The global health community has recognized that social determinants of health account for most of the inequities of health outcomes, including mental health outcomes, across and within countries. Strategies to overcome such inequities must focus on modifiable social factors. In this viewpoint, we argue for the preeminence of employment among social determinants of mental health for several reasons. People with mental health disabilities want to work, and a well-validated model of supported employment that is effective and cost-effective now exists. Employment leads to improvements in income, daily structure, self-esteem, social support, community integration and illness management, and people who are employed experience fewer emergencies and hospitalizations. Employment is empowering because people can use added income to activate their own choices regarding other social determinants. Supported employment actualizes the recovery paradigm: People who are employed in competitive jobs of their choice develop a meaningful functional life, increased self-esteem and new social supports. We provide examples of supported employment developments in diverse settings and discuss the implications of scaling up these services worldwide.

Abstract employment is critically important in mental health care. Unemployment worsens mental health and gaining employment can improve mental health, even for people with the most serious mental illnesses. In this editorial, we argue for a new treatment paradigm in mental health that emphasises employment, because supported employment is an evidence-based intervention that can help the majority of people with mental health disability to succeed in integrated, competitive employment. Unlike most mental health treatments, employment engenders self-reliance and leads to other valued outcomes, including self-confidence, the respect of others, personal income and community integration. It is not only an effective short-term treatment but also one of the only interventions that lessen dependence on the mental health system over time.

People with severe mental disorders in rural India have minimal access to mental health services. Project Shifa entails outreach to patients and families in 75 villages in rural central India. A team of local health workers led by one psychiatrist provide assessment, medications, education and follow-up services.

Mineral separates of five tuffs interbedded in the mammal-bearing Huayquerías and Tunuyán formations in Mendoza Province, west-central Argentina, were dated by the 40K-40Ar method. At the locality of Rio Seco Ultima Aguada on the east side the Meseta Guadal three biotite concentrates of a tuff from a level that apparently corresponds to the very top of the Huayquerias Formation (or less probably to the very bottom of the Tunuyan Formation, sensu Dessanti, 1946) yielded an average age of 5.8 ± 0.1 Ma. The boundary between the Huayquerias Formation (namesake and type formation and fauna of the Huayquerian Land Mammal Age) and the Tunuyan Formation (which contains a Montehermosan age fauna at this locality) is thus about 5.8 Ma. At the locality of Rio Seco de la Salada on the west side of the Meseta Guadal, glass concentrates from two tuffs in the upper part of the Tunuyan Formation yielded ages of 2.6 ± 0.1 and 2.4 ± 0.3 Ma, respectively (the latter date is from a tuff located 90 m stratigraphically above the former). These dates indicate that the rocks and faunas from the upper part of the Tunuyan Formation are of Chapadmalalan (i.e., 2.8 to 2.5 Ma) and Uquian (i.e., 2.5 to 1.5 Ma) age. The faunas from the lower and middle parts of the Tunuyan Formation on the east side of the Meseta Guadal are apparently all of Montehermosan age (i.e., ca. 6.0 to 2.8 Ma).

Fossil land mammals were collected by G. G. Simpson in 1933–1934 at and near the Tapera de López in central Chubut Province, Patagonia, southern Argentina, from rocks now mapped as the Sarmiento Formation. These fossils are assigned to land mammal faunas of Casamayoran (Early Eocene), Mustersan (Middle Eocene), and Deseadan (late Early Oligocene through Early Miocene) age.

40K-40Ar age determinations of eight basalt and two tuff units associated with the Deseadan age local fauna at Scarritt Pocket establish a geochronologic framework that calibrates the biostratigraphic record at this locality. The radioisotope dates obtained at Scarritt Pocket range from 23.4 Ma to about 21.0 Ma, and equate with earliest Miocene time. The Scarritt Pocket local fauna is the youngest dated Deseadan age fauna yet known in South America.

Seven other localities have, or were reputed to have, local faunas of Deseadan age associated with dated volcanic units. Six of these localities are in Argentina (Gran Barranca, Cerro Blanco, Valle Hermoso, Pico Truncado, Cañadón Hondo, Quebrada Fiera de Malargüe) and one in Bolivia (Estratos Salla in the Salla-Luribay Basin). The stratigraphic relationships of the volcanic units with these local faunas is discussed, and the taxonomic content of each is reassessed.

