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GANEing traction: The broad applicability of NE hotspots to diverse cognitive and arousal phenomena

Published online by Cambridge University Press:  05 January 2017

Mara Mather
Davis School of Gerontology, University of Southern California, Los Angeles, CA
David Clewett
Neuroscience Graduate Program, University of Southern California, Los Angeles, CA 90089-2520clewett@usc.edu
Michiko Sakaki
School of Psychology and Clinical Language Sciences, University of Reading, Reading RGX 7BE, United
Carolyn W. Harley
Professor Emeritus, Memorial University of Newfoundland, St. John's, NL A1C 5S7, Canadacharley@play.psych.mun.ca


The GANE (glutamate amplifies noradrenergic effects) model proposes that local glutamate–norepinephrine interactions enable “winner-take-more” effects in perception and memory under arousal. A diverse range of commentaries addressed both the nature of this “hotspot” feedback mechanism and its implications in a variety of psychological domains, inspiring exciting avenues for future research.

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Copyright © Cambridge University Press 2016 

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