16 results
Recent innovations in adaptive trial designs: A review of design opportunities in translational research
- Alexander M. Kaizer, Hayley M. Belli, Zhongyang Ma, Andrew G. Nicklawsky, Samantha C. Roberts, Jessica Wild, Adane F. Wogu, Mengli Xiao, Roy T. Sabo
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- Journal:
- Journal of Clinical and Translational Science / Volume 7 / Issue 1 / 2023
- Published online by Cambridge University Press:
- 28 April 2023, e125
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Clinical trials are constantly evolving in the context of increasingly complex research questions and potentially limited resources. In this review article, we discuss the emergence of “adaptive” clinical trials that allow for the preplanned modification of an ongoing clinical trial based on the accumulating evidence with application across translational research. These modifications may include terminating a trial before completion due to futility or efficacy, re-estimating the needed sample size to ensure adequate power, enriching the target population enrolled in the study, selecting across multiple treatment arms, revising allocation ratios used for randomization, or selecting the most appropriate endpoint. Emerging topics related to borrowing information from historic or supplemental data sources, sequential multiple assignment randomized trials (SMART), master protocol and seamless designs, and phase I dose-finding studies are also presented. Each design element includes a brief overview with an accompanying case study to illustrate the design method in practice. We close with brief discussions relating to the statistical considerations for these contemporary designs.
A history of high-power laser research and development in the United Kingdom
- Part of
- Colin N. Danson, Malcolm White, John R. M. Barr, Thomas Bett, Peter Blyth, David Bowley, Ceri Brenner, Robert J. Collins, Neal Croxford, A. E. Bucker Dangor, Laurence Devereux, Peter E. Dyer, Anthony Dymoke-Bradshaw, Christopher B. Edwards, Paul Ewart, Allister I. Ferguson, John M. Girkin, Denis R. Hall, David C. Hanna, Wayne Harris, David I. Hillier, Christopher J. Hooker, Simon M. Hooker, Nicholas Hopps, Janet Hull, David Hunt, Dino A. Jaroszynski, Mark Kempenaars, Helmut Kessler, Sir Peter L. Knight, Steve Knight, Adrian Knowles, Ciaran L. S. Lewis, Ken S. Lipton, Abby Littlechild, John Littlechild, Peter Maggs, Graeme P. A. Malcolm, OBE, Stuart P. D. Mangles, William Martin, Paul McKenna, Richard O. Moore, Clive Morrison, Zulfikar Najmudin, David Neely, Geoff H. C. New, Michael J. Norman, Ted Paine, Anthony W. Parker, Rory R. Penman, Geoff J. Pert, Chris Pietraszewski, Andrew Randewich, Nadeem H. Rizvi, Nigel Seddon, MBE, Zheng-Ming Sheng, David Slater, Roland A. Smith, Christopher Spindloe, Roy Taylor, Gary Thomas, John W. G. Tisch, Justin S. Wark, Colin Webb, S. Mark Wiggins, Dave Willford, Trevor Winstone
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- Journal:
- High Power Laser Science and Engineering / Volume 9 / 2021
- Published online by Cambridge University Press:
- 27 April 2021, e18
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The first demonstration of laser action in ruby was made in 1960 by T. H. Maiman of Hughes Research Laboratories, USA. Many laboratories worldwide began the search for lasers using different materials, operating at different wavelengths. In the UK, academia, industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications. This historical review looks at the contribution the UK has made to the advancement of the technology, the development of systems and components and their exploitation over the last 60 years.
