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This investigation examines the dynamic response of an accelerating turbulent pipe flow using direct numerical simulation data sets. A low/high-pass Fourier filter is used to investigate the contribution and time dependence of the large-scale motions (LSM) and the small-scale motions (SSM) into the transient Reynolds shear stress. Additionally, it analyses how the LSM and SSM influence the mean wall shear stress using the Fukagata–Iwamoto–Kasagi identity. The results reveal that turbulence is frozen during the early flow excursion. During the pretransition stage, energy growth of the LSM and a subtle decay in the SSM is observed, suggesting a laminarescent trend of SSM. The transition period exhibits rapid energy growth in the SSM energy spectrum at the near-wall region, implying a shift in the dominant contribution from LSM to SSM to the frictional drag. The core-relaxation stage shows a quasisteady behaviour in large- and small-scale turbulence at the near-wall region and progressive growth of small- and large-scale turbulence within the wake region. The wall-normal gradient of the Reynolds shear stress premultiplied energy cospectra was analysed to understand how LSM and SSM influence the mean momentum balance across the different transient stages. A relevant observation is the creation of a momentum sink produced at the buffer region in large- and very large-scale (VLSM) wavelengths during the pretransition. This sink region annihilates a momentum source located in the VLSM spectrum and at the onset of the logarithmic region of the net-force spectra. This region is a source term in steady wall-bounded turbulence.
GnRh agonists are drugs used in various gynecological pathologies, among which is endometriosis. They act by stimulating GnRh receptors in the pituitary gland. This sustained and continuous stimulation of GnRh, will initially generate an increase in the release of luteinizing hormones and follicle-stimulating hormones, subsequently losing sensitivity to the receptors, internalizing them, and thus suppressing the release of these hormones, which would entail an ovarian suppression, thereby inhibiting the release of estrogens and progesterone. Psychiatric adverse effects have been described. Gonzalez-Rodriguez et al (Front Psychiatry 2020; 11:479), described this association with changes in mood, and the presence of a series of cases where the link between GnRh agonist and the possibility of presenting psychotic symptoms is observed. Wieck (Curr Top Behav Neurosci 2011;8:173-87), Frokjaer (J Neurosci Res 2020;98(7):1283-1292), Brzezinski-Sinai et al (Front Psychiatry 2020;11:693) reported that this association could be related with the relationship of the hypothalamic-pituitary-gonadal axis, hormonal fluctuation and its relationship with the dopaminergic regulation, a genetic component that would increase the predisposition to trigger psychiatric pathology in patients with greater sensitivity to hormonal fluctuations, and the loss of neuroprotection generated by the decrease of estrogens in the central nervous system. All of this in the context of multiple environmental and genetic factors that participate together in the appearance of the disease.
Objectives
To describe the importance of detecting the risk factors that can precipitate a psychotic episode, including the use of certain drugs, such as GnRh agonists.
Methods
We describe a case of a 45 year old patient with endometriosis with multiple organ involvement who went to the emergency room due to behavioral changes in the context of a brief psychotic disorder with “ad-integrum” recovery.
Results
A retrospective analysis of the case is conducted, observing an association between the introduction of GnRh agonists and the presentation of a first psychotic episode.
Conclusions
The importance of this case lies in the limited evidence of this association in the literature, and the implication of these drugs in the triggering of psychiatric pathology, being an aspect to be considered by psychiatrists in their patient’s follow-up.
After the success of the first two editions of the Palaeontological Virtual Congress in 2019 (first PVC) and 2021 (second PVC; Crespo & Manzanares 2019; Crespo & Citton 2021), we have decided to try to replicate the success with a third meeting of the PVC (Fig. 1). The appearance of new applications and technological advances has played a crucial role in paving the way for enhanced avenues of effective scientific communication. This became even more pronounced from more than two years of challenges stemming from the COVID-19 pandemic. Due to this crisis, online platforms gained more relevance and proved key to keeping up the drive for science communication and the dissemination of scientific results (Barral 2020).
