–184.Google Scholar PubMed

Rios, S.S., Pereira, L.C., Santos, C.B., et al. Conservative treatment and follow-up of vaginal Gartner’s duct cysts: a case series. J Med Case Rep 2016; 10(1): 147.CrossRef Google Scholar PubMed

Lee, M.Y., Dalpiaz, A., Schwamb, R., et al. Clinical pathology of Bartholin’s glands: a review of the literature. Curr Urol 2015; 8(1): 22–25.Google Scholar

Maluf, H.M., King, M.E., DeLuca, F.R., et al. Giant multilocular prostatic cystadenoma: a distinctive lesion of the retroperitoneum in men: a report of two cases. Am J Surg Pathol 1991; 15(2): 131–135.Google Scholar

Chowdhury, M.M., Abdulkarim, J.A.. Case report: multilocular cystadenoma of the prostate presenting as a giant pelvic mass. Br J Radiol 2009; 82(982): e200–e201.Google Scholar

Allen, E.A., Brinker, D.A., Coppola, D., Diaz, J.I., Epstein, J.I.. Multilocular prostatic cystadenoma with high-grade prostatic intraepithelial neoplasia. Urology 2003; 61(3): 644.Google Scholar

Datta, M.W., Hosenpud, J., Osipov, V., Young, R.H.. Giant multilocular cystadenoma of the prostate responsive to GnRH antagonists. Urology 2003; 61(1): 225.Google Scholar

Henderson-Jackson, E., Sexton, W., Zhang, J., et al. Cystic prostatic ductal adenocarcinoma: an unusual presentation and cytological diagnosis. Ann Clin Lab Sci 2012; 42(1): 81–88.Google Scholar

Tuziak, T., Spiess, P.E., Abrahams, N.A., et al. Multilocular cystadenoma and cystadenocarcinoma of the prostate. Urol Oncol 2007; 25(1): 19–25.Google Scholar

Uguen, A., Doucet, L., Badic, B., et al. Cystic epithelial tumors of the prostate: one case supporting a continuous spectrum from cystadenoma to cystadenocarcinoma with ductal features. Am J Surg Pathol 2016; 40(12): 1719–1721.Google Scholar

Bostwick, D.G., Hossain, D., Qian, J., et al. Phyllodes tumor of the prostate: long-term followup study of 23 cases. J Urol 2004; 172(3): 894–899.CrossRef Google Scholar PubMed

Paner, G.P., Aron, M., Hansel, D.E., Amin, M.B.. Non-epithelial neoplasms of the prostate. Histopathology 2012; 60(1): 166–186.Google Scholar

Lorber, G., Pizov, G., Gofrit, O.N., Pode, D.. Seminal vesicle cystadenoma: a rare clinical perspective. Eur Urol 2011; 60(2): 388–391.Google Scholar

Mazur, M.T., Myers, J.L., Maddox, W.A.. Cystic epithelial-stromal tumor of the seminal vesicle. Am J Surg Pathol 1987; 11(3): 210–217.Google Scholar

Sterling, M.E., Kovell, R.C., Jaffe, W.I.. Primary seminal vesicle adenocarcinoma presenting with bilateral orbital metastasis: a case report. Urol Case Rep 2016; 6: 33–35.Google Scholar

Egevad, L., Ehrnstrom, R., Hakansson, U., Grabe, M.. Primary seminal vesicle carcinoma detected at transurethral resection of prostate. Urology 2007; 69(4): 778e11–778e13.Google Scholar

Thiel, R., Effert, P.. Primary adenocarcinoma of the seminal vesicles. J Urol 2002; 168(5): 1891–1896.CrossRef Google Scholar PubMed

Korytko, T.P., Lowe, G.J., Jimenez, R.E., Pohar, K.S., Martin, D.D.. Prostate-specific antigen response after definitive radiotherapy for Skene’s gland adenocarcinoma resembling prostate adenocarcinoma. Urol Oncol 2012; 30(5): 602–606.Google Scholar

Bhalwal, A.B., Nick, A.M., Dos Reis, R., et al. Carcinoma of the Bartholin gland: a review of 33 cases. Int J Gynecol Cancer 2016; 26(4): 785–789.CrossRef Google Scholar PubMed

Bague, S., Rodriguez, I.M., Prat, J.. Malignant mesonephric tumors of the female genital tract: a clinicopathologic study of 9 cases. Am J Surg Pathol 2004; 28(5): 601–607.Google Scholar

Devouassoux-Shisheboran, M., Silver, S.A., Tavassoli, F.A.. Wolffian adnexal tumor, so-called female adnexal tumor of probable Wolffian origin (FATWO): immunohistochemical evidence in support of a Wolffian origin. Hum Pathol 1999; 30(7): 856–863.Google Scholar

References

McCluggage, W.G.. Mullerian adenosarcoma of the female genital tract. Adv Anat Pathol 2010; 17: 122–129.Google Scholar

Wells, M., Oliva, E., Palacios, J., Prat, J.. Tumours of the uterine corpus: mixed epithelial and mesenchymal tumours. In: Kurman, R.J., Carcangiu, M.L., Herrington, C.S., Young, R.H., editors, WHO Classification of Tumours of Female Reproductive Organs. Lyon: WHO Press; 2014, p. 148–151.Google Scholar

Herawi, M., Montgomery, E.A., Epstein, J.I.. Gastrointestinal stromal tumors (GISTs) on prostate needle biopsy: a clinicopathologic study of 8 cases. Am J Surg Pathol 2006; 30: 1389–1395.Google Scholar

Cheville, J., Algaba, F., Epstein, J.I., Lopez-Beltran, A.. Tumours of the prostate: mesenchymal tumours. In: Moch, H., Humphrey, P.A., Ulbright, T.M., Reuter, V.E., editors, WHO Classification of Tumours of the Urinary System and Male Genital Organs. Lyon: WHO Press; 2016, p. 175–177.Google Scholar

Hansel, D.E., Herawi, M., Montgomery, E.A., Epstein, J.I.. Spindle cell lesions of the adult prostate. Mod Pathol 2007; 20: 148–158.Google Scholar

Herawi, M., Epstein, J.I.. Specialized stromal tumors of the prostate: a clinicopathologic study of 50 cases. Am J Surg Pathol 2006; 30: 694–704.Google Scholar

Reikie, B.A., Yilmaz, A., Medlicott, S., Trpkov, K.. Mixed epithelial-stromal tumor (MEST) of seminal vesicle: a proposal for unified nomenclature. Adv Anat Pathol 2015; 22: 113–120.Google Scholar

Bostwick, D.G., Hossain, D., Qian, J., et al. Phyllodes tumor of the prostate: long-term followup study of 23 cases. J Urol 2004; 172: 894–899.CrossRef Google Scholar PubMed

Gaudin, P.B., Rosai, J., Epstein, J.I.. Sarcomas and related proliferative lesions of specialized prostatic stroma: a clinicopathologic study of 22 cases. Am J Surg Pathol 1998; 22: 148–162.Google Scholar

Dundore, P.A., Cheville, J.C., Nascimento, A.G., Farrow, G.M., Bostwick, D.G.. Carcinosarcoma of the prostate: report of 21 cases. Cancer 1995; 76: 1035–1042.Google Scholar

Hansel, D.E., Epstein, J.I.. Sarcomatoid carcinoma of the prostate: a study of 42 cases. Am J Surg Pathol 2006; 30: 1316–1321.Google Scholar

Shannon, R.L., Ro, J.Y., Grignon, D.J., et al. Sarcomatoid carcinoma of the prostate: a clinicopathologic study of 12 patients. Cancer 1992; 69: 2676–2682.Google Scholar

Baschinsky, D.Y., Niemann, T.H., Maximo, C.B., Bahnson, R.R.. Seminal vesicle cystadenoma: a case report and literature review. Urology 1998; 51: 840–845.Google Scholar

References

Lazzara-Hernandez, O., Molberg, K.H., Lindberg, G., et al. Ectopic prostatic tissue in the uterine cervix. Int J Gynecol Pathol 1997; 16: 291–293.Google Scholar

Nucci, M.R., Ferry, J.A., Young, R.H.. Ectopic prostatic tissue in the uterine cervix: report of four cases and review of ectopic prostatic tissue. Am J Surg Pathol 2000; 24: 1224–1230.Google Scholar

McCluggage, G., Ganesan, R., Hirschowitz, L., et al. Ectopic prostatic tissue in the uterine cervix and vagina: report of a series with a detailed immunohistochemical analysis. Am J Surg Pathol 2006; 30: 209–215.Google Scholar

McCluggage, G., Young, R.H.. Tubulo-squamous polyps: a report of ten cases of a distinctive hitherto uncharacterized vaginal polyps. Am J Surg Pathol 2007; 31: 1013–1019.Google Scholar

Kelly, P., McBride, H.A., Kennedy, K., et al. Misplaced Skene’s glands: glandular elements in the lower female genital tract that are variably immunoreactive with prostate markers and that encompass vaginal tubulosquamous polyps and cervical ectopic prostatic tissue. Int J Gynecol Pathol 2011; 30: 605–612.Google Scholar

Kazarov, D.V., Stewart, C.J.R., Kacerovska, D., et al. Prostatic-type tissue in the lower female genital tract: a morphologic spectrum, including vaginal rubulosquamous polyp, adenomyomatous hyperplasia of paraurethral Skene glands (female prostate), and ectopic lesion in the vulva. Am J Surg Pathol 2010; 34: 950–955.Google Scholar

Pongtippan, A., Malpica, A., Levenback, C., et al. Skene’s gland adenocarcinoma resembling prostatic adenocarcinoma. Int J Gynecol Pathol 2004; 23: 71–74.Google Scholar

Kim, K.R., Park, K.H., Kim, J.W., Cho, K.J., Ro, J.Y.. Transitional cell metaplasia and ectopic prostatic tissue in the uterine cervix and vagina in a patient with adrenogenital syndrome: report of a case suggesting a possible role of androgen in the histogenesis. Int J Gynecol Pathol 2004; 23: 182–187.CrossRef Google Scholar

