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Efficacy and tolerance of venlafaxine in hospitalized and ambulatory patients
- K. Kontis, N.P. Zissis, E. Bouka, A. Vidalis, E. Pappas, L. Polyzoidis, A. Kalogeropoulos
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- Journal:
- European Psychiatry / Volume 13 / Issue S4 / 1998
- Published online by Cambridge University Press:
- 16 April 2020, p. 261s
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P-1025 - Prevalence of Depression in Elderly Long-term Inpatients With Serious Mental Illness and Cognitive Impairment
- P. Ntounas, C. Tsopelas, D. Pappas, M. Dimitraka, P. Chatzimanolis, E. Siouti, C. Touloumis, A. Douzenis, L. Lykouras
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- Journal:
- European Psychiatry / Volume 27 / Issue S1 / 2012
- Published online by Cambridge University Press:
- 15 April 2020, p. 1
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Background
Depression is a very common condition in the elderly, underdiagnosed and often an emerging public health issue, especially in developed countries where population is aging.
MethodsThe participants (103 patients) age 55 years or more, with diagnosis of Schizophrenia and other psychotic disorders, Mood disorders and Mental disorders due to general medical condition. The depressive status of the participants was determined clinically, using the GDS and the Cornell scale for depression in dementia when MMSE was > 15.
ResultsOf the 103 inpatients, 87 had MMSE score less than 24 and were included in the analysis. 23.1% had been clinically diagnosed as suffering from depression and taking antidepressants although 53.8% had CDS>6 and 57.3% had Cornell score >11 both indicative of depression. It appeared that clinicians were able to detect mainly severe major depression with mean CDS score=10.50, (sd = 1.5) and mean Cornell score=18 (sd = 4.3).
ConclusionsIn our sample of an elderly long term inpatient population with primary diagnosis of serious mental disorder, depression was under diagnosed and undertreated. Only severe major depression was detected.
It appears that psychometric scales like Geriatric Depression Scale (GDS) and Cornell Scale for Depression in Dementia (CSDD) are valuable instruments for the detection of depression in elderly populations. As depression is very good in hiding or camouphlage its’ symptoms as part of other disorders, regular use of psychometric scales could prove to be an easy way to detect early signs of depression and treat accordingly.
P-1105 - Polypharmacy in a Psychiatric Department of a General Hospital in Northen Greece
- P. Ntounas, C. Tsopelas, A. Konsta, S. Stamou, M. Chronopoulou, D. Pappas, A. Paraskevopoulou, S. Dimaki, D. Dimitriadis, P. Chatzimanolis, M. Dimitraka, A. Vasiliou, C. Mokas, I. Gogolakis, C. Marmarinou, E. Siouti, E. Rizos, C. Touloumis, A. Douzenis
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- Journal:
- European Psychiatry / Volume 27 / Issue S1 / 2012
- Published online by Cambridge University Press:
- 15 April 2020, p. 1
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Introduction
In spite of the absence of validation by treatment guidelines, the practice of polypharmacy in psychiatry continues to increase. This cross-sectional study tries to describe polypharmacy rates in a psychiatric ward of a general hospital.
MethodParticipants (51 patients) were selected from inpatients in the General University Psychiatric Hospital “Papageorgiou”. The study was conducted from July to September 2011. Patients had to be hospitalized for at least 3 weeks in order to be included. The statistical program SPSS was used in the analysis.
ResultsOur sample consists of 51 patients, of average age 45.4 years (SD = 16,3), males 39,2%, with average starting age of disease 35.8 years (SD = 16,1), 78,4% voluntary hospitalized, with the diagnosis of schizophrenic disorder in 41.2%, bipolar disorder in 19.6% and depression in 39.2%. 29.4% of patients were working before being hospitalized and 7.8% had history of substance use. Their treatment included more than one antipsychotic in 2% of patients, more than one antidepressant in 4% and a benzodiazepine in 33.3%. At the moment of discharge from hospital, the rates of polypharmacy showed no statistically significant difference compared to the ones at admission. The only exception concerned the use of the long-acting formulations which rose to 7.8%.
ConclusionsMost patients hospitalized in the psychiatric department of the University General Hospital was suffering from mood disorders and had short admission time. These factors led to a decreased need of using multiple kinds of medications. A larger sample of patients is necessary to confirm the presented points.
