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Turning from the pulpit to the courtroom, Chapter 4 demonstrates the centrality of frenzy to what would later come to be termed the ‘insanity defence’. The English common law had its own framework for classifying mental illness, one which ran parallel to the medical nosologies explored in Chapter 1. This chapter explores the different categories of ‘madness’ recognizsed by early modern common lawyers – partial versus total, continual versus intermittent – and shows where frenzy fitted within this framework. It then turns to look at how these theories were mobilized in a specific legal context: coroners’ inquests into unexplained drownings. Where suicide was suspected, it argues, a story about frenzy – told right – offered an escape route for suspects and their families. Crucial, here, was the issue of culpability: frantic persons could not be held accountable for what they did while their wits were impaired. Without the capacity for consent, crime was impossible.
In this chapter I give a preliminary argument against suicide, based on the core argument of the book. Suicide is distinguished from permisible acceptance of death as a side effect of some other permissible action.
Predicting suicide risk remains a challenge. We examined whether neurocognitive performance on implicit associations toward suicide, motor speed, response inhibition, and executive functioning predicts suicide attempt and behavior in high-risk psychiatric patients.
Method
Our sample (N = 298) consisted of inpatients (n = 161) and outpatients (n = 83) admitted for a suicide attempt (SA; n = 78), for suicidal ideation (SI; n = 76), or were non-suicidal psychiatric controls (PC; n = 90), and healthy controls (HC; n = 54). Participants were followed for 12 months, with follow-up assessments at 3-, 6-, and 12-months. Neurocognitive tasks were administered at baseline. Clinical symptom measures, suicidality, and electronic health record data were collected at each timepoint. ANCOVA was used to compare groups on neurocognitive performance, and logistic and Cox regressions examined whether neurocognitive performance predicted future actual suicide attempt and suicidal behaviors.
Results
Participants had a mean age of 24.34 years (SD = 3.71). A total of 19 participants made an actual suicide attempt during the study. On neurocognitive tasks at baseline, the SA group had stronger implicit associations with death- and suicide-related words compared to the HC (d = 0.88, p < 0.001) and SI (d = 0.63, p = 0.005) groups and poorer executive functioning than the SI (d = 0.44, p = 0.043) group in multivariate models. Stronger implicit associations with death/suicide predicted higher risk of suicide attempts at the univariate (HR = 1.68 p = 000), but not multivariate level (HR = 1.17 p = 000), while slower motor speed predicted actual suicide attempts (HR = 1.81 p = 000) at the multivariate level.
Conclusions
Slower motor speed predicts actual suicide attempt and may help identify psychiatric patients who are at high risk for suicidal behavior.
The COVID-19 pandemic has exerted significant mental health impacts worldwide, with a major concern in the literature being its potential effect on suicide rates. Brazil, one of the countries most severely affected by the pandemic, still lacks clear evidence regarding the consequences of the crisis on self-inflicted deaths. This paper aims to estimate the impact of the COVID-19 pandemic on suicide rates in Brazil.
Methods
We employed an interrupted time series design with seasonal adjustments to estimate changes in suicide rates per 100,000 population. The analysis was based on deaths from all forms of self-inflicted injury, as classified by the International Classification of Diseases. We estimated trends for the total population, stratified by sex and administrative region.
Results
Suicide rates increased significantly before the pandemic (β₁ = 0.00148, p < 0.001). No significant change in trend was observed after the onset of the pandemic at the national level (β₃ = 0.00092, p > 0.05). Among men, both the pre-pandemic trend (β₁ = 0.00236, p < 0.001) and the post-pandemic increase (β₃ = 0.00155, p < 0.05) were significant. For women, the pre-pandemic trend was modest (β₁ = 0.00065, p < 0.001), and the post-pandemic slope was not significant (β₃ = 0.00033, p = 0.10). Regionally, the Central-West (β₃ = 0.00217, p < 0.01) and North (β₃ = 0.00186, p < 0.05) experienced significant post-pandemic increases, while the Southeast (β₃ = 0.00087, p > 0.05) and South (β₃ = −0.00034, p > 0.05) showed no significant changes. Seasonal effects revealed consistent mid-year declines across all groups and regions.