This investigation characterises the time response and the transient turbulence dynamics undergone by rapidly decelerating turbulent pipe flows. A series of direct numerical simulations of decelerating flows between two steady Reynolds numbers were conducted for this purpose. The statistical analyses reveal that rapidly decelerating turbulent flows undergo four coherent, unambiguous transitional stages: inertial (stage I), a dramatic change of sign in the viscous force associated with the decay of the viscous shear stress at the wall together with a mild turbulence decay in the viscous sublayer; friction recovery (stage II), a recovery in viscous force and progressive decay in the turbulent inertia at the near-wall region; turbulence decay (stage III), a balanced decay in both turbulent inertia and viscous force at the near-wall and overlap regions; core relaxation (stage IV), slow turbulence decay at the core region. The FIK identity derived by Fukagata, Iwamoto and Kasagi (Phys. Fluids, vol. 14, 2002, L73–L76) was used to understand further how the flow dynamics influence the time response of the skin friction coefficient ($C_f$). The results show that although $C_f$ plateaus during the fourth stage, the turbulent contribution keeps decaying, undershoots and finally recovers to attain its final steady value. The time evolution of the azimuthal vorticity ($\omega _\theta$) flux reveals that as the flow is decelerated, a layer of negative $\omega _\theta$ is produced at the wall during the flow excursion. As time progresses, this negative vorticity propagates in the wall-normal direction, attenuating the pre-existing vorticity and producing a decay in the turbulence levels.
The aim of this chapter is to present the medieval, early modern, and modern pottery found during the recent excavations in the Secano of the Alhambra. The analysis of the pottery has been twofold: first, the assemblage was characterized typologically and functionally; second, the clays were analysed by archaeometric methods taking into account mineralogical and geochemical variables, namely X-ray Diffraction (XRD) and Scanning Electron Microscope–Energy Dispersive X-ray Spectroscopy (SEM-EDS). The assemblage found in the Secano appears to confirm that production activities began in the area in the medieval period, became very intensive in the Early Modern Age, and all but ceased in the 18th century. Particularly striking is the virtual absence of high-end medieval ceramics and the enormous increase in pyrotechnological activity in the Early Modern Age. Thin-section analysis, for its part, has yielded important information concerning the technological practices and raw resources available to the craftspeople of the Secano. These studies indicate that the conquest of the Nasrid kingdom of Granada triggered significant technological change and the adoption of new production models. The archaeological and historical analysis of production systems offers a critical perspective on the nature and evolution of interactions between al-Andalus and Castile through the examination of changes in material culture and cultural behaviour over time. The analysis of the ceramics found in the Alhambra has provided a more in-depth perspective on change and continuity in the aftermath of the Castilian conquest.
Keywords: medieval and modern ceramics; ceramic production; typology, archaeometry.
Introduction
The excavation of the area of the Secano in the Alhambra resulted in the collection of a large ceramic assemblage. The analysis of this assemblage has yielded the interesting conclusion that ceramic production in the area was virtually, if not entirely, abandoned in the 18th century, in keeping with the stratigraphic analysis of the two excavation trenches (see Chapters 5 and 6) and the results of archival research. Also in line with the excavation results, the assemblage suggests that the area witnessed substantial production activity in the Early Modern Age.
Methodology
The study of the ceramic assemblage began during the excavation season. After washing, labelling, and joining, diagnostic pieces were catalogued and entered into an ad hoc database. The initial examination consigned such variables as shape, colour of the fabric, clay composition (macroscopic), forming and firing methods, finishing of surfaces, and decoration.
This study examines the precursors and consequences of rare backflow events at the wall using direct numerical simulation of turbulent pipe flow with a high spatiotemporal resolution. The results obtained from conditionally averaged fields reveal that the precursor of a backflow event is the asymmetric collision between a high- and a low-speed streak (LSS) associated with the sinuous mode of the streaks. As the collision occurs, a lifted shear layer with high local azimuthal enstrophy is formed at the trailing end of the LSS. Subsequently, a spanwise or an oblique vortex spontaneously arises. The dominant nonlinear mechanism by which this vortex is engendered is enstrophy intensification due to direct stretching of the lifted vorticity lines in the azimuthal direction. As time progresses, this vortex tilts and orientates towards the streamwise direction and, as its enstrophy increases, it induces the breakdown of the LSS located below it. Subsequently, this vortical structure advects as a quasi-streamwise vortex, as it tilts and stretches with time. As a result, it is shown that reverse flow events at the wall are the signature of the nonlinear mechanism of the self-sustaining process occurring at the near-wall region. Additionally, each backflow event has been tracked in space and time, showing that approximately 50 % of these events are followed by at least one additional vortex generation that gives rise to new backflow events. It is also found that up to a maximum of seven regenerations occur after a backflow event has appeared for the first time.