Ten new insights in climate science 2020 – a horizon scan
- Erik Pihl, Eva Alfredsson, Magnus Bengtsson, Kathryn J. Bowen, Vanesa Cástan Broto, Kuei Tien Chou, Helen Cleugh, Kristie Ebi, Clea M. Edwards, Eleanor Fisher, Pierre Friedlingstein, Alex Godoy-Faúndez, Mukesh Gupta, Alexandra R. Harrington, Katie Hayes, Bronwyn M. Hayward, Sophie R. Hebden, Thomas Hickmann, Gustaf Hugelius, Tatiana Ilyina, Robert B. Jackson, Trevor F. Keenan, Ria A. Lambino, Sebastian Leuzinger, Mikael Malmaeus, Robert I. McDonald, Celia McMichael, Clark A. Miller, Matteo Muratori, Nidhi Nagabhatla, Harini Nagendra, Cristian Passarello, Josep Penuelas, Julia Pongratz, Johan Rockström, Patricia Romero-Lankao, Joyashree Roy, Adam A. Scaife, Peter Schlosser, Edward Schuur, Michelle Scobie, Steven C. Sherwood, Giles B. Sioen, Jakob Skovgaard, Edgardo A. Sobenes Obregon, Sebastian Sonntag, Joachim H. Spangenberg, Otto Spijkers, Leena Srivastava, Detlef B. Stammer, Pedro H. C. Torres, Merritt R. Turetsky, Anna M. Ukkola, Detlef P. van Vuuren, Christina Voigt, Chadia Wannous, Mark D. Zelinka
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- Journal:
- Global Sustainability / Volume 4 / 2021
- Published online by Cambridge University Press:
- 27 January 2021, e5
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Non-technical summary
We summarize some of the past year's most important findings within climate change-related research. New research has improved our understanding of Earth's sensitivity to carbon dioxide, finds that permafrost thaw could release more carbon emissions than expected and that the uptake of carbon in tropical ecosystems is weakening. Adverse impacts on human society include increasing water shortages and impacts on mental health. Options for solutions emerge from rethinking economic models, rights-based litigation, strengthened governance systems and a new social contract. The disruption caused by COVID-19 could be seized as an opportunity for positive change, directing economic stimulus towards sustainable investments.
Technical summaryA synthesis is made of ten fields within climate science where there have been significant advances since mid-2019, through an expert elicitation process with broad disciplinary scope. Findings include: (1) a better understanding of equilibrium climate sensitivity; (2) abrupt thaw as an accelerator of carbon release from permafrost; (3) changes to global and regional land carbon sinks; (4) impacts of climate change on water crises, including equity perspectives; (5) adverse effects on mental health from climate change; (6) immediate effects on climate of the COVID-19 pandemic and requirements for recovery packages to deliver on the Paris Agreement; (7) suggested long-term changes to governance and a social contract to address climate change, learning from the current pandemic, (8) updated positive cost–benefit ratio and new perspectives on the potential for green growth in the short- and long-term perspective; (9) urban electrification as a strategy to move towards low-carbon energy systems and (10) rights-based litigation as an increasingly important method to address climate change, with recent clarifications on the legal standing and representation of future generations.
Social media summaryStronger permafrost thaw, COVID-19 effects and growing mental health impacts among highlights of latest climate science.
Effect of tillage systems, N, and cover crop on the composition of weed flora
- Clarence J. Swanton, Anil Shrestha, Robert C. Roy, Bonnie R. Ball-Coelho, Stevan Z. Knezevic
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- Journal:
- Weed Science / Volume 47 / Issue 4 / August 1999
- Published online by Cambridge University Press:
- 12 June 2017, pp. 454-461
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The adoption of conservation tillage systems has been challenged by concerns potential weed species shifts. A 9-yr study from 1988 to 1996 was conducted Delhi, Ontario, on a loamy sand soil to evaluate the effect of tillage systems (conventional [CT] and no-till [NT]), cover crop Secale cereale, and nitrogen (N) rate (0, 50, 100, 125, 150, and 200 kg N ha−1) on monocrop Zea mays L. (corn) yield and changes in the composition of the weed flora. CT consisted of spring moldboard plowing followed by cultivation with a tooth cultivator. Weed counts were taken in the last 3 yr of the study (1994, 1995, and 1996) prior to postemergence herbicide application and then again 2 to 3 wk after herbicide treatment. Composition or the weed flora was analyzed by canonical discriminant analysis (CDA). The relationship between weed density and tillage system was not consistent. Weed species composition differed between CT and NT systems. Chenopodium album and Amaranthus retroflexus were associated with CT and Digitaria sanguinalis with NT. N rate and cover crop did not affect weed density or species composition. Proper management of weeds with herbicides appeared to minimize any long-term effect on the weed flora resulting from varying N rates. Zea mays yields did not differ between CT and NT systems but were greater in both systems with a cover crop at the higher N rates. Disturbance caused by tillage was more important than N rate and cover crop as a mechanism influencing composition of the weed flora.