Vadmal, M., Hajdu, S.I.. Prostatic tissue in benign cystic ovarian teratoma. Hum Pathol 1996; 27: 428–429.CrossRef Google Scholar

McLachlin, C.M., Srigley, J.R.. Prostatic tissue in mature cystic teratomas of the ovary. Am J Surg Pathol 1992; 16: 780–784.Google Scholar

Nogales, F.F., Vergara, E., Medina, M.T.. Prostate in ovarian mature cystic teratoma. Histopathology 1995; 26: 373–375.Google Scholar

Halabi, M., Oliva, E., Mazal, P.R., et al. Prostatic tissue in mature cystic teratomas of the ovary: a report of four cases, including one with features of prostatic adenocarcinoma, and cytogenetic studies. Int J Gynecol Pathol 2002; 21: 261–267.CrossRef Google Scholar PubMed

Smith, C.E., Toplis, P.J., Nogales, F.F.. Ovarian prostatic tissue originating from ilar mesonephric rests. Am J Surg Pathol 1999; 23: 232–236.Google Scholar

Halat, S., Eble, J.N., Grignon, D.J., et al. Ectopic prostatic tissue: histogenesis and histopathological characteristics. Histopathology 2011; 58: 750–758.Google Scholar

Gledhill, A.. Ectopic prostatic tissue. J Urol 1985; 133: 110–111.Google Scholar

Milburn, J.M., Bluth, E.I., Mitchell, W.T. Jr. Ectopic prostate in the testicle: an unusual cause of a solid testicula mass on ultrasonography. J Ultrasound Med 1994; 13: 578–580.Google Scholar

Vogel, U., Negri, G., Bultmann, B.. Ectopic prostatic tissue in the spleen. Virchows Arch 1996; 427: 543–545.Google Scholar

Bromberg, W.D., Kozlowski, J.M., Oyasu, R.. Prostate-type gland in the epididymis. J Urol 1991; 145: 1273–1274.CrossRef Google Scholar PubMed

Salem, C.E., Gibbs, P.M., Highshaw, R.A., et al. Benign ectopic prostatic tissue involving the seminal vesicle in a patient with prostate cancer: recognition and implications for staging. Urology 1996; 48 490–493.Google Scholar

Gutierrez, J., Nesbit, R.M.. Ectopic prostatic tissue in bladder. J Urol 1967; 98: 474–478.Google Scholar

Ishibe, T.. Ectopic prostate tissue in retrotrigone of the bladder. Eur Urol 1998; 15: 159–160.Google Scholar

Klein, H.Z., Rosemberg, M.L.. Ectopic prostatic tissue in bladder trigone: distinctive cause of hematuria. Urology 1984; 23: 81–82.Google Scholar

Roy, C., Guth, S., Gasser, B., et al. Benign hyperplasia in ectopic prostatic tissue: a rare cause of pelvic mass. Eur Radiol 1997; 7: 35–37.Google Scholar

Adams, J.R. Jr. Adenocarcinoma in ectopic prostate tissue. J Urol 1993; 150: 998–999.Google Scholar

Unger, P.D., Cohen, E.L., Taleman, A.. Mixed germ cell tumor of the testis. A unique combination of seminoma and teratoma composed predominantly of prostatic tissue. J Urol Pathol 1998; 9: 257–263.Google Scholar

References

Huffman, J.W.. Mesonephric remnants in the cervix. Am J Obstet Gynecol 1948; 56: 23–40.Google Scholar

Sneeden, V.D.. Mesonephric lesions of the cervix. A pratical means of demonstration and a suggestion of incidence. Cancer 1958; 11: 334–336.Google Scholar

Jones, M.A., Andrews, J., Tarraza, H.M.. Mesonephric remnants hyperplasia of the cervix: a clinicopathologic analysis of 14 cases. Gynecol Oncol 1993; 49: 41–47.Google Scholar

Welsh, T., Shi Fu, Y., Chan, J., et al. Mesonephric remnants or hyperplasia can cause abnormal pap smear: a study of three cases. Int J Gynecol Pathol 2003; 22: 121–126.Google Scholar

Ferry, J.A., Scully, R.E.. Mesonephric remnants, hyperplasia, and neoplasia in the uterine cervix: a study of 409 cases. Am J Surg Pathol 1990; 14: 1100–1111.Google Scholar

Clement, P.B., Young, R.H., Keh, P., et al. Malignant mesonephric neoplasms of the uterine cervix: a report of eight cases, including four with a malignant spindle cell component. Am J Surg Pathol 1995; 19: 1158–1171.Google Scholar

Kenny, S.L., McBride, H.A., Jamison, J., et al. Mesonephric adenocarcinoma of the uterine cervix and corpus: HPV-negative neoplasms that are commonly PAX8, CA125, and HMGA2 positive and that may be immunoreactive with ttf1 and hepatocyte nuclear factor 1-beta. Am J Surg Pathol 2012; 36: 799–807.Google Scholar

Silver, S.A., Devouassoux-Shisheboran, M., Mezzetti, T.P., et al. Mesonephric adenocarcinomas of the uterine cervix: a study of 11 cases with immunohistochemical findings. Am J Surg Pathol 2001; 25: 379–387.Google Scholar

McCluggage, W.G., Ganesan, R., Hirschowitz, L., Miller, K., Rollason, T.P.. Ectopic prostatic tissue in the uterine cervix and vagina: report of a series with a detailed immunohistochemical analysis. Am J Surg Pathol 2006; 30: 209–215.Google Scholar

Bostwick, D.G., Qian, J., Ma, J., Muir, T.E.. Mesonephric remnants of the prostate: incidence and histologic spectrum. Mod Pathol 2003; 16: 630–635.Google Scholar

Val-Bernal, J.F., Gómez-Ortega, J.M.. Hyperplasia of prostatic mesonephric remnants: a potential pitfall in the evaluation of prostate gland biopsy. J Urol 1995; 154: 1138–1139.Google Scholar

Malpica, A., Ro, J.Y., Troncoso, P., et al. Nephrogenic adenoma of the prostatic urethra involving the prostate gland: a clinicopathologic and immunohistochemical study of eight cases. Hum Pathol 1994; 25: 390–395.Google Scholar

Gikas, P.W., Del Buono, E.A., Epstein, J.I.. Florid hyperplasia of mesonephric remnants involving prostate and periprostatic tissue. Possible confusion with adenocarcinoma. Am J Surg Pathol 1993; 17: 454–460.Google Scholar

References

Risbridger, G.P., Davis, I.D., Birrell, S.N., et al. Breast and prostate cancer: more similar than different. Nat Rev Cancer 2010; 10: 205–212.Google Scholar

McNeal, J.E.. Normal histology of the prostate. Am J Surg Pathol 1988; 12: 619–633.Google Scholar

McNeal, J.E.. Regional morphology and pathology of the prostate. Am J Clin Pathol 1968; 49: 347–357.Google Scholar

Schnitt, S. J., Millis, R.R., Hanby, A. M., et al. The breast. In: Mills, S.E., editor, Diagnostic Surgical Pathology, 4th edn. Philadelphia, PA: Lippincott Williams & Wilkins; 2004, p. 323–395.Google Scholar

Epstein, J.I.. Diagnosis and reporting of limited adenocarcinoma of the prostate on needle biopsy. Mod Pathol 2004; 17: 307–315.Google Scholar

Wright, G.L., Haley, C., Beckett, M.L., et al. Expression of prostate-specific membrane antigen in normal, benign, and malignant prostate tissues. Urol Oncol 1995; 1: 18–28.Google Scholar

Deftos, L.J., Granin, A.. Parathyroid hormone-related protein, and calcitonin gene products in neuroendocrine prostate cancer. Prostate 1998; S8: 23–31.Google Scholar

Xue, Y., Smedts, F., Verhofstad, A., et al. Cell kinetics of prostate exocrine and neuroendocrine epithelium and their differential interrelationship: new perspectives. Prostate 1998; S8: 62–73.Google Scholar

Isaacs, J.T., Coffey, D.S.. Etiology and disease process of benign prostatic hyperplasia. Prostate Suppl 1989; 2: 33–50.Google Scholar

Algaba, F.. Pathophysiology of benign prostatic hyperplasia. Eur Urol 1994; S1: 3–5.Google Scholar

Chagas, M.A., Babinski, M.A., Costa, W.S., et al. Stromal and acinar components of the transition zone in normal and hyperplastic human prostate. BJU Int 2002; 89: 699–702.CrossRef Google Scholar PubMed

Rosenblum, M.K., Purrazzella, R., Rosen, P.P.. Is microglandular adenosis a precancerous disease?: a study of carcinoma arising therein. Am J Surg Pathol 1986; 10: 237–245.Google Scholar

Montironi, R., Mazzucchelli, R., Algaba, F., et al. Morphological identification of the patterns of prostatic intraepithelial Neoplasia and their importance. J Clin Pathol 2000; 53: 655–665.Google Scholar

Epstein, J.I., Grignon, D.J., Humphrey, P.A., et al. Interobserver reproducibility in the diagnosis of prostatic intraepithelial neoplasia. Am J Surg Pathol 1995; 19: 873–886.Google Scholar

Epstein, J.I.. Precursor lesions to prostatic adenocarcinoma. Virchows Arch 2009; 454: 1–16.Google Scholar

Tavassoli, F.A., Norris, H.J.. A comparison of the results of long-term follow-up for atypical intraductal hyperplasia and intraductal hyperplasia of the breast. Cancer 1990; 65: 518–529.Google Scholar

Page, D.L., Dupont, W.D., Rogers, L.W., et al. Atypical hyperplastic lesions of the female breast: a long-term follow-up study. Cancer 1985; 55: 2698–2708.Google Scholar

Lakhani, S.R., Ellis, I.O., Schnitt, S.J., et al., editors. WHO Classification of Tumours of the Breast. Lyon: IARC Press; 2012.Google Scholar

Algaba, F., Epstein, J.I., Aldape, H.C., et al. Assessment of prostate carcinoma in core needle biopsy: definition of minimal criteria for the diagnosis of cancer in biopsy material. Cancer 1996; 78: 376–381.Google Scholar