P-733 - Self Care and Behavioral Disturbances in Elderly Long Term Inpatients With Serious Mental Illness
- P. Ntounas, C. Tsopelas, P. Chatzimanolis, D. Pappas, M. Dimitraka, E. Siouti, C. Touloumis, A. Douzenis, L. Lykouras
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- Journal:
- European Psychiatry / Volume 27 / Issue S1 / 2012
- Published online by Cambridge University Press:
- 15 April 2020, p. 1
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Introduction:
Behavioral disorders, such as agitation and disability in daily skills, include symptoms of disturbed perception, thought content, mood or behavior that frequently occur in patients with dementia. These behavioral disturbances rather than cognitive disorders are the main reason why caregivers place patients in a nursing home.
Methods:The participants (103 patients) age 55 years or more had diagnosis of Schizophrenia and other psychotic disorders, Mood disorders and Mental disorders due to a general medical condition (DSM IV-TR criteria) from the psychogeriatric units of the psychiatric hospital of Attica. They were all assessed using the Neuropsychiatric Inventory (NPI) and Katz Instrumental Activities Scale (KATZ) to evaluate agitation, irritability and daily skills functionality.
Results:Of the sample of 103 Greek long term inpatients, 32% had clinical manifestation of aggression, 43.7% had severe daily skills dysfunction (with KATZ score 1–2), 19.4% moderate (KATZ score 3–4) and 36.9% had no dysfunction. NPI detected agitation in 55.3% of the sample and irritability in 49.5%.
Conclusions:Behavioral disturbances, agitation and disability in daily skills are common among older hospitalized patients, and psychometric scales like NPI and KATZ are valuable instruments that could prove to be an easy way to detect early signs of behavioral manifestations and exacerbation of a variety of mental disorders in elderly populations. They should be implemented in the usual clinical practice.
P-1026 - Metabolic Syndrome and Risk for Coronary Heart Disease in Elderly Inpatients With Serious Mental Illness
- P. Ntounas, C. Tsopelas, P. Chatzimanolis, M. Dimitraka, D. Pappas, E. Siouti, C. Touloumis, A. Douzenis, L. Lykouras
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- Journal:
- European Psychiatry / Volume 27 / Issue S1 / 2012
- Published online by Cambridge University Press:
- 15 April 2020, p. 1
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Introduction
People with severe mental disorders have worse physical health compared with the general population. Metabolic aspects such as obesity, diabetes, hypertension, dyslipidaemia, smoking and antipsychotic medication increase the risk of metabolic syndrome (MetS) and cardiovascular disease. Epidemiological studies have consistently shown excess CVD mortality in patients with schizophrenia, bipolar disorder and depression.
MethodsThe participants (103 patients) age 55 years or more, had diagnosis of Schizophrenia and other psychotic disorders, Mood disorders and Mental disorders due to a general medical condition(DSM IV-TR criteria). Metabolic syndrome was estimated using the ATP III definition.
Framingham risk score was calculated using algorithms developed by Wilson for subjects aged 30 years and older.
ResultsOverall prevalence of MetS was 34%. (37.1% men, 62,9% women). Among patients with MetS 74.3% had schizophrenia, 8.6.% Mood disorder and 17.1% Mental disorders due to a general medical condition. In our sample 18.8% of patients with MetS were receiving FGAs, 78.1% SGAs and 3.1% combination of FGAs and SGAs but this difference wasn’t statistically significant.
Low risk (FRS < = 14) had 68% of participants (21.4% men and 78.6% women). Moderate risk (FRS > 15) had 32% of participants (66.7% men, 33.3% women).
ConclusionsThe results indicate that patients with schizophrenia have higher probability of having MetS, therefore, clinicians should appropriately monitor the risk factors and intervene as required.
P-457 - Dementia in Elderly Long Term Inpatients With Serious Mental Illness
- P. Ntounas, C. Tsopelas, M. Dimitraka, D. Pappas, P. Chatzimanolis, E. Siouti, C. Touloumis, A. Douzenis, L. Lykouras
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- European Psychiatry / Volume 27 / Issue S1 / 2012
- Published online by Cambridge University Press:
- 15 April 2020, p. 1
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Introduction:
Cognitive impairment and loss of functionality are key characteristics of dementia and also highly prevalent among patients with serious mental illness. Our study reports on the prevalence of dementia and the relationship between cognitive decline, behavioral and social functioning disturbances, lifestyle/ physical health parameters and the pharmaceutical approaches, in an elderly population of the psychiatric hospital of Attica.
Methods:103 patients, aged 55 years or more, with diagnosis of Schizophrenia/other psychotic disorders, Mood disorders, and mental disorders due to a general medical condition (DSM-IV-TR) participated. Dementia was also defined according to DSM-IV-TR. Data collection was through their medical records and scales (Mini Mental State Examination, Clock Drawing Test, Global Deterioration Scale, Katz Index of Independence in Activities of Daily Living, Neuropsychiatric Inventory). All variables were statistically analyzed using the SPSS.