Biological Significance and Fate of Atrazine under Aquifer Conditions
- Glenn R. Wehtje, Roy F. Spalding, Orvin C. Burnside, Stephen R. Lowry, J. Robert C. Leavitt
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- Journal:
- Weed Science / Volume 31 / Issue 5 / September 1983
- Published online by Cambridge University Press:
- 12 June 2017, pp. 610-618
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Concentrations of atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-s-triazine] in contaminated groundwater recovered from 41 monitoring wells in Hall and Buffalo counties, Nebraska range from 0.01 to 8.29 μg/L. Over a 1-year period concentrations fluctuated sufficiently in a seasonal pattern to indicate that atrazine dissipation occurs. This reduction in concentration can be attributed to adsorption, dispersion, and degradation. A limited amount of atrazine degraded chemically to hydroxyatrazine [2-hydroxy-4-(ethylamino)-6-(isopropylamino)-s-triazine] under simulated aquifer conditions; microbial degradation could not be detected. A geometrical progression model for predicting long term residue accumulation indicates that current contamination levels probably reflect a steady-state situation between the amount that yearly enters into, and the partial degradation that occurs within, the aquifer. Oat (Avena sativa L. ‘Neal’) bioassays indicate that present levels of groundwater contamination remain well below the threshold necessary for phytotoxicity.
The Mass Balance of Circum-Arctic Glaciers and Recent Climate Change
- Julian A. Dowdeswell, Jon Ove Hagen, Helgi Björnsson, Andrey F. Glazovsky, William D. Harrison, Per Holmlund, Jacek Jania, Roy M. Koerner, Bernard Lefauconnier, C. Simon L. Ommanney, Robert H. Thomas
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- Journal:
- Quaternary Research / Volume 48 / Issue 1 / July 1997
- Published online by Cambridge University Press:
- 20 January 2017, pp. 1-14
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The sum of winter accumulation and summer losses of mass from glaciers and ice sheets (net surface mass balance) varies with changing climate. In the Arctic, glaciers and ice caps, excluding the Greenland Ice Sheet, cover about 275,000 km2of both the widely glacierized archipelagos of the Canadian, Norwegian, and Russian High Arctic and the area north of about 60°N in Alaska, Iceland, and Scandinavia. Since the 1940s, surface mass balance time-series of varying length have been acquired from more than 40 Arctic ice caps and glaciers. Most Arctic glaciers have experienced predominantly negative net surface mass balance over the past few decades. There is no uniform recent trend in mass balance for the entire Arctic, although some regional trends occur. Examples are the increasingly negative mass balances for northern Alaska, due to higher summer temperatures, and increasingly positive mass balances for maritime Scandinavia and Iceland, due to increased winter precipitation. The negative mass balance of most Arctic glaciers may be a response to a step-like warming in the early twentieth century at the termination of the cold Little Ice Age. Arctic ice masses outside Greenland are at present contributing about 0.13 mm yr−1to global sea-level rise.
Contributors
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- By Robert R. H. Anholt, M. Fernanda Ceriani, Ann-Shyn Chiang, Anupama Dahanukar, Brigitte Dauwalder, J. Steven de Belle, Claude Desplan, Taylor R. Fore, Leslie C. Griffith, Yukinori Hirano, Ken Honjo, Junjiro Horiuchi, Bryon N. Hughson, George R. Jackson, Charalambos P. Kyriacou, Ricardo Leitão-Gonçalves, Fritz-Olaf Lehmann, Chih-Yung Lin, Trudy F. C. Mackay, Ian A. Meinertzhagen, Nara I. Muraro, Dick R. Nässel, Daniela Ostrowski, Viet Pham, Carlos Ribeiro, Jessica Robertson, Bidisha Roy, C. Dustin Rubinstein, Shinjiro Saeki, Minoru Saitoe, Christi A. Scott, Lisha Shao, Marla B. Sokolowski, Eric A. Stone, Christopher J. Tabone, W. Daniel Tracey, Nina Vogt, Mariana Wolfner, Troy Zars, Bing Zhang, Yi Zhong
- Edited by Josh Dubnau
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- Book:
- Behavioral Genetics of the Fly (<I>Drosophila Melanogaster</I>)
