We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
In the Federal Republic of Germany about 3 million people suffer from tinnitus/are hit by tinnitus, numerous of them depend on intensive medical care. The repetitive transcranial magnetic stimulation is considered to be an innovative and promising therapy in tinnitus treatment. Low frequency stimulation is meant to reduce the abnormal neural activity in the auditory cortex. This study focuses on the efficacy of rTMS with tinnitus patients in the course of a multi disciplinary / an interdisciplinary therapy concept.
Methods
From November 2008 to June 2009 29 outpatients with chronic tinnitus were treated by low frequency rTMS (1 Hz frequency, 2000 impulses, intensity 110%) for 10 proceedings, stimulating the sinistral auditory cortex with a figure-of-eight-coil. Prior to and afterwards the proceedings questionnaires and assessments of a psychologist took place, afterwards statistical analyses were conducted, the data was explored and systematically discussed.
Results
The severity index of the tinnitus as well as the depression symptoms of the subjects improved significantly. The average reduction rate of the tinnitus score is set at 7 points. With a response criterion at the minimum of 5 points, 57% were declared as responder, 29% as non-responder and 4 patients (14%) described an increase of the tinnitus loudness/annoyance.
Conclusions
The results show that the rTMS works as a helpful treatment tool with tinnitus patients and should be considered as an option in the routine tinnitus treatment.
Patients with untreated obstructive sleep apnea often report depressive symptoms, such as low mood, loss of interest and reduction of drive. In this study we examined the frequency of significant depressive symptoms amongst patients with untreated obstructive sleep apnea over a one year period.
Methods
From January to December 2008 we screened 1260 consecutive patients with untreated obstructive sleep apnea (AHI > 9) seen at our Center for Sleep Medicine were screened for depression. Based on self-administered questionnaires, patients with significant depressive symptoms were defined as having either a BDI II score ≥ 14 or WHO-5 ≤ 13. Additionally, severity of depression was rated based on BDI II scores.
Results
Depressive symptoms were reported frequently. Based on BDI-II, 27.9% of patients report significant depressive symptoms. Of these, 46.2% were mild, 35.9% moderate and 17.9% severe. In addition, 52.6% of patients self-reported feeling unwell based on their WHO-5 scores.
Conclusions
Significant depressive symptoms measured by standardised self-rating scales were detected in over a quarter of our patients with untreated sleep apnea. It remains unknown whether treatment of OSA alone abolishes depressive symptoms, or whether depressive mood may reduce the compliance with treatment. Patients may need an interdisciplinary approach to initial treatment.
The Clinic of Psychiatry and Psychotherapy of Nuremberg established rTMS as a standard tool in the treatment of patients with depressive disorder since 2001. The stimulation protocol was modified in October 2008 to match the current standard procedure reported in the literature. The pulse number was heightened form 800 to 2000 per proceeding. This study examines the effects of the modified stimulation protocol and contrasts the results with the former stimulation efficacy.
Methods
The authors compared patients suffering from depression, who were treated by rTMS with 800 pulses/day and with 2000 pulses/day. The results of psychological examinations (MADRS, HAMD, BDI, grading, cognitive screening) prior to and afterwards the three-weeks-rTMS-cycle were submitted. Variance analyses were used for statistical reason.
Results
The subsamples were comparable by sex, age, premorbid intellectual level as well as by self- and other-rated depression severity at treatment beginning. Statistical analyses showed a significant reduction of the depression symptoms in both stimulation protocol groups. Solely the HAMD score reduction in the 2000 pulse sample exceeded the decrease in the 800 pulse sample. Analogically the grading of human functions partly differed depending on the sample affiliation. Concerning the screening of cognitive functioning neither group was impaired.
Conclusions
rTMS still seems to be a well-functioning tool in the treatment of depressive disorders in the bounds of daily psychiatric health care. Although the modified stimulation protocol didn’t show many advantages in respect to improving depression symptoms, the results indicate the continual adjustment of the stimulation parameter to meet the current standards.
The clinic of psychiatry and psychotherapy and the clinic of otolaryngology of the clinic of Nuremberg offer an interdisciplinary consultation for patients suffering from tinnitus aurium and comorbid major depression and/or insomnia.
Objectives
Prediction variables are needed regarding the treatment of subjective ear noises by low frequency rTMS.
The aim of the present study was to examine
a) if rTMS responders and non-responders differ in significant parameters prior to the rTMS treatment
b) and if improvement of tinnitus complaints is associated with mood change.