Thorson, P., Humphrey, P.A.. Minimal adenocarcinoma in prostate needle biopsy tissue. Am J Clin Pathol 2000; 114: 896–909.Google Scholar

McNeal, J.E., Redwine, E.A., Freiha, F.S., et al. Zonal distribution of prostatic adenocarcinoma: correlation with histologic pattern and direction of spread. Am J Surg Pathol 1988; 12: 897–906.Google Scholar

Abdelsayed, G.A., Danial, T., Kaswick, J.A., et al. Tumors of the anterior prostate: implications for diagnosis and treatment. Urology 2015; 85: 1224–1228.Google Scholar

Erbersdobler, A., Augustin, H., Schlomm, T., et al. Prostate cancers in the transition zone. Part 1: pathological aspects. BJU Int 2004; 94: 1221–1225.Google Scholar

Egawa, S., Takashima, R., Matsumoto, K., et al. Infrequent involvement of the anterior base in low-risk patients with clinically localized prostate cancer and its possible significance in definitive radiation therapy. Jpn J Clin Oncol 2000; 30: 126–130.Google Scholar

Arora, R., Koch, M.O., Eble, J.N., et al. Heterogeneity of Gleason grade in multifocal adenocarcinoma of the prostate. Cancer 2004; 1(100): 2362–2366.Google Scholar

Noguchi, M., Stamey, T.A., McNeal, J.E., et al. Prognostic factors for multifocal prostate cancer in radical prostatectomy specimens: lack of significance of secondary cancers. J Urol 2003; 170: 459–463.Google Scholar

Epstein, J.I., Egevad, L., Amin, M.B., et al.; Grading Committee. The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: definition of grading patterns and proposal for a new grading system. Am J Surg Pathol 2016; 40: 244–252.Google Scholar

Epstein, J.I., Zelefsky, M.J., Sjoberg, D.D., et al. A contemporary prostate cancer grading system: a validated alternative to the Gleason score. Eur Urol 2016; 69: 428–435.Google Scholar

Bloom, H.J., Richardson, W.W.. Histological grading and prognosis in breast cancer: a study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer 1957; 11: 359–377.Google Scholar

Elston, C.W., Ellis, I.O.. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 1991; 19: 403–410.Google Scholar

Guo, C.C, Epstein, J.I.. Intraductal carcinoma of the prostate on needle biopsy: histologic features and clinical significance. Mod Pathol 2006; 19: 1528–1535.Google Scholar

Varma, M., Egevad, L., Algaba, F., et al. Intraductal carcinoma of prostate reporting practice: a survey of expert European uropathologists. J Clin Pathol 2016; 69: 852–857.Google Scholar

The Consensus Conference Committee. Consensus Conference on the Classification of Ductal Carcinoma In Situ. Cancer 1990; 80: 1798–1802.Google Scholar

Humphrey, P.A.. Histological variants of prostatic carcinoma and their significance. Histopathology 2012; 60: 59–74.Google Scholar

Sorlie, T., Perou, C.M., Tibshirani, R., et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001; 98: 10869–10874.Google Scholar

Sotiriou, C., Pusztai, L.. Gene-expression signatures in breast cancer. N Engl J Med 2009; 360: 790–800.Google Scholar

Herawi, M., Epstein, J.I.. Specialized stromal tumors of the prostate: a clinicopathologic study of 50 cases. Am J Surg Pathol 2006; 30: 694–704.Google Scholar

Bates, A.W., Baithun, S.I.. Secondary solid neoplasms of the prostate: a clinico-pathological series of 51 cases. Virchows Arch 2002; 440: 392–396.Google Scholar

Fraga-Guedes, C., Gobbi, H., Mastropasqua, M.G., et al. Primary and secondary angiosarcomas of the breast: a single institution experience. Breast Cancer Res Treat 2011; 132: 1081–1088.Google Scholar

Di Bonito, L., Luchi, M., Giarelli, L., et al. Metastatic tumors to the female breast: an autopsy study of 12 cases. Pathol Res Pract 1991; 187: 432–436.Google Scholar

Hajdu, S.I., Urban, J.A.. Cancers metastatic to the breast. Cancer 1972; 9: 1961–1966.Google Scholar

Aras, E.C., Ali, I.S., Mehmet, A.K., et al. Metastatic tumors in the breast: report of 5 cases and review of the literature. Clin Breast Cancer 2007; 7: 638–643.Google Scholar

Macklin, M.T.. The genetic basis of human mammary cancer. In: Proceedings of the Second National Cancer Conference. New York: American Chemical Society; 1954, p. 1074–1087.Google Scholar

Thiessen, E.U.. Concerning a familial association between breast cancer and both prostatic and uterine malignancies. Cancer 1974; 34: 1102–1107.Google Scholar

Tulinius, H., Egilsson, V., Olafsdóttir, G.H., et al. Risk of prostate, ovarian, and endometrial cancer among relatives of women with breast cancer. Br Med J 1992; 305(6858): 855–857.Google Scholar

Anderson, D.E., Badzioch, M.D.. Breast cancer risks in relatives of male breast cancer patients. J Natl Cancer Inst 1992; 84: 1114–1117.Google Scholar

Andrieu, N., Clave, F., Auquier, A., et al. Association between breast cancer and family malignancies. Eur J Cancer 1991; 27: 244–248.Google Scholar

Rosenblatt, K.A., Thomas, D.B., McTiernan, A., et al. Breast cancer in men: aspects of familial aggregation. J Natl Cancer Inst 1991; 83: 849–854.Google Scholar

López-Otín, C., Diamandis, E.P.. Breast and prostate cancer: an analysis of common epidemiological, genetic, and biochemical features. Endocr Rev 1998; 19: 365–396.Google Scholar

Wooster, R., Mangion, J., Eeles, R., et al. A germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifenstein syndrome. Nat Genet 1992; 2: 132–134.Google Scholar

Lobaccaro, J.M., Lumbroso, S., Belon, C., et al. Androgen receptor gene mutation in male breast cancer. Hum Mol Genet 1993; 2: 1799–1802.Google Scholar

Lobaccaro, J.M., Lumbroso, S., Belon, C., et al. Male breast cancer and the androgen receptor gene. Nat Genet 1993; 5: 109–110.Google Scholar

Hall, R.E., Aspinall, J.O., Horsfall, D.J., et al. Expression of the androgen receptor and an androgen-responsive protein, apolipoprotein D, in human breast cancer. Br J Cancer 1996; 74: 1175–1180.Google Scholar

Zhu, X., Daffada, A.A., Chan, C.M., et al. Identification of an exon 3 deletion splice variant androgen receptor mRNA in human breast cancer. Int J Cancer 1997; 72: 574–580.Google Scholar

Mersch, J., Jackson, M.A., Park, M., et al. Cancers associated with BRCA1 and BRCA2 mutations other than breast and ovarian. Cancer 2015; 121: 269–275.Google Scholar

Walker, R.A., Jones, J.L., Chappell, S., et al. Molecular pathology of breast cancer and its application to clinical management. Cancer Metastasis Rev 1997; 16: 5–27.Google Scholar

Barbacid, M.. Ras genes. Annu Rev Biochem 1987; 56: 779–827.Google Scholar

Spencer, C.A., Groudine, M.. Control of c-myc regulation in normal and neoplastic cells. Adv Cancer Res 1991; 56: 1–48.Google Scholar

Barbier, C.E., Tomlins, S.A.. The prostate cancer genome: perspectives and potential. Urol Oncol 2014; 32(53): e15–e22.Google Scholar

Jonsson, G., Staaf, J., Vallon-Christersson, J., et al. Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics. Breast Cancer Res 2010; 12: R42.Google Scholar

Andre, F., Job, B., Dessen, P., et al. Molecular characterization of breast cancer with high-resolution oligonucleotide comparative genomic hybridization array. Clin Cancer Res 2009; 15: 441–451.Google Scholar

Partin, A.W., Catan, M.W., Subong, E.N.P., et al. Combination of prostate specific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer: a multi-institutional up-date. JAMA 1997; 277: 1445–1451.Google Scholar

Kakehi, Y., Kamoto, T., Okuno, H., et al. Peri-operative frozen section examination of pelvic nodes is unnecessary for the majority of clinically localized prostate cancers in the prostate-specific antigen era. Int J Urol 2000; 7: 281–286.Google Scholar

Beissner, R.S., Stricker, J.B., Speights, V.O., et al. Frozen section diagnosis of metastatic prostate adenocarcinoma in pelvis lymphadenectomy compared with nomogram prediction of metastasis. Urology 2002; 59: 721–725.Google Scholar

Fasolis, G., Degiuli, P., Lancia, M., et al. Periprostatic tissues intraoperative frozen section during retrograde radical retropubic prostatectomy. Arch Ital Urol Androl 2006; 78: 107–111.Google Scholar

Dillenburg, W., Poulakis, V., Witzsch, U., et al. Laparoscopic radical prostatectomy: the value of intraoperative frozen sections. Eur Urol 2005; 48: 614–621.Google Scholar

Shah, O., Melamed, J., Lepor, H.. Analysis of apical soft tissue margins during radical retropubic prostatectomy. J Urol 2001; 165: 1943–1948.Google Scholar

Giuliano, A.E., Hunt, K.K., Ballman, K.V., et al. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA 2011; 305: 569–575.Google Scholar

Tsujimoto, M., Nakabayashi, K., Yoshidome, K., et al. One-step nucleic acid amplification for intraoperative detection of lymph node metastasis in breast cancer patients. Clin Cancer Res 2007; 13: 4807–4816.Google Scholar

Visser, M., Jiwa, M., Horstman, A., et al. Intra-operative rapid diagnostic method based on CK19 mRNA expression for the detection of lymph node metastases in breast cancer. Int J Cancer 2008; 122: 2562–2567.Google Scholar

Schem, C., Maass, N., Bauerschlag, D. O., et al. One-step nucleic acid amplification-a molecular method for the detection of lymph node metastases in breast cancer patients; results of the German study group. Virchows Arch 2009; 454: 203–210.Google Scholar

