Who should read this book?

This book is about how to use the NEURON simulation environment to construct and apply empirically based models of neurons and neural networks. It is written primarily for neuroscience investigators, teachers, and students, but readers with a background in the physical sciences or mathematics who have some knowledge about brain cells and circuits and are interested in computational modeling will also find it helpful. The emphasis is on the most productive use of NEURON as a means for testing hypotheses that are founded on experimental observations, and for exploring ideas that may lead to the design of new experiments. Therefore the book uses a problem-solving approach, with many working examples that readers can try for themselves.

What this book is, and is not, about

Formulating a conceptual model is an attempt to capture the essential features that underlie some particular function. This necessarily involves simplification and abstraction of real-world complexities. Even so, one may not necessarily understand all implications of the conceptual model. To evaluate a conceptual model it is often necessary to devise a hypothesis or test in which the behavior of the model is compared against a prediction.