Early warning for epilepsy patients is crucial for their safety and well being, in particular, to prevent or minimize the severity of seizures. Through the patients’ electroencephalography (EEG) data, we propose a meta learning framework to improve the prediction of early ictal signals. The proposed bilevel optimization framework can help automatically label noisy data at the early ictal stage, as well as optimize the training accuracy of the backbone model. To validate our approach, we conduct a series of experiments to predict seizure onset in various long-term windows, with long short-term memory (LSTM) and ResNet implemented as the baseline models. Our study demonstrates that not only is the ictal prediction accuracy obtained by meta learning significantly improved, but also the resulting model captures some intrinsic patterns of the noisy data that a single backbone model could not learn. As a result, the predicted probability generated by the meta network serves as a highly effective early warning indicator.

High-quality intergenerational relationships positively influence cognitive functioning in older parents. However, there is insufficient information on how they shape the trajectories of mothers’ and fathers’ cognitive functioning decline in multi-child families, owing to the complexity of intergenerational relationships, such as multi-dimensional and ambivalent natures and differences varying across children. Drawing on three waves of data (2014, 2016 and 2018) from a nationally representative survey – the China Longitudinal Ageing Social Survey (N = 9,404) – we used the k-means clustering method to discern patterns of intergenerational relationships in multi-child Chinese families, as well as the growth curve models, to examine the associations between parent–child relationship types and the trajectories of older parents’ cognitive functioning. Five types of intergenerational relationship were identified: alienated, stressfully interacting, independent, beneficially interacting and tight-knit. We then investigated the associations between trajectories of cognitive functioning and the most distant type, the closest type, and the heterogeneity of parent–child relationships across multiple children. The most distant parent–child relationship was significantly related to cognitive functioning trajectories with the alienated (tight-knit) type associated with the lowest (highest) levels of cognitive functioning and the fastest (slowest) cognitive decline. However, the closest parent–child relationship was not significantly related to cognitive functioning trajectories. Moreover, greater variation in relationships with multiple children was correlated with lower levels of cognitive functioning and faster cognitive functioning decline. These associations were stronger among mothers than fathers. This study provides new insights into the potentially protective role of intergenerational relationships in older parents’ cognitive functioning and their gendered differences.

Asymptotic expansions of the maximum likelihood estimator (MLE) and weighted likelihood estimator (WLE) of an examinee’s ability are derived while item parameter estimators are treated as covariates measured with error. The asymptotic formulae present the amount of bias of the ability estimators due to the uncertainty of item parameter estimators. A numerical example is presented to illustrate how to apply the formulae to evaluate the impact of uncertainty about item parameters on ability estimation and the appropriateness of estimating ability using the regular MLE or WLE method.

As a natural clay mineral, halloysite (Hal) possesses a distinctive nanotubular morphology and surface reactivity. Hal calcined at 750°C (Hal750°C; 0.0, 1.0, 2.0, 4.0, 6.0, 8.0 wt.%) was used to replace ground granulated blast furnace slag (GGBFS; 50.0, 49.5, 49.0, 48.0, 47.0, 46.0 wt.%) and fly ash (FA; 50.0, 49.5, 49.0, 48.0, 47.0, 46.0 wt.%) for the preparation of geopolymer in this study. The effects of the replacement ratio of Hal750°C on setting time, compressive strength, flexural strength, chemical composition and microstructure of the geopolymer were investigated. The results indicated that Hal750°C did not significantly alter the setting time. The active SiO2 and Al2O3 generated from Hal750°C participated in the geopolymerization, forming additional geopolymer gel phases (calcium (aluminate) silica hydrate and sodium aluminosilicate hydrate), improving the 28 day compressive strength of the geopolymers. When the amount of Hal750°C was 2.0 wt.%, the 28 day compressive strength of the ternary (GGBFS-FA-Hal750°C-based) geopolymer was 72.9 MPa, 34.8% higher than that of the geopolymer without the addition of Hal750°C. The special nanotubular morphology of residual Hal750°C mainly acted like reinforcing fibres, supplementing the flexural strength of the geopolymer. However, excessive Hal750°C addition (>4.0 wt.%) reduced compressive and flexural strength values due to the low degrees of geopolymerization and the porous microstructure in the ternary geopolymer. These findings demonstrate that the appropriate addition of Hal750°C improved the compressive strength of geopolymers prepared using GGBFS/FA, which provides essential data for future research and supports the utilization of low-value Hal-containing clays in geopolymer preparation.