Peg, V., Espinosa-Bravo, M., Vieites, B., et al. Intraoperative molecular analysis of total tumor load in sentinel lymph node: a new predictor of axillary status in early breast cancer patients. Breast Cancer Res Treat 2013; 139: 87–93.Google Scholar

Espinosa-Bravo, M., Sansano, I., Pérez-Hoyos, S., et al. Prediction of non-sentinel lymph node metastasis in early breast cancer by assessing total tumoral load in the sentinel lymph node by molecular assay. Eur J Surg Oncol 2013; 39: 766–773.Google Scholar

Rubio, I.T., Espinosa-Bravo, M., Rodrigo, M., et al. Nomogram including the total tumoral load in the sentinel nodes assessed by one-step nucleic acid amplification as a new factor for predicting nonsentinel lymph node metastasis in breast cancer patients. Breast Cancer Res Treat 2014; 147: 371–380.Google Scholar

Piñero, A., Canteras, M., Moreno, A., et al. Multicenter validation of two nomograms to predict non-sentinel node involvement in breast cancer. Clin Transl Oncol 2013; 15: 117–123.Google Scholar

Jacobs, L.. Positive margins: the challenge continues for breast surgeons. Ann Surg Oncol 2008; 15: 1271–1272.Google Scholar

Pleijhuis, R.G., Graafland, M., de Vries, J., et al. Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions. Ann Surg Oncol 2009; 16: 2717–2730.Google Scholar

Trpkov, K., Thompson, J., Kulaga, A., et al. How much tissue sampling is required when unsuspected minimal prostate carcinoma is identified on transurethral resection? Arch Pathol Lab Med 2008; 132: 1313–1316.Google Scholar

Samaratunga, H., Montironi, R., True, L., et al. International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 1: specimen handling. Mod Pathol 2011; 24: 6–15.Google Scholar

Azu, M., Abrahamse, P., Katz, S.J., et al. What is an adequate margin for breast-conserving surgery? Surgeon attitudes and correlates. Ann Surg Oncol 2010; 17: 558–563.Google Scholar

Weaver, D.L.. Pathology evaluation of sentinel lymph nodes in breast cancer: protocol recommendations and rationale. Mod Pathol 2010; 23(Suppl 2): S26–S32.Google Scholar

Weaver, D.L., Ashikaga, T., Krag, D.N., et al. Effect of occult metastases on survival in node-negative breast cancer. N Engl J Med 2011; 364: 412–421.Google Scholar

Giuliano, A.E., Hawes, D., Ballman, K.V., et al. Association of occult metastases in sentinel lymph nodes and bone marrow with survival among women with early-stage invasive breast cancer. JAMA 2011; 306: 385–393.Google Scholar

Weaver, D.L., Ashikaga, T., Krag, D.N., et al. Effect of occult metastases on survival in node-negative breast cancer. N Engl J Med 2011; 364: 412–421.Google Scholar

References

Moch, H., Humphrey, P., Ulbright, T.M., Reuter, V.E. (editors). WHO Classification of Tumours of the Urinary System and Male Genital Organs, 4th edn. Lyon: IARC; 2016.Google Scholar

Kattan, M.W., Reuter, V., Motzer, R.J., Katz, J., Russo, P.. A postoperative prognostic nomogram for renal cell carcinoma. J Urol 2001; 166: 63–67.Google Scholar

Leibovich, B.C., Blute, M.L., Cheville, J.C., et al. Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma: a stratification tool for prospective clinical trials. Cancer 2003; 97: 1663–1671.Google Scholar

Kim, S.P., Weight, C.J., Leibovich, B.C., et al. Outcomes and clinicopathologic variables associated with late recurrence after nephrectomy for localised renal cell carcinoma. Urology 2011; 78: 1101–1106.Google Scholar

Ross, H., Martignoni, G., Argani, P.. Renal cell carcinoma with clear cell and papillary features. Arch Pathol Lab Med 2012; 136: 391–399.Google Scholar

Suzigan, S., López-Beltrán, A., Montironi, R., et al. Multilocular cystic renal cell carcinoma: a report of 45 cases of kidney tumor of low malignant potential. Am J Clin Pathol 2006; 125: 217–222.Google Scholar

Williamson, S.R., Halat, S., Eble, J.N., et al. Multilocular cystic renal cell carcinoma: similarities and differences in immunoprofile compared with clear cell renal cell carcinoma. Am J Surg Pathol 2012; 36: 1425–1433.Google Scholar

Williamson, S.R., MacLennan, G.T., Lopez-Beltran, A., et al. Cystic partially regressed clear cell renal cell carcinoma: a potential mimic of multilocular cystic renal cell carcinoma. Histopathology 2013; 63: 767–779.Google Scholar

Mazzucchelli, R., Scarpelli, M., Montironi, R., Cheng, L., Lopez-Beltran, A.. Multilocular cystic renal cell neoplasms of low malignant potential. Anal Quant Cytopathol Histopathol 2012; 34: 235–258.Google Scholar

Halat, S., Eble, J.N., Grignon, D.J., et al. Multilocular cystic renal cell carcinoma is a subtype of clear cell renal cell carcinoma. Mod Pathol 2010; 23: 931–936.Google Scholar

Srigley, J.R., Delahunt, B., Eble, J.N., et al. The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia. Am J Surg Pathol 2013; 37: 1469–1489.Google Scholar

Montironi, R., Mazzucchelli, R., Scarpelli, M., Lopez-Beltran, A., Cheng, L.. Update on selected renal cell tumors with clear cell features with emphasis on multilocular cystic clear cell renal cell carcinoma Histol Histopathol 2013; 28: 1555–1566.Google Scholar

Yang, L., Wu, Q., Xu, L., et al. Increased expression of colony stimulating factor-1 is a predictor of poor prognosis in patients with clear-cell renal cell carcinoma. BMC Cancer 2015; 15: 67–78.Google Scholar

Mazzucchelli, R., Galosi, A.B., Scarpelli, M., et al. Contemporary update on pathology-related issues of adult renal neoplasms. Anal Quant Cytopathol Histopathol 2014; 36: 1–8.Google Scholar

Shuch, B., Amin, A., Armstrong, A.J., et al. Understanding pathologic variants of renal cell carcinoma: distilling therapeutic opportunities from biologic complexity Eur Urol 2015; 67: 85–97.Google Scholar

Kuroda, N., Ohe, C., Mikami, S., et al. Multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects. Histol Histopathol 2012; 27: 969–974.Google Scholar

Cheng, L., Williamson, S.R., Zhang, S., et al. Understanding the molecular genetics of renal cell neoplasia: implications for diagnosis, prognosis and therapy. Expert Rev Anticancer Ther 2010; 10: 843–864.Google Scholar

Cheng, L., Zhang, S., MacLennan, G.T., Lopez-Beltran, A., Montironi, R.. Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms. Hum Pathol 2009; 40: 10–29.Google Scholar

Moch, H.. Cystic renal tumors: new entities and novel concepts. Adv Anat Pathol 2010; 17: 209–214.Google Scholar

You, D., Shim, M., Jeong, I.G., et al. Multilocular cystic renal cell carcinoma: clinicopathological features and preoperative prediction using multiphase computer tomography. BJU Int 2011; 108: 1444–1449.Google Scholar

Raspollini, M.R., Montagnani, I., Montironi, R., et al. A contemporary series of renal masses with emphasis on recently recognized entities and tumors of low malignant potential: a report based on 624 consecutive tumors from a single tertiary center. Pathol Res Pract 2017; 213: 804–808.Google Scholar

Delahunt, B., Cheville, J.C., Martignoni, G., et al.; Members of the ISUP Renal Tumor Panel. The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters. Am J Surg Pathol 2013; 37: 1490–1504.Google Scholar

Lopez-Beltran, A., Cheng, L., Vidal, A., et al. Pathology of renal cell carcinoma: an update. Anal Quant Cytopathol Histopathol 2013; 35: 61–76.Google Scholar

Raspollini, M.R., Castiglione, F., Martignoni, G., et al. Unlike in clear cell renal cell carcinoma, KRAS is not mutated in multilocular cystic clear cell renal cell neoplasm of low potential. Virchows Arch 2015; 467(6): 687-693.CrossRef Google Scholar

Williamson, S.R., Gupta, N.S., Eble, J.N., et al. Clear cell renal cell carcinoma with borderline features of clear cell papillary renal cell carcinoma; combined morphologic, immunohistochemical, and cytogenetic analysis. Int J Surg Pathol 2015; 39: 1502–1510.Google Scholar

May, K.T., Perkins, D.G., Collins, J.P.. Epithelioid variant of renal angyomiolipoma. Histopathology 1996; 28: 277–280.Google Scholar

Pectasides, D., Fountzilas, G., Aravantinos, G., et al. Advanced stage clear-cell epithelial ovarian cancer: the Hellenic Cooperative Oncology Group experience. Gynecol Oncol 2006; 102: 285–291.Google Scholar

Offman, S.L., Longrane, T.A.. Clear cell carcinoma of the female genital tract (not everything is as clear as seem). Adv Anat Pathol 2012; 19: 296–312.Google Scholar

Ogawa, S., Katu, T., Amada, S., et al. Ovarian endometriosis associated with ovarian carcinoma: a clinicopathological and immunohistochemical study. Gynecol Oncol 2000; 77: 294–304.Google Scholar

Koonings, P.P., Campbell, K., Mishell, D.R. Jr, et al. Relative frequency of primary ovarian neoplasms: a ten year review. Obstet Gynecol 1989; 74: 921–926.Google Scholar

Ferlay, J., Shin, H.R., Bray, F., et al. Estimates in wordwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2008; 127: 2893–2917.Google Scholar

Storey, D.J., Rush, R., Stewart, M., et al. Endometrioid epithelial ovarian cancer: 20 years of prospectively collected data from a single centre. Cancer 2008; 112: 2211–2220.Google Scholar

Klemy, P.J., Gronroos, M.. Endometrioid carcinoma of the ovary. A clinico-pathologic, histochemical, and electronic microscopic study. Obstet Gynecol 1979; 53: 572–579.Google Scholar

