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Why replication has more scientific value than original discovery

  • John P. A. Ioannidis (a1)

Abstract

The presumed dominance of “original discovery” over replication is an anomaly. Original discovery has more value than replication primarily when scientific investigation can immediately generate numerous discoveries most of which are true and accurate. This scenario is uncommon. A model shows how original discovery claims typically have small or even negative value. Science becomes worthy mostly because of replication.

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