9 results
P.017 Convergent and contrasting modulation of saccade and pupil responses by several neurodegenerative diseases during free viewing of video clips
- HC Riek, BJ White, DC Brien, BC Coe, J Huang, A Abrahao, SE Black, M Borrie, E Finger, CE Fischer, AR Frank, M Freedman, DA Grimes, M Jog, S Kumar, D Kwan, AE Lang, JM Lawrence-Dewar, C Marras, M Masellis, SH Pasternak, BG Pollock, TK Rajji, DP Seitz, C Shoesmith, TD Steeves, B Tan, DF Tang-Wai, C Tartaglia, J Turnbull, L Zinman, ONDRI Investigators DP Munoz
-
- Journal:
- Canadian Journal of Neurological Sciences / Volume 50 / Issue s2 / June 2023
- Published online by Cambridge University Press:
- 05 June 2023, p. S62
-
- Article
-
- You have access Access
- Export citation
-
Background: Saccade and pupil responses are potential neurodegenerative disease biomarkers due to overlap between oculomotor circuitry and disease-affected areas. Instruction-based tasks have previously been examined as biomarker sources, but are arduous for patients with limited cognitive abilities; additionally, few studies have evaluated multiple neurodegenerative pathologies concurrently. Methods: The Ontario Neurodegenerative Disease Research Initiative recruited individuals with Alzheimer’s disease (AD), mild cognitive impairment (MCI), amyotrophic lateral sclerosis (ALS), frontotemporal dementia, progressive supranuclear palsy, or Parkinson’s disease (PD). Patients (n=274, age 40-86) and healthy controls (n=101, age 55-86) viewed 10 minutes of frequently changing video clips without instruction while their eyes were tracked. We evaluated differences in saccade and pupil parameters (e.g. saccade frequency and amplitude, pupil size, responses to clip changes) between groups. Results: Preliminary data indicates low-level behavioural alterations in multiple disease cohorts: increased centre bias, lower overall saccade rate and reduced saccade amplitude. After clip changes, patient groups generally demonstrated lower saccade rate but higher microsaccade rate following clip change to varying degrees. Additionally, pupil responses were blunted (AD, MCI, ALS) or exaggerated (PD). Conclusions: This task may generate behavioural biomarkers even in cognitively impaired populations. Future work should explore the possible effects of factors such as medication and disease stage.
P.002 Saccade parameters reveal cognitive impairment and differentially associate with cognitive domains across neurodegenerative diseases
- HC Riek, BC Coe, DC Brien, J Huang, A Abrahao, S Arnott, D Beaton, M Binns, S Black, M Borrie, L Casaubon, D Dowlatshahi, E Finger, C Fischer, A Frank, M Freedman, D Grimes, A Hassan, M Jog, S Kumar, D Kwan, A Lang, J Lawrence Dewar, B Levine, W Lou, J Mandzia, C Marras, M Masellis, P McLaughlin, J Orange, S Pasternak, A Peltsch, B Pollock, T Rajji, A Roberts, D Sahlas, G Saposnik, D Seitz, C Shoesmith, T Steeves, S Strother, S Sujanthan, K Sunderland, R Swartz, B Tan, D Tang-Wai, C Tartaglia, A Troyer, J Turnbull, L Zinman, ONDRI Investigators (), DP Munoz
-
- Journal:
- Canadian Journal of Neurological Sciences / Volume 49 / Issue s1 / June 2022
- Published online by Cambridge University Press:
- 24 June 2022, p. S8
-
- Article
-
- You have access Access
- Export citation
-
Background: Eye movements reveal neurodegenerative disease processes due to overlap between oculomotor circuitry and disease-affected areas. Characterizing oculomotor behaviour in context of cognitive function may enhance disease diagnosis and monitoring. We therefore aimed to quantify cognitive impairment in neurodegenerative disease using saccade behaviour and neuropsychology. Methods: The Ontario Neurodegenerative Disease Research Initiative recruited individuals with neurodegenerative disease: one of Alzheimer’s disease, mild cognitive impairment, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson’s disease, or cerebrovascular disease. Patients (n=450, age 40-87) and healthy controls (n=149, age 42-87) completed a randomly interleaved pro- and anti-saccade task (IPAST) while their eyes were tracked. We explored the relationships of saccade parameters (e.g. task errors, reaction times) to one another and to cognitive domain-specific neuropsychological test scores (e.g. executive function, memory). Results: Task performance worsened with cognitive impairment across multiple diseases. Subsets of saccade parameters were interrelated and also differentially related to neuropsychology-based cognitive domain scores (e.g. antisaccade errors and reaction time associated with executive function). Conclusions: IPAST detects global cognitive impairment across neurodegenerative diseases. Subsets of parameters associate with one another, suggesting disparate underlying circuitry, and with different cognitive domains. This may have implications for use of IPAST as a cognitive screening tool in neurodegenerative disease.