The Deseadan Land Mammal Age is defined by the earliest record of the land mammal genus Pyrotherium, which is from below a basalt dated at 33.6 Ma at Pico Truncado. Other early records of Pyrotherium occur below basalts dated at about 29 Ma at the Gran Barranca and Valle Hermoso, and from a 28.5 Ma level of the Estratos Salla. Thus, the lower boundary for Deseadan time is about 34 Ma.

The youngest record of Pyrotherium is in the upper levels of the Estratos Salla dated at about 24 Ma. However, the Scarritt Pocket local fauna, which lacks Pyrotherium, permits placement of the upper boundary for Deseadan time at about 21.0 Ma. Late Deseadan time is surely, and the end of Deseadan time is apparently, marked by the last record of such groups as Proborhyaeninae (Proborhyaena), Rhynchippinae (Rhynchippus), Archaeohyracidae (Archaeohyrax), and the genera Platypittamys (Octodontidae), Scarrittia (Leontiniidae), Propachyrucos and Prohegetotherium (Hegetotheriidae), and Argyrohyrax (Interatheriidae), as these taxa are recorded in the Scarritt Pocket local fauna. Thus, Deseadan time extends from about 34.0 Ma to about 21.0 Ma, making it the Land Mammal Age with the longest known duration in South America.

Substance use disorder is the most frequent and clinically significant comorbidity among schizophrenia patients today. All schizophrenia patients should be assessed and monitored carefully regarding their substance use. Those with any regular use of alcohol or other drugs should be considered at risk for multiple adverse effects. As therapies for co-occurring substance use disorders have evolved over the past 20 years, medication management, psychosocial interventions, and rehabilitation models have increasingly emphasized the integration of mental health and substance abuse treatments, attention to group and residential interventions, matching interventions to stage of treatment, comprehensiveness, and long-term perspectives on recovery. Clinicians should understand the implications of each of these principles of care.

Detergent extracts of Trypanosoma cruzi epimastigotes catalysed the hydrolysis of a range of amino-acyl and peptidyl p-nitro-anilides and aminomethylcoumarins. At least three enzymes were detected that cleave Z–Phe–Arg–MCA. Two of these were optimally active at alkaline pH, the other at pH 4·0. Of the two enzymes with alkaline pH optima, one was a cysteine peptidase and was unable to cleave Bz–Arg–MCA readily, whilst the other cleaved Bz–Arg–MCA and was inhibited by diisopropyl fluorophosphate. The acidic enzyme was similar to cathespin L of other eukayrotes with respect to its pH profile, substrate-specificity and inhibitor-sensitivity. Evidence was presented that epimastigotes contain a cysteine-type dipeptidyl aminopeptidase, one or more aminopeptidases, and a serine peptidase that cleaves Boc–Ala–Ala–pNA. Digitonin solubilization of the activities from cells supports the hypothesis that the cathespin L-like enzyme and the dipeptidyl aminopeptidase are lysosomal, whilst the Bz–Arg–MCA hydrolase, the aminopeptidases and the Boc–Ala–Ala–pNA serine peptidase are cytosolic.

The EEG and MEG studies cited in the target article found reduced gamma band power following pseudowords in comparison with words. Pulvermüller interprets this power difference in terms of reverberating lexical cell assemblies. An alternative interpretation in terms of latency jitter in the gamma band following pseudowords is proposed that does not appeal to lexical cell assemblies.

Schizophrenies who completed suicide were compared with those who made suicide attempts, on the basis of blind ratings of previous hospital records and follow-up interviews with treating clinicians. Results indicated that the two groups were relatively distinct. Suicides tended to live alone and to feel depressed, hopeless, worthless, and suicidal. Attempters, on the other hand, lived with their families or others and were less likely to manifest several features of depression during a period in hospital. In evaluating suicide potential among schizophrenics, living situation and mental state changes indicating depression, suicidal intent, worthlessness, and hopeiessness are more important than a history of suicidal behaviour.