Methods
From June 2008 to July 2010 109 outpatients with chronic tinnitus were treated with rTMS (1 Hz, 2000 impulses, intensity 110% motor-treshold, 10 proceedings, stimulation of left auditory cortex). Prior to and afterwards the proceedings clinical assessment regarding the severity of tinnitus (TQ) and depressive symptoms (BDI II, MADRS) took place.
Results
Response to rTMS was defined as reduction in the TQ score of ≥ 5 points (54 responder, 18 female, 36 male; 55 non-responder, 16 female, 39 male). The samples did not differ in age (MR = 56,4, SDR = 13,3; MNR = 57,3, SDNR = 12,2). The subsamples differed significantly regarding depression symptoms before rTMS, as non-responder being more depressive than rTMS-responder (table 1; MADRS: p = 0.008 **; BDI II: p = 0.01**).
Furthermore there is a significant interaction between BDI and the response/non-response criterion indicating a higher decrease of depression symptoms in rTMS responders.
Field studies were conducted at three locations over 2 yr in southern Ontario to determine the critical period of weed control in soybean. This period generally consisted of two discrete periods, a critical weed-free period and a critical time of weed removal. The critical weed-free period was relatively short in duration and consistent across locations and years. A period of weed control lasting up to the fourth node growth stage (V4), approximately 30 days after emergence (DAE), was adequate to prevent a yield loss of more than 2.5%. The critical time of weed removal was variable across locations and years and ranged, for example, from the second node growth stage (V2) to the beginning pod growth stage (R3), approximately 9 to 38 DAE, at a 2.5% yield loss level. A phenologically based period of most rapid yield loss due to weed interference occurred from beginning bloom stage (R1) to beginning seed stage (R5). The short and consistent critical weed-free period indicates the duration of residual herbicide control necessary in soybean and supports use of nonresidual, postemergence herbicides and mechanical weed control.
Surveys were conducted across the northern Great Plains of Canada in 1996 and 1997 to determine the nature and occurrence of herbicide-resistant (HR) biotypes of wild oat (Avena fatua). The surveys indicated that resistance to acetyl-CoA carboxylase (ACCase) inhibitors (Group 1) occurred most frequently relative to other herbicide groups. Group 1-HR wild oat occurred in over one-half of fields surveyed in each of the three prairie provinces. Of particular concern was the relatively high incidence of multiple-group resistance in wild oat in Saskatchewan and Manitoba. In Saskatchewan, 18% of Group 1-HR populations were also resistant to acetolactate synthase inhibitors (imidazolinones), even though these herbicides were not frequently used. In Manitoba, 27% of fields surveyed had wild oat resistant to herbicides from more than one group. Four populations were resistant to all herbicides registered for use in wheat (Triticum aestivum). Depending on the nature of resistance in wild oat, alternative herbicides available for their control may substantially increase costs to the grower. The cost to growers of managing HR wild oat in Saskatchewan and Manitoba using alternative herbicides is estimated at over $4 million annually. For some HR biotypes, alternative herbicides either are not available or all have the same site of action, which restricts crop or herbicide rotation options and threatens the future sustainability of small-grain annual cropping systems where these infestations occur.
Two field residue studies were conducted from 2005 to 2007 in Simcoe, Ontario, Canada, to evaluate the effects of mesotrione soil residues on injury, plant dry weight, and yield of sugar beet, cucumber, pea, green bean, and soybean and to verify the potential of reducing a 2-yr field-residue study (conventional residue carryover) to a 1-yr field study (simulated residue-carryover study) by growing these crops in soil treated with reduced rates of mesotrione applied in the same year. There was a significant difference in mesotrione carryover between 2006 and 2007 and differences between years can be explained by differences in soil pH and soil moisture. The conventional and the simulated residue-carryover studies successfully measured mesotrione persistence and rotational crop sensitivity. Both studies showed that sugar beet was the most-sensitive crop with injury, plant dry weight reduction, and yield loss because of mesotrione residues as high as 100%. Green bean was the next most-sensitive crop to mesotrione residues followed by pea, cucumber, and soybean. The simulated residue-carryover study provided a more-rigorous test of rotational crop sensitivity to mesotrione residues than the conventional residue-carryover study, especially at higher rates for the more-sensitive crops. For the other crops, responses to mesotrione residues were similar between the conventional and simulated residue-carryover studies.