Foot reflexology is a type of complementary manual therapy that consists of applying pressure or massage to the sole of the foot to produce various therapeutic effects in other body areas or organs. This technique has been used in many different clinical indications, but there is uncertainty about its real effect. A health technology assessment (HTA) was conducted to analyze the efficacy and safety of foot reflexology within the framework of the “Health Protection Plan Against Pseudo-Therapies,” which was established in 2018 by the Spanish Ministry of Health and the Ministry of Science and Innovation.
Methods
A systematic review and metanalysis was conducted to synthesize the available scientific literature on the efficacy and safety of foot reflexology in people of any age with any disease or medical condition.
Results
Sixty-eight randomized controlled studies were included. Pooled estimates indicated that foot reflexology had no effect on pain, fatigue, depression, quality of life, quality of sleep, or blood pressure, compared with non-reflexological foot massage. Improvements in pain (standardized mean difference [SMD] −1.11, 95% CI: −1.70 - −0.52), fatigue (SMD −0.93, 95% CI: −1.36 - −0.51), sleep quality (SMD −1.11, 95% CI: −1.68 - −0.34), and systolic (mean difference [MD] −7.36, 95% CI: −8.49 - −6.23) and diastolic (MD −5.07, 95% CI: −0.98 - −0.22) blood pressure were obtained when reflexology was compared with usual care or no intervention. In the case of anxiety levels, the benefit obtained with foot reflexology compared with any comparator (SMD −0.6, 95% CI: −0.98 - −0.22) was attenuated when compared with non-reflexological foot massage (SMD −0.2, 95% CI: −0.36 - −0.03). Very few studies reported on the safety of foot reflexology.
Conclusions
There was no evidence for any specific effect of reflexology for any condition when compared with non-reflexological foot massage, except for a positive effect on anxiety levels.
The transient dynamics of accelerating turbulent pipe flow has been examined using direct numerical simulation (DNS) data sets with a high spatiotemporal resolution, starting from low and moderate Reynolds numbers. The time-dependent evolution of the mean flow dynamics reveals that internal flows, during and after a rapid increase in the flow rate, experience four unambiguous transient stages: inertial, pre-transition, transition and core relaxation before they reach their final steady-state. The first stage is characterised by a rapid and substantial increment in the viscous forces within the viscous sublayer, together with the frozen behaviour of the existing turbulent eddies. The pre-transitional stage reveals a weak response of the turbulent inertia within the near-wall region, together with a rapid reduction in the viscous forces. At the third stage, termed transition, balanced growth in the magnitude of both the turbulent and the viscous forces within $y^{+0} \lesssim 50$ is observed. The final stage, referred to as core relaxation, shows a quasi-steady behaviour at $y^{+0} < 50$ and reveals the slow propagation of turbulence from the near-wall region into the wake region. A decomposition of the skin friction coefficient ($C_f$), using an FIK identity suitable for unsteady pipe flow, shows a progressive increment in the turbulent contribution during the core-relaxation period. Simultaneously, the unsteady contribution decreases proportionally, maintaining a plateau in $C_f$. The principal mechanism responsible for this slow regeneration in the wake is a temporal turbulence stratification at the inner region of the flow, together with a quiescent core, which maintains geometric coherence across extensive periods.
This work presents a detailed analysis of the flow structures relevant to extreme wall shear stress events for turbulent pipe flow direct numerical simulation data at a friction Reynolds number $\textit {Re}_{\tau} \approx 1000$. The results reveal that extreme positive wall-friction events are located below an intense sweep (Q4) event originated from a strong quasi-streamwise vortex at the buffer region. This vortex transports high streamwise momentum from the overlap and the outer layers towards the wall, giving rise to a high-speed streak within the inner region. This vortical structure also relates to regions with extreme wall-normal velocity. Consequently, the conditional fields of turbulence production and viscous dissipation exhibit peaks whose magnitudes are approximately 25 times higher than the ensemble mean quantities in the vicinity of the extreme positive events. An analysis of the turbulent inertia force reveals that the energetic quasi-streamwise vortex acts as an essential source of momentum at the near-wall region. Similarly, extremely rare backflow events are studied. An examination of the wall-normal vorticity and velocity vector fields shows an identifiable oblique vortical structure along with two other large-scale roll modes. These counter-rotating motions contribute to the formation of backflow events by transporting streamwise momentum from the inner to the outer region, creating a large-scale meandering low-speed streak. It is found that extreme events are clustered below large-scale structures of positive streamwise momentum that interact with near-wall low-speed streaks, related to regions densely populated with vortical structures. Finally, a three-dimensional model is proposed to conceptualise the flow dynamics associated with extreme events.