Insertion site inflammation was associated with central-line–associated bloodstream infections at a tertiary-care center, 2015–2018
- Takaaki Kobayashi, Gosia S. Clore, Mary E. Kukla, Mohammed Alzunitan, Jeffrey Kritzman, Oluchi Abosi, Mireia Puig-Asensio, Alexandre R. Marra, Daniel J. Diekema, Michael B. Edmond, Jorge L. Salinas
-
- Journal:
- Infection Control & Hospital Epidemiology / Volume 42 / Issue 3 / March 2021
- Published online by Cambridge University Press:
- 09 October 2020, pp. 348-350
- Print publication:
- March 2021
-
- Article
- Export citation
-
There are currently no guidelines for central-line insertion site evaluation. Our study revealed an association between insertion site inflammation (ISI) and the development of central-line–associated bloodstream infections (CLABSIs). Automated surveillance for ISI is feasible and could help prevent CLABSI.
Contributors
-
- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
-
- Book:
- The Cambridge Dictionary of Philosophy
- Published online:
- 05 August 2015
- Print publication:
- 27 April 2015, pp ix-xxx
-
- Chapter
- Export citation
Glass Formulation Development in Support of Melter Testing to Demonstrate Enhanced High Level Waste Throughput
- James C. Marra, Kevin M. Fox, David K. Peeler, Thomas B. Edwards, Amanda L. Youchak, James H. Gillam, Jr., John D. Vienna, Sergey V. Stefanovsky, Albert S. Aloy
-
- Journal:
- MRS Online Proceedings Library Archive / Volume 1107 / 2008
- Published online by Cambridge University Press:
- 01 February 2011, 231
- Print publication:
- 2008
-
- Article
- Export citation
-
The U.S. Department of Energy (DOE) is currently processing high-level waste (HLW) through a Joule-heated melter (JHM) at the Savannah River Site (SRS) and plans to vitrify HLW and Low activity waste (LAW) at the Hanford Site. Over the past few years at the Defense Waste Processing Facility (DWPF), work has concentrated on increasing waste throughput. These efforts are continuing with an emphasis on high alumina concentration feeds. High alumina feeds have presented specific challenges for the JHM technology regarding the ability to increase waste loading yet still maintain product quality and adequate throughput. Alternatively, vitrification technology innovations are also being investigated as a means to increase waste throughput. The Cold Crucible Induction Melter (CCIM) technology affords the opportunity for higher vitrification process temperatures as compared to the current reference JHM technology. Higher process temperatures may allow for higher waste loading and higher melt rate.
Glass formulation testing to support melter demonstration testing was recently completed. This testing was specifically aimed at high alumina concentration wastes. Glass composition/property models developed for DWPF were utilized as a guide for formulation development. Both CCIM and JHM testing will be conducted so glass formulation testing was targeted at both technologies with a goal to significantly increase waste loading and maintain melt rate without compromising product quality.
