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Treatment-resistant and Multi-therapy resistant criteria for bipolar depression: A consensus definition – CORRIGENDUM
- Diego Hidalgo-Mazzei, Michael Berk, Andrea Cipriani, Anthony J. Cleare, Arianna Di Florio, Daniel Dietch, John R. Geddes, Guy M. Goodwin, Heinz Grunze, Joseph F. Hayes, Ian Jones, Siegfried Kasper, Karine Macritchie, R. Hamish McAllister-Williams, Richard Morriss, Sam Nayrouz, Sofia Pappa, Jair C. Soares, Daniel J. Smith, Trisha Suppes, Peter Talbot, Eduard Vieta, Stuart Watson, Lakshmi N. Yatham, Allan H. Young, Paul R. A. Stokes
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- Journal:
- The British Journal of Psychiatry / Volume 214 / Issue 5 / May 2019
- Published online by Cambridge University Press:
- 28 February 2019, p. 309
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- May 2019
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Treatment-resistant and multi-therapy-resistant criteria for bipolar depression: consensus definition
- Diego Hidalgo-Mazzei, Michael Berk, Andrea Cipriani, Anthony J. Cleare, Arianna Di Florio, Daniel Dietch, John R. Geddes, Guy M. Goodwin, Heinz Grunze, Joseph F. Hayes, Ian Jones, Siegfried Kasper, Karine Macritchie, R. Hamish McAllister-Williams, Richard Morriss, Sam Nayrouz, Sofia Pappa, Jair C. Soares, Daniel J. Smith, Trisha Suppes, Peter Talbot, Eduard Vieta, Stuart Watson, Lakshmi N. Yatham, Allan H. Young, Paul R. A. Stokes
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- Journal:
- The British Journal of Psychiatry / Volume 214 / Issue 1 / January 2019
- Published online by Cambridge University Press:
- 06 December 2018, pp. 27-35
- Print publication:
- January 2019
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Background
Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to the high levels of disability and mortality associated with the disorder. Despite the importance of bipolar depression, there are only a small number of recognised treatment options available. Consecutive treatment failures can quickly exhaust these options leading to treatment-resistant bipolar depression (TRBD). Remarkably few studies have evaluated TRBD and those available lack a comprehensive definition of multi-therapy-resistant bipolar depression (MTRBD).
AimsTo reach consensus regarding threshold definitions criteria for TRBD and MTRBD.
MethodBased on the evidence of standard treatments available in the latest bipolar disorder treatment guidelines, TRBD and MTRBD criteria were agreed by a representative panel of bipolar disorder experts using a modified Delphi method.
ResultsTRBD criteria in bipolar depression was defined as failure to reach sustained symptomatic remission for 8 consecutive weeks after two different treatment trials, at adequate therapeutic doses, with at least two recommended monotherapy treatments or at least one monotherapy treatment and another combination treatment. MTRBD included the same initial definition as TRBD, with the addition of failure of at least one trial with an antidepressant, a psychological treatment and a course of electroconvulsive therapy.
ConclusionsThe proposed TRBD and MTRBD criteria may provide an important signpost to help clinicians, researchers and stakeholders in judging how and when to consider new non-standard treatments. However, some challenging diagnostic and therapeutic issues were identified in the consensus process that need further evaluation and research.
Declaration of interestIn the past 3 years, M.B. has received grant/research support from the NIH, Cooperative Research Centre, Simons Autism Foundation, Cancer Council of Victoria, Stanley Medical Research Foundation, MBF, NHMRC, Beyond Blue, Rotary Health, Geelong Medical Research Foundation, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Meat and Livestock Board, Organon, Novartis, Mayne Pharma, Servier, Woolworths, Avant and the Harry Windsor Foundation, has been a speaker for Astra Zeneca, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen Cilag, Lundbeck, Merck, Pfizer, Sanofi Synthelabo, Servier, Solvay and Wyeth and served as a consultant to Allergan, Astra Zeneca, Bioadvantex, Bionomics, Collaborative Medicinal Development, Eli Lilly, Grunbiotics, Glaxo SmithKline, Janssen Cilag, LivaNova, Lundbeck, Merck, Mylan, Otsuka, Pfizer and Servier. A.J.C. has in the past 3 years received honoraria for speaking from Astra Zeneca and Lundbeck, honoraria for consulting from Allergan, Janssen, Lundbeck and LivaNova and research grant support from Lundbeck. G.M.G. holds shares in P1Vital and has served as consultant, advisor or CME speaker for Allergan, Angelini, Compass pathways, MSD, Lundbeck, Otsuka, Takeda, Medscape, Minervra, P1Vital, Pfizer, Servier, Shire and Sun Pharma. J.G. has received research funding from National Institute for Health Research, Medical Research Council, Stanley Medical Research Institute and Wellcome. H.G. received grants/research support, consulting fees or honoraria from Gedeon Richter, Genericon, Janssen Cilag, Lundbeck, Otsuka, Pfizer and Servier. R.H.M.