Leake, J., Woolas, R.P., Daniel, J., et al. Immunocytochemical and serological expression of CA 125: a clinico-pathological study of 40 malignant epithelial tumours. Histopathology 1994; 24: 57–64.Google Scholar

Young, R.H., Hart, W.R.. Renal cell carcinoma metastatic to the ovary: a report of three cases emphasizing possible confusion wirh ovarian clear cell carcinoma. Int J Gynecol Pathol 1992; 11: 96–104.Google Scholar

Young, R.H., Hart, W.R.. Metastatic intestinal carcinomas simulating primary ovarian clear cell carcinoma and secretory endometrioid carcinoma: a clinicopathologic and immunohistochemical study of five cases. Am J Surg Pathol 1998; 22: 805–815.Google Scholar

Young, R.H., Dickersin, G.R., Scully, R.E.. Juvenile granulosa cell tumor of the ovary: a clinicopathologic analysis of 125 cases. Am J Surg Pathol 1984; 8: 575–596.Google Scholar

Schneider, D.T., Calaminus, G., Harms, D., et al. Ovarian sex-cord-stromal tumors in children and adolescents. J Reprod Med 2005; 50: 439–446.Google Scholar

Al-Agha, O.M., Huwait, H.F., Chow, C., et al. FOXL2 a sensitive and specific marker for sex cord-stromal tumors of the ovary: an update. Am J Surg Pathol 2011; 35: 484–494.Google Scholar

Zhao, C., Vinh, T.N., McManus, K., et al. Identification of the most sensitive and robust immunohistochemical markers in different categories of ovarian sex cord-stromal tumors. Am J Surg Pathol 2009; 33: 354–366.Google Scholar

Herbst, A.L., Kurman, R.J., Scully, R.E., et al. Clear-cell adenocarcinoma of the genital tract in young females: registry report. N Engl J Med 1974; 287: 1259–1264.Google Scholar

Clement, P.B., Young, R.H.. Endometrioid carcinoma of the uterine corpus: a review of its pathology with emphasis on recent advances and problematic aspects. Adv Anat Pathol 2002; 9: 145–184.Google Scholar

Sherman, M.E., Bitterman, P., Rosenshein, N.B., et al. Uterine serous carcinoma. A morphologically diverse neoplasm with unifying clinicopathologic features. Am J Surg Pathol 1992; 16: 600–610.Google Scholar

Lax, S.F., Pizer, E.S., Ronnett, B.M., et al. Clear cell carcinoma of the endometrium is characterized by a distinctive profile of p53, Ki-67, estrogen, and progesterone receptor expression. Hum Pathol 1998; 29: 551–559.Google Scholar

Acs, G., Pasha, T., Zhang, P.J.. WT1 is differentilly expressed in serous, endometrioid, clear cell, and mucinous carcinoma of the peritoneum, fallopian tube, ovary, and endometrium. Int J Gynecol Pathol 2004; 23: 110–118.Google Scholar

Goldstein, N.S., Uzieblo, A.. WT1 immunoreactivity in uterine papillary serous carcinomas is different from ovarian serous carcinomas. Am J Clin Pathol 2002; 117: 541–545.Google Scholar

References

Moch, H., Humphrey, P.A., Ulbright, T.M., Reuter, V.E.. WHO Classification of Tumours of the Urinary System and Male Genital Organs. Lyon: WHO Press; 2016.Google Scholar

Caliò, A., Eble, J.N., Grignon, D.J., Delahunt, B.. Cystic nephroma in adults: a clinicopathological study of 46 cases. Am J Surg Pathol 2016; 14: 1591–1600.Google Scholar

Caliò, A., Eble, J.N., Grignon, D.J., Delahunt, B.. Mixed epithelial and stromal tumor of the kidney: a clinicopathological study of 53 cases. Am J Surg Pathol 2016; 40: 1538–1549.Google Scholar

Eble, J.N., Bonsib, S.M.. Extensively cystic renal neoplasms: cystic nephroma, cystic partially differentiated nephroblastoma, multilocular cystic renal cell carcinoma, and cystic hamartoma of renal pelvis. Semin Diagn Pathol 1998; 15: 2–20.Google Scholar

Turbiner, J., Amin, M.B., Humphrey, P.A., et al. Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. Am J Surg Pathol 2007; 31: 489–500.Google Scholar

Zhou, M., Kort, E., Hoekstra, P., et al. Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney are the same disease entity: molecular and histologic evidence. Am J Surg Pathol 2009; 33: 72–80.Google Scholar

Mukhopadhyay, S., Valente, A.L., de la Roza, G.. Cystic nephroma: a histologic and immunohistochemical study of 10 cases. Arch Pathol Lab Med 2004; 128: 1404–1411.Google Scholar

Adsay, N.V., Eble, J.N., Srigley, J.R., Jones, E.C., Grignon, D.J.. Mixed epithelial and stromal tumor of the kidney. Am J Surg Pathol 2000; 24: 958–970.Google Scholar

Michal, M., Hes, O., Bisceglia, M., et al. Mixed epithelial and stromal tumors of the kidney: a report of 22 cases. Virchows Arch 2004; 445: 359–367.Google Scholar

Karafin, M., Parwani, A.V., Netto, G.J., et al. Diffuse expression of PAX2 and PAX8 in the cystic epithelium of mixed epithelial stromal tumor, angiomyolipoma with epithelial cysts, and primary renal synovial sarcoma: evidence supporting renal tubular differentiation. Am J Surg Pathol 2011; 35: 1264–1273.Google Scholar

Bettaieb, I., Mekni, A., Bellil, K., et al. Endometrial adenofibroma: a rare entity. Arch Gynecol Obstet 2007; 275: 191–193.Google Scholar

Clement, P.B., Scully, R.E.. Mullerian adenosarcoma of the uterus: a clinicopathologic analysis of 100 cases with a review of the literature. Hum Pathol 1990; 21: 363–381.Google Scholar

Kurman, R.J., Carcangiu, M.L., Herrington, S.C., Young, R.H.. WHO Classification of Tumours of Female Reproductive Organs. Lyon: WHO Press; 2014.Google Scholar

Eichhorn, J.H., Young, R.H., Clement, P.B., Scully, R.E.. Mesodermal (mullerian) adenosarcoma of the ovary: a clinicopathologic analysis of 40 cases and a review of the literature. Am J Surg Pathol 2002; 26: 1243–1258.Google Scholar

References

Wells, M., Oliva, E., Palacios, J., Prat, J.. Mixed epithelial and mesenchymal tumours of the uterus. In: Kurman, R.J., Carcangiu, M.L., Herrington, S., Young, R.H., editors, WHO Classification of Tumours of the Female Reproductive Organs. Lyon: IARC Press; 2014.Google Scholar

Gilks, C.B., Young, R.H., Clement, P.B., Hart, W.R., Scully, R.E.. Adenomyomas of the uterine cervix of endocervical type: a report of ten cases of a benign cervical tumor that may be confused with adenoma malignum [corrected]. Mod Pathol 1996; 9(3): 220–224.Google Scholar

Gilks, C.B., Clement, P.B., Hart, W.R., Young, R.H.. Uterine adenomyomas excluding atypical polypoid adenomyomas and adenomyomas of endocervical type: a clinicopathologic study of 30 cases of an underemphasized lesion that may cause diagnostic problems with brief consideration of adenomyomas of other female genital tract sites. Int J Gynecol Pathol 2000; 19(3): 195–205.Google Scholar

Tahlan, A., Nanda, A., Mohan, H.. Uterine adenomyoma: a clinicopathologic review of 26 cases and a review of the literature. Int J Gynecol Pathol 2006; 25(4): 361–365.Google Scholar

Longacre, T.A., Chung, M.H., Rouse, R.V., Hendrickson, M.R.. Atypical polypoid adenomyofibromas (atypical polypoid adenomyomas) of the uterus. A clinicopathologic study of 55 cases. Am J Surg Pathol 1996; 20(1): 1–20.Google Scholar

Young, R.H., Treger, T., Scully, R.E.. Atypical polypoid adenomyoma of the uterus: a report of 27 cases. Am J Clin Pathol 1986; 86(2): 139–145.Google Scholar

Soslow, R.A., Chung, M.H., Rouse, R.V., Hendrickson, M.R., Longacre, T.A.. Atypical polypoid adenomyofibroma (APA) versus well-differentiated endometrial carcinoma with prominent stromal matrix: an immunohistochemical study. Int J Gynecol Pathol 1996; 15(3): 209–216.Google Scholar

Mazur, M.T.. Atypical polypoid adenomyomas of the endometrium. Am J Surg Pathol 1981; 5(5): 473–482.Google Scholar

Zaloudek, C.J., Norris, H.J.. Adenofibroma and adenosarcoma of the uterus: a clinicopathologic study of 35 cases. Cancer 1981;48(2): 354–366.Google Scholar

Zaloudek, C., Hendrickson, M.R., Soslow, R.A.. Mesenchymal tumors of the uterus. In: Kurman, R.J., Wellenson, L.H., Ronnett, B.M., editors, Blaustein’s Pathology of the Female Genital Tract, 6th edn. New York: Springer; 2011, p. 453–578.Google Scholar

Gallardo, A., Prat, J.. Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. Am J Surg Pathol 2009; 33(2): 278–288.Google Scholar

Soslow, R.A., Ali, A., Oliva, E.. Mullerian adenosarcomas: an immunophenotypic analysis of 35 cases. Am J Surg Pathol 2008; 32(7): 1013–1021.Google Scholar

Clement, P.B., Oliva, E., Young, R.H.. Mullerian adenosarcoma of the uterine corpus associated with tamoxifen therapy: a report of six cases and a review of tamoxifen-associated endometrial lesions. Int J Gynecol Pathol 1996; 15(3): 222–229.Google Scholar

Clement, P.B., Scully, R.E.. Uterine tumors resembling ovarian sex-cord tumors: a clinicopathologic analysis of fourteen cases. Am J Clin Pathol 1976; 66(3): 512–525.Google Scholar

Clement, P.B., Scully, R.E.. Mullerian adenosarcomas of the uterus with sex cord-like elements: a clinicopathologic analysis of eight cases. Am J Clin Pathol 1989; 91(6): 664–672.Google Scholar