To describe the relation of psychosocial factors of care (phase illness, years of care, free time, extra help and symptoms of depression) influence the care burden of dementia family caregivers. To measure the relation of the level of depressive symptoms on an intense level of burden of the dementia family caregivers.
Methods
Is selected a sample of 102 primary caregivers by criteria of inclusion to which a surveys do to those that the following information gathered: sociodemographic dates of the caregivers and of the dementia patients, care burden (Zarit Interview) and depressive symptoms (Beck Depression Inventory) of the family caregivers.
Results
Most of the sample experiences an intense burden level (74%) opposite to a light level (26%). Psychosocial characteristics are as per statistics significant in increasing the care burden there were free time, extra help and presence of symptoms of depression. Presence of serious symptoms of depression on the intense burden level are differently front or those who had a minor burden, 22% and 5% respectively.
Conclusions
There are most of the daughter-father/mother and spouse-spouse caregiver couples with a high percentage of caregivers of feminine sex (as in most of the studies realized on caregiver of dependent persons at European and international level). The need for free time and psychic self-care are cost-effective strategies to prevent the depressive disorders, as well as, to improve their caregiver's work. The psychoeducation programs that have being realized at European level directed to family caregiver are necessary in our country.
The objective of the present study was to examine the predictive value of clinical and cognitive -including the cognitive reserve (CR) - variables on the severity of the patient's illness at one year of follow-up.
Methods
A study was held with 45 patients with first episode psychosis (FEP) from 3 main hospitals in the Basque Country (Spain). All patients underwent cognitive, clinical, and functional assessments at baseline and at 6 months follow-up. The cognitive measures included were: the Stroop test, Vocabulary sub-test from WAIS-III, the WCST, and Trail Making Test. The clinical and functional measures included were: Positive and Negative Syndrome Scale (PANSS), Young Mania Scale, Montgomery-Asberg Depression scale, and CGI (Clinical Global Impression).
Results
Six-months follow-up data were available for 29 patients. Regression analysis was performed with the 6-month follow-up CGI measure as a dependent variable. Results showed that after controlling for CGI at baseline, -PANSS Negative Symptoms Scale (B = 0.47, p ≤ .05) and the CR measure -Vocabulary from WAIS-III- (B = 0.36, p ≤ .05) were the only two which significantly predicted severity of illness after 6 months (R2 = 0.44) and remained significant when CGI at base line was controlled in the regression analysis. The rest variables did not reach statistical significance.
Conclusions
These findings emphasize that CR have a role on outcome in first episode psychosis, and enhance that exist a relation between cognition and clinical measures in psychosis.
Funding
Basque Government, Health Department (2008111010); EITB-Maratoia (BIO 09/EM/015).
The brain functional correlates of autobiographical recall are well established, but have been little studied in schizophrenia. Additionally, autobiographical memory is one of a small number of cognitive tasks that activates rather than de-activates the default mode network, which has been found to be dysfunctional in this disorder.
Methods
Twenty-seven schizophrenic patients and 30 healthy controls underwent functional magnetic resonance imaging while viewing cue words that evoked autobiographical memories. Control conditions included both non-memory-evoking cues and a low level baseline (cross fixation).
Results
Compared to both non-memory evoking cues and low level baseline, autobiographical recall was associated with activation in default mode network regions in the controls including the medial frontal cortex, the posterior cingulate cortex and the hippocampus, as well as other areas. Clusters of de-activation were seen outside the default mode network. There were no activation differences between the schizophrenic patients and the controls, but the patients showed clusters of failure of de-activation in non-default mode network regions.