-W. has received support for research, expenses to attend conferences and fees for lecturing and consultancy work (including attending advisory boards) from various pharmaceutical companies including Astra Zeneca, Cyberonics, Eli Lilly, Janssen, Liva Nova, Lundbeck, MyTomorrows, Otsuka, Pfizer, Roche, Servier, SPIMACO and Sunovion. R.M. has received research support from Big White Wall, Electromedical Products, Johnson and Johnson, Magstim and P1Vital. S.N. received honoraria from Lundbeck, Jensen and Otsuka. J.C.S. has received funds for research from Alkermes, Pfizer, Allergan, J&J, BMS and been a speaker or consultant for Astellas, Abbott, Sunovion, Sanofi. S.W has, within the past 3 years, attended advisory boards for Sunovion and LivaNova and has undertaken paid lectures for Lundbeck. D.J.S. has received honoraria from Lundbeck. T.S. has reported grants from Pathway Genomics, Stanley Medical Research Institute and Palo Alto Health Sciences; consulting fees from Sunovion Pharamaceuticals Inc.; honoraria from Medscape Education, Global Medical Education and CMEology; and royalties from Jones and Bartlett, UpToDate and Hogrefe Publishing. S.P. has served as a consultant or speaker for Janssen, and Sunovion. P.T. has received consultancy fees as an advisory board member from the following companies: Galen Limited, Sunovion Pharmaceuticals Europe Ltd, myTomorrows and LivaNova. E.V. received grants/ research support, consulting fees or honoraria from Abbott, AB-Biotics, Allergan, Angelini, Dainippon Sumitomo, Ferrer, Gedeon Richter, Janssen, Lundbeck, Otsuka and Sunovion. L.N.Y. has received grants/research support, consulting fees or honoraria from Allergan, Alkermes, Dainippon Sumitomo, Janssen, Lundbeck, Otsuka, Sanofi, Servier, Sunovion, Teva and Valeant. A.H.Y. has undertaken paid lectures and advisory boards for all major pharmaceutical companies with drugs used in affective and related disorders and LivaNova. He has also previously received funding for investigator-initiated studies from AstraZeneca, Eli Lilly, Lundbeck and Wyeth. P.R.A.S. has received research funding support from Corcept Therapeutics Inc. Corcept Therapeutics Inc fully funded attendance at their internal conference in California USA and all related expenses. He has received grant funding from the Medical Research Council UK for a collaborative study with Janssen Research and Development LLC. Janssen Research and Development LLC are providing non-financial contributions to support this study. P.R.A.S. has received a presentation fee from Indivior and an advisory board fee from LivaNova.
Adsorption, dissipation, and movement of fluometuron in three southeastern United States soils
- William T. Willian, Thomas C. Mueller, Robert M. Hayes, Charles E. Snipes, David C. Bridges
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- Journal:
- Weed Science / Volume 45 / Issue 1 / February 1997
- Published online by Cambridge University Press:
- 12 June 2017, pp. 183-189
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Fluometuron adsorption and dissipation under field and laboratory conditions, and distribution within the soil profile was determined in 3 soils from Tennessee, Mississippi, and Georgia that are representative of the cotton-growing regions of the southeastern United States. Fluometuron adsorption was correlated with organic matter, but not with clay content or soil pH. First-order kinetics explained fluometuron dissipation under field and controlled conditions (r2 ≥ 0.82). Field dissipation of fluometuron was slower under dry conditions. Fluometuron was not detected below 15 cm in the soil profile in any soil, and concentrations in the 8- to 15-cm soil zone were < 15 ppbw 112 d after treatment. Fluometuron dissipation was more rapid in soil from the 0- to 8-cm depth in Tennessee soil than in Mississippi soil under controlled conditions. Dissipation was more rapid under field conditions than under laboratory conditions at 2 of 3 locations. Fluometuron half-lives in soils from the 0- to 8-cm depth ranged from 9 to 28 d under field conditions and from 11 to 43 d in the laboratory. Fluometuron dissipation in soils from 30- to 45- and 60- to 90-cm depths was not different among soils, with half-lives ranging from 58 to 99 d under laboratory conditions. Fluometuron half-life was positively correlated with soil depth and inversely correlated with organic matter. These data indicate that organic matter, soil depth, and environmental conditions affect fluometuron dissipation.
Norflurazon adsorption and dissipation in three southern soils
- William T. Willian, Thomas C. Mueller, Robert M. Hayes, David C. Bridges, Charles E. Snipes
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- Journal:
- Weed Science / Volume 45 / Issue 2 / April 1997
- Published online by Cambridge University Press:
- 12 June 2017, pp. 301-306
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Norflurazon adsorption and dissipation under field and laboratory conditions, and distribution within the soil profile were determined in three soils representative of cotton-growing regions of the southeastern U.S. Norflurazon adsorption was greater in soil from 0 to 8 cm in a Lexington silt loam (Tennessee) and a Beulah silt loam (Mississippi) than in a Dothan loamy sand (Georgia). Adsorption was directly related to organic matter. Norflurazon degradation under controlled conditions in soil from 0 to 8 cm from each state was not different among locations, with half-lives ranging from 63 to 167 d. Degradation at 30 C in soil from the 30- to 45- and 60- to 90-cm depths was not different among locations, and was slower at the 60- to 90-cm depth than in surface soil. Norflurazon dissipation was more rapid under field conditions than under laboratory conditions, with half-lives ranging from 7 to 79 d in the 0- to 8-cm soil horizon. Dry field conditions slowed norflurazon dissipation. Norflurazon was not detected below 15 cm in the profile in any soil, and concentrations in the 8- to 15-cm soil zone were < 36 ppbw 112 d after treatment.