Natural infection by Trichinella sp. has been reported in humans and more than 150 species of animals, especially carnivorous and omnivorous mammals. Although the presence of Trichinella sp. infection in wild boars (Sus scrofa) has been documented worldwide, limited information is known about Trichinella circulation in farmed wild boars in China. This study intends to investigate the prevalence of Trichinella sp. in farmed wild boars in China. Seven hundred and sixty-one (761) muscle samples from farmed wild boars were collected in Jilin Province of China from 2017 to 2020. The diaphragm muscles were examined by artificial digestion method. The overall prevalence of Trichinella in farmed wild boars was 0.53% [95% confidence interval (CI): 0.51–0.55]. The average parasite loading was 0.076 ± 0.025 larvae per gram (lpg), and the highest burden was 0.21 lpg in a wild boar from Fusong city. Trichinella spiralis was the only species identified by multiplex polymerase chain reaction. The 5S rDNA inter-genic spacer region of Trichinella was amplified and sequenced. The results showed that the obtained sequence (GenBank accession number: OQ725583) shared 100% identity with the T. spiralis HLJ isolate (GenBank accession number: MH289505). Since the consumption of farmed wild boars is expected to increase in the future, these findings highlight the significance of developing exclusive guidelines for the processing of slaughtered farmed wild boar meat in China.

Instability and rupture dynamics of a liquid nano-thread, subjected to external hydrodynamic perturbations, are captured by a stochastic lubrication equation (SLE) incorporating thermal fluctuations via Gaussian white noise. Linear instability analysis of the SLE is conducted to derive the spectra and distribution functions of thermal capillary waves influenced by external perturbations and thermal fluctuations. The SLE is also solved numerically using a second-order finite difference method with a correlated noise model. Both theoretical and numerical solutions, validated through molecular dynamics, indicate that surface tension forces due to specific external perturbations overcome the random effects of thermal fluctuations, determining both the thermal capillary waves and the evolution of perturbation growth. The results also show two distinct regimes: (i) the hydrodynamic regime, where external perturbations dominate, leading to uniform ruptures, and (ii) the thermal-fluctuation regime, where external perturbations are surpassed by thermal fluctuations, resulting in non-uniform ruptures. The transition between these regimes, modelled by a criterion developed from linear instability theory, exhibits a strong dependence on the amplitudes and wavenumbers of the external perturbations.

Halloysite nanotubes (HNTs) have attracted much attention as delivery carriers for various drugs, but the loading of one such drug, quercetin, on HNTs has been investigated only rarely and usually involved cyclic vacuum pumping. The main objective of the present study was to develop a novel carrier system based on HNTs for quercetin delivery without a vacuum process and to investigate the effect of chemical modification of HNTs on the loading and release of quercetin. For this purpose, comparative studies of five chemical modification reagents (sodium lauroamphoacetate, cocoamidopropyl betaine, 1-hydroxyethyl 2-nonyl imidazoline betaine, triethanolamine, and dipicolinic acid) functionalized on HNTs were investigated for quercetin loading and in vitro release. Characterization of raw halloysite, modified halloysite, and quercetin-loaded halloysite were done by X-ray diffraction (XRD), Fourier-transform infrared spectrometry (FTIR), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). The results indicated that chemical modification could improve the interactions between HNTs and quercetin. After chemical modification, quercetin was anchored to both the inner and outer surfaces of HNTs by electrostatic attraction, hydrogen bonding, and van der Waals forces. Sodium lauroamphoacetate-modified HNTs were given the highest loading of 1.96 wt.% among the five reagents. Cocamidopropyl betaine-modified HNTs exhibited the best sustained-release profile with only 29.07% for initial burst release and 480 h of consecutive release. Carboxyl groups of the modification reagent improved the loading capacity of quercetin. Amide groups prolonged drug release due to the strong affinity between amine and phenolic hydroxyl groups of quercetin. The release of quercetin from the cocamidopropyl betaine-modified HNTs fitted a first-order kinetics model well. The present study suggested that cocamidopropyl betaine-modified HNTs offer promise as vehicles for delivery of quercetin and for extending the application of quercetin.