Zelmanowicz, A., Hildesheim, A., Sherman, M.E., et al. Evidence for a common etiology for endometrial carcinomas and malignant mixed mullerian tumors. Gynecol Oncol 1998; 69(3): 253–257.Google Scholar

Thompson, L., Chang, B., Barsky, S.H.. Monoclonal origins of malignant mixed tumors (carcinosarcomas): evidence for a divergent histogenesis. Am J Surg Pathol 1996; 20(3): 277–285.Google Scholar

Wada, H., Enomoto, T., Fujita, M., et al. Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors. Cancer Res 1997; 57(23): 5379–5385.Google Scholar

Fujii, H., Yoshida, M., Gong, Z.X., et al. Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity. Cancer Res 2000; 60(1): 114–120.Google Scholar

Blom, R., Guerrieri, C., Stal, O., et al. Malignant mixed Mullerian tumors of the uterus: a clinicopathologic, DNA flow cytometric, p53, and mdm-2 analysis of 44 cases. Gynecol Oncol 1998; 68(1): 18–24.Google Scholar

Meis, J.M., Lawrence, W.D.. The immunohistochemical profile of malignant mixed mullerian tumor. Overlap with endometrial adenocarcinoma. Am J Clin Pathol 1990; 94(1): 1–7.Google Scholar

Vaidya, A.P., Horowitz, N.S., Oliva, E., Halpern, E.F., Duska, L.R.. Uterine malignant mixed mullerian tumors should not be included in studies of endometrial carcinoma. Gynecol Oncol 2006; 103(2): 684–687.Google Scholar

Yamada, S.D., Burger, R.A., Brewster, W.R., et al. Pathologic variables and adjuvant therapy as predictors of recurrence and survival for patients with surgically evaluated carcinosarcoma of the uterus. Cancer 2000; 88(12): 2782–2786.Google Scholar

Silverberg, S.G., Major, F.J., Blessing, J.A., et al. Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus: a Gynecologic Oncology Group pathologic study of 203 cases. Int J Gynecol Pathol 1990; 9(1): 1–19.Google Scholar

Inthasorn, P., Carter, J., Valmadre, S., et al. Analysis of clinicopathologic factors in malignant mixed Mullerian tumors of the uterine corpus. Int J Gynecol Cancer 2002; 12(4): 348–353.Google Scholar

Mikami, Y., Hata, S., Kiyokawa, T., Manabe, T.. Expression of CD10 in malignant mullerian mixed tumors and adenosarcomas: an immunohistochemical study. Mod Pathol 2002; 15(9): 923–930.Google Scholar

Clement, P.B., Scully, R.E.. Uterine tumors with mixed epithelial and mesenchymal elements. Semin Diagn Pathol 1988; 5(2): 199–222.Google Scholar

References

Lee, K.R., Tavassoli, F.A., Prat, J., et al. Tumours of the ovary and peritoneum: surface epithelial-stromal tumours. In: Tavassoli, F.A., Devilee, P., editors, World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Lyon: IARC Press; 2003.Google Scholar

Scully, R.E., Young, R.H., Clement, P.B.. Tumors of the ovary, maldeveloped gonads, fallopian tube, and broad ligament. In: Atlas of Tumor Pathology, Third series, Fascicle 23. Washington, DC: Armed Forces Institute of Pathology; 1998, p. 153–164.Google Scholar

Abeln, E.C., Smit, V.T., Wessels, J.W., et al. Molecular genetic evidence for the conversion hypothesis of the origin of malignant mixed mullerian tumours. J Pathol 1997; 183: 424–431.Google Scholar

Thompson, L., Chang, B., Barsky, S.H.. Monoclonal origins of malignant mixed tumors (carcinosarcomas): evidence for a divergent histogenesis. Am J Surg Pathol 1996; 20: 277–285.Google Scholar

McCluggage, W.G.. Uterine carcinosarcomas (malignant mixed Mullerian tumors) are metaplastic carcinomas. Int J Gynecol Cancer 2002; 12: 687–690.Google Scholar

Bitterman, P., Chun, B., Kurman, R.J.. The significance of epithelial differentiation in mixed mesodermal tumors of the uterus: a clinicopathologic and immunohistochemical study. Am J Surg Pathol 1990; 14: 317–328.Google Scholar

Jin, Z., Ogata, S., Tamura, G., et al. Carcinosarcomas (malignant mullerian mixed tumors) of the uterus and ovary: a genetic study with special reference to histogenesis. Int J Gynecol Pathol 2003; 22: 368–373.Google Scholar

Gallardo, A., Matias-Guiu, X., Lagarda, H., et al. Malignant mullerian mixed tumor arising from ovarian serous carcinoma: a clinicopathologic and molecular study of two cases. Int J Gynecol Pathol 2002; 21: 268–272.Google Scholar

Becker, J.L., Papenhausen, P.R., Widen, R.H.. Cytogenetic, morphologic and oncogene analysis of a cell line derived from a heterologous mixed mullerian tumor of the ovary. In Vitro Cell Dev Biol 1997; 33: 325–331.Google Scholar

Eichhorn, J.H., Young, R.H., Clement, P.B., Scully, R.E.. Mesodermal (Müllerian) adenosarcoma of the ovary: a clinicopathologic analysis of 40 cases and review of the literature. Am J Surg Pathol 2002; 26: 1243–1258.Google Scholar

Prat, J., Scully, R.E.. Sarcomas in ovarian mucinous tumors: a report of two cases. Cancer 1979; 44: 1327–1331.Google Scholar

De Nictolis, M., di Loreto, C., Cinti, S., Prat, J.. Fibrosarcomatous mural nodule in an ovarian mucinous cystadenoma. Surg Pathol 1990; 3: 309–315.Google Scholar

Ongkasuwan, C., Taylor, J.E., Tang, C.K., Prempree, T.. Angiosarcomas of the uterus and ovary: clinicopathologic report. Cancer 1982; 49: 1469–1475.Google Scholar

Walts, A.E., Lichtenstein, I.. Primary leiomyosarcoma associated with serous cystadenocarcinoma of the ovary. Gynecol Oncol 1977; 5: 81–86.Google Scholar

Tsujimura, T., Kawano, K.. Rhabdomyosarcoma coexistent with ovarian mucinous cystadenocarcinoma: a case report. Int J Gynecol Pathol 1992; 11: 58–62.Google Scholar

References

Pea, M., Martignoni, G., Zamboni, G., Bonetti, F.. Perivascular epithelioid cell. Am J Surg Pathol 1996; 20: 1149–1153.Google Scholar

Bonetti, F., Chiodera, P.L., Pea, M., et al. Transbronchial biopsy in lymphangiomyomatosis of the lung. HMB45 for diagnosis. Am J Surg Pathol 1993; 17: 1092–1102.Google Scholar

Zavala-Pompa, A., Folpe, A.L., Jimenez, R.E., et al. Immunohistochemical study of microphthalmia transcription factor and tyrosinase in angiomyolipoma of the kidney, renal cell carcinoma, and renal and retroperitoneal sarcomas: comparative evaluation with traditional diagnostic markers. Am J Surg Pathol 2001; 25: 65–70.Google Scholar

Stone, C.H., Lee, M.W., Amin, M.B., et al. Renal angiomyolipoma: further immunophenotypic characterization of an expanding morphologic spectrum. Arch Pathol Lab Med 2001; 125: 751–758.Google Scholar

Pan, C.C., Jong, Y.J., Chai, C.Y., Huang, S.H., Chen, Y.J.. Comparative genomic hybridization study of perivascular epithelioid cell tumor: molecular genetic evidence of perivascular epithelioid cell tumor as a distinctive neoplasm. Hum Pathol 2006; 37: 606–612.Google Scholar

Martignoni, G., Pea, M., Zampini, C., et al. PEComas of the kidney and of the genitourinary tract. Semin Diagn Pathol 2015; 32: 140–159.Google Scholar

Carbonara, C., Longa, L., Grosso, E., et al. Apparent preferential loss of heterozygosity at TSC2 over TSC1 chromosomal region in tuberous sclerosis hamartomas. Genes Chromosomes Cancer 1996; 15: 18–25.Google Scholar

Chilosi, M., Pea, M., Martignoni, G., et al. Cathepsin-K expression in pulmonary lymphangioleiomyomatosis. Mod Pathol 2009; 22: 161–166.Google Scholar

Martignoni, G., Bonetti, F., Chilosi, M., et al. Cathepsin K expression in the spectrum of perivascular epithelioid cell (PEC) lesions of the kidney. Mod Pathol 2012; 25: 100–111.Google Scholar

Zheng, G., Martignoni, G., Antonescu, C., et al. A broad survey of cathepsin K immunoreactivity in human neoplasms. Am J Clin Pathol 2013; 139: 151–159.Google Scholar

Caliò, A., Warfel, K.A., Eble, J.N.. Pathological features and clinical associations of 58 small incidental angiomyolipomas of the kidney. Hum Pathol 2016; 58: 41–46.Google Scholar

Martignoni, G., Bonetti, F., Pea, M., et al. Renal disease in adults with TSC2/PKD1 contiguous gene syndrome. Am J Surg Pathol 2002; 26: 198–205.Google Scholar

Fine, S.W., Reuter, V.E., Epstein, J.I., Argani, P.. Angiomyolipoma with epithelial cysts (AMLEC): a distinct cystic variant of angiomyolipoma. Am J Surg Pathol 2006; 30: 593–599.Google Scholar

Martignoni, G., Pea, M., Bonetti, F., Brunelli, M., Eble, J.N.. Oncocytoma-like angiomyolipoma. A clinicopathologic and immunohistochemical study of 2 cases. Arch Pathol Lab Med 2002; 126: 610–612.Google Scholar

Matsui, K., Tatsuguchi, A., Valencia, J., et al. Extrapulmonary lymphangioleiomyomatosis (LAM): clinicopathologic features in 22 cases. Hum Pathol 2000; 31: 1242–1248.Google Scholar

Brimo, F., Robinson, B., Guo, C., et al. Renal epithelioid angiomyolipoma with atypia: a series of 40 cases with emphasis on clinicopathologic prognostic indicators of malignancy. Am J Surg Pathol 2010; 34: 715–722.Google Scholar