Results:Of the sample of 103 participants, 35.9% men, 64.1% women (mean age of 71), 60.2% had Schizophrenia, 7.8% Mood disorder, 32% Mental disorders due to a general medical condition. Dementia was diagnosed in 42 patients. 43,7% had severe daily skills dysfunction. Only 12,6% had no concomitant physical illness. Although they all had cognitive impairment, only 1/3 were treated with cognitive enhancers.
Conclusions:Long term mental disorder and long term hospitalization lead to severe deterioration of both cognitive function and daily skills abilities. Along with early screening for dementia, psychogeriatric patients need specific therapeutic approaches, promotion of favourable physical profile and amelioration of the consequences of the long term medication in their fragile health.
1197 – Social-psychological Differences Between Men And Women Greek Doctors
- C. Hatzoglou, K. Gourgoulianis, P. Pappas, E. Kotrotsiou, M. Gouva
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- Journal:
- European Psychiatry / Volume 28 / Issue S1 / 2013
- Published online by Cambridge University Press:
- 15 April 2020, 28-E568
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Introduction
Many studies have concluded that doctors -irrelevant of their specialties- have higher levels of hostility and psychological problems compared to these observed in the general population.
ObjectivesThe investigation of psychological characteristics of Greek male and female resident doctors.
AimsTo demonstrate the high hostility rates among physicians.
Materials and methods102 Greek resident doctors in the field of Internal Medicine, 45 male and 57 female, participated in the present study. The scientific tools used were: a) the Other As Shamer Scale (OAS), b) the Experience of Shame Scale (ESS), c) the Hostility and Direction of Hostility Questionnaire (HDHQ), d) The Symptom Checklist-90-R (SCL-90-R), e) a questionnaire concerning socio-demographic information.
ResultsThe 52% of the sample(73,3% of male and 33,5% of female) are single with mean age 33,9 and 34,2 correspondingly. In their comparison using the T-Test it was observed that the male resident doctors showed a statistically higher mean value in the subscales of: behavioral shame (P=0,045), criticism of others (P=0,031), extrapunitiveness (P=0,048). No other significant differences were demonstrated between the two groups.
ConclusionThere were not demonstrated significant differences between male and female doctors. Both male as well as female resident doctors of the sample showed high levels of hostility, a result that is supported by many other international studies. Concerning the socio-demographic results of the study it must be stressed that the medical doctors used in the sample are married at a higher age compared to the general Greek population of their coevals.
1192 – Investigation Of Psychological Characteristics Of Greek Doctors Specializing In General-family Medicine And In Internal Medicine
- P. Pappas, K. Gourgoulianis, C. Hatzoglou, E. Kotrotsiou, M. Gouva
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- European Psychiatry / Volume 28 / Issue S1 / 2013
- Published online by Cambridge University Press:
- 15 April 2020, 28-E563
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Introduction
The relatively recent propagation of the specialty of Family Medicine in Greece has created a new reality in the Greek society. This resulted in the “co-inhabitation” of the Family Medicine specialists and the Internal Medicine specialists in various Primary Care units of the country.
ObjectivesTo investigate the internal and external shame of the residents in Family Medicine and Internal Medicine and the comparison of both groups.
AimsTo demonstrate the distinct role that Family doctors must have in Primary Care.
Methods102 Greek resident doctors, 52 specializing in Family Medicine and 50 specializing in Internal Medicine participated in the study. The scientific tools used were: a)the Other As Shamer Scale, b) the Experience of Shame Scale, c) the Hostility and Direction of Hostility Questionnaire, d) The Symptom Checklist-90-R, e) Eysenck Personality Questionnaire.
ResultsComparing the two groups using the T-Test, it was observed that the residents of Family Medicine showed a statistically significant higher mean value compared to the residents Internal Medicine in the subscales of: characterological shame, behavioral shame, bodily shame, total shame, emptiness, criticism of others, self-criticism, guilt, intropunitiveness, total hostility, neuroticism and an statistically lower mean value compared to the residents of Internal Medicine in the subscales of: mistakes, Anxiety, Phobic Anxiety and Psychotism.
ConclusionThe results of the study are supporting the common belief that the specialty of Family Medicine has not yet obtained a specific and distinct role and furthermore has not yet gained the necessary recognition by the Greek society.