As 1:1 dioctahedral clay minerals, kaolinite and halloysite have similar chemical compositions. However, halloysite often possesses a nanotubular structure and special surface reactivity compared to platy kaolinite. The objective of this current work was to determine the effect of the SiO2/Al2O3 ratio on the microstructure and properties of geopolymers derived from two kinds of kaolin: platy kaolinite and nanotubular halloysite. The chemical structures and compositions of the geopolymers obtained were characterized through X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, and nuclear magnetic resonance (NMR), whereas the microstructural analysis was performed by scanning electron microscopy (SEM), the Brunauer–Emmett–Teller (BET) method, and N2 physisorption analysis. The results indicated that calcined halloysite showed greater geopolymerization reactivity than calcined kaolinite. In addition, the mechanical properties of the clay-based geopolymers depended not only on the SiO2/Al2O3 ratio but also on the morphology of the clay. Crystalline zeolite A and geopolymer were produced after alkali-activation of kaolin with a SiO2/Al2O3 ratio of 2.5; these products possessed porous and heterogeneous microstructures having poor compressive strength. As SiO2/Al2O3 ratios increased to >2.5, geopolymers with compact microstructure and high compressive strength were produced after alkali-activation of kaolin. Notably, at a given condition, halloysite-based geopolymers exhibited greater early compressive strength, more compactness, and more homogeneous microstructure than kaolinite-based geopolymers. This can be attributed to the nanotubular microstructure of halloysite, which can release more Si and Al during alkali activation than platy kaolinite. These results indicated that the various morphologies and microstructures among clays have significant impact on the microstructure and compressive strength of geopolymers.

This paper is devoted to the study of the propagation dynamics of a mutualistic model of mistletoes and birds with nonlocal dispersal. By applying the theory of asymptotic speeds of spread and travelling waves for monotone semiflows, we establish the existence of the asymptotic spreading speed $c^*$, the existence of travelling wavefronts with the wave speed $c\ge c^*$ and the nonexistence of travelling wavefronts with $c\lt c^*$. It turns out that the spreading speed coincides with the minimal wave speed of travelling wavefronts. Moreover, some lower and upper bound estimates of the spreading speed $c^*$ are provided.

Reward processing dysfunctions are considered a candidate mechanism underlying anhedonia and apathy in depression. Neuroimaging studies have documented that neurofunctional alterations in mesocorticolimbic circuits may neurally mediate these dysfunctions. However, common and distinct neurofunctional alterations during motivational and hedonic evaluation of monetary and natural rewards in depression have not been systematically examined. Here, we capitalized on pre-registered neuroimaging meta-analyses to (1) establish general reward-related neural alterations in depression, (2) determine common and distinct alterations during the receipt and anticipation of monetary v. natural rewards, and, (3) characterize the differences on the behavioral, network, and molecular level. The pre-registered meta-analysis (https://osf.io/ay3r9) included 633 depressed patients and 644 healthy controls and revealed generally decreased subgenual anterior cingulate cortex and striatal reactivity toward rewards in depression. Subsequent comparative analyses indicated that monetary rewards led to decreased hedonic reactivity in the right ventral caudate while natural rewards led to decreased reactivity in the bilateral putamen in depressed individuals. These regions exhibited distinguishable profiles on the behavioral, network, and molecular level. Further analyses demonstrated that the right thalamus and left putamen showed decreased activation during the anticipation of monetary reward. The present results indicate that distinguishable neurofunctional alterations may neurally mediate reward-processing alterations in depression, in particular, with respect to monetary and natural rewards. Given that natural rewards prevail in everyday life, our findings suggest that reward-type specific interventions are warranted and challenge the generalizability of experimental tasks employing monetary incentives to capture reward dysregulations in everyday life.

An example of a nonfinitely based involution monoid of order five has recently been discovered. We confirm that this example is, up to isomorphism, the unique smallest among all involution monoids.