Comparison of PRZM and GLEAMS Computer Model Predictions with Field Data for Fluometuron and Norflurazon Behavior in Soil
- William T. Willian, Thomas C. Mueller, Robert M. Hayes, David C. Bridges, Charles E. Snipes
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- Journal:
- Weed Technology / Volume 13 / Issue 3 / September 1999
- Published online by Cambridge University Press:
- 12 June 2017, pp. 561-570
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The ability of the pesticide root zone model (PRZM) and the groundwater-loading effects of agricultural management systems (GLEAMS) model to predict movement of two herbicides in soil was evaluated using site-specific environmental data from sites in three states. Predictions of herbicide movement with site-specific data were compared to predictions using more generalized database soil and pesticide data within each model. Field experiments examined fluometuron and norflurazon movement in three soils representative of the cotton-growing regions of the southeastern United States. In comparing the use of site-specific vs. database values, the small increase in accuracy using site-specific inputs would not justify the large cost to obtain the data. The databases for each model gave predictions similar to those using the site-specific numbers. Both the PRZM and the GLEAMS model had similar accuracy levels in predicting the presence of fluometuron or norflurazon present in three surface soils, although each model tended to overpredict movement and total herbicide concentration, especially at lower herbicide concentrations. At higher herbicide concentrations, prediction accuracy was less than that probably needed to predict agronomically relevant herbicide concentrations in surface soils.
Johnsongrass (Sorghum halepense) Competition in Soybeans (Glycine max)
- C. S. Williams, Robert M. Hayes
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- Journal:
- Weed Science / Volume 32 / Issue 4 / July 1984
- Published online by Cambridge University Press:
- 12 June 2017, pp. 498-501
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Johnsongrass [Sorghum halepense (L.) Pers., ♯3 SORHA] dry weight and johnsongrass culms/ha at harvest were more negatively correlated with soybean yield reductions than the number of johnsongrass plants/ha present at 4 to 6 weeks after planting. However, plant numbers can be determined in sufficient time to implement control measures to prevent yield reduction. Prediction equations for estimating soybean yield at various johnsongrass populations are Ŷ = 1776 + 424e-.023x2 for 0.25-m row spacing and Ŷ = 1668 + 643e-.004x2 for the 1-m row spacing, where Ŷ = estimated yield and x = the number of johnsongrass plants/10 m2. Full-season heavy johnsongrass competition reduced soybean yields from 59 to 88%. Soybeans in the 1-m row spacing were more competitive with low johnsongrass densities than in the 0.25-m row spacing. The johnsongrass-free requirement for soybeans was 4 weeks after planting and soybeans could not tolerate heavy infestations of johnsongrass for more than 5 weeks without loss in yield potential. Application of sethoxydim {2-[1-(ethoxyimino)-butyl]-5-[2-ethylthio)propyl]-3-hydroxy-2-cyclohexen-1-one} at 3 or 4 weeks after planting was effective in controlling heavy infestations of johnsongrass and preventing yield reductions due to competition.
Clomazone Dissipation in Two Tennessee Soils
- K. Bruce Kirksey, Robert M. Hayes, William A. Krueger, Charles A. Mullins, Thomas C. Mueller
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- Journal:
- Weed Science / Volume 44 / Issue 4 / December 1996
- Published online by Cambridge University Press:
- 12 June 2017, pp. 959-963
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Clomazone dissipation in soil was examined in field and laboratory experiments. Field studies suggested a potential for injury to rotational crops such as wheat. Field half-lives were 5 to 29 d (average of 9 field studies was 19 d) for the Etowah clay loam (fine-loamy, siliceous, thermic typic Paleudult) and Lily loam (fine-loamy, siliceous, thermic typic Hapludult) soils. Clomazone had an average half-life of 34 d under lab conditions, indicating slower dissipation in the lab than in the field. Clomazone was moderately adsorbed to soil as indicated by a Kd of about 1, and a Kom of 52 in the two soils.
Site-Specific Weed Management in Corn (Zea mays)
- Joyce Tredaway-Ducar, Gaylon D. Morgan, John B. Wilkerson, William E. Hart, Robert M. Hayes, Thomas C. Mueller
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- Journal:
- Weed Technology / Volume 17 / Issue 4 / December 2003
- Published online by Cambridge University Press:
- 20 January 2017, pp. 711-717
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Site-specific weed management can increase crop production efficiency by minimizing herbicide input costs without compromising crop yields. A reduction in herbicide inputs resulting from site-specific weed management may also decrease the probability level of nonpoint pollution compared with conventional herbicide applications. A 4.5-ha field was selected to compare site-specific and conventional weed management techniques in 1997 and 1998 at Knoxville, TN. Variable rate applications (VRAs) of atrazine preemergence (PRE) followed by dicamba postemergence (POST) were investigated for the reduction of herbicide inputs and their resulting impact on weed control and corn yield. VRAs of atrazine were on the basis of weed density data collected in 1996. VRAs of dicamba were according to common cocklebur density evaluations within the field. Compared with conventional applications, atrazine usage was decreased by 43 and 32% in the site-specific application treatments in 1997 and 1998, respectively. VRAs of dicamba reduced herbicide inputs by greater than 45% for 1997 and 1998. Corn yields were similar for the conventional and site-specific treatments in both years. On the basis of these data, site-specific herbicide applications have the greatest potential and least risk for managing weeds when POST or PRE + POST variable rate herbicide applications are used.