Nese, N., Martignoni, G., Fletcher, C.D., et al. Pure epithelioid PEComas (so-called epithelioid angiomyolipoma) of the kidney: a clinicopathologic study of 41 cases: detailed assessment of morphology and risk stratification. Am J Surg Pathol 2011; 35: 161–176.Google Scholar

He, W., Cheville, J.C., Sadow, P.M., et al. Epithelioid angiomyolipoma of the kidney: pathological features and clinical outcome in a series of consecutively resected tumors. Mod Pathol 2013; 26: 1355–1364.Google Scholar

Eble, J.N., Amin, M.B., Young, R.H.. Epithelioid angiomyolipoma of the kidney: a report of five cases with a prominent and diagnostically confusing epithelioid smooth muscle component. Am J Surg Pathol 1997; 21: 1123–1130.Google Scholar

Pan, C.C., Chung, M.Y., Ng, K.F., et al. Constant allelic alteration on chromosome 16p (TSC2 gene) in perivascular epithelioid cell tumour (PEComa): genetic evidence for the relationship of PEComa with angiomyolipoma. J Pathol 2008; 214: 387–393.Google Scholar

Ohe, C., Kuroda, N., Hes, O., et al. A renal epithelioid angiomyolipoma/perivascular epithelioid cell tumor with TFE3 gene break visualized by FISH. Med Mol Morphol 2012; 45: 234–237.Google Scholar

Sato, K., Ueda, Y., Tachibana, H., et al. Malignant epithelioid angiomyolipoma of the kidney in a patient with tuberous sclerosis: an autopsy case report with p53 gene mutation analysis. Pathol Res Pract 2008; 204: 771–777.Google Scholar

Chen, J., Wang, P., Wang, C.J., et al. Highly aggressive epithelioid renal angiomyolipoma with a very poor prognosis. Chin Med J (Engl) 2010; 123: 765–766.Google Scholar

Mehta, V., Ananthanarayanan, V., Antic, T., et al. Primary benign vascular tumors and tumorlike lesions of the kidney: a clinicopathologic analysis of 15 cases. Virchows Arch 2012; 461: 669–676.Google Scholar

Gobbo, S., Eble, J.N., Huang, J., et al. Schwannoma of the kidney. Mod Pathol 2008; 21: 779–783.Google Scholar

Martin, S.A., Mynderse, L.A., Lager, D.J., Cheville, J.C.. Juxtaglomerular cell tumor: a clinicopathologic study of four cases and review of the literature. Am J Clin Pathol 2001; 116: 854–863.Google Scholar

Patil, P.A., McKenney, J.K., Trpkov, K., et al. Renal leiomyoma: a contemporary multi-institution study of an infrequent and frequently misclassified neoplasm. Am J Surg Pathol 2015; 39: 349–356.Google Scholar

Caliò, A., Warfel, K.A., Eble, J.N.. Renomedullary interstitial cell tumors: pathological features and clinical correlations. Am J Surg Pathol 2016; 40: 1693–1701.Google Scholar

Kuroda, N., Ohe, C., Sakaida, N., et al. Solitary fibrous tumor of the kidney with focus on clinical and pathobiological aspects. Int J Clin Exp Pathol 2014; 7: 2737–2742.Google Scholar

Conlon, N., Soslow, R.A., Murali, R.. Perivascular epithelioid tumours (PEComas) of the gynaecological tract. J Clin Pathol 2015; 68: 418–426.Google Scholar

Folpe, A.L., Mentzel, T., Lehr, H.A., et al. Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature. Am J Surg Pathol 2005; 29: 1558–1575.Google Scholar

Schoolmeester, J.K., Howitt, B.E., Hirsch, M.S., et al. Perivascular epithelioid cell neoplasm (PEComa) of the gynecologic tract: clinicopathologic and immunohistochemical characterization of 16 cases. Am J Surg Pathol 2014; 38: 176–188.Google Scholar

References

Oliva, E., Carcangiu, M.L., Carinelli, S.G., et al. Mesenchymal tumours of the corpus uteri. In: Kurman, R.J., Carcangiu, M.L., Herrington, S., Young, R.H., editors, Tumours of the Female Reproductive Organs. Lyon: IARC Press; 2014, p. 135–147.Google Scholar

Zaloudek, C., Hendrickson, M.R., Soslow, R.A.. Mesenchymal tumors of the uterus. In: Kurman, R.J., Ellenson, L.H., Ronnett, B.M., editors, Blaustein’s Pathology of the Female Genital Tract, 6th edn. New York: Springer; 2011, p. 453–578.Google Scholar

Ellenson, L.H., Carinelli, S.G., Cho, K.R., et al. Mesenchymal tumours of the ovary. In: Kurman, R.J., Carcangiu, M.L., Herrington, S., Young, R.H., editors, WHO Classification of, Tumours of the Female Reproductive Organs. Lyon: IARC Press; 2014, p. 41.Google Scholar

Zaloudek, C., Hendrickson, M.R.. Mesenchymal tumors of the uterus. In: Kurman, R.J., editor, Blaustein’s Pathology of the Female Genital Tract. New York: Springer; 2003, p. 561–615.Google Scholar

Croce, S., Young, R.H., Oliva, E..Uterine leiomyomas with bizarre nuclei: a clinicopathologic study of 59 cases. Am J Surg Pathol 2014; 38(10): 1330–1339.Google Scholar

Bell, S.W., Kempson, R.L., Hendrickson, M.R.. Problematic uterine smooth muscle neoplasms: a clinicopathologic study of 213 cases. Am J Surg Pathol 1994; 18(6): 535–558.Google Scholar

O’Connor, D.M., Norris, H.J.. Mitotically active leiomyomas of the uterus. Hum Pathol 1990; 21(2): 223–227.Google Scholar

Perrone, T., Dehner, L.P.. Prognostically favorable “mitotically active” smooth-muscle tumors of the uterus: a clinicopathologic study of ten cases. Am J Surg Pathol 1988; 12(1): 1–8.Google Scholar

Evans, H.L., Chawla, S.P., Simpson, C., Finn, K.P.. Smooth muscle neoplasms of the uterus other than ordinary leiomyoma: a study of 46 cases, with emphasis on diagnostic criteria and prognostic factors. Cancer 1988; 62(10): 2239–2247.Google Scholar

Prayson, R.A., Goldblum, J.R., Hart, W.R.. Epithelioid smooth-muscle tumors of the uterus: a clinicopathologic study of 18 patients. Am J Surg Pathol 1997; 21(4): 383–391.Google Scholar

Chuang, S.S., Lin, C.N., Li, C.Y., Wu, C.H.. Uterine leiomyoma with massive lymphocytic infiltration simulating malignant lymphoma: a case report with immunohistochemical study showing that the infiltrating lymphocytes are cytotoxic T cells. Pathol Res Pract 2001; 197(2): 135–138.Google Scholar

Botsis, D., Koliopoulos, C., Kondi-Pafitis, A., Creatsas, G.. Frequency, histological, and immunohistochemical properties of massive inflammatory lymphocytic infiltration of leiomyomas of the uterus: an entity causing diagnostic difficulties. Int J Gynecol Pathol 2005; 24(4): 326–329.Google Scholar

Boyd, C., McCluggage, W.G.. Unusual morphological features of uterine leiomyomas treated with progestogens. J Clin Pathol 2011; 64(6): 485–489.Google Scholar

Donnez, J., Tomaszewski, J., Vazquez, F., et al. Ulipristal acetate versus leuprolide acetate for uterine fibroids. N Engl J Med 2012; 366(5): 421–432.Google Scholar

Ip, P.P., Cheung, A.N., Clement, P.B.. Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases. Am J Surg Pathol 2009; 33(7): 992–1005.Google Scholar

Veras, E., Zivanovic, O., Jacks, L., et al. “Low-grade leiomyosarcoma” and late-recurring smooth muscle tumors of the uterus: a heterogenous collection of frequently misdiagnosed tumors associated with an overall favorable prognosis relative to conventional uterine leiomyosarcomas. Am J Surg Pathol 2011; 35(11): 1626–1637.Google Scholar

Sung, C.O., Ahn, G., Song, S.Y., Choi, Y.L., Bae, D.S.. Atypical leiomyomas of the uterus with long-term follow-up after myomectomy with immunohistochemical analysis for p16INK4A, p53, Ki-67, estrogen receptors, and progesterone receptors. Int J Gynecol Pathol 2009; 28(6): 529–534.Google Scholar

Lim, D., Alvarez, T., Nucci, M.R., et al. Interobserver variability in the interpretation of tumor cell necrosis in uterine leiomyosarcoma. Am J Surg Pathol 2013; 37(5): 650–658.Google Scholar

Oliva, E., Young, R.H., Amin, M.B., Clement, P.B.. An immunohistochemical analysis of endometrial stromal and smooth muscle tumors of the uterus: a study of 54 cases emphasizing the importance of using a panel because of overlap in immunoreactivity for individual antibodies. Am J Surg Pathol 2002; 26(4): 403–412.Google Scholar

Raspollini, M.R., Pinzani, P., Simi, L., et al. Uterine leiomyosarcomas express KIT protein but lack mutation(s) in exon 9 of c-KIT. Gynecol Oncol 2005; 98(2): 334–335.Google Scholar

Sah, S.P., McCluggage, W.G.. DOG1 immunoreactivity in uterine leiomyosarcomas. J Clin Pathol 2013; 66(1): 40–43.Google Scholar

Markowski, D.N., Huhle, S., Nimzyk, R., et al. MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors. Genes Chromosomes Cancer 2013; 52(3): 297–304.Google Scholar

Yang, C.Y., Liau, J.Y., Huang, W.J., et al. Targeted next-generation sequencing of cancer genes identified frequent TP53 and ATRX mutations in leiomyosarcoma. Am J Transl Res 2015; 7(10): 2072–2081.Google Scholar

Harrison, W.J., Andrici, J., Maclean, F., et al. Fumarate hydratase-deficient uterine leiomyomas occur in both the syndromic and sporadic settings. Am J Surg Pathol 2016; 40(5): 599–607.Google Scholar