- Published online:
- 05 July 2014
- Print publication:
- 26 June 2014, pp vi-viii
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Contributors
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- By Lenard A. Adler, Pinky Agarwal, Rehan Ahmed, Jagga Rao Alluri, Fawaz Al-Mufti, Samuel Alperin, Michael Amoashiy, Michael Andary, David J. Anschel, Padmaja Aradhya, Vandana Aspen, Esther Baldinger, Jee Bang, George D. Baquis, John J. Barry, Jason J. S. Barton, Julius Bazan, Amanda R. Bedford, Marlene Behrmann, Lourdes Bello-Espinosa, Ajay Berdia, Alan R. Berger, Mark Beyer, Don C. Bienfang, Kevin M. Biglan, Thomas M. Boes, Paul W. Brazis, Jonathan L. Brisman, Jeffrey A. Brown, Scott E. Brown, Ryan R. Byrne, Rina Caprarella, Casey A. Chamberlain, Wan-Tsu W. Chang, Grace M. Charles, Jasvinder Chawla, David Clark, Todd J. Cohen, Joe Colombo, Howard Crystal, Vladimir Dadashev, Sarita B. Dave, Jean Robert Desrouleaux, Richard L. Doty, Robert Duarte, Jeffrey S. Durmer, Christyn M. Edmundson, Eric R. Eggenberger, Steven Ender, Noam Epstein, Alberto J. Espay, Alan B. Ettinger, Niloofar (Nelly) Faghani, Amtul Farheen, Edward Firouztale, Rod Foroozan, Anne L. Foundas, David Elliot Friedman, Deborah I. Friedman, Steven J. Frucht, Oded Gerber, Tal Gilboa, Martin Gizzi, Teneille G. Gofton, Louis J. Goodrich, Malcolm H. Gottesman, Varda Gross-Tsur, Deepak Grover, David A. Gudis, John J. Halperin, Maxim D. Hammer, Andrew R. Harrison, L. Anne Hayman, Galen V. Henderson, Steven Herskovitz, Caitlin Hoffman, Laryssa A. Huryn, Andres M. Kanner, Gary P. Kaplan, Bashar Katirji, Kenneth R. Kaufman, Annie Killoran, Nina Kirz, Gad E. Klein, Danielle G. Koby, Christopher P. Kogut, W. Curt LaFrance, Patrick J.M. Lavin, Susan W. Law, James L. Levenson, Richard B. Lipton, Glenn Lopate, Daniel J. Luciano, Reema Maindiratta, Robert M. Mallery, Georgios Manousakis, Alan Mazurek, Luis J. Mejico, Dragana Micic, Ali Mokhtarzadeh, Walter J. Molofsky, Heather E. Moss, Mark L. Moster, Manpreet Multani, Siddhartha Nadkarni, George C. Newman, Rolla Nuoman, Paul A. Nyquist, Gaia Donata Oggioni, Odi Oguh, Denis Ostrovskiy, Kristina Y. Pao, Juwen Park, Anastas F. Pass, Victoria S. Pelak, Jeffrey Peterson, John Pile-Spellman, Misha L. Pless, Gregory M. Pontone, Aparna M. Prabhu, Michael T. Pulley, Philip Ragone, Prajwal Rajappa, Venkat Ramani, Sindhu Ramchandren, Ritesh A. Ramdhani, Ramses Ribot, Heidi D. Riney, Diana Rojas-Soto, Michael Ronthal, Daniel M. Rosenbaum, David B. Rosenfield, Durga Roy, Michael J. Ruckenstein, Max C. Rudansky, Eva Sahay, Friedhelm Sandbrink, Jade S. Schiffman, Angela Scicutella, Maroun T. Semaan, Robert C. Sergott, Aashit K. Shah, David M. Shaw, Amit M. Shelat, Claire A. Sheldon, Anant M. Shenoy, Yelizaveta Sher, Jessica A. Shields, Tanya Simuni, Rajpaul Singh, Eric E. Smouha, David Solomon, Mehri Songhorian, Steven A. Sparr, Egilius L. H. Spierings, Eve G. Spratt, Beth Stein, S.H. Subramony, Rosa Ana Tang, Cara Tannenbaum, Hakan Tekeli, Amanda J. Thompson, Michael J. Thorpy, Matthew J. Thurtell, Pedro J. Torrico, Ira M. Turner, Scott Uretsky, Ruth H. Walker, Deborah M. Weisbrot, Michael A. Williams, Jacques Winter, Randall J. Wright, Jay Elliot Yasen, Shicong Ye, G. Bryan Young, Huiying Yu, Ryan J. Zehnder
- Edited by Alan B. Ettinger, Albert Einstein College of Medicine, New York, Deborah M. Weisbrot, State University of New York, Stony Brook
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- Book:
- Neurologic Differential Diagnosis
- Published online:
- 05 June 2014
- Print publication:
- 17 April 2014, pp xi-xx
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Notes on Contributors
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- By E. Jennifer Ashworth, J. L. Berggren, Charles Burnett, Joan Cadden, Bruce S. Eastwood, Edward Grant, Danielle Jacquart, Elaheh Kheirandish, Tomomi Kinukawa, Walter Roy Laird, Y. Tzvi Langermann, David C. Lindberg, Stephen C. McCcluskey, A. George Molland, Robert G. Morrison, William R. Newman, John North, Vivian Nutton, George Ovitt, Katharine Park, F. Jamil Ragep, Karen Meier Reeds, Emilie Savage-Smith, Michael H. Shank, Katherine H. Tachau, Anne Tihon, David Woodward
- David C. Lindberg, Michael H. Shank