EPA-1594 - Regression Model for Subjective well being in Patients with Diabetes Mellitus
- G. Lyrakos, D. Damigos, E. Chatziaggelaki, A.K. Papazafiropoulou, A. Koutsovasilis, C. Batistaki, S. Bousboulas, S. Pappas, V. Spinaris
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- Journal:
- European Psychiatry / Volume 29 / Issue S1 / 2014
- Published online by Cambridge University Press:
- 15 April 2020, p. 1
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Introduction
Subjective well being (SWB) is really an umbrella term, that includes several different components and these components are somewhat independent, while Diabetes Mellitus (DM) is a chronic condition affected by many biopsychosocial factors.
ObjectivesTo measure the impact of SWB in adult patients with DM
AimsTo explore possible demographic, physical, and psychosocial correlates in SWB.
Methods293 DM patients(115(39.2%) males/178(60.8%) females), in two outpatients’ clinics in Athens-Greece took part in the study. Satisfaction with Life Scale(SWLS) was used for SWB, along with SF12 for health related quality of life Depression Anxiety Stress Scale(DASS), Life Orientation Test(GrLOT-R) for dispositional optimism and a questionnaire about sociodemographic characteristics. Statistical analysis was performed with SPSS 21.
Resultsinternal Almost half of the patients(54.5%) scored below average(<24) in SWLS while 20% were highly satisfied (score 30-35) and 25% satisfied(25-29). No existing differences were present in SWB according to sex(t=1.605-p=NS). Multivariate analysis revealed that depression(beta=-.423), Physical component score (SF12-PCS) (beta=.317), fatigue(beta=.211), income(beta=.186), stress(beta=-.150) and pain intensity (beta=.139), explained 52.9% of the variance in SWB(adjusted R2=.529-p=0.001). Sex, education, marital status, anxiety, Mental Composite Score, HbA1c, insulin therapy, and diabetes complications had a NS effect in the model.
ConclusionsOur results indicates that SWB is affected equally from biological, psychological and societal variables, giving strong evidence to the biopsychosocial model of subjective health and suggests that multidisciplinary treatment with psychological screening should be applied in these patients in order to help and motivate them feel better.
P-1106 - Agression and Drug Treatment Choices Concerning Inpatients With Serious Mental Disorder
- P. Ntounas, C. Tsopelas, P. Chatzimanolis, D. Dimitriadis, D. Pappas, S. Stamou, I. Gogolakis, A. Paraskevopoulou, S. Dimaki, M. Chronopoulou, C. Mokas, A. Vasiliou, M. Dimitraka, C. Marmarinou, E. Siouti, A. Konsta, E. Rizos, C. Touloumis, A. Douzenis
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- Journal:
- European Psychiatry / Volume 27 / Issue S1 / 2012
- Published online by Cambridge University Press:
- 15 April 2020, p. 1
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Introduction
Psyhiatrists who work in hospitals and treat patients who show aggression present particular challenges. The course and treatment of serious psychiatric disorders can be complicated because of the comorbidity with substance abuse. The objective of the present study is the drug treatment of aggression among in-patients with serious mental disorder.
MethodThe participants (423 patients) were randomly screened among the in-patients of the 9 acute departments of PHA (Psyhiatric Hospital of Attica). For the statistical analysis, the program SPSS was used.
ResultsThe participants (423 patients): average age 45.9 years old (sd = 13.1), 60.8% men, 63.7% involuntary admitted, disorder onset: 28.4 years (sd = 12.1), diagnosis of Schizophrenia 72.1%, Bipolar disorder 16.8%, Depression 11.1% with substance abuse in 18.7%, and reason of admission: auto/hetero- agression 24.3%, relapse of the disease 46.1%, interruption of drug therapy 27%. 67,5% showed aggression at the admission, 25.6% were administered more than one antipsychotic drug at the admission, along with benzodiazepines in 53.7%. During their hospitalization, aggression was reduced to 22.9%, with verbal aggression first in line with 14.4%, and 41.9% of the patients were administered more than one antipsychotic drug. The SGAs dominated and were administered in combination with stabilizers, antidepressants and benzodiazepines.
ConclusionsThere are few documented points to guide daily practice, and it seems that case reports, advices from other colleagues and/or personal experience may influence in an important way the therapy of psychiatric patients who show aggressive behavior.