Conclusions
The COVID-19 pandemic did not produce a statistically significant shift in national suicide trends but coincided with the persistence of pre-existing upward patterns in specific demographic and regional contexts. These findings underscore the need for targeted and region-specific suicide prevention strategies.
In The Netherlands, it is unknown whether the number of youth suicide-related emergency department visits has changed over time. Also, insight is needed in the hospital costs for managing these patients, as a first step toward the economic evaluation of suicide prevention measures.
Aims
This study examines (a) changes in emergency department-recorded suicide attempts, suicidal ideation and non-suicidal self-injury in youth, including repeat emergency department visits; and (b) related hospital costs for these patients, from a health insurer perspective.
Method
In this cross-sectional study, data from various sources was combined to identify all youth aged ≤27 years visiting a Dutch inner-city emergency department between 2016 and 2023 for a suicide attempt, suicidal ideation or non-suicidal self-injury. Hospital records were reviewed manually to determine inclusion. Ambiguities were discussed within an expert panel and descriptive analyses, Poisson regression and logistic regression analyses were performed. For a subset of 30 patients, invoiced costs were determined.
Results
The number of suicide attempts increased by approximately 5% annually, peaking in 2022 (n = 172); there were significantly more female patients (71%), and the median age was 21 years. Cases of suicidal ideation showed a similar trend, whereas the number of recorded non-suicidal self-injuries reduced. A total of 28.5% of all patients (n = 281) had one or multiple repeat visits for the above reasons. Median suicide attempt-related costs per case were €930, range €385–€33 473.
Conclusions
Since 2016, an increasing number of youth visited the emergency department of a Dutch hospital after a suicide attempt, but this increase does not seem to continue after 2022. Hospital-invoiced costs differ substantially between patients.
Although clinically framed as a public health concern, the meanings of suicide are fundamentally shaped by cultural narratives and visual representations.
Aims
To examine the evolution of sculptural representations of suicide from antiquity to the present, and to interpret these works through psychiatric and sociological lenses relevant to contemporary clinical and public health discourse.
Method
A structured search across PubMed, Scopus and Web of Science (up to August 2025) was integrated with museum archives and art-historical catalogues. Selected sculptural works were analysed as interpretive case studies using iconographic, semiotic and contextual approaches. Interpretation focused on affective and relational processes such as psychological pain (psychache), shame, entrapment and social disconnection prioritising cultural formulation over retrospective diagnostic attribution in historical cases.
Results
Sculptural representations frame suicide through shifting moral and social logics: from honour-bound self-death in antiquity and virtue-coded narratives in the early-modern period to interiority and estrangement in modernity. Contemporary public installations shift this focus towards visibility, urban space and prevention. These works externalise private suffering and structural conditions (e.g. isolation, stigma), actively shaping collective imaginaries of self-destruction.
Conclusions
Sculpture provides a unique medium for the translation of individual suffering and the collective meanings of suicide into public form. An interdisciplinary reading of these works supports culturally informed clinical reflection and contributes to ethically attentive public communication and prevention strategies.
The debate on euthanasia for mental suffering in young people in The Netherlands has become highly polarised, with a novel, apparently epidemiological argument taking centre stage: that psychiatric euthanasia is necessary to prevent suicide. This article evaluates that claim. Using data from 353 young applicants (annual suicide risk 2.9%) and optimistic assumptions (80% sensitivity and specificity), the number needed to treat was 10 and the number needed to harm 9. Thus, ten youths would need to undergo assisted dying to prevent one suicide, and nine would die without a preventive purpose having been served. Empirically and ethically, the prevention argument does not appear to hold; real prevention requires other, previously well-debated factors such as relational continuity, trauma-informed care and social inclusion in response to mental suffering.