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- Book:
- The Cambridge History of Science
- Published online:
- 05 September 2013
- Print publication:
- 07 October 2013, pp xvii-xxii
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Summary for Policy Makers
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- By Thomas B. Johansson, Lund University, Nebojsa Nakicenovic, International Institute for Applied Systems Analysis and Vienna University of Technology, Anand Patwardhan, Indian Institute of Technology-Bombay), Luis Gomez-Echeverri, International Institute for Applied Systems Analysis, Rangan Banerjee, Indian Institute of Technology, Sally M. Benson, Stanford University, Daniel H. Bouille, Bariloche Foundation, Abeeku Brew-Hammond, Kwame Nkrumah University of Science and Technology, Aleh Cherp, Central European University, Suani T. Coelho, National Reference Center on Biomass, University of São Paulo, Lisa Emberson, Stockholm Environment Institute, University of York, Maria Josefina Figueroa, Technical University, Arnulf Grubler, International Institute for Applied Systems Analysis, Austria and Yale University, Kebin He, Tsinghua University, Mark Jaccard, Simon Fraser University, Suzana Kahn Ribeiro, Federal University of Rio de Janeiro, Stephen Karekezi, AFREPREN/FWD, Eric D. Larson, Princeton University and Climate Central, Zheng Li, Tsinghua University, Susan McDade, United Nations Development Programme), Lynn K. Mytelka, United Nations University-MERIT, Shonali Pachauri, International Institute for Applied Systems Analysis, Keywan Riahi, International Institute for Applied Systems Analysis, Johan Rockström, Stockholm Environment Institute, Stockholm University, Hans-Holger Rogner, International Atomic Energy Agency, Joyashree Roy, Jadavpur University, Robert N. Schock, World Energy Council, UK and Center for Global Security Research, Ralph Sims, Massey University, Kirk R. Smith, University of California, Wim C. Turkenburg, Utrecht University, Diana Ürge-Vorsatz, Central European University, Frank von Hippel, Princeton University, Kurt Yeager, Electric Power Research Institute and Galvin Electricity Initiative
- Global Energy Assessment Writing Team
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- Book:
- Global Energy Assessment
- Published online:
- 05 September 2012
- Print publication:
- 27 August 2012, pp 3-30
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Summary
Introduction
Energy is essential for human development and energy systems are a crucial entry point for addressing the most pressing global challenges of the 21st century, including sustainable economic and social development, poverty eradication, adequate food production and food security, health for all, climate protection, conservation of ecosystems, peace and security. Yet, more than a decade into the 21st century, current energy systems do not meet these challenges.
A major transformation is therefore required to address these challenges and to avoid potentially catastrophic future consequences for human and planetary systems. The Global Energy Assessment (GEA) demonstrates that energy system change is the key for addressing and resolving these challenges. The GEA identifies strategies that could help resolve the multiple challenges simultaneously and bring multiple benefits. Their successful implementation requires determined, sustained and immediate action.
Transformative change in the energy system may not be internally generated; due to institutional inertia, incumbency and lack of capacity and agility of existing organizations to respond effectively to changing conditions. In such situations clear and consistent external policy signals may be required to initiate and sustain the transformative change needed to meet the sustainability challenges of the 21st century.
The industrial revolution catapulted humanity onto an explosive development path, whereby, reliance on muscle power and traditional biomass was replaced mostly by fossil fuels. In 2005, some 78% of global energy was based on fossil energy sources that provided abundant and ever cheaper energy services to more than half the people in the world.