Miettinen, M., Felisiak-Golabek, A., Wasag, B., et al. Fumarase-deficient uterine leiomyomas: an immunohistochemical, molecular genetic, and clinicopathologic study of 86 cases. Am J Surg Pathol 2016; 40(12): 1661–1669.Google Scholar

Trpkov, K., Hes, O., Agaimy, A., et al. Fumarate hydratase-deficient renal cell carcinoma is strongly correlated with fumarate hydratase mutation and hereditary leiomyomatosis and renal cell carcinoma syndrome. Am J Surg Pathol 2016; 40(7): 865–875.Google Scholar

Chang, K.L., Crabtree, G.S., Lim-Tan, S.K., Kempson, R.L., Hendrickson, M.R.. Primary uterine endometrial stromal neoplasms: a clinicopathologic study of 117 cases. Am J Surg Pathol 1990; 14(5): 415–438.Google Scholar

Tavassoli, F.A., Norris, H.J.. Mesenchymal tumours of the uterus. VII. A clinicopathological study of 60 endometrial stromal nodules. Histopathology 1981; 5(1): 1–10.Google Scholar

Dionigi, A., Oliva, E., Clement, P.B., Young, R.H.. Endometrial stromal nodules and endometrial stromal tumors with limited infiltration: a clinicopathologic study of 50 cases. Am J Surg Pathol 2002; 26(5): 567–581.Google Scholar

Hrzenjak, A., Moinfar, F., Tavassoli, F.A., et al. JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue. J Mol Diagn 2005; 7(3): 388–395.Google Scholar

Oliva, E., de Leval, L., Soslow, R.A., Herens, C.. High frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal tumors with smooth muscle differentiation by interphase FISH detection. Am J Surg Pathol 2007; 31(8): 1277–1284.Google Scholar

D’Angelo, E., Ali, R.H., Espinosa, I., et al. Endometrial stromal sarcomas with sex cord differentiation are associated with PHF1 rearrangement. Am J Surg Pathol 2013; 37(4): 514–521.Google Scholar

Micci, F., Gorunova, L., Agostini, A., et al. Cytogenetic and molecular profile of endometrial stromal sarcoma. Genes Chromosomes Cancer 2016; 55(11): 834–846.Google Scholar

Kurihara, S., Oda, Y., Ohishi, Y., et al. Endometrial stromal sarcomas and related high-grade sarcomas: immunohistochemical and molecular genetic study of 31 cases. Am J Surg Pathol 2008; 32(8): 1228–1238.Google Scholar

Lee, C.H., Ali, R.H., Rouzbahman, M., et al. Cyclin D1 as a diagnostic immunomarker for endometrial stromal sarcoma with YWHAE-FAM22 rearrangement. Am J Surg Pathol 2012; 36(10): 1562–1570.Google Scholar

Lee, C.H., Marino-Enriquez, A., Ou, W., et al. The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor. Am J Surg Pathol 2012; 36(5): 641–653.Google Scholar

Hoang, L.N., Aneja, A., Conlon, N., et al. Novel high-grade endometrial stromal sarcoma: a morphologic mimicker of myxoid leiomyosarcoma. Am J Surg Pathol 2017; 41(1): 12–24.Google Scholar

Czernobilsky, B.. Uterine tumors resembling ovarian sex cord tumors: an update. Int J Gynecol Pathol 2008; 27(2): 229–235.Google Scholar

Hurrell, D.P., McCluggage, W.G.. Uterine tumour resembling ovarian sex cord tumour is an immunohistochemically polyphenotypic neoplasm which exhibits coexpression of epithelial, myoid and sex cord markers. J Clin Pathol 2007; 60(10): 1148–1154.Google Scholar

Clement, P.B., Scully, R.E.. Uterine tumors resembling ovarian sex-cord tumors. A clinicopathologic analysis of fourteen cases. Am J Clin Pathol 1976; 66(3): 512–525.Google Scholar

Silva, E.G., Deavers, M.T., Bodurka, D.C., Malpica, A.. Uterine epithelioid leiomyosarcomas with clear cells: reactivity with HMB-45 and the concept of PEComa. Am J Surg Pathol 2004; 28(2): 244–249.Google Scholar

Malinowska, I., Kwiatkowski, D.J., Weiss, S., et al. Perivascular epithelioid cell tumors (PEComas) harboring TFE3 gene rearrangements lack the TSC2 alterations characteristic of conventional PEComas: further evidence for a biological distinction. Am J Surg Pathol 2012; 36(5): 783–784.Google Scholar

Fadare, O.. Perivascular epithelioid cell tumor (PEComa) of the uterus: an outcome-based clinicopathologic analysis of 41 reported cases. Adv Anat Pathol 2008; 15(2): 63–75.Google Scholar

Rabban, J.T., Zaloudek, C.J., Shekitka, K.M., Tavassoli, F.A.. Inflammatory myofibroblastic tumor of the uterus: a clinicopathologic study of 6 cases emphasizing distinction from aggressive mesenchymal tumors. Am J Surg Pathol 2005; 29(10): 1348–1355.Google Scholar

Gilks, C.B., Taylor, G.P., Clement, P.B.. Inflammatory pseudotumor of the uterus. Int J Gynecol Pathol 1987; 6(3): 275–286.Google Scholar

Euscher, E.D., Deavers, M.T., Lopez-Terrada, D., et al. Uterine tumors with neuroectodermal differentiation: a series of 17 cases and review of the literature. Am J Surg Pathol 2008; 32(2): 219–228.Google Scholar

Nucci, M.R., McCluggage, W.G., Nielsen, G.P., Oliva, E.. Mesenchymal tumours of the vagina. In: Kurman, R.J., Carcangiu, M.L., Herrington, S., Young, R.H., editors, WHO Classification of Tumours of the Female Reproductive Organs. Lyon: IARC Press; 2014, p. 218–221.Google Scholar

Li, R.F., Gupta, M., McCluggage, W.G., Ronnett, B.M.. Embryonal rhabdomyosarcoma (botryoid type) of the uterine corpus and cervix in adult women: report of a case series and review of the literature. Am J Surg Pathol 2013; 37(3): 344–355.Google Scholar

Nielsen, G.P., Oliva, E., Young, R.H., et al. Alveolar soft-part sarcoma of the female genital tract: a report of nine cases and review of the literature. Int J Gynecol Pathol 1995; 14(4): 283–292.Google Scholar

Ladanyi, M., Lui, M.Y., Antonescu, C.R., et al. The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25. Oncogene 2001; 20(1): 48–57.Google Scholar

McDonald, A.G., Dal Cin, P., Ganguly, A., et al. Liposarcoma arising in uterine lipoleiomyoma: a report of 3 cases and review of the literature. Am J Surg Pathol 2011; 35(2): 221–227.Google Scholar

Schoolmeester, J.K., Stamatakos, M.D., Moyer, A.M., et al. Pleomorphic liposarcoma arising in a lipoleiomyosarcoma of the uterus: report of a case with genetic profiling by a next generation sequencing panel. Int J Gynecol Pathol 2016; 35(4): 321–326.Google Scholar

Schammel, D.P., Tavassoli, F.A.. Uterine angiosarcomas: a morphologic and immunohistochemical study of four cases. Am J Surg Pathol 1998; 22(2): 246–250.Google Scholar

Proppe, K.H., Scully, R.E., Rosai, J.. Postoperative spindle cell nodules of genitourinary tract resembling sarcomas: a report of eight cases. Am J Surg Pathol 1984; 8(2): 101–108.Google Scholar

Young, R.H., Harris, N.L., Scully, R.E.. Lymphoma-like lesions of the lower female genital tract: a report of 16 cases. Int J Gynecol Pathol 1985; 4(4): 289–299.Google Scholar

Geyer, J.T., Ferry, J.A., Harris, N.L., et al. Florid reactive lymphoid hyperplasia of the lower female genital tract (lymphoma-like lesion): a benign condition that frequently harbors clonal immunoglobulin heavy chain gene rearrangements. Am J Surg Pathol 2010; 34(2): 161–168.Google Scholar

McCluggage, W.G., White, R.G.. Angiomyofibroblastoma of the vagina. J Clin Pathol 2000; 53(10): 803.Google Scholar

Nielsen, G.P., Rosenberg, A.E., Young, R.H., et al. Angiomyofibroblastoma of the vulva and vagina. Mod Pathol 1996; 9(3): 284–291.Google Scholar

Dahiya, K., Jain, S., Duhan, N., Nanda, S., Kundu, P.. Aggressive angiomyxoma of vulva and vagina: a series of three cases and review of literature. Arch Gynecol Obstet 2011; 283(5): 1145–1148.Google Scholar

Nucci, M.R., Weremowicz, S., Neskey, D., et al. Chromosomal translocation t(8;12) induces aberrant HMGIC expression in aggressive angiomyxoma of the vulva. Genes Chromosomes Cancer 2001; 32(2): 172–176.Google Scholar

Ganesan, R., McCluggage, W.G., Hirschowitz, L., Rollason, T.P.. Superficial myofibroblastoma of the lower female genital tract: report of a series including tumours with a vulval location. Histopathology 2005; 46(2): 137–143.Google Scholar

Laskin, W.B., Fetsch, J.F., Tavassoli, F.A.. Superficial cervicovaginal myofibroblastoma: fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract. Hum Pathol 2001; 32(7): 715–725.Google Scholar

Amador-Ortiz, C., Roma, A.A., Huettner, P.C., Becker, N., Pfeifer, J.D.. JAZF1 and JJAZ1 gene fusion in primary extrauterine endometrial stromal sarcoma. Hum Pathol 2011; 42(7): 939–946.Google Scholar

Lerwill, M.F., Sung, R., Oliva, E., Prat, J., Young, R.H.. Smooth muscle tumors of the ovary: a clinicopathologic study of 54 cases emphasizing prognostic criteria, histologic variants, and differential diagnosis. Am J Surg Pathol 2004; 28(11): 1436–1451.Google Scholar

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Section 3 - Prostatic Lesions and Tumors

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