This article tries to construct an ethical framework to address the issue of infertility through a creative use of Thomas Aquinas’ thought. Involuntary childlessness is one of the forgotten issues among Christian communities in West and Central Africa. Starting with the scientific definition of infertility, the article shows the gender differences and biases in the perception of childlessness in that region. Although infertility equally affects men and women, the latter, most of the time, are blamed for it. Although Scripture contains some ambivalent elements concerning infertility, on the whole it offers valuable insights by presenting childlessness as a type of life also blessed by God. Likewise, the language of the church since Vatican II has done away with the hierarchical view of the ends of marriage (or the idea that procreation is the primary goal of marriage over and against the unity of the spouses). Aquinas teaches us about the true nature of marriage and the value of childlessness. In addition, Aquinas’ understanding of love helps articulate areas that could guide infertile individuals and childless couples, on the one hand, and Christian communities, on the other hand, who have to deal with childless members.