Conclusions
According to this study, patients with schizophrenia show intact activation of the default mode network and other regions associated with recall of autobiographical memories. The finding of failure of de-activation outside the network suggests that schizophrenia may be associated with a general difficulty in de-activation rather than dysfunction of the default mode network per se.
New routes in additive devices fabrication techniques and advances in printable materials are required to meet the ever increasing demands for low-cost and large-area flexible electronics. In particular, perovskite-based materials have gained an appeal due to their unique optoelectronics and ferroelectrics properties, which may replace p-n junction in semiconductor devices. Metal-organic methylammonium lead trihalide perovskite formulations have been extensively studied in the last few years as promising materials for use in printed electronics, which do not require high temperatures or vacuum environment, contrary to conventional semiconductor fabrication techniques. In this work, digital inkjet-printing in ambient atmosphere is proposed as a deposition pathway for the fabrication of perovskite active layers in photodetector and thin-film photovoltaic device architectures. The device architecture containing a printed perovskite active layer sandwiched between TiO2 and Spiro-OMeTAD as electron and hole transport layers, respectively, as well as layer-on-layer fabrication and responsivity spectra of the perovskite-based device are presented.
We present deep optical spectroscopy of seven planetary nebulae (PNe) in the substructures of M31, three in the Northern Spur and four associated with the Giant Stream. The spectra were obtained with the OSIRIS spectrograph on the 10.4 m GTC. The detection of the [O iii] λ4363 auroral line in all PNe of our sample enables reliable abundance determinations. Our targets have low N/O (<0.5) and He/H ratios, indicating that they are probably Type II PNe. The PNe in our sample have rather homogeneous oxygen abundances, with an average value of 8.56±0.10. Based on the abundances as well as the spatial and kinematical information of our targets, we speculate that the Northern Spur and the Giant Stream might have the same origin. We raise a hypothesis that the dwarf satellite M32 might be responsible for these two substructures. New observations have recently been made to assess this hypothesis.
We present studies using different observational techniques, along different frequencies, aiming to resolve and investigate jets, outflows, as well as compact and innermost regions of asymmetric planetary nebulae (PNe) and objects in transition to PN. All the information gathered allow us to explore the kinematics and other important properties of the structures that play a crucial role in the shaping of complex PNe morphologies, in particular, we explore the role of disks/tori as collimating engine of extreme axisymmetric PNe.
The aim of this work was to test the performance of a shrimp-tomato culture system (STCS) in an arid-semiarid region (Sonora, Mexico) and to evaluate the water quality variables and phytoplankton variation of shrimp effluent and that water returning from the tomato module culture. The field study was conducted using groundwater and consisted of three circular tanks that were used for shrimp (Litopenaeus vannamei) farming and were coupled to one culture module of tomato plants (Lycopersicon esculentum). The shrimp effluent was used to irrigate the tomato plants. The yield was 11.1±0.2 kg shrimp per tank (3.9±2.0 ton ha−1) and 33.3 kg tomatoes per 45 plants (36.1±2.3 ton ha−1). During the culture, the concentrations of nutrients were (mg L−1): total N-ammonia, <0.001–0.848; N-nitrite, <0.001–1.45; N-nitrate, 5.2–172.2; dissolved reactive-P, <0.005–0.343. A total of 35 taxa belonging to three different algal classes were observed: Chlorophyta (87 to 98%), Bacilliariophyta (2 to 9%) and Cyanophyta (0–3%). This STCS allowed us to harvest the equivalent of 3.9 ton ha−1 of shrimp and 36.3 ton ha−1 of tomatoes, with a water consumption of 2.1 m3 per kg harvested of both products.
Since the IUE satellite produced a vast collection of high-resolution UV spectra of the central stars of planetary nebulae (CSPNe), there has not been any further systematic study of the stellar winds of these stars. The high spectral resolution, sensitivity and large number of archival observations in the FUSE archive allow the study of the stellar winds of CSPNe in the far-UV domain where lines of species spanning a wide excitation range can be observed. We present here a preliminary analysis of the P Cygni profiles of a sample of ∼60 CSPNe observed by FUSE. P Cygni profiles providing evidence for fast stellar winds with velocities between 200 and 4300 km s−1 have been found in 40 CSPNe. In many cases, this is the first time that fast stellar winds have been reported for these planetary nebulae (PNe). A detailed study of these far-UV spectra is on-going.