Technical Summary
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- By Thomas B. Johansson, Lund University, Nebojsa Nakicenovic, International Institute for Applied Systems Analysis and Vienna University of Technology, Anand Patwardhan, Indian Institute of Technology, Luis Gomez-Echeverri, International Institute for Applied Systems Analysis, Doug J. Arent, National Renewable Energy Laboratory, Rangan Banerjee, Indian Institute of Technology, Sally M. Benson, Stanford University, Daniel H. Bouille, Bariloche Foundation, Abeeku Brew-Hammond, Kwame Nkrumah University of Science and Technology, Aleh Cherp, Central European University, Suani T. Coelho, National Reference Center on Biomass, University of São Paulo, Lisa Emberson, Stockholm Environment Institute, University of York, Maria Josefina Figueroa, Technical University, Arnulf Grubler, International Institute for Applied Systems Analysis, Austria and Yale University, Kebin He, Tsinghua University, Mark Jaccard, Simon Fraser University, Suzana Kahn Ribeiro, Federal University of Rio de Janeiro, Stephen Karekezi, AFREPREN/FWD, Eric D. Larson, Princeton University and Climate Central, Zheng Li, Tsinghua University, Susan McDade, United Nations Development Programme, Lynn K. Mytelka, United Nations University-MERIT, Shonali Pachauri, International Institute for Applied Systems Analysis, Keywan Riahi, International Institute for Applied Systems Analysis, Johan Rockström, Stockholm Environment Institute, Stockholm University, Hans-Holger Rogner, International Atomic Energy Agency, Joyashree Roy, Jadavpur University, Robert N. Schock, World Energy Council, UK and Center for Global Security Research, Ralph Sims, Massey University, Kirk R. Smith, University of California, Wim C. Turkenburg, Utrecht University, Diana Ürge-Vorsatz, Central European University, Frank von Hippel, Princeton University, Kurt Yeager, Electric Power Research Institute and Galvin Electricity Initiative
- Global Energy Assessment Writing Team
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- Book:
- Global Energy Assessment
- Published online:
- 05 September 2012
- Print publication:
- 27 August 2012, pp 31-94
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Summary
Introduction
Energy is essential for human development and energy systems are a crucial entry point for addressing the most pressing global challenges of the 21st century, including sustainable economic, and social development, poverty eradication, adequate food production and food security, health for all, climate protection, conservation of ecosystems, peace, and security. Yet, more than a decade into the 21st century, current energy systems do not meet these challenges.
In this context, two considerations are important. The first is the capacity and agility of the players within the energy system to seize opportunities in response to these challenges. The second is the response capacity of the energy system itself, as the investments are long-term and tend to follow standard financial patterns, mainly avoiding risks and price instabilities. This traditional approach does not embrace the transformation needed to respond properly to the economic, environmental, and social sustainability challenges of the 21st century.
A major transformation is required to address these challenges and to avoid potentially catastrophic consequences for human and planetary systems. The GEA identifies strategies that could help resolve the multiple challenges simultaneously and bring multiple benefits. Their successful implementation requires determined, sustained, and immediate action.
The industrial revolution catapulted humanity onto an explosive development path, whereby reliance on muscle power and traditional biomass was replaced mostly by fossil fuels. In 2005, approximately 78% of global energy was based on fossil energy sources that provided abundant and ever cheaper energy services to more than half the world's population.
Contributors