Sulfentrazone Persistence in Southern Soils: Bioavailable Concentration and Effect on a Rotational Cotton Crop
- Christopher L. Main, Thomas C. Mueller, Robert M. Hayes, John W. Wilcut, Thomas F. Peeper, Ronald E. Talbert, William W. Witt
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- Journal:
- Weed Technology / Volume 18 / Issue 2 / June 2004
- Published online by Cambridge University Press:
- 20 January 2017, pp. 346-352
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Field studies were conducted from 1998 to 2000 in Tennessee, North Carolina, Arkansas, and Oklahoma to determine the effects of sulfentrazone carryover to a cotton rotational crop from sulfentrazone applied the previous year. Sulfentrazone applied the previous year at 400 g/ha caused no yield loss in Tennessee, >30% yield reduction in Oklahoma, and 20% yield loss in Arkansas and North Carolina. In most experiments in this study, visual evaluations of injury closely correlated with final cotton lint yield (r2 =0.84).
Effect of Venturi-Type Nozzles and Application Volume on Postemergence Herbicide Efficacy
- Robert E. Etheridge, William E. Hart, Robert M. Hayes, Thomas C. Mueller
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- Journal:
- Weed Technology / Volume 15 / Issue 1 / March 2001
- Published online by Cambridge University Press:
- 20 January 2017, pp. 75-80
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Field studies were conducted to compare venturi-type nozzles to a fan nozzle with respect to the efficacy of postemergence herbicides applied to common cocklebur and broadleaf signalgrass. Spray solutions of glufosinate, glyphosate, and paraquat were applied through all combinations of three nozzles and two application volumes. Venturi nozzles were a Delavan Raindrop Ultra (RU) and a Spraying Systems AI Teejet (AI). A Spraying Systems XR Teejet (XR) fan nozzle was included as a standard. Previous work indicated droplet size spectra differed among these nozzles. There was a difference in common cocklebur control among nozzles (AI = XR > RU), although control was at least 90% for all nozzles. Herbicide choice had a greater effect on broadleaf signalgrass control than nozzle type. Broadleaf signalgrass control differed among herbicides (glufosinate = paraquat > glyphosate) and among nozzles (AI = XR > RU). Herbicide performance varied between nozzles (AI > RU), but the AI nozzle was as effective as the XR fan nozzle.
What Explains the Incidence of the Use of a Common Sediment Control on Lots with Houses Under Construction?
- Scott R. Templeton, William T. Sessions, Liv M. Haselbach, Wallace A. Campbell, John C. Hayes
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- Journal:
- Journal of Agricultural and Applied Economics / Volume 42 / Issue 1 / February 2010
- Published online by Cambridge University Press:
- 26 January 2015, pp. 57-68
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To analyze compliance with one aspect of the regulation of stormwater discharge, we estimate a random-utility model of the probability that a builder uses a silt fence to control sediments on a lot with a house under construction in an urbanizing county of South Carolina. The probability increases if the builder is responsible to the subdivision's developer or if a homeowners association exists. The probability also increases as the cost to install a silt fence decreases or the number of houses under construction per built house in a subdivision increases. The results can help county officials target inspection to improve compliance.