EPA-1197 – Agomelatine for Treating Apathy in Alzheimer's Disease
- D. Karaiskos, D. Pappa, E. Katirtzoglou, K. Siarkos, E. Tzavellas, G.N. Papadimitriou, A. Politis
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- Journal:
- European Psychiatry / Volume 29 / Issue S1 / 2014
- Published online by Cambridge University Press:
- 15 April 2020, p. 1
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Introduction:
Depression and apathy are common behavioral symptom of Alzheimer's disease (AD) and antidepressants, despite their role in improving depression have a minimum impact in improving apathy. Agomelatine has been shown to be effective in alleviating depression and reversing treatment emergent apathy.
The purpose of the current pilot study is to determine the efficacy of agomelatine in depressed patients with AD and comorbid apathy.
Methods:In this prospective 4 month study, twenty depressed elderly AD patients (age 65-85) who had been treated with SSRI and/or SNRI and shown a partial response to the antidepressant prescribed, in terms of apathy, were switched to agomelatine. Subjects were monitored for depression (Hamilton Rating Scale for Depression, HDRS), cognitive functions (Mini–Mental State Examination, MMSE) and apathy (Neuropsychiatric Inventory –apathy item, NPI-a).
Within groups, differences of HDRS, CSDD, MMSE and NPI-a scores at baseline, 2nd and 4th month of agomelatine treatment were estimated with repeated measure analysis of variance.
Results:Following agomelatine, a numeric but not statistically significant improvement was observed in depression scores (8.2±3.5 vs 7.8±3.1, p=0.234, 7.8±3.1 vs5.8±2.3, p=0.421). A marked improvement in MMSE score was observed at both 2nd (22.2±4.9 vs 20.9± 5.4, p=0.05) and 3rd assessment(22.2±4.9 vs 23.9±4.9, p<0.05). Apathy score was also improved over the consecutive assessments (25.3±5.9 vs 18.6±3.9, p<0.05 and 18.6±3.9 15.5±4.3, p<0.05).
Conclusions:The present study demonstrated a good therapeutic response to agomelatine in elderly AD patients with depression and apathy symptoms in terms of alleviating apathy.
Effects of ghrelin on activation of Akt1 and ERK1/2 pathways during in vitro maturation of bovine oocytes
- Thomas-Markos Chouzouris, Eleni Dovolou, Fotini Krania, Ioannis S. Pappas, Konstantinos Dafopoulos, Ioannis E. Messinis, George Anifandis, Georgios S. Amiridis
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The purpose of this study was to investigate the possible molecular pathways through which ghrelin accelerates in vitro oocyte maturation. Bovine cumulus–oocyte complexes (COCs), after 18 or 24 h maturation in the absence or the presence of 800 pg ml–1 of acylated ghrelin were either assessed for nuclear maturation or underwent in vitro fertilization in standard media and putative zygotes were cultured in vitro for 8 days. In a subset of COCs the levels of phosphorylated Akt1 and ERK1/2 (MAPK1/3) were assessed at the 0th, 6th, 10th, 18th and 24th hours of in vitro maturation (IVM). At 18 and 24 h no difference existed in the proportion of matured oocytes in the ghrelin-treated group, while in the control group more (P < 0.05) matured oocyte were found at 24 h. Oocyte maturation for 24 h in the presence of ghrelin resulted in substantially reduced (P < 0.05) blastocyst yield(16.3%) in comparison with that obtained after 18 h (30.0%) or to both control groups (29.3% and 26.9%, for 18 and 24 h in maturation, respectively). Ghrelin-treated oocytes expressed lower Akt1 phosphorylation rate at the 10th hour of IVM, and higher ERK1/2 at the 6th and 10th hours of IVM compared with controls. In cumulus cells, at the 18th and 24th hours of IVM Akt1 phosphorylation rate was higher in ghrelin-treated oocytes. Our results imply that ghrelin acts in a different time-dependent manner on bovine oocytes and cumulus cells modulating Akt1 and ERK1/2 phosphorylation, which brings about acceleration of the oocyte maturation process.