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- By Graeme J.M. Alexander, Heung Bae Kim, Michael Burch, Andrew J. Butler, Tanveer Butt, Roy Calne, Edward Cantu, Robert B. Colvin, Paul Corris, Charles Crawley, Hiroshi Date, Francis L. Delmonico, Bimalangshu R. Dey, Kate Drummond, John Dunning, John D. Firth, John Forsythe, Simon M. Gabe, Robert S. Gaston, William Gelson, Paul Gibbs, Alex Gimson, Leo C. Ginns, Samuel Goldfarb, Ryoichi Goto, Walter K. Graham, Simon J.F. Harper, Koji Hashimoto, David G. Healy, Hassan N. Ibrahim, David Ip, Fadi G. Issa, Neville V. Jamieson, David P. Jenkins, Dixon B. Kaufman, Kiran K. Khush, Heung Bae Kim, Andrew A. Klein, John Klinck, Camille Nelson Kotton, Vineeta Kumar, Yael B. Kushner, D. Frank. P. Larkin, Clive J. Lewis, Yvonne H. Luo, Richard S. Luskin, Ernest I. Mandel, James F. Markmann, Lorna Marson, Arthur J. Matas, Mandeep R. Mehra, Stephen J. Middleton, Giorgina Mieli-Vergani, Charles Miller, Sharon Mulroy, Faruk Özalp, Can Ozturk, Jayan Parameshwar, J.S. Parmar, Hari K. Parthasarathy, Nick Pritchard, Cristiano Quintini, Axel O. Rahmel, Chris J. Rudge, Stephan V.B. Schueler, Maria Siemionow, Jacob Simmonds, Peter Slinger, Thomas R. Spitzer, Stuart C. Sweet, Nina E. Tolkoff-Rubin, Steven S.L. Tsui, Khashayar Vakili, R.V. Venkateswaran, Hector Vilca-Melendez, Vladimir Vinarsky, Kathryn J. Wood, Heidi Yeh, David W. Zaas, Jonathan G. Zaroff
- Edited by Andrew A. Klein, Clive J. Lewis, Joren C. Madsen
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- Book:
- Organ Transplantation
- Published online:
- 07 September 2011
- Print publication:
- 11 August 2011, pp vii-x
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Contributors
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- By Alex Abou-Chebl, Andrei V. Alexandrov, Carlos E. Baccin, Deepak L. Bhatt, Kirk Conrad, Steve M. Cordina, Randall C. Edgell, Mustapha A. Ezzeddine, Matthew D. Ford, Alexandros L. Georgiadis, Camilo R. Gomez, Nancy Gruell, Stephen J. Haines, Ameer E. Hassan, L. Nelson Hopkins, Haitham H. Hussein, Tudor G. Jovin, Stanley H. Kim, Osman Kozak, Giuseppe Lanzino, Alberto Maud, Muhammad Z. Memon, Jefferson T. Miley, Herbert B. Newton, Thanh N. Nguyen, YihLin Nien, Raul G. Nogueira, Alexander M. Norbash, Anant I. Patel, Edgard Pereira, Johnny C. Pryor, Rabia Qaiser, Adnan I. Qureshi, Mushtaq H. Qureshi, Jean Raymond, José Rafael Romero, Daniel Roy, Qaisar A. Shah, Farhan Siddiq, Amit Singla, David A. Steinman, Dorothea Strozyk, Jose I. Suarez, M. Fareed K. Suri, Nauman Tariq, Robert A. Taylor, Georgios Tsivgoulis, Young J. Yu, Haralabos Zacharatos
- Edited by Adnan I. Qureshi, University of Minnesota
- Edited in association with Alexandros L. Georgiadis, University of Minnesota
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- Book:
- Textbook of Interventional Neurology
- Published online:
- 01 June 2011
- Print publication:
- 14 April 2011, pp vi-x
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Contributors
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- By Ashok Agarwal, Carrie Bedient, Nick Brook, Michelle Catenacci, Ying Cheong, Francisco Domínguez, Thomas Elliott, Sandro C. Esteves, Tommaso Falcone, Gabriel de la Fuente, Eugene Galdones, Juan A. Garcia-Velasco, David K. Gardner, Tamara Garrido, Robert B. Gilchrist, Georg Griesinger, Roy Homburg, Jeanine Cieslak Janzen, Mark T. Johnson, Jennifer Kahn, David L. Keefe, Efstratios M Kolibianakis, Laurie J. McKenzie, Nick Macklon, David Meldrum, Ashley R. Mott, Tetsunori Mukaida, Zsolt Peter Nagy, Edurne Novella-Maestre, Chris O’Neill, Chikaharo Oka, Steven F. Palta, Lewis K. Pannell, Antonio Pellicer, Valeria Pugni, Botros R. M. B. Rizk, Christopher B. Rizk, Claude Robert, Denny Sakkas, Hassan N. Sallam, William B. Schoolcraft, Lonnie D. Shea, Carlos Simón, Manuela Simoni, Marc-Andre Sirard, Johan E. J. Smitz, Eric S. Surrey, Jan Tesarik, Raquel Mendoza Tesarik, Jeremy G. Thompson, Andrew J. Watson, Teresa K. Woodruff
- Edited by David K. Gardner, University of Melbourne, Botros R. M. B. Rizk, University of South Alabama, Tommaso Falcone
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- Book:
- Human Assisted Reproductive Technology
- Published online:
- 16 May 2011
- Print publication:
- 31 March 2011, pp ix-xii
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Contributors