Contributors
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. Kirk-Duggan, Clifton Kirkpatrick, Leonid Kishkovsky, Nadieszda Kizenko, Jeffrey Klaiber, Hans-Josef Klauck, Sidney Knight, Samuel Kobia, Robert Kolb, Karla Ann Koll, Heikki Kotila, Donald Kraybill, Philip D. W. Krey, Yves Krumenacker, Jeffrey Kah-Jin Kuan, Simanga R. Kumalo, Peter Kuzmic, Simon Shui-Man Kwan, Kwok Pui-lan, André LaCocque, Stephen E. Lahey, John Tsz Pang Lai, Emiel Lamberts, Armando Lampe, Craig Lampe, Beverly J. Lanzetta, Eve LaPlante, Lizette Larson-Miller, Ariel Bybee Laughton, Leonard Lawlor, Bentley Layton, Robin A. Leaver, Karen Lebacqz, Archie Chi Chung Lee, Marilyn J. Legge, Hervé LeGrand, D. L. LeMahieu, Raymond Lemieux, Bill J. Leonard, Ellen M. Leonard, Outi Leppä, Jean Lesaulnier, Nantawan Boonprasat Lewis, Henrietta Leyser, Alexei Lidov, Bernard Lightman, Paul Chang-Ha Lim, Carter Lindberg, Mark R. Lindsay, James R. Linville, James C. Livingston, Ann Loades, David Loades, Jean-Claude Loba-Mkole, Lo Lung Kwong, Wati Longchar, Eleazar López, David W. Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. Douglas Meeks, Monica Jyotsna Melanchthon, Ilie Melniciuc-Puica, Everett Mendoza, Raymond A. Mentzer, William W. Menzies, Ina Merdjanova, Franziska Metzger, Constant J. Mews, Marvin Meyer, Carol Meyers, Vasile Mihoc, Gunner Bjerg Mikkelsen, Maria Inêz de Castro Millen, Clyde Lee Miller, Bonnie J. Miller-McLemore, Alexander Mirkovic, Paul Misner, Nozomu Miyahira, R. W. L. Moberly, Gerald Moede, Aloo Osotsi Mojola, Sunanda Mongia, Rebeca Montemayor, James Moore, Roger E. Moore, Craig E. Morrison O.Carm, Jeffry H. Morrison, Keith Morrison, Wilson J. Moses, Tefetso Henry Mothibe, Mokgethi Motlhabi, Fulata Moyo, Henry Mugabe, Jesse Ndwiga Kanyua Mugambi, Peggy Mulambya-Kabonde, Robert Bruce Mullin, Pamela Mullins Reaves, Saskia Murk Jansen, Heleen L. Murre-Van den Berg, Augustine Musopole, Isaac M. T. Mwase, Philomena Mwaura, Cecilia Nahnfeldt, Anne Nasimiyu Wasike, Carmiña Navia Velasco, Thulani Ndlazi, Alexander Negrov, James B. Nelson, David G. Newcombe, Carol Newsom, Helen J. Nicholson, George W. E. Nickelsburg, Tatyana Nikolskaya, Damayanthi M. A. Niles, Bertil Nilsson, Nyambura Njoroge, Fidelis Nkomazana, Mary Beth Norton, Christian Nottmeier, Sonene Nyawo, Anthère Nzabatsinda, Edward T. Oakes, Gerald O'Collins, Daniel O'Connell, David W. Odell-Scott, Mercy Amba Oduyoye, Kathleen O'Grady, Oyeronke Olajubu, Thomas O'Loughlin, Dennis T. Olson, J. Steven O'Malley, Cephas N. Omenyo, Muriel Orevillo-Montenegro, César Augusto Ornellas Ramos, Agbonkhianmeghe E. Orobator, Kenan B. Osborne, Carolyn Osiek, Javier Otaola Montagne, Douglas F. Ottati, Anna May Say Pa, Irina Paert, Jerry G. Pankhurst, Aristotle Papanikolaou, Samuele F. Pardini, Stefano Parenti, Peter Paris, Sung Bae Park, Cristián G. Parker, Raquel Pastor, Joseph Pathrapankal, Daniel Patte, W. Brown Patterson, Clive Pearson, Keith F. Pecklers, Nancy Cardoso Pereira, David Horace Perkins, Pheme Perkins, Edward N. Peters, Rebecca Todd Peters, Bishop Yeznik Petrossian, Raymond Pfister, Peter C. Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. Rubenstein, Rosemary Radford Ruether, Markku Ruotsila, John E. Rybolt, Risto Saarinen, John Saillant, Juan Sanchez, Wagner Lopes Sanchez, Hugo N. Santos, Gerhard Sauter, Gloria L. Schaab, Sandra M. Schneiders, Quentin J. Schultze, Fernando F. Segovia, Turid Karlsen Seim, Carsten Selch Jensen, Alan P. F. Sell, Frank C. Senn, Kent Davis Sensenig, Damían Setton, Bal Krishna Sharma, Carolyn J. Sharp, Thomas Sheehan, N. Gerald Shenk, Christian Sheppard, Charles Sherlock, Tabona Shoko, Walter B. Shurden, Marguerite Shuster, B. Mark Sietsema, Batara Sihombing, Neil Silberman, Clodomiro Siller, Samuel Silva-Gotay, Heikki Silvet, John K. Simmons, Hagith Sivan, James C. Skedros, Abraham Smith, Ashley A. Smith, Ted A. Smith, Daud Soesilo, Pia Søltoft, Choan-Seng (C. S.) Song, Kathryn Spink, Bryan Spinks, Eric O. Springsted, Nicolas Standaert, Brian Stanley, Glen H. Stassen, Karel Steenbrink, Stephen J. Stein, Andrea Sterk, Gregory E. Sterling, Columba Stewart, Jacques Stewart, Robert B. Stewart, Cynthia Stokes Brown, Ken Stone, Anne Stott, Elizabeth Stuart, Monya Stubbs, Marjorie Hewitt Suchocki, David Kwang-sun Suh, Scott W. Sunquist, Keith Suter, Douglas Sweeney, Charles H. Talbert, Shawqi N. Talia, Elsa Tamez, Joseph B. Tamney, Jonathan Y. Tan, Yak-Hwee Tan, Kathryn Tanner, Feiya Tao, Elizabeth S. Tapia, Aquiline Tarimo, Claire Taylor, Mark Lewis Taylor, Bishop Abba Samuel Wolde Tekestebirhan, Eugene TeSelle, M. Thomas Thangaraj, David R. Thomas, Andrew Thornley, Scott Thumma, Marcelo Timotheo da Costa, George E. “Tink” Tinker, Ola Tjørhom, Karen Jo Torjesen, Iain R. Torrance, Fernando Torres-Londoño, Archbishop Demetrios [Trakatellis], Marit Trelstad, Christine Trevett, Phyllis Trible, Johannes Tromp, Paul Turner, Robert G. Tuttle, Archbishop Desmond Tutu, Peter Tyler, Anders Tyrberg, Justin Ukpong, Javier Ulloa, Camillus Umoh, Kristi Upson-Saia, Martina Urban, Monica Uribe, Elochukwu Eugene Uzukwu, Richard Vaggione, Gabriel Vahanian, Paul Valliere, T. J. Van Bavel, Steven Vanderputten, Peter Van der Veer, Huub Van de Sandt, Louis Van Tongeren, Luke A. Veronis, Noel Villalba, Ramón Vinke, Tim Vivian, David Voas, Elena Volkova, Katharina von Kellenbach, Elina Vuola, Timothy Wadkins, Elaine M. Wainwright, Randi Jones Walker, Dewey D. Wallace, Jerry Walls, Michael J. Walsh, Philip Walters, Janet Walton, Jonathan L. Walton, Wang Xiaochao, Patricia A. Ward, David Harrington Watt, Herold D. Weiss, Laurence L. Welborn, Sharon D. Welch, Timothy Wengert, Traci C. West, Merold Westphal, David Wetherell, Barbara Wheeler, Carolinne White, Jean-Paul Wiest, Frans Wijsen, Terry L. Wilder, Felix Wilfred, Rebecca Wilkin, Daniel H. Williams, D. Newell Williams, Michael A. Williams, Vincent L. Wimbush, Gabriele Winkler, Anders Winroth, Lauri Emílio Wirth, James A. Wiseman, Ebba Witt-Brattström, Teofil Wojciechowski, John Wolffe, Kenman L. Wong, Wong Wai Ching, Linda Woodhead, Wendy M. Wright, Rose Wu, Keith E. Yandell, Gale A. Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