Experiments on divergent Richtmyer–Meshkov (RM) instability at a heavy gas layer are performed in a specially designed shock tube. A novel soap-film technique is extended to generate gas layers with controllable thicknesses and shapes. An unperturbed gas layer is first examined and its two interfaces are found to move uniformly at the early stage and be decelerated later. A general one-dimensional theory applicable to an arbitrary-thickness layer is established, which gives a good prediction of the layer motion in divergent geometry. Then, six kinds of perturbed SF$_6$ layers with various thicknesses and shapes surrounded by air are examined. At the early stage, the amplitude growths of the inner interface for various-thickness layers collapse quite well and also can be predicted by the Bell model for cylindrical RM instability at a single interface, which indicates a negligible interface coupling effect. Later, a rarefaction wave accelerates the inner interface, causing a dramatic rise in the growth rate. It is found that a thicker gas layer will result in a larger extent that the rarefaction wave can promote the instability growth. A modified Bell model accounting for both Rayleigh–Taylor (RT) instability and interface stretching caused by a rarefaction wave is established, which well reproduces the quick instability growth. At late stages, reverberating waves inside the layer are negligibly weak such that the inner interface growth is dominated by RM instability and RT stability. The major factors driving the outer interface development are a compression wave and interface coupling. A new interface coupling phenomenon existing uniquely in divergent geometry caused by the gradual thinning of the gas layer is observed and also modelled.

Circulating n-3 PUFA, which integrate endogenous and exogenous n-3 PUFA, can be better used to investigate the relationship between n-3 PUFA and disease. However, studies examining the associations between circulating n-3 PUFA and colorectal cancer (CRC) risk were limited, and the results remained inconclusive. This case–control study aimed to examine the association between serum n-3 PUFA and CRC risk in Chinese population. A total of 680 CRC cases and 680 sex- and age-matched (5-year interval) controls were included. Fatty acids were assayed by GC. OR and 95 % CI were calculated using multivariable logistic regression after adjustment for potential confounders. Higher level of serum α-linolenic acid (ALA), docosapentaenoic acid (DPA), DHA, long-chain n-3 PUFA and total n-3 PUFA were associated with lower odds of CRC. The adjusted OR and 95 % CI were 0·34 (0·24, 0·49, Pfor trend < 0·001) for ALA, 0·57 (0·40, 0·80, Pfor trend < 0·001) for DPA, 0·48 (0·34, 0·68, Pfor trend < 0·001) for DHA, 0·39 (0·27, 0·56, Pfor trend < 0·001) for long-chain n-3 PUFA and 0·31 (0·22, 0·45, Pfor trend < 0·001) for total n-3 PUFA comparing the highest with the lowest quartile. However, there was no statistically significant association between EPA and odds of CRC. Analysis stratified by sex showed that ALA, DHA, long-chain n-3 PUFA and total n-3 PUFA were inversely associated with odds of CRC in both sexes. This study indicated that serum ALA, DPA, DHA, long-chain n-3 PUFA and total n-3 PUFA were inversely associated with odds of having CRC in Chinese population.

We present experimental results of irregular long-crested waves propagating over a submerged trapezoidal bar with the presence of a background current in a wave flume. We investigate the non-equilibrium phenomenon (NEP) induced by significant changes of water depth and mean horizontal flow velocity as wave trains pass over the bar. Using skewness and kurtosis as proxies, we show evidence that an accelerating following current could increase the sea-state non-Gaussianity and enhance both the magnitude and spatial extent of the NEP. We also find that below a ‘saturation relative water depth’ $k_p h_2 \approx 0.5$ ($k_p$ being the peak wavenumber in the shallow area of depth $h_2$), although the NEP manifests, the decrease of the relative water depth does not further enhance the maximum skewness and kurtosis over the bar crest. This work highlights the nonlinear physics according to which a following current could provoke higher freak wave risk in coastal areas where modulation instability plays an insignificant role.

Boundary conditions at a liquid–solid interface are crucial to dynamics of a liquid film coated on a fibre. Here, a theoretical framework based on axisymmetric Stokes equations is developed to explore the influence of liquid–solid slip on the Rayleigh–Plateau instability of a cylindrical film on a fibre. The new model not only shows that the slip-enhanced growth rate of perturbations is overestimated by the classical lubrication model, but also indicates a slip-dependent dominant wavelength, instead of a constant value obtained by the lubrication method, which leads to larger drops formed on a more slippery fibre. The theoretical findings are validated by direct numerical simulations of Navier–Stokes equations via a volume-of-fluid method. Additionally, the slip-dependent dominant wavelengths predicted by our model agree with the experimental results provided by Haefner et al. (Nat. Commun., vol. 6, issue 1, 2015, 7409).