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- The Cambridge Dictionary of Philosophy
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- 05 August 2015
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- 27 April 2015, pp ix-xxx
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59 - Urethritis and dysuria
- from Part VIII - Clinical syndromes: genitourinary tract
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- By George Pappas, Institute for Continuing Medical Education of Ioannina, Ioannis A. Bliziotis, Alfa Institute of Biomedical Sciences (AIBS), Matthew E. Falagas, Tufts University School of Medicine
- Edited by David Schlossberg, Temple University, Philadelphia
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- Clinical Infectious Disease
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- 05 April 2015
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- 23 April 2015, pp 386-391
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Meta-analysis of selenium accumulation and expression of antioxidant enzymes in chicken tissues
- E. Zoidis, N. Demiris, A. Kominakis, A. C. Pappas
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A meta-analysis integrating results of 40 selenium (Se) supplementation experiments that originated from 35 different controlled randomized trials was carried out in an attempt to identify significant factors that affect tissue Se accumulation in chicken. Examined factors included: Se source (12 different sources examined), type of chicken (laying hens or broilers), age of birds at the beginning of supplementation, duration of supplementation, year during which the study was conducted, sex of birds, number of chickens per treatment, method of analysis, tissue type, concentration of Se determined and Se added to feed. A correlation analysis was also carried out between tissue Se concentration and glutathione peroxidase activity. Data analysis showed that the factors significantly affecting tissue Se concentration include type of chicken (P=0.006), type of tissue (P<0.001) and the analytical method used (P=0.014). Although Se source was not found to affect tissue Se concentration (overall P>0.05), certain inorganic (sodium selenite), calcium selenite, sodium selenate and organic sources (B-Traxim Se), Se-yeast, Se-malt, Se-enriched cabbage and Se-enriched garlic as well as background Se level from feed ingredients were found to significantly affect tissue Se concentration. The Se accumulation rate (estimated as linear regression coefficient of Se concentrations to Se added to feed) discriminated between the various tissues with highest values estimated in the leg muscle and lowest in blood plasma. Correlation analysis has also shown that tissue Se concentration (pooled data) was correlated to Se added to feed (r=0.529, P<0.01, log values) and to glutathione peroxidase activity (r=0.332, P=0.0478), with the latter not being correlated with Se added to feed. Although significant factors affecting Se concentration were reported in the present study, they do not necessarily indicate the in vivo function of the antioxidant system or the level of accumulated Se as other factors, not examined in the present study, may interact at the level of trace element absorption, distribution and retention.
Exploration of verbal and non-verbal semantic knowledge and autobiographical memories starting from popular songs in Alzheimer's disease
- S. Basaglia-Pappas, M. Laterza, C. Borg, A. Richard-Mornas, E. Favre, C. Thomas-Antérion
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- Journal:
- International Psychogeriatrics / Volume 25 / Issue 5 / May 2013
- Published online by Cambridge University Press:
- 07 February 2013, pp. 785-795
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Background: In mild Alzheimer's disease (AD), a deficit in episodic memory, particularly autobiographical memory, is clearly established. Several recent studies have also shown impaired semantic memory from the onset of the disease. Musical memory capacities may be especially preserved and listening to music might encourage autobiographical recall. The aim of this study was to explore recall of popular songs in AD.
Methods: We tested 12 patients with mild AD and 12 control subjects. We created a tool made up of old French popular songs: POP 10. This tool is a questionnaire composed of several subtests: melodic free recall, chorus free recall, melodic recognition, chorus recognition, semantic knowledge, autobiographical recall about the song, and autobiographical recall about the interpreter.
Results: We used non-parametric tests, the Mann–Whitney test (M–W), the Friedman test, and the a posteriori Wilcoxon test. Results of AD patients were rather similar to those of control participants for melodic memory. Concerning chorus memory (except recognition), semantic knowledge, and autobiographical recall about the interpreter, results of AD patients were significantly weaker than those of control participants. The most important result concerned autobiographical recall about the song: we found no impairment-related differences between the two groups.
Conclusion: Our findings demonstrate that popular songs can be excellent stimuli for reminiscence, such as the ability to produce an autobiographical memory related to a song. Thus, we confirm that musical semantic knowledge associated with a song may be relatively preserved in the early stages of AD. This leads to new possibilities for cognitive stimulation.
The role of organic selenium in cadmium toxicity: effects on broiler performance and health status
- A. Al-Waeli, E. Zoidis, A. C. Pappas, N. Demiris, G. Zervas, K. Fegeros
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This work was part of a project designed to assess whether organic selenium (Se) can protect against the toxic effects of cadmium (Cd). A total of 300 1-day-old, as hatched, broilers were randomly distributed in four dietary treatments with five replicate pens per treatment. In T1 treatment, broilers were fed a diet with 0.3 mg/kg added Se, as Se-yeast, without added Cd; in T2, broilers were fed a diet with 0.3 mg/kg Se and 10 mg/kg Cd; in T3, broilers were fed a diet with 0.3 mg/kg Se and 100 mg/kg of Cd; and in T4 treatment broilers were fed a diet with 3 mg/kg Se and 100 mg/kg Cd. The Cd was added to diets T2, T3 and T4 as CdCl2. On the 4th and 6th week, two broilers per replicate pen were killed in order to obtain whole blood, liver, kidney and breast samples. Body mass, feed conversion ratio and mortality were assessed and haematological analyses were performed. Se and Cd levels in tissues were analysed by inductively coupled plasma mass spectrometry. Broilers supplemented with 0.3 mg/kg Se can tolerate low levels of Cd added to the diets, as there were no significant negative effects on the examined performance parameters, whereas addition of excess Cd led to an impairment of broilers’ performance. Mortality of broilers did not differ between the four dietary treatments at any interval point or the whole period. The examined haematological parameters such as haematocrit, total blood protein concentration, and leukocytes types ranged within physiological values, revealing no negative health effects after simultaneous Cd and Se addition. The present study indicated that Se can help against the negative effects of Cd, but cannot counteract all of its negative effects.