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- 05 August 2012
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- 20 September 2010, pp xi-xliv
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The synergic action of penicillin and sulphathiazole on S. typhi
- John C. Thomas, William Hayes
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- Journal of Hygiene / Volume 45 / Issue 3 / August 1947
- Published online by Cambridge University Press:
- 15 May 2009, pp. 313-326
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Due to earlier reports of the relative resistance of S. typhi and other members of the salmonella group to penicillin, and to the prevalent preoccupation of most workers with those organisms against which treatment with penicillin was more obviously applicable, little attention was payed to the chemotherapy of enteric fever until Bigger (1946) published his findings on the synergic action of a more reliable guide to the occurrence of synergism than sterilization, might be demonstrated. In conformity with the previous results, however, treated broth was also used to demonstrate synergic killing effect. Results are given in Table 12.
T455, when tested under similar conditions, was inhibited by 6·25 u./ml. penicillin and showed a twofold inhibitory synergism in the presence of sulphathiazole. It will be seen that all the strains tested showed some degree of inhibitory synergism but that, in the majority, the concentration required to inhibit growth was considerably higher than in the case of S. typhi. With the majority of strains the concentration of penicillin required to destroy the inoculum in 24 hr. at 37° C. was greater than 25 u./ml., even in the presence of sulphathiazole, while in one case no bactericidal synergism at all penicillin and sulphathiazole against S. typhi. Although, therefore, much work has been published concerning the synergic action of the sulphonamide group on penicillin activity in general, little information is available on the in vitro behaviour of the salmonellas in this respect despite the present wide, though tentative, application of the principle in the treatment of enteric fever. The experiments presented above were undertaken with the object of confirming those findings hitherto reported and of studying in detail the effects of sulphathiazole and penicillin, and of combinations of the two, on the salmonella group, with special reference to S. typhi.
For purposes of discussion it is convenient to summarize our results under the principal headings used in the text.
Identifying hazards in complex ecological systems. Part 3: Hierarchical Holographic Model for herbicide tolerant oilseed rape
- Keith R. Hayes, Peter C. Gregg, V. V.S.R. Gupta, R. Jessop, W. M. Lonsdale, B. Sindel, J. Stanley, C. K. Williams
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- Journal:
- Environmental Biosafety Research / Volume 3 / Issue 2 / April 2004
- Published online by Cambridge University Press:
- 15 September 2004, pp. 109-128
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- April 2004
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This paper is the third in a series designed to demonstrate the application of rigorous, systematic hazard identification techniques to ecological systems. Here we use Hierarchical Holographic Modelling to identify the potential ecological hazards associated with the commercial release of herbicide tolerant oilseed rape. Hierarchical Holographic Models decompose complex systems into a series of sub-systems and consider interactions between the components and processes of these sub-systems in order to identify hazards. In this example we considered 1356 potential interactions between the biological, chemical and physical components and processes of the herbicide tolerant oilseed rape environment, and identified 152 potential hazards, grouped into 14 categories. The hazards were subsequently scored for degree of concern and plausibility, and then compared with an equivalent list of hazards generated independently by a checklist approach. The incidence of herbicide tolerant volunteers (and weeds) both on and off the farm had the highest average score of all the ecological hazard categories. The checklist based approach identified or implied 44% of the hazards identified in the Hierarchical Holographic Model, including nine of the ten hazards ranked most important. The checklist approach focussed almost exclusively on the phenotypic and genotypic hazards associated with herbicide tolerant oilseed rape and largely ignored the hazards associated with the circumstances surrounding its use. As a result the checklist identified only 6 out of the 79 potential hazards associated with changes to farming practice. The commercial release of herbicide tolerant oilseed rape will be associated with changes in tillage and the application of post-emergent herbicides. It may also lead to changes in spray schedules of insecticide and fungicide. Many of the environmental hazards identified with these changes are plausible and may warrant further investigation or targeted monitoring.