This case report presents the case of a 25-year-old woman who developed ketamine addiction following a single sub-anaesthetic dose of intranasal ketamine in a pilot study investigating intranasal racemic ketamine for acute suicidality. She had a history of depression, obsessive–compulsive disorder, autism spectrum disorder and anorexia nervosa, and she had sporadically used alcohol and cannabis. Following the intervention, she reported a transient reduction in suicidal ideation but later sought illicit ketamine to recreate its calming effects on intrusive thoughts. Subsequently she also started abusing cocaine and 3-methylmethcathinone (3-MMC). Within weeks she had escalated to daily use, which led to financial distress, housing instability and a suicide attempt when access was cut off. Although she initially ceased use, she later relapsed into ketamine and cocaine addiction. This case highlights the addictive risk of ketamine, even in controlled settings. Given ketamine’s rising use in psychiatric treatment, careful screening, monitoring and awareness of addiction potential are essential. Future research should evaluate patient-specific risk factors and dosing strategies to minimise abuse liability.
C-reactive protein (CRP) has been studied in relation to bipolar disorder (BD) and suicidality independently. Although suicide risk is elevated in youth with BD, little is known about the association of CRP with suicidality in this population.
Methods
211 youth participated, including 23 BD with lifetime suicide attempts (BDSA), 45 BD with lifetime non-suicidal self-injury (NSSI; BDNSSI), 39 BD without lifetime suicide attempt or NSSI (BDNo-SA/NSSI), and 104 healthy controls (HC). Suicide attempts and NSSI were assessed systematically. Fasting blood samples yielded CRP levels. Primary analyses controlled for age, sex, and body mass index percentile.
Results
CRP levels differed across groups (F3,204 = 3.40, p = 0.02, ηp2 = 0.05). In post hoc analyses, CRP levels were significantly higher among BDSA (3.44 ± 6.42 mg/L) vs HC (0.81 ± 0.90 mg/L; p < 0.01) and BDNo-SA/NSSI (1.42 ± 3.31 mg/L; p = 0.01) groups; however, no difference was seen with the BDNSSI group (1.83 ± 2.22 mg/L; p = 0.12). Between-group differences in CRP levels persisted in independent sensitivity analyses controlling for current mood symptoms, lifetime mania score, lifetime smoking, and medications, but not with lifetime depression score.
Conclusions
Suicide attempts among youth with BD are associated with elevated CRP. Given accessibility of CRP testing, the present findings have potential clinical implications. Larger, longitudinal studies with repeated measures are needed to examine time-varying associations between CRP and suicide risk among youth with BD.
Edited by
Liz McDonald, East London NHS Foundation Trust,Roch Cantwell, Perinatal Mental Health Service and West of Scotland Mother & Baby Unit,Ian Jones, Cardiff University
Suicide remains a leading cause of maternal death in the UK and in other high-income countries. While there are clear risks in severe mental disorder, those who die have experienced a range of mental illnesses and often come from more deprived communities. The Confidential Enquiries highlight the distinctive patterns of occurrence and progression in perinatal mental illness and the need for improvements in clinical evaluation of risk, effective risk management and the availability of high-quality perinatal mental healthcare as important factors in helping reduce progression to suicide.
Everyone recognizes that it is, in general, wrong to intentionally kill a human being. But are there exceptions to that rule? In Killing and Christian Ethics, Christopher Tollefsen argues that there are no exceptions: the rule is absolute. The absolute view on killing that he defends has important implications for bioethical issues at the beginning and end of life, such as abortion and euthanasia. It has equally important implications for the morality of capital punishment and the morality of killing in war. Tollefsen argues that a lethal act is morally permissible only when it is an unintended side effect of one's action. In this way, some lethal acts of force, such as personal self-defense, or defense of a polity in a defensive war, may be justified -- but only if they involve no intension of causing death. Even God, Tollefsen argues, neither intends death, nor commands the intentional taking of life.
Interpersonal violence is a known risk factor for suicide, but its impact across racial and ethnic groups, particularly among Black and Indigenous youth, remains underexplored.
Methods
We conducted a nationwide longitudinal study involving 9,788,264 individuals aged 10–29 years who were enrolled in the 100 Million Brazilian Cohort and linked to Notifiable Diseases Information System (SINAN), National Hospital Information System (SIH) and Mortality Information System (SIM) (2011–2018). Exposure was any recorded interpersonal violence; the outcome was suicide (ICD-10 X60–X84). Cox models adjusted for demographic, socioeconomic, household factors, prior psychiatric hospitalization, and self-harm. Analyses were stratified by race.