16 - A novel understanding of the three-way interaction between Trichoderma spp., the colonized plant and fungal pathogens
- from V - Fungal biocontrol of pests
-
- By S. L. Woo, Dipartimento di Arboricoltura Botanica e Patologia Vegetale Sezione Patologia Vegetale Universita degli Studi di Napoli Federico II Via Universita 100–80055 Portici (NA) Italy, M. Ruocco, Dipartimento di Arboricoltura Botanica e Patologia Vegetale Sezione Patologia Vegetale Universita degli Studi di Napoli Federico II Via Universita 100–80055 Portici (NA) Italy, R. Ciliento, Dipartimento di Arboricoltura Botanica e Patologia Vegetale Sezione Patologia Vegetale Universita degli Studi di Napoli Federico II Via Universita 100–80055 Portici (NA) Italy, P. Ambrosino, Dipartimento di Arboricoltura Botanica e Patologia Vegetale Sezione Patologia Vegetale Universita degli Studi di Napoli Federico II Via Universita 100–80055 Portici (NA) Italy, R. Marra, Dipartimento di Arboricoltura Botanica e Patologia Vegetale Sezione Patologia Vegetale Universita degli Studi di Napoli Federico II Via Universita 100–80055 Portici (NA) Italy, F. Vinale, Dipartimento di Arboricoltura Botanica e Patologia Vegetale Sezione Patologia Vegetale Universita degli Studi di Napoli Federico II Via Universita 100–80055 Portici (NA) Italy, S. Lanzuise, Dipartimento di Arboricoltura Botanica e Patologia Vegetale Sezione Patologia Vegetale Universita degli Studi di Napoli Federico II Via Universita 100–80055 Portici (NA) Italy, D. Turrà, Dipartimento di Arboricoltura Botanica e Patologia Vegetale Sezione Patologia Vegetale Universita degli Studi di Napoli Federico II Via Universita 100–80055 Portici (NA) Italy, S. Ferraioli, Dipartimento di Arboricoltura Botanica e Patologia Vegetale Sezione Patologia Vegetale Universita degli Studi di Napoli Federico II Via Universita 100–80055 Portici (NA) Italy, I. Soriente, Dipartimento di Arboricoltura Botanica e Patologia Vegetale Sezione Patologia Vegetale Universita degli Studi di Napoli Federico II Via Universita 100–80055 Portici (NA) Italy, S. Gigante, Dipartimento di Arboricoltura Botanica e Patologia Vegetale Sezione Patologia Vegetale Universita degli Studi di Napoli Federico II Via Universita 100–80055 Portici (NA) Italy, F. Scala, Dipartimento di Arboricoltura Botanica e Patologia Vegetale Sezione Patologia Vegetale Universita degli Studi di Napoli Federico II Via Universita 100–80055 Portici (NA) Italy, M. Lorito, Dipartimento di Arboricoltura Botanica e Patologia Vegetale Sezione Patologia Vegetale Universita degli Studi di Napoli Federico II Via Universita 100–80055 Portici (NA) Italy
- Edited by G. D. Robson, University of Manchester, Pieter van West, University of Aberdeen, Geoffrey Gadd, University of Dundee
-
- Book:
- Exploitation of Fungi
- Published online:
- 05 October 2013
- Print publication:
- 24 May 2007, pp 291-309
-
- Chapter
- Export citation
-
Summary
Abstract
Trichoderma-based biofungicides are a reality in agriculture, with more than 50 formulations available today as registered products worldwide. Several strategies have been applied to identify the main genes and compounds involved in this complex cross-talk between the fungal antagonist and the microbial pathogen, as mediated by the plant. Proteome and genome analysis have greatly enhanced our ability to conduct holistic and genome-based functional studies. We have identified and determined the role of a variety of novel genes and gene-products, including ABC transporters, enzymes and other proteins that produce or act as novel elicitors of induced systemic resistance, proteins recognized by the plant as avirulence factors, as well as molecules that generally activate the antagonistic activity in Trichoderma spp. We have cloned mycoparasitism-related promoters and used them in combination with GFP and other markers to study the interaction in vivo and in situ between Trichoderma and the fungal pathogen or the plant. Finally, we have transgenically improved the ability of the antagonist to kill other microbes and to activate plant defence mechanisms.
Introduction
Plant diseases caused by pathogenic fungi infections represent a major limiting factor for the cultivation and the conservation of agricultural plants of interest. The consequences of parasite attack result in both quantitative and qualitative reduction of crop production, large economic losses and represent a risk for human and animal health due to the accumulation of residues in the environment and mycotoxin contaminants in food products.