Contributors
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- By Aakash Agarwala, Linda S. Aglio, Rae M. Allain, Paul D. Allen, Houman Amirfarzan, Yasodananda Kumar Areti, Amit Asopa, Edwin G. Avery, Patricia R. Bachiller, Angela M. Bader, Rana Badr, Sibinka Bajic, David J. Baker, Sheila R. Barnett, Rena Beckerly, Lorenzo Berra, Walter Bethune, Sascha S. Beutler, Tarun Bhalla, Edward A. Bittner, Jonathan D. Bloom, Alina V. Bodas, Lina M. Bolanos-Diaz, Ruma R. Bose, Jan Boublik, John P. Broadnax, Jason C. Brookman, Meredith R. Brooks, Roland Brusseau, Ethan O. Bryson, Linda A. Bulich, Kenji Butterfield, William R. Camann, Denise M. Chan, Theresa S. Chang, Jonathan E. Charnin, Mark Chrostowski, Fred Cobey, Adam B. Collins, Mercedes A. Concepcion, Christopher W. Connor, Bronwyn Cooper, Jeffrey B. Cooper, Martha Cordoba-Amorocho, Stephen B. Corn, Darin J. Correll, Gregory J. Crosby, Lisa J. Crossley, Deborah J. Culley, Tomas Cvrk, Michael N. D'Ambra, Michael Decker, Daniel F. Dedrick, Mark Dershwitz, Francis X. Dillon, Pradeep Dinakar, Alimorad G. Djalali, D. John Doyle, Lambertus Drop, Ian F. Dunn, Theodore E. Dushane, Sunil Eappen, Thomas Edrich, Jesse M. Ehrenfeld, Jason M. Erlich, Lucinda L. Everett, Elliott S. Farber, Khaldoun Faris, Eddy M. Feliz, Massimo Ferrigno, Richard S. Field, Michael G. Fitzsimons, Hugh L. Flanagan Jr., Vladimir Formanek, Amanda A. Fox, John A. Fox, Gyorgy Frendl, Tanja S. Frey, Samuel M. Galvagno Jr., Edward R. Garcia, Jonathan D. Gates, Cosmin Gauran, Brian J. Gelfand, Simon Gelman, Alexander C. Gerhart, Peter Gerner, Omid Ghalambor, Christopher J. Gilligan, Christian D. Gonzalez, Noah E. Gordon, William B. Gormley, Thomas J. Graetz, Wendy L. Gross, Amit Gupta, James P. Hardy, Seetharaman Hariharan, Miriam Harnett, Philip M. Hartigan, Joaquim M. Havens, Bishr Haydar, Stephen O. Heard, James L. Helstrom, David L. Hepner, McCallum R. Hoyt, Robert N. Jamison, Karinne Jervis, Stephanie B. Jones, Swaminathan Karthik, Richard M. Kaufman, Shubjeet Kaur, Lee A. Kearse Jr., John C. Keel, Scott D. Kelley, Albert H. Kim, Amy L. Kim, Grace Y. Kim, Robert J. Klickovich, Robert M. Knapp, Bhavani S. Kodali, Rahul Koka, Alina Lazar, Laura H. Leduc, Stanley Leeson, Lisa R. Leffert, Scott A. LeGrand, Patricio Leyton, J. Lance Lichtor, John Lin, Alvaro A. Macias, Karan Madan, Sohail K. Mahboobi, Devi Mahendran, Christine Mai, Sayeed Malek, S. Rao Mallampati, Thomas J. Mancuso, Ramon Martin, Matthew C. Martinez, J. A. Jeevendra Martyn, Kai Matthes, Tommaso Mauri, Mary Ellen McCann, Shannon S. McKenna, Dennis J. McNicholl, Abdel-Kader Mehio, Thor C. Milland, Tonya L. K. Miller, John D. Mitchell, K. Annette Mizuguchi, Naila Moghul, David R. Moss, Ross J. Musumeci, Naveen Nathan, Ju-Mei Ng, Liem C. Nguyen, Ervant Nishanian, Martina Nowak, Ala Nozari, Michael Nurok, Arti Ori, Rafael A. Ortega, Amy J. Ortman, David Oxman, Arvind Palanisamy, Carlo Pancaro, Lisbeth Lopez Pappas, Benjamin Parish, Samuel Park, Deborah S. Pederson, Beverly K. Philip, James H. Philip, Silvia Pivi, Stephen D. Pratt, Douglas E. Raines, Stephen L. Ratcliff, James P. Rathmell, J. Taylor Reed, Elizabeth