15 - Integrating landscape ecology into fisheries management: A rationale and practical considerations
- Edited by Jianguo Liu, Michigan State University, William W. Taylor, Michigan State University
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- Integrating Landscape Ecology into Natural Resource Management
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- 14 January 2010
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- 01 August 2002, pp 366-389
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Introduction
Fisheries exist throughout the world wherever people and water meet (Nielsen, 1999). Essentially, a fishery can be defined as a complex system made up of three interacting components: habitat, the aquatic environment where an organism lives; biota, the living organisms in the aquatic ecosystem; and people, who harvest the biotic resource or who change the condition of its environment (Willis and Murphy, 1996). Throughout its history, the principal goal of fisheries management has been “to provide people with a sustained, high, and ever increasing benefit from their use of living aquatic resources” by manipulating these three components (Nielsen, 1999). Over time, the primary focus of fisheries management has shifted from providing the maximum sustainable harvest to providing a variety of different benefits that arise as a result of the interaction of people, habitats, and organisms (see Nielsen, 1999 for a brief history of fisheries management).
In the beginning, fisheries management was primarily concerned with providing food, and secondarily with providing economic benefit, for an everincreasing human population. For this reason, fish were viewed as crops, and the efficient use of fish populations, or providing maximum sustainable yield (MSY), became the driving philosophy during the early twentieth century (Nielsen, 1999). To provide MSY, fishery managers focused on a single-species, single-habitat approach, using population dynamics and biological yield models to predict the maximum harvest level a fishery could sustain. However, as the human population grew, demands on fishery resources and aquatic habitats increased, and fishery scientists began to realize that maximizing the weight or number of fish harvested was not always the most appropriate goal for a fishery.
The Use of Micro-Raman Spectroscopy to Monitor High-Pressure High Temperature Annealing of Ion-Implanted GaN Films
- M. Kuball, J.M. Hayes, T. Suski, J. Jun, H.H. Tan, J.S. Williams, C. Jagadish
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- Materials Research Society Internet Journal of Nitride Semiconductor Research / Volume 5 / Issue S1 / 2000
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- 13 June 2014, pp. 740-746
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- 2000
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We have investigated the high-pressure high-temperature annealing of Mg/P-implanted GaN films using visible and ultraviolet (UV) micro-Raman spectroscopy. The results illustrate the use of Raman spectroscopy to monitor processing of GaN where fast feedback is required. The structural quality and the stress in ion-implanted GaN films was monitored in a 40nm-thin surface layer of the sample as well as averaged over the sample layer thickness. We find the nearly full recovery of the crystalline quality of ion-implanted GaN films after annealing at 1400-1500°C under nitrogen overpressures of 1.5GPa. No significant degradation effects occurred in the GaN surface layer during the annealing. The high nitrogen overpressures proved very effective in preventing the nitrogen out-diffusion from the GaN surface. Stress introduced during the annealing was monitored. Raman spectra of ion-implanted GaN films were investigated at different temperatures and excitation wavelengths to study the GaN phonon density of states.
The Use of Micro-Raman Spectroscopy to Monitor High-Pressure High-Temperature Annealing of Ion-Implanted GaN Films
- M. Kuball, J.M. Hayes, T. Suski, J. Jun, H.H. Tan, J.S. Williams, C. Jagadish
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- Journal:
- MRS Online Proceedings Library Archive / Volume 595 / 1999
- Published online by Cambridge University Press:
- 03 September 2012, F99W11.46
- Print publication:
- 1999
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We have investigated the high-pressure high-temperature annealing of Mg/P-implanted GaN films using visible and ultraviolet (UV) micro-Raman spectroscopy. The results illustrate the use of Raman spectroscopy to monitor processing of GaN where fast feedback is required. The structural quality and the stress in ion-implanted GaN films was monitored in a 40nm-thin surface layer of the sample as well as averaged over the sample layer thickness. We find the nearly full recovery of the crystalline quality of ion-implanted GaN films after annealing at 1400-1500°C under nitrogen overpressures of 1.5GPa. No significant degradation effects occurred in the GaN surface layer during the annealing. The high nitrogen overpressures proved very effective in preventing the nitrogen out-diffusion from the GaN surface. Stress introduced during the annealing was monitored. Raman spectra of ion-implanted GaN films were investigated at different temperatures and excitation wavelengths to study the GaN phonon density of states.