Tc-99 and Cs-137 Volatility from the DWPF Production Melter During Vitrification of the First Macrobatch of HLW Sludge at the Savannah River Site
- N. E. Bibler, T. L. Fellinger, S. L. Marra, R. J. O'driscoll, J. W. Ray, W. T. Boyce
-
- Journal:
- MRS Online Proceedings Library Archive / Volume 608 / 1999
- Published online by Cambridge University Press:
- 10 February 2011, 697
- Print publication:
- 1999
-
- Article
- Export citation
-
Technetium-99 and cesium-137 are two radionuclides in high level waste (HLW) that can volatilize from high temperature melters during the immobilization of the HLW into a borosilicate glass. At Savannah River Site (SRS) we have obtained data that indicate that this volatilization is small from the full scale production melter in the Defense Waste Processing Facility (DWPF). These data were obtained during the vitrification of the first HLW macrobatch at SRS. This campaign lasted ∼2.5 years and produced ∼9 hundred metric tons of glass from ∼1.6 million liters of HLW. Losses of Tc-99 and Cs-137 were determined by comparing their measured concentrations in the glass with their respective predicted concentrations based on the composition of the HLW being vitrified. For three glass samples taken during the campaign, the measured and predicted concentrations agreed within 7% or better indicating a small loss of either radionuclide. The DWPF melter operates with a cold cap on the surface of the melt. This cold cap could enhance the radionuclide retention, especially Tc-99.
The prediction of total body water from bioelectrical impedance in patients with anorexia nervosa
- L. Scalfi, G. Bedogni, M. Marra, G. Di Biase, A. Caldara, S. Severi, F. Contaldo, N. Battistini
-
- Journal:
- British Journal of Nutrition / Volume 78 / Issue 3 / September 1997
- Published online by Cambridge University Press:
- 09 March 2007, pp. 357-365
- Print publication:
- September 1997
-
- Article
-
- You have access Access
- Export citation
-
Total body water (TBW) was measured by deuterium oxide (D2O) dilution and predicted from bioelectrical impedance (Z) in nineteen anorexic and twenty-seven control women. The equation of Kushner et al. (1992) based on the impedance index (ZI = height2/Z) gave biases of 0.9 (sd 2.5) and 0.8 (sd 2.5) litres in controls and patients respectively (NS, ANOVA). The ZI-based equation of Deurenberg et al. (1993) gave biases of 1.5 (sd 2.4) litres (NS) and 3.0 (sd 2.1) litres (P <0.001) in controls and patients respectively. Despite the fact that weight was the most powerful predictor of TBW on the study sample (n 46, r2 0.90, P < 0.0001, se of the estimate 1.6 litres, CV 5.7%), the formulas of Segal et al. (1991) and Kushner et al. (1992) based on the association of weight and ZI gave an inaccurate prediction of TBW in both control and anorexic subjects, with a bias ranging from -3.2 (sd 2.4) to 2.9 (sd 2.1) litres (P ≤0.001). Population-specific formulas based on ZI (n 46) gave a more accurate prediction of TBW by bioelectrical impedance analysis on the study subjects, with biases of -0.1 (sd 1.8) and 0.5 (sd 1.7) litres in controls and patients respectively (NS). However, the individual bias was sometimes high. It is concluded that bioelectrical impedance analysis can be used to predict TBW in anorexic women at a population level, but the predictions are less good than those based on body weight alone.
Further Development of the Jantzen - Plodinec Model of Glass Durability
- B. A. Shakhmatkin, N. M. Vedishcheva, A. S. Aloy, M. J. Plodinec, S. L. Marra
-
- Journal:
- MRS Online Proceedings Library Archive / Volume 465 / 1996
- Published online by Cambridge University Press:
- 03 September 2012, 181
- Print publication:
- 1996
-
- Article
- Export citation
-
The hydration thermodynamic approach to the prediction of glass durability was originally applied to nuclear waste glasses by Jantzen and Plodinec. This approach is useful for control of the production of nuclear waste glasses. However, improvements are necessary if the approach is to be extended to different glasses, particularly those with higher alkali metal concentrations. This is of special significance for vitrification of the salt wastes at Hanford. Various methods for improving the predictive power of the approach have been examined. Combining a more accurate representation of the alkali metal species in the glass with a more rigorous thermodynamic approach is a promising avenue to improved predictive power.
![](/core/cambridge-core/public/images/lazy-loader.gif)