False cleavers and catchweed bedstraw are problematic weeds of field crops in high-latitude regions of the northern Great Plains of North America. The abundance of these species has been increasing in areas of greater tillage intensity and frequency. Field experiments were established over 4 site-yr in Manitoba, Canada, and results indicated that the recruitment of false cleavers and catchweed bedstraw was strongly promoted by a single shallow tillage operation with a sweep cultivator in the spring. Percent recruitment levels in 2001 (pooled over sites) were 17 and 46% for the untilled and tilled treatments, respectively. In 2002, the percent recruitment levels for the untilled and tilled treatments, respectively, were 28 and 38% for the Komarno site and 13 and 28% for the Petersfield site. Only a few and minor differences in microsite conditions (soil temperature, soil moisture, and bulk density) resulted from the single spring tillage pass. The single tillage pass caused a significant relocation of simulated seeds (plastic beads) to below the soil surface and deeper into the soil profile (2–4 cm). Mean bulk density and volumetric soil moisture increased significantly with soil depth. The results of this study suggest that the positive effect of tillage on cleavers recruitment was not due to the effect of tillage on microsite conditions per se. Rather, the vertical redistribution of seed by tillage moved these seeds to a place in which the microsite conditions differed from those on the surface and were more favorable for recruitment. False cleavers and catchweed bedstraw recruitment is clearly promoted by tillage (even minor tillage) under field conditions, and farmers might be able to limit recruitment by limiting spring tillage.
Halosulfuron-methyl, a sulfonylurea herbicide, was registered for broadleaf weed control in dry bean. This herbicide has an adequate margin of crop safety in white bean, but causes unacceptable injury to adzuki bean. Halosulfuron-methyl absorption, translocation, and metabolism were evaluated in white and adzuki bean using radiolabeled herbicide to determine if differences in these parameters could explain the difference in crop safety between these two species. Adzuki bean had more rapid halosulfuron-methyl absorption than white bean. Adzuki bean reached 90% absorption (t90) 26.2 h after treatment (HAT), whereas white bean required 40.1 HAT to reach t90. The maximum halosulfuron-methyl absorption was higher in adzuki bean (75.7%) than in white bean (65.3%). More 14C-halosulfuron was translocated to the apex, first trifoliate, stem above the treated leaf, and roots in aduzki bean than in white bean. The maximum radioactivity translocated out of treated leaf was higher in adzuki bean (17.7%) than in white bean (12.1%). Halosulfuron-methyl was broken down to the same metabolites in white and adzuki bean. The half-life of halosulfuron-methyl in adzuki bean was 16 HAT, compared with less than 6 HAT in white bean. More herbicide remained as the free acid in adzuki bean compared with white bean over the entire 48-h time course. The differential tolerance of white and adzuki bean to halosulfuron can be attributed to greater absorption and translocation and decreased metabolism in adzuki bean.
Avena fatua seeds remaining on the plant at harvest and taken into the combine harvester may be dispersed over large areas. The objective of this study was to characterize the development of A. fatua in comparison to spring Triticum aestivum. As part of this objective, the rate of seed shed in A. fatua relative to development of T. aestivum was determined. Avena fatua and T. aestivum had similar phyllochron intervals within locations but differed between locations. Plant development as measured by the Zadoks plant development scale was consistent within plant species between locations. Seed shed in A. fatua was also consistent between locations. Most of the seed shed occurred within 2 wk, and the cumulative seed shed followed a sigmoidal pattern. The seed shed occurred as T. aestivum was ripening, and the percentage of seed shed appears to be related to the water content of the T. aestivum spike. Because of this relationship, the proportion of seed remaining on A. fatua at harvest could be managed by changing the timing of crop harvest.
Differences in the depth of weed seedling recruitment due to agronomic management practices, such as reduced tillage, have implications for weed competitive ability and management strategies. Depth of seedling recruitment of Avena fatua, Triticum aestivum, Setaria viridis, Polygonum convolvulus, and Echinochloa crus-galli was measured in situ in 1997 and 1998 prior to seeding (preseeding) and before in-crop spraying (prespray) in a total of 44 zero-tillage and 44 conventional-tillage fields located across approximately 3 million ha of southern Manitoba, Canada. For the monocot species, depth of recruitment was measured from the soil surface to the intact seed coats, which marked the point of germination. For P. convolvulus, a dicot, greenhouse studies were conducted prior to sampling in the field to identify a reliable morphological marker indicating the point of germination. For all species, mean recruitment depth was found to be significantly shallower in zero- vs. conventional-tillage fields and significantly shallower in the preseeding vs. the prespray period. There were relatively few differences in mean recruitment depth among weed species. Within a sampling period and tillage system, for example, the greatest difference in mean recruitment depth between species was less than 1.2 cm, and the maximum mean recruitment depth across species, sampling times, and tillage practice was very shallow (less than 4.2 cm). Locating weed seedling recruitment depth is the first step in characterizing weed seedling recruitment microsites. Results indicate this information should be specific to tillage and sampling time.