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. Kirk-Duggan, Clifton Kirkpatrick, Leonid Kishkovsky, Nadieszda Kizenko, Jeffrey Klaiber, Hans-Josef Klauck, Sidney Knight, Samuel Kobia, Robert Kolb, Karla Ann Koll, Heikki Kotila, Donald Kraybill, Philip D. W. Krey, Yves Krumenacker, Jeffrey Kah-Jin Kuan, Simanga R. Kumalo, Peter Kuzmic, Simon Shui-Man Kwan, Kwok Pui-lan, André LaCocque, Stephen E. Lahey, John Tsz Pang Lai, Emiel Lamberts, Armando Lampe, Craig Lampe, Beverly J. Lanzetta, Eve LaPlante, Lizette Larson-Miller, Ariel Bybee Laughton, Leonard Lawlor, Bentley Layton, Robin A. Leaver, Karen Lebacqz, Archie Chi Chung Lee, Marilyn J. Legge, Hervé LeGrand, D. L. LeMahieu, Raymond Lemieux, Bill J. Leonard, Ellen M. Leonard, Outi Leppä, Jean Lesaulnier, Nantawan Boonprasat Lewis, Henrietta Leyser, Alexei Lidov, Bernard Lightman, Paul Chang-Ha Lim, Carter Lindberg, Mark R. Lindsay, James R. Linville, James C. Livingston, Ann Loades, David Loades, Jean-Claude Loba-Mkole, Lo Lung Kwong, Wati Longchar, Eleazar López, David W. 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Douglas Meeks, Monica Jyotsna Melanchthon, Ilie Melniciuc-Puica, Everett Mendoza, Raymond A. Mentzer, William W. Menzies, Ina Merdjanova, Franziska Metzger, Constant J. Mews, Marvin Meyer, Carol Meyers, Vasile Mihoc, Gunner Bjerg Mikkelsen, Maria Inêz de Castro Millen, Clyde Lee Miller, Bonnie J. Miller-McLemore, Alexander Mirkovic, Paul Misner, Nozomu Miyahira, R. W. L. Moberly, Gerald Moede, Aloo Osotsi Mojola, Sunanda Mongia, Rebeca Montemayor, James Moore, Roger E. Moore, Craig E. Morrison O.Carm, Jeffry H. Morrison, Keith Morrison, Wilson J. Moses, Tefetso Henry Mothibe, Mokgethi Motlhabi, Fulata Moyo, Henry Mugabe, Jesse Ndwiga Kanyua Mugambi, Peggy Mulambya-Kabonde, Robert Bruce Mullin, Pamela Mullins Reaves, Saskia Murk Jansen, Heleen L. Murre-Van den Berg, Augustine Musopole, Isaac M. T. Mwase, Philomena Mwaura, Cecilia Nahnfeldt, Anne Nasimiyu Wasike, Carmiña Navia Velasco, Thulani Ndlazi, Alexander Negrov, James B. Nelson, David G. Newcombe, Carol Newsom, Helen J. 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Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. 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Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- Book:
- The Cambridge Dictionary of Christianity
- Published online:
- 05 August 2012
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- 20 September 2010, pp xi-xliv
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Relapse prevention in bipolar I disorder: 18-month comparison of olanzapine plus mood stabiliser v. mood stabiliser alone
- Mauricio Tohen, K. N. Roy Chengappa, Trisha Suppes, Robert W. Baker, Carlos A. Zarate, Charles L. Bowden, Gary S. Sachs, David J. Kupfer, S. Nassir Ghaemi, Peter D. Feldman, Richard C. Risser, Angela R. Evans, Joseph R. Calabrese
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- Journal:
- The British Journal of Psychiatry / Volume 184 / Issue 4 / April 2004
- Published online by Cambridge University Press:
- 02 January 2018, pp. 337-345
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- April 2004
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Background
Few controlled studies have examined the use of atypical antipsychotic drugs for prevention of relapse in patients with bipolar I disorder.
AimsTo evaluate whether olanzapine plus either lithium or valproate reduces the rate of relapse, compared with lithium or valproate alone.
MethodPatients achieving syndromic remission after 6 weeks'treatment with olanzapine plus either lithium (0.6–1.2 mmol/l) or valproate (50–125 μg/ml) received lithium or valproate plus either olanzapine 5–20 mg/day (combination therapy) or placebo (monotherapy), and were followed in a double-masked trial for 18 months.
ResultsThe treatment difference in time to relapse into either mania or depression was not significant for syndromic relapse (median time to relapse: combination therapy 94 days, monotherapy40.5 days; P=0.742), but was significant for symptomatic relapse (combination therapy 163 days, monotherapy42 days; P=0.023).
ConclusionsPatients taking olanzapine added to lithium or valproate experienced sustained symptomatic remission, but not syndromic remission, for longer than those receiving lithium or valproate monotherapy.