M. Rickerson, Selwyn O. Rogers Jr., Thomas M. Romanelli, William H. Rosenblatt, Carl E. Rosow, Edgar L. Ross, J. Victor Ryckman, Mônica M. Sá Rêgo, Nicholas Sadovnikoff, Warren S. Sandberg, Annette Y. Schure, B. Scott Segal, Navil F. Sethna, Swapneel K. Shah, Shaheen F. Shaikh, Fred E. Shapiro, Torin D. Shear, Prem S. Shekar, Stanton K. Shernan, Naomi Shimizu, Douglas C. Shook, Kamal K. Sikka, Pankaj K. Sikka, David A. Silver, Jeffrey H. Silverstein, Emily A. Singer, Ken Solt, Spiro G. Spanakis, Wolfgang Steudel, Matthias Stopfkuchen-Evans, Michael P. Storey, Gary R. Strichartz, Balachundhar Subramaniam, Wariya Sukhupragarn, John Summers, Shine Sun, Eswar Sundar, Sugantha Sundar, Neelakantan Sunder, Faraz Syed, Usha B. Tedrow, Nelson L. Thaemert, George P. Topulos, Lawrence C. Tsen, Richard D. Urman, Charles A. Vacanti, Francis X. Vacanti, Joshua C. Vacanti, Assia Valovska, Ivan T. Valovski, Mary Ann Vann, Susan Vassallo, Anasuya Vasudevan, Kamen V. Vlassakov, Gian Paolo Volpato, Essi M. Vulli, J. Matthias Walz, Jingping Wang, James F. Watkins, Maxwell Weinmann, Sharon L. Wetherall, Mallory Williams, Sarah H. Wiser, Zhiling Xiong, Warren M. Zapol, Jie Zhou
- Edited by Charles Vacanti, Scott Segal, Pankaj Sikka, Richard Urman
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- Essential Clinical Anesthesia
- Published online:
- 05 January 2012
- Print publication:
- 11 July 2011, pp xv-xxviii
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Contributors
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- By Leonard A. Adler, Henrik Anckarsäter, L. Eugene Arnold, Philip J. Asherson, Russell Barkley, Joseph Biederman, Andrew D. Blackwell, Jessica Bramham, Thomas E. Brown, Richard Bruggeman, Jan K. Buitelaar, C. Keith Conners, Jonathan H. Dowson, Steve V. Faraone, Christopher Gibbins, Christopher Gillberg, I. Carina Gillberg, Ylva Ginsberg, Laurence L. Greenhill, Julia D. Hunter, Cornelis C. Kan, Ronald C. Kessler, Scott H. Kollins, J. J. Sandra Kooij, Johanna Krause, Jonna Kuntsi, Florence Levy, Stephen P. McDermott, Gráinne McLoughlin, Mitul A. Mehta, Asko Niemela, Eleni Paliokosta, Yannis Paloyelis, Vangelis Pappas, Patricia Quinn, Maria Råstam, Doris Ryffel, David Shaw, Seija Sirviö, Thomas Spencer, Lacramioara Spetie, Siegfried Tuinier, Fiona E. van Dijk, Anne M. D. N. van Lammeren, Wim J. C. Verbeeck, Margaret Weiss, Timothy E. Wilens, Kiriakos Xenitidis
- Edited by Jan K. Buitelaar, Cornelis C. Kan, Philip Asherson, Institute of Psychiatry, London
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- ADHD in Adults
- Published online:
- 04 April 2011
- Print publication:
- 03 March 2011, pp vii-ix
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Anaesthetic considerations in parathyrotoxic crisis
- A. Papadima, E. E. Lagoudianakis, H. Markogiannakis, A. Pappas, L. Georgiou, A. Manouras
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- European Journal of Anaesthesiology / Volume 25 / Issue 9 / September 2008
- Published online by Cambridge University Press:
- 01 September 2008, pp. 772-774
- Print publication:
- September 2008
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