CHAPTER IX - EGYPT: INTERNAL AFFAIRS FROM TUTHMOSIS I TO THE DEATH OF AMENOPHIS III
- Edited by I. E. S. Edwards, C. J. Gadd, N. G. L. Hammond, E. Sollberger
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- The Cambridge Ancient History
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- 28 March 2008
- Print publication:
- 03 May 1973, pp 313-416
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Summary
THE RULE OF THE MILITARY KING
Out of the struggles to regain her independence and her ascendancy over the warlike nations of Western Asia, Egypt during the Eighteenth Dynasty emerged, for the first time in her history, as a predominantly military state under the rule of a king dedicated from early youth to the leadership of his army and navy and to the expansion and consolidation of his empire by force of arms.
Elevated while scarcely more than a boy to the rank of commander-in-chief of the armed forces, the heir apparent to the Egyptian throne under Tuthmosis I and his successors devoted a considerable portion of his early years to training himself in the arts of war. Proficiency as an archer, a charioteer, and a ship-handler, achieved under the supervision of his father's veterans, ranked high among the qualifications demanded of the future king and were the accomplishments in which throughout his life he took his greatest pride. Experience in actual combat followed shortly after the young ruler's accession to the throne, an occasion almost invariably seized upon by the princes of Nubia and Asia to revolt against their Egyptian overlord. Following the conquests of Tuthmosis III one or two campaigns usually sufficed to restore order throughout the empire and eliminated the need for further show of force on the part of the pharaoh. Nevertheless, the military point of view remained with the king throughout his reign and profoundly affected the nature of his government and the internal conditions of the land which he governed.
CHAPTER II - EGYPT: FROM THE DEATH OF AMMENEMES III TO SEQENENRE II
- Edited by I. E. S. Edwards, C. J. Gadd, N. G. L. Hammond, E. Sollberger
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- The Cambridge Ancient History
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- 28 March 2008
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- 03 May 1973, pp 42-76
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THE LAST YEARS OF THE TWELFTH DYNASTY
When, in 1798 B.C., King Makherure Ammenemes IV ascended the throne of Egypt his father and grandfather before him had ruled the land for the greater part of a century. It is inevitable that he himself should have been well advanced in age at the time of his accession and it is hardly surprising that his reign, including a period of co-regency with his father, did not exceed ten years. In spite of its brevity, an understandable absence of brilliant achievement, and a slight falling off in the quality of the works of art produced, the reign shows little evidence of a serious decline in Egyptian prosperity and prestige. The monuments of Ammenemes IV are fairly numerous and frequently of excellent workmanship. They include a small, but handsome, temple at Medīnet Ma‘ādi in the Faiyūm which he and his father together dedicated to the harvest-goddess Renenutet. At Semna in the northern Sudan the height of the Nile was recorded in the king's fifth regnal year, and at Sinai working parties of Years 4, 6, 8, and 9 have left testimonials of continued activity in the turquoise mines.
Syria evidently acknowledged Egypt's ascendancy as of old. Beirut has yielded a gold pectoral and a small diorite sphinx of Ammenemes IV and in the tomb of Prince Ypshomuibi of Byblos were found a gold-mounted obsidian casket and a fine grey stone vase with his cartouches.
CHAPTER XX - THE MIDDLE KINGDOM IN EGYPT: INTERNAL HISTORY FROM THE RISE OF THE HERACLEOPOLITANS TO THE DEATH OF AMMENEMES III
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- By William C. Hayes, Metropolitan Museum of Art, New York
- Edited by I. E. S. Edwards, C. J. Gadd, N. G. L. Hammond
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- The Cambridge Ancient History
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- 28 March 2008
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- 31 October 1971, pp 464-531
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THE HERACLEOPOLITAN KINGDOM
About 2160 b.c., after several decades of nominal occupancy by the weak rulers of the end of the Sixth Dynasty and the Memphite kinglets of the Seventh and Eighth Dynasties, the throne of Egypt was claimed by Achthoes, the governor of the Twentieth Nome of Upper Egypt, whose city, called by the Egyptians Heneneswe and by the Greeks Heracleopolis, occupied the site of present-day Ihnāsya el-Medīna, on the west side of the Nile, just south of the entrance to the Faiyūm. Assuming the throne-name Meryibre, Achthoes evidently set about imposing his rule upon his fellow nomarchs with such vigour that he has been described by Manetho as ‘behaving more cruelly than his predecessors’ and doing ‘evil to the people of all Egypt’. Though his control of the eastern Delta and its mixed Egyptian and Asiatic population is open to question, he was apparently recognized as king throughout the rest of Egypt as far south as Aswān, where his name has been noted in a rock inscription at the First Cataract. It is by no means certain, as was once thought, that his adherents failed to take over This and the sovereignty of his second successor, Neferkare, seems to have been acknowledged in the three southernmost nomes of Upper Egypt. Elsewhere the names of Achthoes I occur on an openwork bronze vessel from Asyūt, a stronghold of the new regime in the Thirteenth Nome of Upper Egypt, on an ebony staff from Meir in the Fourteenth Nome, and on a fragment of an ivory coffer from El-Lisht, eighteen miles south of Memphis.