Findings
During follow-up, 92,287 (0·94%) individuals had a record of interpersonal violence, and 1,657 suicides were identified. Exposure to violence was associated with a higher risk of suicide (HR 2·92; 95% CI 2·06–4·15). Associations were strongest among Indigenous youth (HR 10.61; 95% CI 4.34–25.94), followed by Black youth (HR 3.14; 95% CI 1.92–5.14). No significant association was observed among White youth.
Interpretation
Interpersonal violence is a major risk factor for youth suicide in Brazil, disproportionately affecting Indigenous and Black populations. Addressing systemic racism and structural inequalities is essential for equitable suicide prevention.
Suicidal ideation and trauma exposure are significant health challenges worldwide, and their interaction increases their burden on individuals and communities. However, limited research has been devoted to these conditions in low- and middle-income countries, where the majority of the burden of these disorders exists. Additionally, unique cultural factors that may contribute to differential relationships in these symptoms and disorders make this an important area to explore. This study examines relationships between the number and types of adverse exposures, PTSD symptoms and severity, depression and suicidal ideation in a sample of Cambodian women with experiences of trauma using logistic and linear regressions. Overall, PTSD severity significantly contributes to suicidal ideation, with hyperarousal symptoms playing a particularly influential role in this association. Further, adverse experiences, including physical abuse and parental mental health problems, contributed significantly to increased suicidal ideation. Lastly, depression severity partially mediates the relationship between PTSD severity and suicidal ideation. These results illustrate the significant role of PTSD in the experience of suicidal ideation, particularly within regions like Cambodia with high trauma loads. These findings point to psychological constructs that may be especially important to include in suicidality screening tools and to target within prevention and intervention efforts.
Emergency department mental health practitioners (MHPs) decide onward care for individuals presenting with self-harm or suicidal ideation. However, their experiences and practices in making these decisions remain underexplored.
Aims
To synthesise research on MHPs’ experiences and practices in making decisions about onward care for patients presenting to emergency departments with self-harm or suicidal ideation.
Method
We searched six databases (inception to July 2024) for empirical studies of MHPs making care decisions for self-harm or suicidal patients in emergency departments. We used a segregated mixed-methods design, applying narrative synthesis of quantitative data and thematic synthesis of qualitative data.
Results
Eleven studies were included (one quantitative, one mixed-methods, nine qualitative). Narrative synthesis of quantitative data produced two themes: (a) subjective decision-making and variability among MHPs and (b) impact of the institutional mandate to discharge within 4 h on referral outcomes. Thematic synthesis of qualitative data generated five themes: (a) risk-centric culture is anti-therapeutic and shapes defensive practice, scepticism toward patients and burnout; (b) time and environmental pressures impact therapeutic potential of assessments; (c) ‘battling’ to access services: gatekeeping, cycles of repeat attendances affecting patient safety and staff moral injury; (d) strategies to facilitate access and extending care to overcome challenges in the emergency department and (e) potential for training to counter negative attitudes and stereotypes.
Conclusions
Intersecting institutional, systemic and emotional pressures shape MHPs’ practices, undermining assessment quality and access to care. System-level reforms and training should promote relational, compassionate care. Limited quantitative evidence restricted integration, and the review reflects high-income Western settings.
Proposed assisted dying legislation does not adequately consider comorbid mental illness, such as depression, which variably compromises decision-making capacity. Current tests of capacity are limited in their ability to assess any such compromise, and therefore we highlight these concerns and put forward suggestions as to how this may be rectified.