Whole-plant bioassays using sugar beet, lettuce, cucumber, green bean, pea, and soybean as test crops were used to detect mesotrione residues in the soil. The test crops were planted in soil treated with mesotrione in the field the previous year at rates of 0 to 560 g ai ha−1 and in nontreated soil from the same field, with mesotrione added at concentrations of 0 to 320 μg kg−1. Experiments were conducted in the greenhouse for a 21-d period. Values for the dose giving a 50% response (I50) were predicted using a log-logistic nonlinear regression model. I50 values (mean ± SE) of 8.6 ± 1.8, 14.9 ± 2.0, 29.8 ± 11.0, 41.6 ± 7.3, 52.9 ± 6.4, and 67.9 ± 30.3 g ai ha−1 for sugar beet, lettuce, green bean, cucumber, pea, and soybean, respectively, indicate that these crops were effective bioassay test species for quantifying mesotrione residues. A greenhouse bioassay was a simple and sensitive tool to detect mesotrione at concentrations of less than 1.0 μg kg−1 with sugar beet and lettuce being the most sensitive test species. The I50 values for soil treated with known concentrations of mesotrione were lower than for field soil treated with mesotrione the previous year. Knowing the level of mesotrione residues in the soil, growers have flexibility in crop rotations following mesotrione use on corn. Growers can use this information to minimize risk of crop injury by choosing appropriate rotation crops that suffer little or no yield reduction.
Non-linear regression (NLR) techniques are used widely to fit weed field emergence patterns to soil microclimatic indices using S-type functions. Artificial neural networks (ANNs) present interesting and alternative features for such modelling purposes. In the present work, a univariate hydrothermal-time based Weibull model and a bivariate (hydro-time and thermal-time) ANN were developed to study wild oat emergence under non-moisture restriction conditions using data from different locations worldwide. Results indicated a higher accuracy of the neural network in comparison with the NLR approach due to the improved descriptive capacity of thermal-time and the hydro-time as independent explanatory variables. The bivariate ANN model outperformed the conventional Weibull approach, in terms of RMSE of the test set, by 70·8%. These outcomes suggest the potential applicability of the proposed modelling approach in the design of weed management decision support systems.
Recent Hα surveys such as SHS and IPHAS have improved the completeness of the Galactic planetary nebula (PN) census. We now know of ∼3000 PNe in the Galaxy, but this is far short of most estimates, typically ~25 000 or more for the total population. The size of the Galactic PN population is required to derive an accurate estimate of the chemical enrichment rates of nitrogen, carbon, and helium. In addition, a high PN count (>20 000) is strong evidence that most main-sequence stars of mass 1–8 M⊙ will go through a PN phase, while a low count (<10 000) argues that special conditions (e.g. close binary interactions) are required to form a PN. We describe a technique for finding hundreds more PNe using the existing data collections of the digital sky surveys, thereby improving the census of Galactic PNe.
We have found the central star of Abell 70 (PN G038.1–25.4, hereafter A 70) to be a binary consisting of a G8 IV-V secondary and a hot white dwarf. The secondary shows enhanced Ba II and Sr II features, firmly classifying it as a barium star. The nebula is found to have Type-I chemical abundances with helium and nitrogen enrichment, which combined with future abundance studies of the central star, will establish A 70 as a unique laboratory for studying s-process AGB nucleosynthesis.
Over the last decade Galactic planetary nebula discoveries have entered a golden age due to the emergence of high sensitivity, high resolution narrow-band surveys of the Galactic plane. These have been coupled with access to complimentary, deep, multi-wavelength surveys across near-IR, mid-IR and radio regimes in particular from both ground-based and space-based telescopes. These have provided powerful diagnostic and discovery capabilities. In this review these advances are put in the context of what has gone before, what we are uncovering now and through the window of opportunity that awaits in the future. The astrophysical potential of this brief but key phase of late stage stellar evolution is finally being realised.
Nebular emission lines are easy to observe, and their spectrum contains a lot of information. We explain the mechanisms of production of the emissions, and the relation between the intensity of the recombination and forbidden lines, and the physical parameters of the objects. A gallery of emission lines spectra is presented, and a rough analysis will clarify their differences. The case of Planetary Nebulae will be developed, in order to determine the extinction constant, the plasma parameters (electron density and temperature), the chemical abundances, and also the properties of the central star (temperature, mass, stellar wind velocity, age).