The role of Law enforcement agencies (LEA) is significant in suicide prevention efforts as first responders. Nevertheless, no published study to date has systematically compiled the body of knowledge about suicide prevention efforts involving LEA. The current scoping review aims to methodically map and examine the peer-reviewed literature and grey literature on the role of LEA in suicide prevention. Electronic searches of the databases like Medline, PsycINFO, Google Scholar, Web of Science, Scopus, CINAHL and Google were conducted using a comprehensive search strategy to identify relevant resources. Grey literature was searched searches were undertaken on relevant databases and, as well as government and organisational websites. The reporting of the review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines. The inclusion criteria comprised research articles, reports, and guidelines/policy documents on the role of law enforcement agencies (LEAs) in suicide prevention. Studies on prevalence, custodial settings, non-English publications, and reviews were excluded. Inclusion criteria comprised research articles, reports and guidelines/policy documents focusing on law enforcement’s role in suicide prevention. Studies focusing solely on prevalence or epidemiology, studies confined strictly to custodial settings, publications not in English and systematic reviews or meta-analyses were excluded. Out of 3,327 records screened, the full texts of 82 resources were included in the review. All the resources identified were categorised between peer-reviewed literature and grey literature. Resources were thematically categorised based on functional roles into- I. Strategic and System-Embedded Roles of LEA, II. Capacity Building and Training Oriented Engagements, III. Surveillance Reporting and Data Systems Role, IV. Community Facing and Preventive Engagement, and V. Means Restriction and Environmental Prevention Roles. The chronological development of the resources was inconsistent. Most resources were from high-income countries, focusing on the evaluation of training, capacity building programmes, surveillance initiatives and the exploration of varied roles of LEA across custodial, community and crisis settings and other interdisciplinary collaborations. Notably, the resources show increased disparity in quantity and research methodological approaches across geographies. The review highlights substantial heterogeneity and a limited resource base from low- and middle-income countries on the role of LEA in suicide prevention, with a dearth of structured, evidence-based, scalable models in these settings. These gaps point to an urgent need for locally relevant and cross-sectoral models that position law enforcement as integral partners in suicide prevention efforts, especially where these agencies play a major role as first responders.
This chapter considers how self-harm, suicide, and views of the afterlife reveal the radical shift between Greco-Roman tradition and Christianity with regard to the self. Classical Greek language uses the same auto- compound words to indicate self-willed action, suicide and kin-murder. From Homer through to Roman ideals of masculinity, significant action is generally understood with regard to the possibility of lasting fame, not with regard to a punishment or reward in an afterlife. In contrast to this picture, Christianity insists that each action is evaluated after death and contributes either to punishment or reward in an afterlife: life is a preparation for the afterlife. In particular, and in contrast to the earlier tradition, suicide becomes now a morally reprehensible act. For the faithful, however, martyrs become a model of willing death, which must be kept separate from suicide in evaluation. Ascetics enact a bodily self-harm to perfect their own holiness: physical self-harm becomes a positive gesture of self-fulfilment, dependent on the promise of a life after death. The Western model of the self is deeply influenced by this Christian modelling – and yet neither self-harm nor death play any role in Charles Taylor’s discussions of the history of the self
Intimate partner violence (IPV) victimization is associated with suicidal behaviour. Suicidal behaviour may also be raised among those who perpetrate IPV compared to those who do not; general population-based evidence is, however, lacking. We aimed to investigate the associations between using violence against an intimate partner with suicidal thoughts, suicide attempt and non-suicidal self-harm in the past year.
Methods
We analysed data from the 2014 Adult Psychiatric Morbidity Survey. Logistic regressions estimated associations between IPV perpetration and suicide attempt, suicidal ideation, and self-harm. Associations were estimated for men and women separately, and we explored interaction in estimates by IPV victimization.
Results
After adjustment for demographic and socioeconomic covariates, lifetime IPV perpetration was strongly associated with past-year suicide attempt (men: odds ratio [OR] 3.6, 95% confidence interval 1.0–13.2, women: OR 4.2, 1.9–9.4), suicidal ideation (men: OR 2.7, 1.5–4.9, women: OR 2.6, 1.7–4.1) and self-harm (men: OR 4.9, 1.5–15.2, women: OR 3.3, 1.8–6.0). Estimates were substantially attenuated with adjustment for non-IPV life adversities, hazardous alcohol use, drug use and IPV victimization. Only the association with lifetime suicide attempt in women remained significant (OR 1.6, 1.1–2.3). Estimates were generally higher among those who had not experienced IPV victimization, although we found no evidence for interaction by IPV victimization on the association between IPV perpetration and suicidal behaviour.
Conclusions
There were greater odds of suicidality and self-harm among self-reported perpetrators of IPV compared to the general population. Many of these associations were accounted for by non-IPV life adversities, IPV victimization and substance use. Improving the identification and management of IPV perpetration, and developing targeted safety planning and interventions for this group could reduce suicide for perpetrators and victims of IPV.